ID   BPHC1_RHOGO             Reviewed;         291 AA.
AC   P47231;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-MAR-2009, entry version 48.
DE   RecName: Full=Biphenyl-2,3-diol 1,2-dioxygenase 1;
DE            EC=1.13.11.39;
DE   AltName: Full=Biphenyl-2,3-diol 1,2-dioxygenase I;
DE   AltName: Full=23OHBP oxygenase I;
DE   AltName: Full=2,3-dihydroxybiphenyl dioxygenase I;
DE            Short=DHBD I;
GN   Name=bphC1;
OS   Rhodococcus globerulus.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=33008;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=P6;
RX   MEDLINE=94171820; PubMed=8126007;
RA   Asturias J.A., Eltis L.D., Prucha M., Timmis K.N.;
RT   "Analysis of three 2,3-dihydroxybiphenyl 1,2-dioxygenases found in
RT   Rhodococcus globerulus P6. Identification of a new family of extradiol
RT   dioxygenases.";
RL   J. Biol. Chem. 269:7807-7815(1994).
CC   -!- CATALYTIC ACTIVITY: Biphenyl-2,3-diol + O(2) = 2-hydroxy-6-oxo-6-
CC       phenylhexa-2,4-dienoate + H(2)O.
CC   -!- COFACTOR: Fe(2+) ion.
CC   -!- PATHWAY: Xenobiotic degradation; biphenyl degradation; 2-hydroxy-
CC       2,4-pentadienoic acid and benzoic acid from biphenyl: step 3/4.
CC   -!- SIMILARITY: Belongs to the extradiol ring-cleavage dioxygenase
CC       family.
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DR   EMBL; X75633; CAA53297.1; -; Genomic_DNA.
DR   PIR; B53419; B53419.
DR   HSSP; P47228; 1KND.
DR   BRENDA; 1.13.11.39; 189189.
DR   GO; GO:0018583; F:biphenyl-2,3-diol 1,2-dioxygenase activity; IEA:EC.
DR   GO; GO:0008198; F:ferrous iron binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0042178; P:xenobiotic catabolic process; IEA:InterPro.
DR   InterPro; IPR017626; DiOHbiphenyl_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   InterPro; IPR000486; Xdiol_dOase_1_2.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   ProDom; PD002334; Gly_diox; 2.
DR   TIGRFAMs; TIGR03213; 23dbph12diox; 1.
DR   PROSITE; PS00082; EXTRADIOL_DIOXYGENAS; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Dioxygenase; Iron; Metal-binding;
KW   Oxidoreductase.
FT   CHAIN         1    291       Biphenyl-2,3-diol 1,2-dioxygenase 1.
FT                                /FTId=PRO_0000085037.
FT   METAL       146    146       Iron (By similarity).
FT   METAL       210    210       Iron (By similarity).
FT   METAL       260    260       Iron (By similarity).
SQ   SEQUENCE   291 AA;  32081 MW;  104F189FE1EDDA6A CRC64;
     MSVQRLGYLG IEVSDVDAWR TYATMRLGAM EAPAPEGTAR FRLDSRAWRF MVTPGPADDL
     SVAGYEVDSE GALMQVKTRL EAYGVKVTSE SSELAAERGV LGLISCVDPA GTRLEIYYGG
     TEMFEVPFAS PTGVKEFRTD DQGMGHYVLA VPDVDAALDF YVQGLGFHLS DVIDWQVSPE
     VSVRLHFLHC NGRHHTLAVV GMPSDKKMHH LMIETTNLDD VGLAYDRCVE DDAVILTLGR
     HTNDHMVSFY GATPSGFAVE FGWGSRVVEP GWSVVRYDAI SIWGHKIMRG E
//