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Protein

Paired box protein Pax-7

Gene

Pax7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi215 – 27460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: MGI
  2. sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cartilage development Source: MGI
  2. chromatin remodeling Source: MGI
  3. dorsal/ventral neural tube patterning Source: MGI
  4. embryonic skeletal system development Source: MGI
  5. muscle tissue morphogenesis Source: MGI
  6. neuron fate commitment Source: MGI
  7. organ morphogenesis Source: MGI
  8. positive regulation of histone methylation Source: MGI
  9. positive regulation of myoblast proliferation Source: MGI
  10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  11. regulation of cell fate commitment Source: MGI
  12. regulation of gene expression Source: MGI
  13. regulation of protein binding Source: MGI
  14. regulation of transcription, DNA-templated Source: MGI
  15. skeletal muscle satellite cell commitment Source: MGI
  16. skeletal muscle tissue development Source: MGI
  17. skeletal muscle tissue regeneration Source: MGI
  18. spinal cord association neuron differentiation Source: MGI
  19. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Myogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-7
Gene namesi
Name:Pax7
Synonyms:Pax-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:97491. Pax7.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Paired box protein Pax-7PRO_0000050195Add
BLAST

Proteomic databases

PRIDEiP47239.

PTM databases

PhosphoSiteiP47239.

Expressioni

Developmental stagei

Expressed specifically during the development of the nervous and muscular system.

Gene expression databases

BgeeiP47239.
CleanExiMM_PAX7.
ExpressionAtlasiP47239. baseline and differential.
GenevestigatoriP47239.

Interactioni

Subunit structurei

Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX (By similarity). Interacts with PAXBP1; the interaction links PAX7 to a WDR5-containing histone methyltransferase complex.By similarity1 Publication

Protein-protein interaction databases

BioGridi202034. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP47239.
SMRiP47239. Positions 35-158, 215-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 161128PairedPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 208182Sufficient to mediate interaction with PAXBP1Add
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiNOG326044.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
InParanoidiP47239.
KOiK09381.
OrthoDBiEOG7WT431.
PhylomeDBiP47239.
TreeFamiTF351610.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022106. Pax7.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALPGAVPR MMRPGPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP
60 70 80 90 100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA
110 120 130 140 150
IGGSKPRQVA TPDVEKKIEE YKRENPGMFS WEIRDRLLKD GHCDRSTVPS
160 170 180 190 200
VSSISRVLRI KFGKKEDDEE GDKKEEDGEK KAKHSIDGIL GDKGNRLDEG
210 220 230 240 250
SDVESEPDLP LKRKQRRSRT TFTAEQLEEL EKAFERTHYP DIYTREELAQ
260 270 280 290 300
RTKLTEARVQ VWFSNRRARW RKQAGANQLA AFNHLLPGGF PPTGMPTLPP
310 320 330 340 350
YQLPDSTYPT TTISQDGGST VHRPQPLPPS TMHQGGLAAA AAAADTSSAY
360 370 380 390 400
GARHSFSSYS DSFMNPGAPS NHMNPVSNGL SPQVMSILSN PSAVPPQPQA
410 420 430 440 450
DFSISPLHGG LDSASSISAS CSQRADSIKP GDSLPTSQSY CPPTYSTTGY
460 470 480 490 500
SVDPVAGYQY SQYGQTAVDY LAKNVSLSTQ RRMKLGEHSA VLGLLPVETG

QAY
Length:503
Mass (Da):54,939
Last modified:September 27, 2004 - v2
Checksum:i8ECC952C5C2FCA27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601V → VV in AAA64491 (PubMed:1982921).Curated
Sequence conflicti137 – 1371L → W in AAA64491 (PubMed:1982921).Curated
Sequence conflicti202 – 2021D → G in AAA64491 (PubMed:1982921).Curated
Sequence conflicti259 – 2591V → F in AAA64491 (PubMed:1982921).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254422 mRNA. Translation: AAG16663.3.
U20792 mRNA. Translation: AAA64491.1.
CCDSiCCDS18850.1.
PIRiI49265.
RefSeqiNP_035169.1. NM_011039.2.
UniGeneiMm.218760.

Genome annotation databases

EnsembliENSMUST00000030508; ENSMUSP00000030508; ENSMUSG00000028736.
GeneIDi18509.
KEGGimmu:18509.
UCSCiuc008vms.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254422 mRNA. Translation: AAG16663.3.
U20792 mRNA. Translation: AAA64491.1.
CCDSiCCDS18850.1.
PIRiI49265.
RefSeqiNP_035169.1. NM_011039.2.
UniGeneiMm.218760.

3D structure databases

ProteinModelPortaliP47239.
SMRiP47239. Positions 35-158, 215-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202034. 1 interaction.

PTM databases

PhosphoSiteiP47239.

Proteomic databases

PRIDEiP47239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030508; ENSMUSP00000030508; ENSMUSG00000028736.
GeneIDi18509.
KEGGimmu:18509.
UCSCiuc008vms.1. mouse.

Organism-specific databases

CTDi5081.
MGIiMGI:97491. Pax7.

Phylogenomic databases

eggNOGiNOG326044.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.
HOVERGENiHBG009115.
InParanoidiP47239.
KOiK09381.
OrthoDBiEOG7WT431.
PhylomeDBiP47239.
TreeFamiTF351610.

Miscellaneous databases

NextBioi294240.
PROiP47239.
SOURCEiSearch...

Gene expression databases

BgeeiP47239.
CleanExiMM_PAX7.
ExpressionAtlasiP47239. baseline and differential.
GenevestigatoriP47239.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022106. Pax7.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Pax7 is required for the specification of myogenic satellite cells."
    Seale P., Sabourin L.A., Girgis-Gabardo A., Mansouri A., Gruss P., Rudnicki M.A.
    Cell 102:777-786(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Skeletal muscle.
  2. "The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system."
    Jostes B., Walther C., Gruss P.
    Mech. Dev. 33:27-37(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-324.
  3. "Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism."
    Diao Y., Guo X., Li Y., Sun K., Lu L., Jiang L., Fu X., Zhu H., Sun H., Wang H., Wu Z.
    Cell Stem Cell 11:231-241(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PAXBP1.

Entry informationi

Entry nameiPAX7_MOUSE
AccessioniPrimary (citable) accession number: P47239
Secondary accession number(s): Q9ES16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2004
Last modified: January 7, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.