Reviewed, UniProtKB/Swiss-Prot P47276 (UPP_MYCGE)

Names and origin

Protein names

Recommended name:
    Uracil phosphoribosyltransferase
    EC=2.4.2.9
Alternative name(s):
    UMP pyrophosphorylase
    UPRTase

Gene names

Name:	upp
Ordered Locus Names:	MG030

Organism

Mycoplasma genitalium [Complete proteome] [HAMAP]

Taxonomic identifier

2097 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01218
Cofactor	Magnesium By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP MF_01218
Sequence similarities	Belongs to the UPRTase family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro uracil salvage Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP uracil phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Uracil phosphoribosyltransferase HAMAP MF_01218		PRO_0000120850
Regions
	Nucleotide binding	190 – 198	9	UMP By similarity
	Region	124 – 136	13	5-phosphoribose 1-diphosphate binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47276-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 26B021599F8CC303	FASTA	206	22,973
	10 20 30 40 50 60 MIKKVQHALI LNELTKLRDK NTTTSQFRMA LNQITSLLFF EATKQLPLAT VEVETPFAKT 70 80 90 100 110 120 KGYKLKNDIV LVPIMRAGLG MIDAIVRYSD KIRVGHLGIY RQTQTTSVIS YYKKMPENIS 130 140 150 160 170 180 DSHVIILDPM LATGTTLLTA IKSIKEDKPI KISVIAIVAA PEGINKVEKM HPHVDIFLAA 190 200 IDEKLNDNRY IIPGLGDAGD RLFGTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed: 8253680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 139-206. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43967 Genomic DNA. Translation: AAC71246.1. U01773 Genomic DNA. Translation: AAD10592.1.
PIR	C64203.
RefSeq	NP_072690.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	875326.
KEGG	mge:MG_030.
TIGR	MG030.
Phylogenomic databases
HOGENOM	HBG326432.
OMA	IQHKLSH.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_030-MON.
BRENDA	2.4.2.9. 110.
Family and domain databases
HAMAP	MF_01218. [Tree]
InterPro	IPR000836. PRibTrfase. IPR005765. Ura_phspho_trans. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPP_MYCGE

Accession

Primary (citable) accession number: P47276

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 15, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)