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Protein

Probable glycerol uptake facilitator protein

Gene

glpF

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGlycerol metabolism, Transport

Enzyme and pathway databases

BioCyciMGEN243273:G1GJ2-33-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol uptake facilitator protein
Gene namesi
Name:glpF
Ordered Locus Names:MG033
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000807 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640871 – 258Probable glycerol uptake facilitator proteinAdd BLAST258

Proteomic databases

PRIDEiP47279

Interactioni

Protein-protein interaction databases

STRINGi243273.MgenG_010200000990

Structurei

3D structure databases

ProteinModelPortaliP47279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 79NPA 13
Motifi206 – 208NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107R3W Bacteria
COG0580 LUCA
KOiK02440
OMAiQVVATMF
OrthoDBiPOG091H00B1

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR000425 MIP
IPR022357 MIP_CS
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

P47279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFQNSTQLG WWFLAELIGT FILIIFGNGA VAQVNLKKMA TSETKAKFLT
60 70 80 90 100
VALTWGIGVL FGVLTANAIF KGSGHLNPAI SLFYAINGSI KSPTALIWPG
110 120 130 140 150
FVIGILAQFL GAMIAQTTLN FLFWKQLSST DPQTVLAMHC TSPSVFNITR
160 170 180 190 200
NFLTEFIATL ILIGGVVAAS HFLHNNPNSV PPGFMGLWLV AGIIIAFGGA
210 220 230 240 250
TGSAINPARD LGTRIVFQLT PIKNKDANWK YSWIPVIAPL SAGLVLSIII

GFSPAPVL
Length:258
Mass (Da):27,667
Last modified:November 1, 1997 - v2
Checksum:i238DBE6ABA4E1438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA Translation: AAC71249.1
RefSeqiWP_009885697.1, NZ_AAGX01000003.1

Genome annotation databases

EnsemblBacteriaiAAC71249; AAC71249; MG_033
KEGGimge:MG_033

Similar proteinsi

Entry informationi

Entry nameiGLPF_MYCGE
AccessioniPrimary (citable) accession number: P47279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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