P47268 (RPOE_MYCGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable DNA-directed RNA polymerase subunit delta

Alternative name(s):
RNAP delta factor

Gene names

Name:	rpoE
Ordered Locus Names:	MG022

Organism

Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195) [Complete proteome] [HAMAP]

Taxonomic identifier

243273 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma genitalium

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling By similarity. HAMAP-Rule MF_00357
Subunit structure	RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors By similarity.
Sequence similarities	Belongs to the RpoE family.
Sequence caution	The sequence AAC43196.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Probable DNA-directed RNA polymerase subunit delta HAMAP-Rule MF_00357		PRO_0000204318
Regions
	Compositional bias	93 – 145	53	Asp/Glu-rich (acidic) HAMAP-Rule MF_00357

Sequences

	Sequence		Length	Mass (Da)
	P47268 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: C7A1901C94E2A41F	FASTA	145	17,057
	10 20 30 40 50 60 MQLEYLNLIS QAKVIAEKQF KANPFSFETI WKEVVKHFKI SKQDEPSLIG RFYQDFLEDP 70 80 90 100 110 120 NFVYLGDRKW KLRDFMKFDE WNKISQSMFV TKEIFEEGYE DLSNKKVEPE EGVGDFIMGN 130 140 DGDDNETGSE IVQGLINDSF SEENQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.
[2]	"A survey of the Mycoplasma genitalium genome by using random sequencing." Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-95. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43967 Genomic DNA. Translation: AAC71238.1. U01721 Unassigned DNA. Translation: AAC43196.1. Different initiation.
PIR	D64202.
RefSeq	NP_072682.1. NC_000908.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	243273.MG_022.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC71238; AAC71238; MG_022.
GeneID	875707.
KEGG	mge:MG_022.
PATRIC	20009420. VBIMycGen98045_0020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3343.
KO	K03048.
OMA	ISKQDEP.
ProtClustDB	PRK02363.
Enzyme and pathway databases
BioCyc	MGEN243273:GH2R-61-MONOMER.
Family and domain databases
HAMAP	MF_00357. RNApol_bact_RpoE.
InterPro	IPR007759. DNA-dir_RNA_pol_delta. [Graphical view]
Pfam	PF05066. RNA_pol_delta. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPOE_MYCGE

Accession

Primary (citable) accession number: P47268
Secondary accession number(s): Q49195

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program