Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P47242

- PAX9_MOUSE

UniProt

P47242 - PAX9_MOUSE

Protein

Paired box protein Pax-9

Gene

Pax9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.1 Publication

    GO - Molecular functioni

    1. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cellular response to growth factor stimulus Source: MGI
    2. endoderm development Source: MGI
    3. face morphogenesis Source: MGI
    4. negative regulation of transcription, DNA-templated Source: Ensembl
    5. odontogenesis Source: MGI
    6. organ morphogenesis Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    8. regulation of odontogenesis Source: MGI
    9. regulation of transcription, DNA-templated Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired box protein Pax-9
    Gene namesi
    Name:Pax9
    Synonyms:Pax-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:97493. Pax9.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Death shortly after birth. Mice lack thymus, parathyroid glands, ultimobranchial bodies and teeth. They show craniofacial and visceral malformations as well as malformations of their distal limbs.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Paired box protein Pax-9PRO_0000050208Add
    BLAST

    Proteomic databases

    PRIDEiP47242.

    PTM databases

    PhosphoSiteiP47242.

    Expressioni

    Tissue specificityi

    In the embryo, expressed in pharyngeal pouches and derivatives, developing vertebral column, tail, head and limbs.

    Developmental stagei

    In the embryo, expression increases slightly from day 9.5 to day 11.5, remains almost constant until day 14.5 and then decreases.

    Gene expression databases

    ArrayExpressiP47242.
    BgeeiP47242.
    CleanExiMM_PAX9.
    GenevestigatoriP47242.

    Interactioni

    Subunit structurei

    Interacts with KDM5B.By similarity

    Protein-protein interaction databases

    BioGridi202036. 2 interactions.
    IntActiP47242. 2 interactions.
    STRINGi10090.ENSMUSP00000001538.

    Structurei

    3D structure databases

    ProteinModelPortaliP47242.
    SMRiP47242. Positions 8-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 130127PairedPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni168 – 18922Interaction with KDM5BBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 paired domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Paired box

    Phylogenomic databases

    eggNOGiNOG252808.
    HOGENOMiHOG000230938.
    HOVERGENiHBG009115.
    InParanoidiP47242.
    KOiK09382.
    OMAiWQHAGST.
    OrthoDBiEOG79KPH3.
    PhylomeDBiP47242.
    TreeFamiTF315397.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47242-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH    50
    GCVSKILARY NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW 100
    EIRDRLLADG VCDKYNVPSV SSISRILRNK IGNLAQQGHY DSYKQHQPAP 150
    QPALPYNHIY SYPSPITAAA AKVPTPPGVP AIPGSVALPR TWPSSHSVTD 200
    ILGIRSITDQ GVSDSSPYHS PKVEEWSSLG RNNFPAAAPH AVNGLEKGAL 250
    EQEAKYGQAP NGLPAVSSFV SASSMAPYPT PAQVSPYMTY SAAPSGYVAG 300
    HGWQHAGSTP LSPHNCDIPA SLAFKGMQAA REGSHSVTAS AL 342
    Length:342
    Mass (Da):36,389
    Last modified:February 1, 1996 - v1
    Checksum:iA4FB714FE541A96C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84000 mRNA. Translation: CAA58824.1.
    BC005794 mRNA. Translation: AAH05794.1.
    X73037 Genomic DNA. Translation: CAA51518.1.
    CCDSiCCDS25924.1.
    PIRiI48740. S57652.
    RefSeqiNP_035171.1. NM_011041.2.
    XP_006515642.1. XM_006515579.1.
    XP_006515643.1. XM_006515580.1.
    XP_006515644.1. XM_006515581.1.
    UniGeneiMm.5035.

    Genome annotation databases

    EnsembliENSMUST00000001538; ENSMUSP00000001538; ENSMUSG00000001497.
    ENSMUST00000153250; ENSMUSP00000117928; ENSMUSG00000001497.
    GeneIDi18511.
    KEGGimmu:18511.
    UCSCiuc007npi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84000 mRNA. Translation: CAA58824.1 .
    BC005794 mRNA. Translation: AAH05794.1 .
    X73037 Genomic DNA. Translation: CAA51518.1 .
    CCDSi CCDS25924.1.
    PIRi I48740. S57652.
    RefSeqi NP_035171.1. NM_011041.2.
    XP_006515642.1. XM_006515579.1.
    XP_006515643.1. XM_006515580.1.
    XP_006515644.1. XM_006515581.1.
    UniGenei Mm.5035.

    3D structure databases

    ProteinModelPortali P47242.
    SMRi P47242. Positions 8-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202036. 2 interactions.
    IntActi P47242. 2 interactions.
    STRINGi 10090.ENSMUSP00000001538.

    PTM databases

    PhosphoSitei P47242.

    Proteomic databases

    PRIDEi P47242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001538 ; ENSMUSP00000001538 ; ENSMUSG00000001497 .
    ENSMUST00000153250 ; ENSMUSP00000117928 ; ENSMUSG00000001497 .
    GeneIDi 18511.
    KEGGi mmu:18511.
    UCSCi uc007npi.1. mouse.

    Organism-specific databases

    CTDi 5083.
    MGIi MGI:97493. Pax9.

    Phylogenomic databases

    eggNOGi NOG252808.
    HOGENOMi HOG000230938.
    HOVERGENi HBG009115.
    InParanoidi P47242.
    KOi K09382.
    OMAi WQHAGST.
    OrthoDBi EOG79KPH3.
    PhylomeDBi P47242.
    TreeFami TF315397.

    Miscellaneous databases

    NextBioi 294248.
    PROi P47242.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47242.
    Bgeei P47242.
    CleanExi MM_PAX9.
    Genevestigatori P47242.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1."
      Neubuesser A., Koseki H., Balling R.
      Dev. Biol. 170:701-716(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-111.
      Strain: C57BR/Y.
    4. "Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities."
      Peters H., Neubuser A., Kratochwil K., Balling R.
      Genes Dev. 12:2735-2747(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiPAX9_MOUSE
    AccessioniPrimary (citable) accession number: P47242
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3