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P47242 (PAX9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired box protein Pax-9
Gene names
Name:Pax9
Synonyms:Pax-9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Ref.4

Subunit structure

Interacts with KDM5B By similarity.

Subcellular location

Nucleus.

Tissue specificity

In the embryo, expressed in pharyngeal pouches and derivatives, developing vertebral column, tail, head and limbs.

Developmental stage

In the embryo, expression increases slightly from day 9.5 to day 11.5, remains almost constant until day 14.5 and then decreases.

Disruption phenotype

Death shortly after birth. Mice lack thymus, parathyroid glands, ultimobranchial bodies and teeth. They show craniofacial and visceral malformations as well as malformations of their distal limbs. Ref.4

Sequence similarities

Contains 1 paired domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainPaired box
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to growth factor stimulus

Inferred from direct assay PubMed 9244299. Source: MGI

endoderm development

Inferred from mutant phenotype PubMed 11932925. Source: MGI

face morphogenesis

Inferred from genetic interaction PubMed 20123092. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

odontogenesis

Inferred from genetic interaction PubMed 20123092. Source: MGI

organ morphogenesis

Traceable author statement PubMed 10197584. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 15024065. Source: MGI

regulation of odontogenesis

Inferred from genetic interaction PubMed 20123092. Source: MGI

regulation of transcription, DNA-templated

Traceable author statement PubMed 10197584. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Traceable author statement PubMed 10197584. Source: MGI

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Traceable author statement PubMed 10197584. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Paired box protein Pax-9
PRO_0000050208

Regions

Domain4 – 130127Paired
Region168 – 18922Interaction with KDM5B By similarity

Sequences

Sequence LengthMass (Da)Tools
P47242 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: A4FB714FE541A96C

FASTA34236,389
        10         20         30         40         50         60 
MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH GCVSKILARY 

        70         80         90        100        110        120 
NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW EIRDRLLADG VCDKYNVPSV 

       130        140        150        160        170        180 
SSISRILRNK IGNLAQQGHY DSYKQHQPAP QPALPYNHIY SYPSPITAAA AKVPTPPGVP 

       190        200        210        220        230        240 
AIPGSVALPR TWPSSHSVTD ILGIRSITDQ GVSDSSPYHS PKVEEWSSLG RNNFPAAAPH 

       250        260        270        280        290        300 
AVNGLEKGAL EQEAKYGQAP NGLPAVSSFV SASSMAPYPT PAQVSPYMTY SAAPSGYVAG 

       310        320        330        340 
HGWQHAGSTP LSPHNCDIPA SLAFKGMQAA REGSHSVTAS AL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1."
Neubuesser A., Koseki H., Balling R.
Dev. Biol. 170:701-716(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[3]"A new Pax gene, Pax-9, maps to mouse chromosome 12."
Wallin J., Mizutani Y., Imai K., Miyashita N., Moriwaki K., Taniguchi M., Koseki H., Balling R.
Mamm. Genome 4:354-358(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-111.
Strain: C57BR/Y.
[4]"Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities."
Peters H., Neubuser A., Kratochwil K., Balling R.
Genes Dev. 12:2735-2747(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X84000 mRNA. Translation: CAA58824.1.
BC005794 mRNA. Translation: AAH05794.1.
X73037 Genomic DNA. Translation: CAA51518.1.
CCDSCCDS25924.1.
PIRS57652. I48740.
RefSeqNP_035171.1. NM_011041.2.
XP_006515642.1. XM_006515579.1.
XP_006515643.1. XM_006515580.1.
XP_006515644.1. XM_006515581.1.
UniGeneMm.5035.

3D structure databases

ProteinModelPortalP47242.
SMRP47242. Positions 8-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202036. 2 interactions.
IntActP47242. 2 interactions.
STRING10090.ENSMUSP00000001538.

PTM databases

PhosphoSiteP47242.

Proteomic databases

PRIDEP47242.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001538; ENSMUSP00000001538; ENSMUSG00000001497.
ENSMUST00000153250; ENSMUSP00000117928; ENSMUSG00000001497.
GeneID18511.
KEGGmmu:18511.
UCSCuc007npi.1. mouse.

Organism-specific databases

CTD5083.
MGIMGI:97493. Pax9.

Phylogenomic databases

eggNOGNOG252808.
HOGENOMHOG000230938.
HOVERGENHBG009115.
InParanoidP47242.
KOK09382.
OMAWQHAGST.
OrthoDBEOG79KPH3.
PhylomeDBP47242.
TreeFamTF315397.

Gene expression databases

ArrayExpressP47242.
BgeeP47242.
CleanExMM_PAX9.
GenevestigatorP47242.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
InterProIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00292. PAX. 1 hit.
[Graphical view]
PRINTSPR00027. PAIREDBOX.
SMARTSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294248.
PROP47242.
SOURCESearch...

Entry information

Entry namePAX9_MOUSE
AccessionPrimary (citable) accession number: P47242
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot