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Reviewed, UniProtKB/Swiss-Prot P47247 (DPO3B_MYCGE)

Last modified November 3, 2009. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA polymerase III subunit beta
    EC=2.7.7.7
Gene names
Name: dnaN
Ordered Locus Names: MG001
OrganismMycoplasma genitalium [Complete proteome] [HAMAP]
Taxonomic identifier2097 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Subcellular location

Cytoplasm By similarity.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentCytoplasm
   Molecular functionDNA-directed DNA polymerase
Nucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3'-5' exonuclease activity

Inferred from electronic annotation. Source: InterPro

DNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed DNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364DNA polymerase III subunit beta
PRO_0000105445

Sequences

Sequence LengthMass (Da)Tools
P47247-1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 4D8C23EF9BC48624

FASTA36442,399
        10         20         30         40         50         60 
MNNVIISNNK IKPHHSYFLI EAKEKEINFY ANNEYFSVKC NLNKNIDILE QGSLIVKGKI 

        70         80         90        100        110        120 
FNDLINGIKE EIITIQEKDQ TLLVKTKKTS INLNTINVNE FPRIRFNEKN DLSEFNQFKI 

       130        140        150        160        170        180 
NYSLLVKGIK KIFHSVSNNR EISSKFNGVN FNGSNGKEIF LEASDTYKLS VFEIKQETEP 

       190        200        210        220        230        240 
FDFILESNLL SFINSFNPEE DKSIVFYYRK DNKDSFSTEM LISMDNFMIS YTSVNEKFPE 

       250        260        270        280        290        300 
VNYFFEFEPE TKIVVQKNEL KDALQRIQTL AQNERTFLCD MQINSSELKI RAIVNNIGNS 

       310        320        330        340        350        360 
LEEISCLKFE GYKLNISFNP SSLLDHIESF ESNEINFDFQ GNSKYFLITS KSEPELKQIL 


VPSR 

« Hide

Cross-references

Sequence databases

L43967 Genomic DNA. Translation: AAC71217.1.
U09251 Genomic DNA. Translation: AAA57069.1.
RefSeqNP_072661.2.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID875454.
GenomeReviewsGene locus MG001 in contig L43967_GR.
KEGGmge:MG_001.
TIGRMG001.

Phylogenomic databases

HOGENOMP47247.
OMAFYANNEY

Enzyme and pathway databases

BioCycMGEN243273:MG_001-MON.
BRENDA2.7.7.7. 110.

Family and domain databases

InterProIPR001001. DNA_polIII_beta.
[Graphical view]
Gene3DG3DSA:3.10.150.10. DNA_polIII_beta. 3 hits.
PfamPF00712. DNA_pol3_beta. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
[Graphical view]
SMARTSM00480. POL3Bc. 1 hit.
[Graphical view]
TIGRFAMsTIGR00663. dnan. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDPO3B_MYCGE
AccessionPrimary (citable) accession number: P47247
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: November 3, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Mycoplasma genitalium

Mycoplasma genitalium (strain G-37): entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents