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P47281 (SYH_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase
EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:MG035
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127

Subunit structure

Homodimer By similarity. HAMAP MF_00127

Subcellular location

Cytoplasm HAMAP MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Histidine--tRNA ligase HAMAP MF_00127
PRO_0000136198

Sequences

Sequence LengthMass (Da)Tools
P47281 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 9419FD5BDB12110A

FASTA41448,324
        10         20         30         40         50         60 
MNFLQKPRGV KDWFGDELVY FNWIVKKIRS LAFNWGFSEV KTPLFENAQL FQRSNANADI 

        70         80         90        100        110        120 
VQKELYQFFD KSQRELALRP EATTPIVRLA CENKLMQEAN FPLKLFCIGS MYRYERPQNN 

       130        140        150        160        170        180 
RFREHWQFSC EVFGFSNLFI FLDTLLFANS LLEALGITGY VLKINNLANF ETLSKWNKAL 

       190        200        210        220        230        240 
KDYLTPYKLE LTELSQKRLE KNPLRILDDK IDQKKSFVKN APKITDFLDA SAKQDSELLK 

       250        260        270        280        290        300 
TQLKKHNISF EWTDNLVRGL DYYTGFVFEY VKNQDTILAG GVYDNLVEEL SSNPTPALGF 

       310        320        330        340        350        360 
ACGIERLINC LEIDKKAFIL NTKPKQMLVI CLFEEALEEL VWLAKLWREY NQVTIYPKVI 

       370        380        390        400        410 
KVDNGIRLAN RLGYTFIGIV GKTDFDKKAI TIKNLVSKQQ TIYTWNELGE RNVF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L43967 Genomic DNA. Translation: AAC71251.1.
PIRH64203.
RefSeqNP_072695.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47281.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID875525.
GenomeReviewsGene locus MG035 in contig L43967_GR.
KEGGmge:MG_035.
PATRIC20009446. VBIMycGen98045_0033.
TIGRMG035.

Phylogenomic databases

HOGENOMHBG616575.
OMAVFEWVTT.
PhylomeDBP47281.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycMGEN243273:MG_035-MONOMER.
BRENDA6.1.1.21. 3528.

Family and domain databases

HAMAPMF_00127. His_tRNA_synth.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-synth_IIa_subgr.
IPR004516. His-tRNA_synth_IIA.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
KOK01892.
PANTHERPTHR11476. His-tRNA_synth. 1 hit.
PfamPF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. Anticodon_bd. 1 hit.
TIGRFAMsTIGR00442. HisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_MYCGE
AccessionPrimary (citable) accession number: P47281
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

SIMILARITY comments

Index of protein domains and families

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