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P47298 (CDD_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytidine deaminase

Short name=CDA
EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Gene names
Name:cdd
Ordered Locus Names:MG052
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.

Catalytic activity

Cytidine + H2O = uridine + NH3.

2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactor

Binds 1 zinc ion By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncytidine deaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 130130Cytidine deaminase
PRO_0000171679

Regions

Domain5 – 10399CMP/dCMP deaminase zinc-binding
Region43 – 453Substrate binding By similarity

Sites

Active site561Proton donor By similarity
Metal binding541Zinc; catalytic By similarity
Metal binding881Zinc; catalytic By similarity
Metal binding911Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
P47298 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 1DF02B1718F9495F

FASTA13014,974
        10         20         30         40         50         60 
MKVNLEWIIK QLQMIVKRAY TPFSNFKVAC MIIANNQTFF GVNIENSSFP VTLCAERSAI 

        70         80         90        100        110        120 
ASMVTSGHRK IDYVFVYFNT KNKSNSPCGM CRQNLLEFSH QKTKLFCIDN DSSYKQFSID 

       130 
ELLMNGFKKS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71268.1.
U02108 Genomic DNA. Translation: AAD12378.1.
PIRG64205.
RefSeqNP_072712.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_052.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71268; AAC71268; MG_052.
GeneID875728.
KEGGmge:MG_052.
PATRIC20009484. VBIMycGen98045_0052.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
KOK01489.
OMACIPCAIC.
OrthoDBEOG6XDH25.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-52-MONOMER.

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMSSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_MYCGE
AccessionPrimary (citable) accession number: P47298
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names