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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 7615-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei101 – 10115-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei191 – 1911Uracil; via amide nitrogenUniRule annotation
Binding sitei197 – 19715-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. uracil salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-30-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:MG030
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Uracil phosphoribosyltransferasePRO_0000120850Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243273.MG_030.

Structurei

3D structure databases

ProteinModelPortaliP47276.
SMRiP47276. Positions 3-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 13695-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
Regioni196 – 1983Uracil bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0035.
KOiK00761.
OMAiTIEGWCG.
OrthoDBiEOG6HF5WX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

P47276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKKVQHALI LNELTKLRDK NTTTSQFRMA LNQITSLLFF EATKQLPLAT
60 70 80 90 100
VEVETPFAKT KGYKLKNDIV LVPIMRAGLG MIDAIVRYSD KIRVGHLGIY
110 120 130 140 150
RQTQTTSVIS YYKKMPENIS DSHVIILDPM LATGTTLLTA IKSIKEDKPI
160 170 180 190 200
KISVIAIVAA PEGINKVEKM HPHVDIFLAA IDEKLNDNRY IIPGLGDAGD

RLFGTK
Length:206
Mass (Da):22,973
Last modified:February 1, 1996 - v1
Checksum:i26B021599F8CC303
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71246.1.
U01773 Genomic DNA. Translation: AAD10592.1.
PIRiC64203.
RefSeqiNP_072690.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71246; AAC71246; MG_030.
GeneIDi875326.
KEGGimge:MG_030.
PATRICi20009436. VBIMycGen98045_0028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71246.1.
U01773 Genomic DNA. Translation: AAD10592.1.
PIRiC64203.
RefSeqiNP_072690.1. NC_000908.2.

3D structure databases

ProteinModelPortaliP47276.
SMRiP47276. Positions 3-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MG_030.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71246; AAC71246; MG_030.
GeneIDi875326.
KEGGimge:MG_030.
PATRICi20009436. VBIMycGen98045_0028.

Phylogenomic databases

eggNOGiCOG0035.
KOiK00761.
OMAiTIEGWCG.
OrthoDBiEOG6HF5WX.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00636.
BioCyciMGEN243273:GH2R-30-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 139-206.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiUPP_MYCGE
AccessioniPrimary (citable) accession number: P47276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.