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Protein

Paired box protein Pax-9

Gene

Pax9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.1 Publication

GO - Molecular functioni

  • DNA binding transcription factor activity Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • cellular response to growth factor stimulus Source: MGI
  • endoderm development Source: MGI
  • face morphogenesis Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • odontogenesis Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of odontogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-9
Gene namesi
Name:Pax9
Synonyms:Pax-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:97493 Pax9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death shortly after birth. Mice lack thymus, parathyroid glands, ultimobranchial bodies and teeth. They show craniofacial and visceral malformations as well as malformations of their distal limbs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502081 – 342Paired box protein Pax-9Add BLAST342

Proteomic databases

PaxDbiP47242
PRIDEiP47242
TopDownProteomicsiP47242

PTM databases

iPTMnetiP47242
PhosphoSitePlusiP47242

Expressioni

Tissue specificityi

In the embryo, expressed in pharyngeal pouches and derivatives, developing vertebral column, tail, head and limbs.

Developmental stagei

In the embryo, expression increases slightly from day 9.5 to day 11.5, remains almost constant until day 14.5 and then decreases.

Gene expression databases

BgeeiENSMUSG00000001497
CleanExiMM_PAX9
ExpressionAtlasiP47242 baseline and differential
GenevisibleiP47242 MM

Interactioni

Subunit structurei

Interacts with KDM5B.By similarity

Protein-protein interaction databases

BioGridi202036, 2 interactors
IntActiP47242, 2 interactors
STRINGi10090.ENSMUSP00000001538

Structurei

3D structure databases

ProteinModelPortaliP47242
SMRiP47242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 130PairedPROSITE-ProRule annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 189Interaction with KDM5BBy similarityAdd BLAST22

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3517 Eukaryota
ENOG4111FI9 LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230938
HOVERGENiHBG009115
InParanoidiP47242
KOiK09382
OMAiWQHAGST
OrthoDBiEOG091G0S4E
PhylomeDBiP47242
TreeFamiTF315397

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR033204 PAX9
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR24329:SF297 PTHR24329:SF297, 1 hit
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH
60 70 80 90 100
GCVSKILARY NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW
110 120 130 140 150
EIRDRLLADG VCDKYNVPSV SSISRILRNK IGNLAQQGHY DSYKQHQPAP
160 170 180 190 200
QPALPYNHIY SYPSPITAAA AKVPTPPGVP AIPGSVALPR TWPSSHSVTD
210 220 230 240 250
ILGIRSITDQ GVSDSSPYHS PKVEEWSSLG RNNFPAAAPH AVNGLEKGAL
260 270 280 290 300
EQEAKYGQAP NGLPAVSSFV SASSMAPYPT PAQVSPYMTY SAAPSGYVAG
310 320 330 340
HGWQHAGSTP LSPHNCDIPA SLAFKGMQAA REGSHSVTAS AL
Length:342
Mass (Da):36,389
Last modified:February 1, 1996 - v1
Checksum:iA4FB714FE541A96C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84000 mRNA Translation: CAA58824.1
BC005794 mRNA Translation: AAH05794.1
X73037 Genomic DNA Translation: CAA51518.1
CCDSiCCDS25924.1
PIRiI48740 S57652
RefSeqiNP_035171.1, NM_011041.3
XP_006515642.1, XM_006515579.3
XP_006515643.1, XM_006515580.3
XP_006515644.1, XM_006515581.3
XP_017170480.1, XM_017314991.1
UniGeneiMm.5035

Genome annotation databases

EnsembliENSMUST00000001538; ENSMUSP00000001538; ENSMUSG00000001497
ENSMUST00000153250; ENSMUSP00000117928; ENSMUSG00000001497
GeneIDi18511
KEGGimmu:18511
UCSCiuc007npi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPAX9_MOUSE
AccessioniPrimary (citable) accession number: P47242
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health