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P47276 (UPP_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uracil phosphoribosyltransferase

EC=2.4.2.9
Alternative name(s):
UMP pyrophosphorylase
UPRTase
Gene names
Name:upp
Ordered Locus Names:MG030
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity. HAMAP-Rule MF_01218

Catalytic activity

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01218

Cofactor

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.

Enzyme regulation

Allosterically activated by GTP By similarity. HAMAP-Rule MF_01218

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP-Rule MF_01218

Sequence similarities

Belongs to the UPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Uracil phosphoribosyltransferase HAMAP-Rule MF_01218
PRO_0000120850

Regions

Region128 – 13695-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Region196 – 1983Uracil binding By similarity

Sites

Binding site7615-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding site10115-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding site1911Uracil; via amide nitrogen By similarity
Binding site19715-phospho-alpha-D-ribose 1-diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P47276 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 26B021599F8CC303

FASTA20622,973
        10         20         30         40         50         60 
MIKKVQHALI LNELTKLRDK NTTTSQFRMA LNQITSLLFF EATKQLPLAT VEVETPFAKT 

        70         80         90        100        110        120 
KGYKLKNDIV LVPIMRAGLG MIDAIVRYSD KIRVGHLGIY RQTQTTSVIS YYKKMPENIS 

       130        140        150        160        170        180 
DSHVIILDPM LATGTTLLTA IKSIKEDKPI KISVIAIVAA PEGINKVEKM HPHVDIFLAA 

       190        200 
IDEKLNDNRY IIPGLGDAGD RLFGTK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71246.1.
U01773 Genomic DNA. Translation: AAD10592.1.
PIRC64203.
RefSeqNP_072690.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47276.
SMRP47276. Positions 3-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_030.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71246; AAC71246; MG_030.
GeneID875326.
KEGGmge:MG_030.
PATRIC20009436. VBIMycGen98045_0028.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0035.
KOK00761.
OMATIEGWCG.
OrthoDBEOG6HF5WX.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-30-MONOMER.
UniPathwayUPA00574; UER00636.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01218_B. Upp_B.
InterProIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01091. upp. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPP_MYCGE
AccessionPrimary (citable) accession number: P47276
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names