Reviewed, UniProtKB/Swiss-Prot P47280 (KITH_MYCGE)

Names and origin

Protein names

Recommended name:
    Thymidine kinase
    EC=2.7.1.21

Gene names

Name:	tdk
Ordered Locus Names:	MG034

Organism

Mycoplasma genitalium [Complete proteome] [HAMAP]

Taxonomic identifier

2097 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Thymidine kinase HAMAP MF_00124		PRO_0000174994
Regions
	Nucleotide binding	20 – 27	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47280-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 08E9C93CE4556326	FASTA	213	24,101
	10 20 30 40 50 60 MGKYQPSFQT KKGWTEVICG PMFSGKTEKL LHKIKRWKIA KISVVIFKPI IDTRQTNIVK 70 80 90 100 110 120 SRNGEYDQAI TINSPFEIYD HLVDKNYQIV AIDEAQFFSN EIIEVVTTLN EIGTNVIISG 130 140 150 160 170 180 LDTDFRAEPF GCIPQLLAIA DVVNKLDAIC NVCGSLAQRT QRLVNKNTND NLVLIGDAEA 190 200 210 YEARCKLHHS FLTKKHVTVK TKNFKEQVQG KTQ

References

[1]

"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43967 Genomic DNA. Translation: AAC71250.1.
PIR	G64203.
RefSeq	NP_072694.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	875417.
GenomeReviews	Gene locus MG034 in contig L43967_GR.
KEGG	mge:MG_034.
TIGR	MG034.
Phylogenomic databases
HOGENOM	P47280.
OMA	FLENTVN
Enzyme and pathway databases
BioCyc	MGEN243273:MG_034-MON.
BRENDA	2.7.1.21. 110.
Family and domain databases
HAMAP	MF_00124. [Tree]
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. TK_cell. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_MYCGE

Accession

Primary (citable) accession number: P47280

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)