Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P47239

- PAX7_MOUSE

UniProt

P47239 - PAX7_MOUSE

Protein

Paired box protein Pax-7

Gene

Pax7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (27 Sep 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi215 – 27460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: MGI
    3. sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cartilage development Source: MGI
    2. chromatin remodeling Source: MGI
    3. dorsal/ventral neural tube patterning Source: MGI
    4. embryonic skeletal system development Source: MGI
    5. muscle tissue morphogenesis Source: MGI
    6. neuron fate commitment Source: MGI
    7. organ morphogenesis Source: MGI
    8. positive regulation of histone methylation Source: MGI
    9. positive regulation of myoblast proliferation Source: MGI
    10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    11. regulation of cell fate commitment Source: MGI
    12. regulation of gene expression Source: MGI
    13. regulation of protein binding Source: MGI
    14. regulation of transcription, DNA-templated Source: MGI
    15. skeletal muscle satellite cell commitment Source: MGI
    16. skeletal muscle tissue development Source: MGI
    17. skeletal muscle tissue regeneration Source: MGI
    18. spinal cord association neuron differentiation Source: MGI
    19. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Myogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired box protein Pax-7
    Gene namesi
    Name:Pax7
    Synonyms:Pax-7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:97491. Pax7.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Paired box protein Pax-7PRO_0000050195Add
    BLAST

    Proteomic databases

    PRIDEiP47239.

    PTM databases

    PhosphoSiteiP47239.

    Expressioni

    Developmental stagei

    Expressed specifically during the development of the nervous and muscular system.

    Gene expression databases

    BgeeiP47239.
    CleanExiMM_PAX7.
    GenevestigatoriP47239.

    Interactioni

    Subunit structurei

    Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX By similarity. Interacts with PAXBP1; the interaction links PAX7 to a WDR5-containing histone methyltransferase complex.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi202034. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP47239.
    SMRiP47239. Positions 35-158, 215-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 161128PairedPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni27 – 208182Sufficient to mediate interaction with PAXBP1Add
    BLAST

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 paired domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Paired box

    Phylogenomic databases

    eggNOGiNOG326044.
    GeneTreeiENSGT00680000099553.
    HOGENOMiHOG000230939.
    HOVERGENiHBG009115.
    InParanoidiP47239.
    KOiK09381.
    OrthoDBiEOG7WT431.
    PhylomeDBiP47239.
    TreeFamiTF351610.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR022106. Pax7.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00292. PAX. 1 hit.
    PF12360. Pax7. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00389. HOX. 1 hit.
    SM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47239-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALPGAVPR MMRPGPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP    50
    LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA 100
    IGGSKPRQVA TPDVEKKIEE YKRENPGMFS WEIRDRLLKD GHCDRSTVPS 150
    VSSISRVLRI KFGKKEDDEE GDKKEEDGEK KAKHSIDGIL GDKGNRLDEG 200
    SDVESEPDLP LKRKQRRSRT TFTAEQLEEL EKAFERTHYP DIYTREELAQ 250
    RTKLTEARVQ VWFSNRRARW RKQAGANQLA AFNHLLPGGF PPTGMPTLPP 300
    YQLPDSTYPT TTISQDGGST VHRPQPLPPS TMHQGGLAAA AAAADTSSAY 350
    GARHSFSSYS DSFMNPGAPS NHMNPVSNGL SPQVMSILSN PSAVPPQPQA 400
    DFSISPLHGG LDSASSISAS CSQRADSIKP GDSLPTSQSY CPPTYSTTGY 450
    SVDPVAGYQY SQYGQTAVDY LAKNVSLSTQ RRMKLGEHSA VLGLLPVETG 500
    QAY 503
    Length:503
    Mass (Da):54,939
    Last modified:September 27, 2004 - v2
    Checksum:i8ECC952C5C2FCA27
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601V → VV in AAA64491. (PubMed:1982921)Curated
    Sequence conflicti137 – 1371L → W in AAA64491. (PubMed:1982921)Curated
    Sequence conflicti202 – 2021D → G in AAA64491. (PubMed:1982921)Curated
    Sequence conflicti259 – 2591V → F in AAA64491. (PubMed:1982921)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254422 mRNA. Translation: AAG16663.3.
    U20792 mRNA. Translation: AAA64491.1.
    CCDSiCCDS18850.1.
    PIRiI49265.
    RefSeqiNP_035169.1. NM_011039.2.
    UniGeneiMm.218760.

    Genome annotation databases

    EnsembliENSMUST00000030508; ENSMUSP00000030508; ENSMUSG00000028736.
    GeneIDi18509.
    KEGGimmu:18509.
    UCSCiuc008vms.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254422 mRNA. Translation: AAG16663.3 .
    U20792 mRNA. Translation: AAA64491.1 .
    CCDSi CCDS18850.1.
    PIRi I49265.
    RefSeqi NP_035169.1. NM_011039.2.
    UniGenei Mm.218760.

    3D structure databases

    ProteinModelPortali P47239.
    SMRi P47239. Positions 35-158, 215-273.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202034. 1 interaction.

    PTM databases

    PhosphoSitei P47239.

    Proteomic databases

    PRIDEi P47239.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030508 ; ENSMUSP00000030508 ; ENSMUSG00000028736 .
    GeneIDi 18509.
    KEGGi mmu:18509.
    UCSCi uc008vms.1. mouse.

    Organism-specific databases

    CTDi 5081.
    MGIi MGI:97491. Pax7.

    Phylogenomic databases

    eggNOGi NOG326044.
    GeneTreei ENSGT00680000099553.
    HOGENOMi HOG000230939.
    HOVERGENi HBG009115.
    InParanoidi P47239.
    KOi K09381.
    OrthoDBi EOG7WT431.
    PhylomeDBi P47239.
    TreeFami TF351610.

    Miscellaneous databases

    NextBioi 294240.
    PROi P47239.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47239.
    CleanExi MM_PAX7.
    Genevestigatori P47239.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR022106. Pax7.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00292. PAX. 1 hit.
    PF12360. Pax7. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00389. HOX. 1 hit.
    SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pax7 is required for the specification of myogenic satellite cells."
      Seale P., Sabourin L.A., Girgis-Gabardo A., Mansouri A., Gruss P., Rudnicki M.A.
      Cell 102:777-786(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Skeletal muscle.
    2. "The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system."
      Jostes B., Walther C., Gruss P.
      Mech. Dev. 33:27-37(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-324.
    3. "Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism."
      Diao Y., Guo X., Li Y., Sun K., Lu L., Jiang L., Fu X., Zhu H., Sun H., Wang H., Wu Z.
      Cell Stem Cell 11:231-241(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PAXBP1.

    Entry informationi

    Entry nameiPAX7_MOUSE
    AccessioniPrimary (citable) accession number: P47239
    Secondary accession number(s): Q9ES16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3