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P47297 (TYPH_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:MG051
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Thymidine phosphorylase
PRO_0000059078

Experimental info

Sequence conflict3921V → I in AAD12476. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47297 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 649CD517CD6E5E62

FASTA42146,355
        10         20         30         40         50         60 
MNIINLINKK QRGKALNLAE INWFVNAVLN KTIADYQITA FLMAIWFKGM NPNELFLLTK 

        70         80         90        100        110        120 
AMVDTGEIIK FNHHGKISVD KHSTGGIGDK VSLALVPILT SLGFSVAKLS GRGLGYTGGT 

       130        140        150        160        170        180 
IDKLEAVGVK TELTDQQAQA CLDKNDCFII GQSKDIAPVD KVLYGLRDIT GTVDSLPLIA 

       190        200        210        220        230        240 
SSIMSKKLAV MNEYIFIDLK YGKGAFCKTK KIANELAKLM QSIAKSFKRK LSVKLSDMNQ 

       250        260        270        280        290        300 
VLGKAVGNVI EVNEAVNFLK QDLDQVGQDF IDLMQTIVIN ILLETKQAKT KQKAIELYQD 

       310        320        330        340        350        360 
VLTSKKAWNR FLSFIESQGG NVELFTQKEG FFKPKYKASI KAEKSGILHF TDPIDLAKIG 

       370        380        390        400        410        420 
INLGAGRMKK TDQIDPMAGL FLMKKDNESV AVGDTVLNLY SSSPISNEYI SAAQKTIIIN 


K 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71267.1.
U02191 Genomic DNA. Translation: AAD12476.1.
PIRF64205.
RefSeqNP_072711.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_051.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71267; AAC71267; MG_051.
GeneID875553.
KEGGmge:MG_051.
PATRIC20009482. VBIMycGen98045_0051.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
KOK00758.
OMANDCFIIG.
OrthoDBEOG61ZTGG.
ProtClustDBPRK05820.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-51-MONOMER.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_MYCGE
AccessionPrimary (citable) accession number: P47297
Secondary accession number(s): Q49312
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 13, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names