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P47280 (KITH_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:MG034
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Thymidine kinase HAMAP-Rule MF_00124
PRO_0000174994

Regions

Nucleotide binding20 – 278ATP By similarity
Nucleotide binding93 – 964ATP By similarity

Sites

Active site941Proton acceptor Potential
Metal binding1501Zinc By similarity
Metal binding1531Zinc By similarity
Metal binding1851Zinc By similarity
Metal binding1881Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P47280 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 08E9C93CE4556326

FASTA21324,101
        10         20         30         40         50         60 
MGKYQPSFQT KKGWTEVICG PMFSGKTEKL LHKIKRWKIA KISVVIFKPI IDTRQTNIVK 

        70         80         90        100        110        120 
SRNGEYDQAI TINSPFEIYD HLVDKNYQIV AIDEAQFFSN EIIEVVTTLN EIGTNVIISG 

       130        140        150        160        170        180 
LDTDFRAEPF GCIPQLLAIA DVVNKLDAIC NVCGSLAQRT QRLVNKNTND NLVLIGDAEA 

       190        200        210 
YEARCKLHHS FLTKKHVTVK TKNFKEQVQG KTQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71250.1.
PIRG64203.
RefSeqNP_072694.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47280.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71250; AAC71250; MG_034.
GeneID875417.
KEGGmge:MG_034.
PATRIC20009444. VBIMycGen98045_0032.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
KOK00857.
OMADHISEST.
OrthoDBEOG69D3J2.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-34-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_MYCGE
AccessionPrimary (citable) accession number: P47280
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names