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P47212 (GALA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin peptides

Cleaved into the following 2 chains:

  1. Galanin
  2. Galanin message-associated peptide
    Short name=GMAP
Gene names
Name:Gal
Synonyms:Galn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length124 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.

Subcellular location

Secreted.

Sequence similarities

Belongs to the galanin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 3011 By similarity
PRO_0000010451
Peptide33 – 6129Galanin By similarity
PRO_0000010452
Peptide65 – 12460Galanin message-associated peptide By similarity
PRO_0000010453

Amino acid modifications

Modified residue611Threonine amide By similarity
Modified residue1181Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P47212 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: B49B03B60FACEFD7

FASTA12413,471
        10         20         30         40         50         60 
MARGSVILLG WLLLVVTLSA TLGLGMPAKE KRGWTLNSAG YLLGPHAIDN HRSFSDKHGL 

        70         80         90        100        110        120 
TGKRELQLEV EERRPGSVDV PLPESNIVRT IMEFLSFLHL KEAGALDSLP GIPLATSSED 


LEKS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterisation of the mouse preprogalanin gene."
Kofler B., Liu M.L., Jacoby A.S., Shine J., Iismaa T.P.
Gene 182:71-75(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[3]"cDNA sequence, ligand biding, and regulation of galanin/GMAP in mouse brain."
Lundkvist J., Land T., Kahl U., Bedecs K., Bartfai T.
Neurosci. Lett. 200:121-124(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-124.
Tissue: Hypothalamus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L38580 expand/collapse EMBL AC list , L38576, L38577, L38578, L38579 Genomic DNA. Translation: AAB41545.1.
BC044055 mRNA. Translation: AAH44055.1.
Z23069 mRNA. Translation: CAA80610.1.
PIRJC5480.
S34301.
RefSeqNP_034383.1. NM_010253.3.
UniGeneMm.4655.

3D structure databases

ProteinModelPortalP47212.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025842.

PTM databases

PhosphoSiteP47212.

Proteomic databases

PRIDEP47212.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025842; ENSMUSP00000025842; ENSMUSG00000024907.
GeneID14419.
KEGGmmu:14419.
UCSCuc008fwj.1. mouse.

Organism-specific databases

CTD51083.
MGIMGI:95637. Gal.

Phylogenomic databases

eggNOGNOG44932.
HOGENOMHOG000112690.
HOVERGENHBG005799.
InParanoidP47212.
KOK05244.
OMAHAIDNHR.
OrthoDBEOG79SF01.
PhylomeDBP47212.
TreeFamTF335850.

Gene expression databases

ArrayExpressP47212.
BgeeP47212.
CleanExMM_GAL.
GenevestigatorP47212.

Family and domain databases

InterProIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSPR00273. GALANIN.
ProDomPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286005.
PROP47212.
SOURCESearch...

Entry information

Entry nameGALA_MOUSE
AccessionPrimary (citable) accession number: P47212
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot