P47297 (TYPH_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Name:	deoA
Ordered Locus Names:	MG051

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro pyrimidine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Thymidine phosphorylase		PRO_0000059078
Experimental info
	Sequence conflict	392	1	V → I in AAD12476. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P47297 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 649CD517CD6E5E62	FASTA	421	46,355
	10 20 30 40 50 60 MNIINLINKK QRGKALNLAE INWFVNAVLN KTIADYQITA FLMAIWFKGM NPNELFLLTK 70 80 90 100 110 120 AMVDTGEIIK FNHHGKISVD KHSTGGIGDK VSLALVPILT SLGFSVAKLS GRGLGYTGGT 130 140 150 160 170 180 IDKLEAVGVK TELTDQQAQA CLDKNDCFII GQSKDIAPVD KVLYGLRDIT GTVDSLPLIA 190 200 210 220 230 240 SSIMSKKLAV MNEYIFIDLK YGKGAFCKTK KIANELAKLM QSIAKSFKRK LSVKLSDMNQ 250 260 270 280 290 300 VLGKAVGNVI EVNEAVNFLK QDLDQVGQDF IDLMQTIVIN ILLETKQAKT KQKAIELYQD 310 320 330 340 350 360 VLTSKKAWNR FLSFIESQGG NVELFTQKEG FFKPKYKASI KAEKSGILHF TDPIDLAKIG 370 380 390 400 410 420 INLGAGRMKK TDQIDPMAGL FLMKKDNESV AVGDTVLNLY SSSPISNEYI SAAQKTIIIN K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 388-421. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71267.1. U02191 Genomic DNA. Translation: AAD12476.1.
PIR	F64205.
RefSeq	NP_072711.1. NC_000908.2.
3D structure databases
ProteinModelPortal	P47297.
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_051.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71267; AAC71267; MG_051.
GeneID	875553.
KEGG	mge:MG_051.
PATRIC	20009482. VBIMycGen98045_0051.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
KO	K00758.
OMA	VARETHV.
ProtClustDB	PRK05820.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-90-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02644. Y_phosphoryl. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_MYCGE

Accession

Primary (citable) accession number: P47297
Secondary accession number(s): Q49312

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program