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P47242

- PAX9_MOUSE

UniProt

P47242 - PAX9_MOUSE

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Protein

Paired box protein Pax-9

Gene

Pax9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.1 Publication

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cellular response to growth factor stimulus Source: MGI
  2. endoderm development Source: MGI
  3. face morphogenesis Source: MGI
  4. negative regulation of transcription, DNA-templated Source: Ensembl
  5. odontogenesis Source: MGI
  6. organ morphogenesis Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  8. regulation of odontogenesis Source: MGI
  9. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-9
Gene namesi
Name:Pax9
Synonyms:Pax-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:97493. Pax9.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death shortly after birth. Mice lack thymus, parathyroid glands, ultimobranchial bodies and teeth. They show craniofacial and visceral malformations as well as malformations of their distal limbs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Paired box protein Pax-9PRO_0000050208Add
BLAST

Proteomic databases

PRIDEiP47242.

PTM databases

PhosphoSiteiP47242.

Expressioni

Tissue specificityi

In the embryo, expressed in pharyngeal pouches and derivatives, developing vertebral column, tail, head and limbs.

Developmental stagei

In the embryo, expression increases slightly from day 9.5 to day 11.5, remains almost constant until day 14.5 and then decreases.

Gene expression databases

BgeeiP47242.
CleanExiMM_PAX9.
ExpressionAtlasiP47242. baseline and differential.
GenevestigatoriP47242.

Interactioni

Subunit structurei

Interacts with KDM5B.By similarity

Protein-protein interaction databases

BioGridi202036. 2 interactions.
IntActiP47242. 2 interactions.
STRINGi10090.ENSMUSP00000001538.

Structurei

3D structure databases

ProteinModelPortaliP47242.
SMRiP47242. Positions 8-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 130127PairedPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 18922Interaction with KDM5BBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiNOG252808.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiP47242.
KOiK09382.
OMAiWQHAGST.
OrthoDBiEOG79KPH3.
PhylomeDBiP47242.
TreeFamiTF315397.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47242-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH
60 70 80 90 100
GCVSKILARY NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW
110 120 130 140 150
EIRDRLLADG VCDKYNVPSV SSISRILRNK IGNLAQQGHY DSYKQHQPAP
160 170 180 190 200
QPALPYNHIY SYPSPITAAA AKVPTPPGVP AIPGSVALPR TWPSSHSVTD
210 220 230 240 250
ILGIRSITDQ GVSDSSPYHS PKVEEWSSLG RNNFPAAAPH AVNGLEKGAL
260 270 280 290 300
EQEAKYGQAP NGLPAVSSFV SASSMAPYPT PAQVSPYMTY SAAPSGYVAG
310 320 330 340
HGWQHAGSTP LSPHNCDIPA SLAFKGMQAA REGSHSVTAS AL
Length:342
Mass (Da):36,389
Last modified:February 1, 1996 - v1
Checksum:iA4FB714FE541A96C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84000 mRNA. Translation: CAA58824.1.
BC005794 mRNA. Translation: AAH05794.1.
X73037 Genomic DNA. Translation: CAA51518.1.
CCDSiCCDS25924.1.
PIRiI48740. S57652.
RefSeqiNP_035171.1. NM_011041.2.
XP_006515642.1. XM_006515579.1.
XP_006515643.1. XM_006515580.1.
XP_006515644.1. XM_006515581.1.
UniGeneiMm.5035.

Genome annotation databases

EnsembliENSMUST00000001538; ENSMUSP00000001538; ENSMUSG00000001497.
ENSMUST00000153250; ENSMUSP00000117928; ENSMUSG00000001497.
GeneIDi18511.
KEGGimmu:18511.
UCSCiuc007npi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84000 mRNA. Translation: CAA58824.1 .
BC005794 mRNA. Translation: AAH05794.1 .
X73037 Genomic DNA. Translation: CAA51518.1 .
CCDSi CCDS25924.1.
PIRi I48740. S57652.
RefSeqi NP_035171.1. NM_011041.2.
XP_006515642.1. XM_006515579.1.
XP_006515643.1. XM_006515580.1.
XP_006515644.1. XM_006515581.1.
UniGenei Mm.5035.

3D structure databases

ProteinModelPortali P47242.
SMRi P47242. Positions 8-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202036. 2 interactions.
IntActi P47242. 2 interactions.
STRINGi 10090.ENSMUSP00000001538.

PTM databases

PhosphoSitei P47242.

Proteomic databases

PRIDEi P47242.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001538 ; ENSMUSP00000001538 ; ENSMUSG00000001497 .
ENSMUST00000153250 ; ENSMUSP00000117928 ; ENSMUSG00000001497 .
GeneIDi 18511.
KEGGi mmu:18511.
UCSCi uc007npi.1. mouse.

Organism-specific databases

CTDi 5083.
MGIi MGI:97493. Pax9.

Phylogenomic databases

eggNOGi NOG252808.
HOGENOMi HOG000230938.
HOVERGENi HBG009115.
InParanoidi P47242.
KOi K09382.
OMAi WQHAGST.
OrthoDBi EOG79KPH3.
PhylomeDBi P47242.
TreeFami TF315397.

Miscellaneous databases

NextBioi 294248.
PROi P47242.
SOURCEi Search...

Gene expression databases

Bgeei P47242.
CleanExi MM_PAX9.
ExpressionAtlasi P47242. baseline and differential.
Genevestigatori P47242.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
InterProi IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00292. PAX. 1 hit.
[Graphical view ]
PRINTSi PR00027. PAIREDBOX.
SMARTi SM00351. PAX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1."
    Neubuesser A., Koseki H., Balling R.
    Dev. Biol. 170:701-716(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-111.
    Strain: C57BR/Y.
  4. "Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities."
    Peters H., Neubuser A., Kratochwil K., Balling R.
    Genes Dev. 12:2735-2747(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiPAX9_MOUSE
AccessioniPrimary (citable) accession number: P47242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3