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P47269

- ALF_MYCGE

UniProt

P47269 - ALF_MYCGE

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Glyceraldehyde 3-phosphateBy similarity
Active sitei84 – 841Proton donorBy similarity
Metal bindingi85 – 851Zinc 1; catalyticBy similarity
Metal bindingi105 – 1051Zinc 2By similarity
Metal bindingi135 – 1351Zinc 2By similarity
Metal bindingi177 – 1771Zinc 1; catalyticBy similarity
Binding sitei178 – 1781Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi206 – 2061Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-23-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:tsr
Ordered Locus Names:MG023
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Fructose-bisphosphate aldolasePRO_0000178719Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243273.MG_023.

Structurei

3D structure databases

ProteinModelPortaliP47269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2093Dihydroxyacetone phosphate bindingBy similarity
Regioni228 – 2314Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
KOiK01624.
OMAiCTTRYEA.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47269-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVNFKLMLQ KAKLGKYAIP HININNYEWA KAVLTAANQA NSPIIVSVSE
60 70 80 90 100
GALKYMSGYS VVIPLVKGLI ESLSVKVPVT LHLDHGSYDA CIQALQAGFS
110 120 130 140 150
SVMFDGSHLP FEENFNKSKK LIEIAQKTNA SVELEVGTIG GEEDGVIGQG
160 170 180 190 200
ELANVDECKQ IASLKPDALA AGIGNIHGIY PKNWKGLNFP LIETISKITN
210 220 230 240 250
LPLVLHGGSG ILENDVKKAI SLGICKLNIN TECQLAFAHE IRKYIESNKD
260 270 280
LDLNKKGYDP RKLLKEPTQA IVDTCLEKID LCGSRNKA
Length:288
Mass (Da):31,310
Last modified:February 1, 1996 - v1
Checksum:iBD09F4683DD6A32F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71239.1.
PIRiE64202.
RefSeqiNP_072683.1. NC_000908.2.
WP_009885917.1. NZ_AAGX01000010.1.

Genome annotation databases

EnsemblBacteriaiAAC71239; AAC71239; MG_023.
GeneIDi875427.
KEGGimge:MG_023.
PATRICi20009422. VBIMycGen98045_0021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43967 Genomic DNA. Translation: AAC71239.1 .
PIRi E64202.
RefSeqi NP_072683.1. NC_000908.2.
WP_009885917.1. NZ_AAGX01000010.1.

3D structure databases

ProteinModelPortali P47269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243273.MG_023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC71239 ; AAC71239 ; MG_023 .
GeneIDi 875427.
KEGGi mge:MG_023.
PATRICi 20009422. VBIMycGen98045_0021.

Phylogenomic databases

eggNOGi COG0191.
KOi K01624.
OMAi CTTRYEA.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci MGEN243273:GH2R-23-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiALF_MYCGE
AccessioniPrimary (citable) accession number: P47269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3