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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-52-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:deoA
Ordered Locus Names:MG051
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000590781 – 421Thymidine phosphorylaseAdd BLAST421

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243273.MgenG_010200001130

Structurei

3D structure databases

ProteinModelPortaliP47297
SMRiP47297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CMW Bacteria
COG0213 LUCA
KOiK00758
OMAiVHSIGGV
OrthoDBiPOG091H02BC

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02644 Y_phosphoryl, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

P47297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIINLINKK QRGKALNLAE INWFVNAVLN KTIADYQITA FLMAIWFKGM
60 70 80 90 100
NPNELFLLTK AMVDTGEIIK FNHHGKISVD KHSTGGIGDK VSLALVPILT
110 120 130 140 150
SLGFSVAKLS GRGLGYTGGT IDKLEAVGVK TELTDQQAQA CLDKNDCFII
160 170 180 190 200
GQSKDIAPVD KVLYGLRDIT GTVDSLPLIA SSIMSKKLAV MNEYIFIDLK
210 220 230 240 250
YGKGAFCKTK KIANELAKLM QSIAKSFKRK LSVKLSDMNQ VLGKAVGNVI
260 270 280 290 300
EVNEAVNFLK QDLDQVGQDF IDLMQTIVIN ILLETKQAKT KQKAIELYQD
310 320 330 340 350
VLTSKKAWNR FLSFIESQGG NVELFTQKEG FFKPKYKASI KAEKSGILHF
360 370 380 390 400
TDPIDLAKIG INLGAGRMKK TDQIDPMAGL FLMKKDNESV AVGDTVLNLY
410 420
SSSPISNEYI SAAQKTIIIN K
Length:421
Mass (Da):46,355
Last modified:February 1, 1996 - v1
Checksum:i649CD517CD6E5E62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti392V → I in AAD12476 (PubMed:8253680).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71267.1
U02191 Genomic DNA Translation: AAD12476.1
PIRiF64205
RefSeqiWP_009885713.1, NZ_AAGX01000003.1

Genome annotation databases

EnsemblBacteriaiAAC71267; AAC71267; MG_051
KEGGimge:MG_051

Similar proteinsi

Entry informationi

Entry nameiTYPH_MYCGE
AccessioniPrimary (citable) accession number: P47297
Secondary accession number(s): Q49312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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