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Protein

Probable DNA-directed RNA polymerase subunit delta

Gene

rpoE

Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity).By similarity

GO - Molecular functioni

  1. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  2. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-22-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-directed RNA polymerase subunit delta
Alternative name(s):
RNAP delta factor
Gene namesi
Name:rpoE
Ordered Locus Names:MG022
OrganismiMycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Taxonomic identifieri243273 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000807: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Probable DNA-directed RNA polymerase subunit deltaPRO_0000204318Add
BLAST

Interactioni

Subunit structurei

RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors (By similarity).By similarity

Protein-protein interaction databases

STRINGi243273.MG_022.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi93 – 14553Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the RpoE family.Curated

Phylogenomic databases

eggNOGiCOG3343.
KOiK03048.
OrthoDBiEOG6S26DH.

Family and domain databases

HAMAPiMF_00357. RNApol_bact_RpoE.
InterProiIPR007759. DNA-dir_RNA_pol_delta/Asxl.
IPR029757. RpoE.
[Graphical view]
PfamiPF05066. HARE-HTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47268-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLEYLNLIS QAKVIAEKQF KANPFSFETI WKEVVKHFKI SKQDEPSLIG
60 70 80 90 100
RFYQDFLEDP NFVYLGDRKW KLRDFMKFDE WNKISQSMFV TKEIFEEGYE
110 120 130 140
DLSNKKVEPE EGVGDFIMGN DGDDNETGSE IVQGLINDSF SEENQ
Length:145
Mass (Da):17,057
Last modified:February 1, 1996 - v1
Checksum:iC7A1901C94E2A41F
GO

Sequence cautioni

The sequence AAC43196.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71238.1.
U01721 Unassigned DNA. Translation: AAC43196.1. Different initiation.
PIRiD64202.
RefSeqiNP_072682.1. NC_000908.2.

Genome annotation databases

EnsemblBacteriaiAAC71238; AAC71238; MG_022.
GeneIDi875707.
KEGGimge:MG_022.
PATRICi20009420. VBIMycGen98045_0020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43967 Genomic DNA. Translation: AAC71238.1.
U01721 Unassigned DNA. Translation: AAC43196.1. Different initiation.
PIRiD64202.
RefSeqiNP_072682.1. NC_000908.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243273.MG_022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC71238; AAC71238; MG_022.
GeneIDi875707.
KEGGimge:MG_022.
PATRICi20009420. VBIMycGen98045_0020.

Phylogenomic databases

eggNOGiCOG3343.
KOiK03048.
OrthoDBiEOG6S26DH.

Enzyme and pathway databases

BioCyciMGEN243273:GH2R-22-MONOMER.

Family and domain databases

HAMAPiMF_00357. RNApol_bact_RpoE.
InterProiIPR007759. DNA-dir_RNA_pol_delta/Asxl.
IPR029757. RpoE.
[Graphical view]
PfamiPF05066. HARE-HTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33530 / G-37 / NCTC 10195.
  2. "A survey of the Mycoplasma genitalium genome by using random sequencing."
    Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III
    J. Bacteriol. 175:7918-7930(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-95.
    Strain: ATCC 33530 / G-37 / NCTC 10195.

Entry informationi

Entry nameiRPOE_MYCGE
AccessioniPrimary (citable) accession number: P47268
Secondary accession number(s): Q49195
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Mycoplasma genitalium
    Mycoplasma genitalium (strain G-37): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.