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Protein

Probable glycerol uptake facilitator protein

Gene

glpF

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. glycerol metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Glycerol metabolism, Transport

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-33-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol uptake facilitator protein
Gene namesi
Name:glpF
Ordered Locus Names:MG033
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Probable glycerol uptake facilitator proteinPRO_0000064087Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_033.

Structurei

3D structure databases

ProteinModelPortaliP47279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi77 – 793NPA 1
Motifi206 – 2083NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
KOiK02440.
OMAiRYLIAKN.
OrthoDBiEOG6P8TRZ.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFQNSTQLG WWFLAELIGT FILIIFGNGA VAQVNLKKMA TSETKAKFLT
60 70 80 90 100
VALTWGIGVL FGVLTANAIF KGSGHLNPAI SLFYAINGSI KSPTALIWPG
110 120 130 140 150
FVIGILAQFL GAMIAQTTLN FLFWKQLSST DPQTVLAMHC TSPSVFNITR
160 170 180 190 200
NFLTEFIATL ILIGGVVAAS HFLHNNPNSV PPGFMGLWLV AGIIIAFGGA
210 220 230 240 250
TGSAINPARD LGTRIVFQLT PIKNKDANWK YSWIPVIAPL SAGLVLSIII

GFSPAPVL
Length:258
Mass (Da):27,667
Last modified:November 1, 1997 - v2
Checksum:i238DBE6ABA4E1438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71249.1.
RefSeqiNP_072693.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71249; AAC71249; MG_033.
GeneIDi875476.
KEGGimge:MG_033.
PATRICi20009442. VBIMycGen98045_0031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71249.1.
RefSeqiNP_072693.1. NC_000908.2.

3D structure databases

ProteinModelPortaliP47279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MG_033.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71249; AAC71249; MG_033.
GeneIDi875476.
KEGGimge:MG_033.
PATRICi20009442. VBIMycGen98045_0031.

Phylogenomic databases

eggNOGiCOG0580.
KOiK02440.
OMAiRYLIAKN.
OrthoDBiEOG6P8TRZ.

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-33-MONOMER.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiGLPF_MYCGE
AccessioniPrimary (citable) accession number: P47279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.