P47276 (UPP_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uracil phosphoribosyltransferase
EC=2.4.2.9

Alternative name(s):
UMP pyrophosphorylase
UPRTase

Gene names

Name:	upp
Ordered Locus Names:	MG030

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity. HAMAP MF_01218_B
Catalytic activity	UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01218_B
Cofactor	Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.
Enzyme regulation	Allosterically activated by GTP By similarity. HAMAP MF_01218_B
Pathway	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP MF_01218_B
Sequence similarities	Belongs to the UPRTase family.

Ontologies

Keywords
Ligand	GTP-binding Magnesium Nucleotide-binding
Molecular function	Glycosyltransferase Transferase
Technical term	Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro uracil salvage Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW uracil phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Uracil phosphoribosyltransferase HAMAP MF_01218_B		PRO_0000120850
Regions
	Region	128 – 136	9	5-phospho-alpha-D-ribose 1-diphosphate binding By similarity
	Region	196 – 198	3	Uracil binding By similarity
Sites
	Binding site	76	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity
	Binding site	101	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity
	Binding site	191	1	Uracil; via amide nitrogen By similarity
	Binding site	197	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47276 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 26B021599F8CC303	FASTA	206	22,973
	10 20 30 40 50 60 MIKKVQHALI LNELTKLRDK NTTTSQFRMA LNQITSLLFF EATKQLPLAT VEVETPFAKT 70 80 90 100 110 120 KGYKLKNDIV LVPIMRAGLG MIDAIVRYSD KIRVGHLGIY RQTQTTSVIS YYKKMPENIS 130 140 150 160 170 180 DSHVIILDPM LATGTTLLTA IKSIKEDKPI KISVIAIVAA PEGINKVEKM HPHVDIFLAA 190 200 IDEKLNDNRY IIPGLGDAGD RLFGTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed: 8253680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 139-206. Strain: ATCC 33530 / G-37 / NCTC 10195.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71246.1. U01773 Genomic DNA. Translation: AAD10592.1.
PIR	C64203.
RefSeq	NP_072690.1. NC_000908.2.
3D structure databases
ProteinModelPortal	P47276.
SMR	P47276. Positions 3-206.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875326.
GenomeReviews	Gene locus MG030 in contig L43967_GR.
KEGG	mge:MG_030.
PATRIC	20009436. VBIMycGen98045_0028.
TIGR	MG030.
Phylogenomic databases
HOGENOM	HBG326432.
OMA	IQHKLSH.
PhylomeDB	P47276.
ProtClustDB	PRK00129.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_030-MONOMER.
Family and domain databases
HAMAP	MF_01218_B. Upp_B. [Tree]
InterPro	IPR000836. PRibTrfase. IPR005765. Ura_phspho_trans. [Graphical view]
KO	K00761.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01091. Upp. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPP_MYCGE

Accession

Primary (citable) accession number: P47276

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program