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P47269 (ALF_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase

Short name=FBP aldolase
Short name=FBPA
EC=4.1.2.13
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene names
Name:fba
Synonyms:tsr
Ordered Locus Names:MG023
OrganismMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]
Taxonomic identifier243273 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactor

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the class II fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfructose 1,6-bisphosphate metabolic process

Inferred from electronic annotation. Source: InterPro

glycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Fructose-bisphosphate aldolase
PRO_0000178719

Regions

Region207 – 2093Dihydroxyacetone phosphate binding By similarity
Region228 – 2314Dihydroxyacetone phosphate binding By similarity

Sites

Active site841Proton donor By similarity
Metal binding851Zinc 1; catalytic By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1351Zinc 2 By similarity
Metal binding1771Zinc 1; catalytic By similarity
Metal binding2061Zinc 1; catalytic By similarity
Binding site491Glyceraldehyde 3-phosphate By similarity
Binding site1781Dihydroxyacetone phosphate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
P47269 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: BD09F4683DD6A32F

FASTA28831,310
        10         20         30         40         50         60 
MLVNFKLMLQ KAKLGKYAIP HININNYEWA KAVLTAANQA NSPIIVSVSE GALKYMSGYS 

        70         80         90        100        110        120 
VVIPLVKGLI ESLSVKVPVT LHLDHGSYDA CIQALQAGFS SVMFDGSHLP FEENFNKSKK 

       130        140        150        160        170        180 
LIEIAQKTNA SVELEVGTIG GEEDGVIGQG ELANVDECKQ IASLKPDALA AGIGNIHGIY 

       190        200        210        220        230        240 
PKNWKGLNFP LIETISKITN LPLVLHGGSG ILENDVKKAI SLGICKLNIN TECQLAFAHE 

       250        260        270        280 
IRKYIESNKD LDLNKKGYDP RKLLKEPTQA IVDTCLEKID LCGSRNKA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L43967 Genomic DNA. Translation: AAC71239.1.
PIRE64202.
RefSeqNP_072683.1. NC_000908.2.

3D structure databases

ProteinModelPortalP47269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243273.MG_023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC71239; AAC71239; MG_023.
GeneID875427.
KEGGmge:MG_023.
PATRIC20009422. VBIMycGen98045_0021.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0191.
KOK01624.
OMAMQASQGA.
OrthoDBEOG6HXJ7B.
ProtClustDBCLSK542101.

Enzyme and pathway databases

BioCycMGEN243273:GH2R-23-MONOMER.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF_MYCGE
AccessionPrimary (citable) accession number: P47269
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 13, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names