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P47276

- UPP_MYCGE

UniProt

P47276 - UPP_MYCGE

Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 7615-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei101 – 10115-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei191 – 1911Uracil; via amide nitrogenUniRule annotation
    Binding sitei197 – 19715-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. UMP salvage Source: UniProtKB-UniPathway
    2. uracil salvage Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMGEN243273:GH2R-30-MONOMER.
    UniPathwayiUPA00574; UER00636.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Alternative name(s):
    UMP pyrophosphorylaseUniRule annotation
    UPRTaseUniRule annotation
    Gene namesi
    Name:uppUniRule annotation
    Ordered Locus Names:MG030
    OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
    Taxonomic identifieri243273 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000807: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Uracil phosphoribosyltransferasePRO_0000120850Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243273.MG_030.

    Structurei

    3D structure databases

    ProteinModelPortaliP47276.
    SMRiP47276. Positions 3-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 13695-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
    Regioni196 – 1983Uracil bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the UPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0035.
    KOiK00761.
    OMAiTIEGWCG.
    OrthoDBiEOG6HF5WX.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01218_B. Upp_B.
    InterProiIPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01091. upp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P47276-1 [UniParc]FASTAAdd to Basket

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    MIKKVQHALI LNELTKLRDK NTTTSQFRMA LNQITSLLFF EATKQLPLAT    50
    VEVETPFAKT KGYKLKNDIV LVPIMRAGLG MIDAIVRYSD KIRVGHLGIY 100
    RQTQTTSVIS YYKKMPENIS DSHVIILDPM LATGTTLLTA IKSIKEDKPI 150
    KISVIAIVAA PEGINKVEKM HPHVDIFLAA IDEKLNDNRY IIPGLGDAGD 200
    RLFGTK 206
    Length:206
    Mass (Da):22,973
    Last modified:February 1, 1996 - v1
    Checksum:i26B021599F8CC303
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71246.1.
    U01773 Genomic DNA. Translation: AAD10592.1.
    PIRiC64203.
    RefSeqiNP_072690.1. NC_000908.2.

    Genome annotation databases

    EnsemblBacteriaiAAC71246; AAC71246; MG_030.
    GeneIDi875326.
    KEGGimge:MG_030.
    PATRICi20009436. VBIMycGen98045_0028.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43967 Genomic DNA. Translation: AAC71246.1 .
    U01773 Genomic DNA. Translation: AAD10592.1 .
    PIRi C64203.
    RefSeqi NP_072690.1. NC_000908.2.

    3D structure databases

    ProteinModelPortali P47276.
    SMRi P47276. Positions 3-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243273.MG_030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC71246 ; AAC71246 ; MG_030 .
    GeneIDi 875326.
    KEGGi mge:MG_030.
    PATRICi 20009436. VBIMycGen98045_0028.

    Phylogenomic databases

    eggNOGi COG0035.
    KOi K00761.
    OMAi TIEGWCG.
    OrthoDBi EOG6HF5WX.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00636 .
    BioCyci MGEN243273:GH2R-30-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01218_B. Upp_B.
    InterProi IPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01091. upp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33530 / G-37 / NCTC 10195.
    2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
      Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
      J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 139-206.
      Strain: ATCC 33530 / G-37 / NCTC 10195.

    Entry informationi

    Entry nameiUPP_MYCGE
    AccessioniPrimary (citable) accession number: P47276
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. Mycoplasma genitalium
      Mycoplasma genitalium (strain G-37): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3