Reviewed,
UniProtKB/Swiss-Prot P47269 (ALF_MYCGE)
Last modified
December 15, 2009.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Fructose-bisphosphate aldolase Short name=FBP aldolase Short name=FBPA EC=4.1.2.13 Alternative name(s): Fructose-1,6-bisphosphate aldolase | ||||||
| Gene names |
| ||||||
| Organism | Mycoplasma genitalium [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 2097 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma |
Protein attributes
| Sequence length | 288 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity. |
| Catalytic activity | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. |
| Cofactor | Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the class II fructose-bisphosphate aldolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Metal-binding Zinc |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fructose 1,6-bisphosphate metabolic process Inferred from electronic annotation. Source: InterPro glycolysisInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 288 | 288 | Fructose-bisphosphate aldolase | PRO_0000178719 | |||||
Regions | |||||||||
| Region | 207 – 209 | 3 | Dihydroxyacetone phosphate binding By similarity | ||||||
| Region | 228 – 231 | 4 | Dihydroxyacetone phosphate binding By similarity | ||||||
Sites | |||||||||
| Active site | 84 | 1 | Proton donor By similarity | ||||||
| Metal binding | 85 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 105 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 135 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 177 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 206 | 1 | Zinc 1; catalytic By similarity | ||||||
| Binding site | 49 | 1 | Glyceraldehyde 3-phosphate By similarity | ||||||
| Binding site | 178 | 1 | Dihydroxyacetone phosphate; via amide nitrogen By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. Venter J.C.Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195. |
Cross-references
Sequence databases | |
|---|---|
| L43967 Genomic DNA. Translation: AAC71239.1. | |
| PIR | E64202. |
| RefSeq | NP_072683.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 875427. |
| KEGG | mge:MG_023. |
| TIGR | MG023. |
Phylogenomic databases | |
| HOGENOM | HBG327581. |
| OMA | IEKIHER. |
Enzyme and pathway databases | |
| BioCyc | MGEN243273:MG_023-MON. |
| BRENDA | 4.1.2.13. 110. |
Family and domain databases | |
| InterPro | IPR013785. Aldolase_TIM. IPR011289. Fruc_bis_ald_. IPR000771. Ketose_bisP_aldolase_II. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01116. F_bP_aldolase. 1 hit. [Graphical view] |
| PIRSF | PIRSF001359. F_bP_aldolase_II. 1 hit. |
| PROSITE | PS00602. ALDOLASE_CLASS_II_1. 1 hit. PS00806. ALDOLASE_CLASS_II_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ALF_MYCGE | ||||||||
| Accession | Primary (citable) accession number: P47269 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Mycoplasma genitalium Mycoplasma genitalium (strain G-37): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


