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Protein

Galanin peptides

Gene

Gal

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin peptides
Cleaved into the following 2 chains:
Gene namesi
Name:Gal
Synonyms:Galn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95637. Gal.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001045120 – 30By similarityAdd BLAST11
PeptideiPRO_000001045233 – 61GalaninBy similarityAdd BLAST29
PeptideiPRO_000001045365 – 124Galanin message-associated peptideBy similarityAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61Threonine amideBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei118PhosphoserineBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP47212.
PRIDEiP47212.

PTM databases

iPTMnetiP47212.
PhosphoSitePlusiP47212.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024907.
CleanExiMM_GAL.
ExpressionAtlasiP47212. baseline and differential.
GenevisibleiP47212. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025842.

Structurei

3D structure databases

ProteinModelPortaliP47212.
SMRiP47212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZPR. Eukaryota.
ENOG410YNUP. LUCA.
GeneTreeiENSGT00390000009663.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP47212.
KOiK05244.
OMAiWSPAKEK.
OrthoDBiEOG091G109K.
PhylomeDBiP47212.
TreeFamiTF335850.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGSVILLG WLLLVVTLSA TLGLGMPAKE KRGWTLNSAG YLLGPHAIDN
60 70 80 90 100
HRSFSDKHGL TGKRELQLEV EERRPGSVDV PLPESNIVRT IMEFLSFLHL
110 120
KEAGALDSLP GIPLATSSED LEKS
Length:124
Mass (Da):13,471
Last modified:February 1, 1996 - v1
Checksum:iB49B03B60FACEFD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38580
, L38576, L38577, L38578, L38579 Genomic DNA. Translation: AAB41545.1.
BC044055 mRNA. Translation: AAH44055.1.
Z23069 mRNA. Translation: CAA80610.1.
CCDSiCCDS29396.1.
PIRiJC5480.
S34301.
RefSeqiNP_034383.1. NM_010253.4.
UniGeneiMm.4655.

Genome annotation databases

EnsembliENSMUST00000025842; ENSMUSP00000025842; ENSMUSG00000024907.
GeneIDi14419.
KEGGimmu:14419.
UCSCiuc008fwj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38580
, L38576, L38577, L38578, L38579 Genomic DNA. Translation: AAB41545.1.
BC044055 mRNA. Translation: AAH44055.1.
Z23069 mRNA. Translation: CAA80610.1.
CCDSiCCDS29396.1.
PIRiJC5480.
S34301.
RefSeqiNP_034383.1. NM_010253.4.
UniGeneiMm.4655.

3D structure databases

ProteinModelPortaliP47212.
SMRiP47212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025842.

PTM databases

iPTMnetiP47212.
PhosphoSitePlusiP47212.

Proteomic databases

PaxDbiP47212.
PRIDEiP47212.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025842; ENSMUSP00000025842; ENSMUSG00000024907.
GeneIDi14419.
KEGGimmu:14419.
UCSCiuc008fwj.1. mouse.

Organism-specific databases

CTDi51083.
MGIiMGI:95637. Gal.

Phylogenomic databases

eggNOGiENOG410IZPR. Eukaryota.
ENOG410YNUP. LUCA.
GeneTreeiENSGT00390000009663.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP47212.
KOiK05244.
OMAiWSPAKEK.
OrthoDBiEOG091G109K.
PhylomeDBiP47212.
TreeFamiTF335850.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP47212.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024907.
CleanExiMM_GAL.
ExpressionAtlasiP47212. baseline and differential.
GenevisibleiP47212. MM.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALA_MOUSE
AccessioniPrimary (citable) accession number: P47212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.