Reviewed, UniProtKB/Swiss-Prot P47252 (KTHY_MYCGE)

Names and origin

Protein names

Recommended name:
    Thymidylate kinase
    EC=2.7.4.9
Alternative name(s):
    dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	MG006

Organism

Mycoplasma genitalium [Complete proteome] [HAMAP]

Taxonomic identifier

2097 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity.
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Thymidylate kinase HAMAP MF_00165		PRO_0000155302
Regions
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P47252-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 10641CA5DCD202F6	FASTA	210	24,248
	10 20 30 40 50 60 MNKGVFVVIE GVDGAGKTAL IEGFKKLYPT KFLNYQLTYT REPGGTLLAE KIRQLLLNET 70 80 90 100 110 120 MEPLTEAYLF AAARTEHISK LIKPAIEKEQ LVISDRFVFS SFAYQGLSKK IGIDTVKQIN 130 140 150 160 170 180 HHALRNMMPN FTFILDCNFK EALQRMQKRG NDNLLDEFIK GKNDFDTVRS YYLSLVDKKN 190 200 210 CFLINGDNKQ EHLEKFIELL TRCLQQPTHY

References

[1]

"The minimal gene complement of Mycoplasma genitalium." Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M., Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L., Nguyen D.T., Utterback T.R., Saudek D.M. , Phillips C.A., Merrick J.M., Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S., Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C. Science 270:397-403(1995) [PubMed: 7569993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33530 / G-37 / NCTC 10195.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L43967 Genomic DNA. Translation: AAC71222.1.
PIR	F64200.
RefSeq	NP_072666.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	875708.
KEGG	mge:MG_006.
TIGR	MG006.
Phylogenomic databases
HOGENOM	HBG626009.
OMA	FLFDIEP.
Enzyme and pathway databases
BioCyc	MGEN243273:MG_006-MON.
BRENDA	2.7.4.9. 110.
Family and domain databases
HAMAP	MF_00165. [Tree]
InterPro	IPR018094. Thymidylate_kin. IPR000062. Thymidylate_kin-like. IPR018095. Thymidylate_kin_CS. [Graphical view]
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_MYCGE

Accession

Primary (citable) accession number: P47252

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 15, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)