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P47276

- UPP_MYCGE

UniProt

P47276 - UPP_MYCGE

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Protein

Uracil phosphoribosyltransferase

Gene
upp, MG030
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.

Enzyme regulationi

Allosterically activated by GTP By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 7615-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding sitei101 – 10115-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding sitei191 – 1911Uracil; via amide nitrogen By similarity
Binding sitei197 – 19715-phospho-alpha-D-ribose 1-diphosphate By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. uracil salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-30-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferase (EC:2.4.2.9)
Alternative name(s):
UMP pyrophosphorylase
UPRTase
Gene namesi
Name:upp
Ordered Locus Names:MG030
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Uracil phosphoribosyltransferaseUniRule annotationPRO_0000120850Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_030.

Structurei

3D structure databases

ProteinModelPortaliP47276.
SMRiP47276. Positions 3-206.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 13695-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Regioni196 – 1983Uracil binding By similarity

Sequence similaritiesi

Belongs to the UPRTase family.

Phylogenomic databases

eggNOGiCOG0035.
KOiK00761.
OMAiTIEGWCG.
OrthoDBiEOG6HF5WX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

P47276-1 [UniParc]FASTAAdd to Basket

« Hide

MIKKVQHALI LNELTKLRDK NTTTSQFRMA LNQITSLLFF EATKQLPLAT    50
VEVETPFAKT KGYKLKNDIV LVPIMRAGLG MIDAIVRYSD KIRVGHLGIY 100
RQTQTTSVIS YYKKMPENIS DSHVIILDPM LATGTTLLTA IKSIKEDKPI 150
KISVIAIVAA PEGINKVEKM HPHVDIFLAA IDEKLNDNRY IIPGLGDAGD 200
RLFGTK 206
Length:206
Mass (Da):22,973
Last modified:February 1, 1996 - v1
Checksum:i26B021599F8CC303
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71246.1.
U01773 Genomic DNA. Translation: AAD10592.1.
PIRiC64203.
RefSeqiNP_072690.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71246; AAC71246; MG_030.
GeneIDi875326.
KEGGimge:MG_030.
PATRICi20009436. VBIMycGen98045_0028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71246.1 .
U01773 Genomic DNA. Translation: AAD10592.1 .
PIRi C64203.
RefSeqi NP_072690.1. NC_000908.2.

3D structure databases

ProteinModelPortali P47276.
SMRi P47276. Positions 3-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71246 ; AAC71246 ; MG_030 .
GeneIDi 875326.
KEGGi mge:MG_030.
PATRICi 20009436. VBIMycGen98045_0028.

Phylogenomic databases

eggNOGi COG0035.
KOi K00761.
OMAi TIEGWCG.
OrthoDBi EOG6HF5WX.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00636 .
BioCyci MGEN243273:GH2R-30-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01218_B. Upp_B.
InterProi IPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01091. upp. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 139-206.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiUPP_MYCGE
AccessioniPrimary (citable) accession number: P47276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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