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P47239 (PAX7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired box protein Pax-7
Gene names
Name:Pax7
Synonyms:Pax-7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation. Ref.3

Subunit structure

Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX By similarity. Interacts with PAXBP1; the interaction links PAX7 to a WDR5-containing histone methyltransferase complex. Ref.3

Subcellular location

Nucleus.

Developmental stage

Expressed specifically during the development of the nervous and muscular system.

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Contains 1 paired domain.

Ontologies

Keywords
   Biological processMyogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
Paired box
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcartilage development

Inferred from mutant phenotype PubMed 8631261. Source: MGI

chromatin remodeling

Inferred from mutant phenotype PubMed 23070814. Source: MGI

dorsal/ventral neural tube patterning

Inferred from direct assay PubMed 18590716. Source: MGI

embryonic skeletal system development

Inferred from mutant phenotype PubMed 8631261. Source: MGI

muscle tissue morphogenesis

Inferred from genetic interaction PubMed 19531352. Source: MGI

neuron fate commitment

Inferred from genetic interaction PubMed 9858722. Source: MGI

organ morphogenesis

Traceable author statement PubMed 10197584. Source: MGI

positive regulation of histone methylation

Inferred from direct assay Ref.3. Source: MGI

positive regulation of myoblast proliferation

Inferred from mutant phenotype Ref.3. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype Ref.3. Source: MGI

regulation of cell fate commitment

Inferred from mutant phenotype PubMed 23070814. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 23070814. Source: MGI

regulation of protein binding

Inferred from mutant phenotype PubMed 23070814. Source: MGI

regulation of transcription, DNA-templated

Traceable author statement PubMed 10197584. Source: MGI

satellite cell commitment

Inferred from mutant phenotype Ref.1. Source: MGI

skeletal muscle tissue development

Inferred from mutant phenotype Ref.1. Source: MGI

skeletal muscle tissue regeneration

Inferred from mutant phenotype PubMed 9608680. Source: MGI

spinal cord association neuron differentiation

Inferred from genetic interaction PubMed 9858722. Source: MGI

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 23070814. Source: GOC

   Cellular_componentnucleus

Inferred from direct assay PubMed 21131290PubMed 9230312. Source: MGI

transcription factor complex

Traceable author statement PubMed 10197584. Source: MGI

   Molecular_functionRNA polymerase II core promoter sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 23070814. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 23070814. Source: MGI

sequence-specific DNA binding transcription factor activity

Traceable author statement PubMed 10197584. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Paired box protein Pax-7
PRO_0000050195

Regions

Domain34 – 161128Paired
DNA binding215 – 27460Homeobox
Region27 – 208182Sufficient to mediate interaction with PAXBP1

Experimental info

Sequence conflict601V → VV in AAA64491. Ref.2
Sequence conflict1371L → W in AAA64491. Ref.2
Sequence conflict2021D → G in AAA64491. Ref.2
Sequence conflict2591V → F in AAA64491. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P47239 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 8ECC952C5C2FCA27

FASTA50354,939
        10         20         30         40         50         60 
MAALPGAVPR MMRPGPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV 

        70         80         90        100        110        120 
EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPRQVA TPDVEKKIEE 

       130        140        150        160        170        180 
YKRENPGMFS WEIRDRLLKD GHCDRSTVPS VSSISRVLRI KFGKKEDDEE GDKKEEDGEK 

       190        200        210        220        230        240 
KAKHSIDGIL GDKGNRLDEG SDVESEPDLP LKRKQRRSRT TFTAEQLEEL EKAFERTHYP 

       250        260        270        280        290        300 
DIYTREELAQ RTKLTEARVQ VWFSNRRARW RKQAGANQLA AFNHLLPGGF PPTGMPTLPP 

       310        320        330        340        350        360 
YQLPDSTYPT TTISQDGGST VHRPQPLPPS TMHQGGLAAA AAAADTSSAY GARHSFSSYS 

       370        380        390        400        410        420 
DSFMNPGAPS NHMNPVSNGL SPQVMSILSN PSAVPPQPQA DFSISPLHGG LDSASSISAS 

       430        440        450        460        470        480 
CSQRADSIKP GDSLPTSQSY CPPTYSTTGY SVDPVAGYQY SQYGQTAVDY LAKNVSLSTQ 

       490        500 
RRMKLGEHSA VLGLLPVETG QAY 

« Hide

References

[1]"Pax7 is required for the specification of myogenic satellite cells."
Seale P., Sabourin L.A., Girgis-Gabardo A., Mansouri A., Gruss P., Rudnicki M.A.
Cell 102:777-786(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Skeletal muscle.
[2]"The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system."
Jostes B., Walther C., Gruss P.
Mech. Dev. 33:27-37(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-324.
[3]"Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism."
Diao Y., Guo X., Li Y., Sun K., Lu L., Jiang L., Fu X., Zhu H., Sun H., Wang H., Wu Z.
Cell Stem Cell 11:231-241(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PAXBP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF254422 mRNA. Translation: AAG16663.3.
U20792 mRNA. Translation: AAA64491.1.
PIRI49265.
RefSeqNP_035169.1. NM_011039.2.
UniGeneMm.218760.

3D structure databases

ProteinModelPortalP47239.
SMRP47239. Positions 35-158, 215-273.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202034. 1 interaction.

PTM databases

PhosphoSiteP47239.

Proteomic databases

PRIDEP47239.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030508; ENSMUSP00000030508; ENSMUSG00000028736.
GeneID18509.
KEGGmmu:18509.
UCSCuc008vms.1. mouse.

Organism-specific databases

CTD5081.
MGIMGI:97491. Pax7.

Phylogenomic databases

eggNOGNOG326044.
GeneTreeENSGT00680000099553.
HOGENOMHOG000230939.
HOVERGENHBG009115.
InParanoidP47239.
KOK09381.
OrthoDBEOG7WT431.
PhylomeDBP47239.
TreeFamTF351610.

Gene expression databases

BgeeP47239.
CleanExMM_PAX7.
GenevestigatorP47239.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022106. Pax7.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSPR00027. PAIREDBOX.
SMARTSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294240.
PROP47239.
SOURCESearch...

Entry information

Entry namePAX7_MOUSE
AccessionPrimary (citable) accession number: P47239
Secondary accession number(s): Q9ES16
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2004
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot