Reviewed, UniProtKB/Swiss-Prot P47297 (TYPH_MYCGE)

Names and origin

Protein names

Recommended name:
    Thymidine phosphorylase
    EC=2.4.2.4
Alternative name(s):
    TdRPase

Gene names

Name:	deoA
Ordered Locus Names:	MG051

Organism

Mycoplasma genitalium [Complete proteome] [HAMAP]

Taxonomic identifier

2097 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	thymidine phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Thymidine phosphorylase		PRO_0000059078
Experimental info
	Sequence conflict	392	1	V → I in AAD12476. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P47297-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 649CD517CD6E5E62	FASTA	421	46,355
	10 20 30 40 50 60 MNIINLINKK QRGKALNLAE INWFVNAVLN KTIADYQITA FLMAIWFKGM NPNELFLLTK 70 80 90 100 110 120 AMVDTGEIIK FNHHGKISVD KHSTGGIGDK VSLALVPILT SLGFSVAKLS GRGLGYTGGT 130 140 150 160 170 180 IDKLEAVGVK TELTDQQAQA CLDKNDCFII GQSKDIAPVD KVLYGLRDIT GTVDSLPLIA 190 200 210 220 230 240 SSIMSKKLAV MNEYIFIDLK YGKGAFCKTK KIANELAKLM QSIAKSFKRK LSVKLSDMNQ 250 260 270 280 290 300 VLGKAVGNVI EVNEAVNFLK QDLDQVGQDF IDLMQTIVIN ILLETKQAKT KQKAIELYQD 310 320 330 340 350 360 VLTSKKAWNR FLSFIESQGG NVELFTQKEG FFKPKYKASI KAEKSGILHF TDPIDLAKIG 370 380 390 400 410 420 INLGAGRMKK TDQIDPMAGL FLMKKDNESV AVGDTVLNLY SSSPISNEYI SAAQKTIIIN K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed: 8253680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 388-421. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43967 Genomic DNA. Translation: AAC71267.1. U02191 Genomic DNA. Translation: AAD12476.1.
PIR	F64205.
RefSeq	NP_072711.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	875553.
GenomeReviews	Gene locus MG051 in contig L43967_GR.
KEGG	mge:MG_051.
TIGR	MG051.
Phylogenomic databases
HOGENOM	P47297.
OMA	ILLRGMD
Enzyme and pathway databases
BioCyc	MGEN243273:MG_051-MON.
BRENDA	2.4.2.4. 110.
Family and domain databases
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1030.10. Glyco_trans_3. 1 hit.
PANTHER	PTHR10515. Pyrmidine_PPase. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
TIGRFAMs	TIGR02644. Y_phosphoryl. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_MYCGE

Accession

Primary (citable) accession number: P47297
Secondary accession number(s): Q49312

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 24, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)