Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P47298

- CDD_MYCGE

UniProt

P47298 - CDD_MYCGE

Protein

Cytidine deaminase

Gene

cdd

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

    Catalytic activityi

    Cytidine + H2O = uridine + NH3.
    2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Zinc; catalyticBy similarity
    Active sitei56 – 561Proton donorBy similarity
    Metal bindingi88 – 881Zinc; catalyticBy similarity
    Metal bindingi91 – 911Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. cytidine deaminase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-52-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Short name:
    CDA
    Alternative name(s):
    Cytidine aminohydrolase
    Gene namesi
    Name:cdd
    Ordered Locus Names:MG052
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 130130Cytidine deaminasePRO_0000171679Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi243273.MG_052.

    Structurei

    3D structure databases

    ProteinModelPortaliP47298.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 10399CMP/dCMP deaminase zinc-bindingAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni43 – 453Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    KOiK01489.
    OMAiCIPCAIC.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47298-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVNLEWIIK QLQMIVKRAY TPFSNFKVAC MIIANNQTFF GVNIENSSFP    50
    VTLCAERSAI ASMVTSGHRK IDYVFVYFNT KNKSNSPCGM CRQNLLEFSH 100
    QKTKLFCIDN DSSYKQFSID ELLMNGFKKS 130
    Length:130
    Mass (Da):14,974
    Last modified:February 1, 1996 - v1
    Checksum:i1DF02B1718F9495F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71268.1.
    U02108 Genomic DNA. Translation: AAD12378.1.
    PIRiG64205.
    RefSeqiNP_072712.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71268; AAC71268; MG_052.
    GeneIDi875728.
    KEGGimge:MG_052.
    PATRICi20009484. VBIMycGen98045_0052.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71268.1 .
    U02108 Genomic DNA. Translation: AAD12378.1 .
    PIRi G64205.
    RefSeqi NP_072712.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71268 ; AAC71268 ; MG_052 .
    GeneIDi 875728.
    KEGGi mge:MG_052.
    PATRICi 20009484. VBIMycGen98045_0052.

    Phylogenomic databases

    eggNOGi COG0295.
    KOi K01489.
    OMAi CIPCAIC.
    OrthoDBi EOG6XDH25.

    Enzyme and pathway databases

    BioCyci MGEN243273:GH2R-52-MONOMER.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 108-130.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiCDD_MYCGE
    AccessioniPrimary (citable) accession number: P47298
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3