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Protein

Galanin peptides

Gene

Gal

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Neuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin peptides
Cleaved into the following 2 chains:
Gene namesi
Name:Gal
Synonyms:Galn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95637 Gal

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001045120 – 30By similarityAdd BLAST11
PeptideiPRO_000001045233 – 61GalaninBy similarityAdd BLAST29
PeptideiPRO_000001045365 – 124Galanin message-associated peptideBy similarityAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61Threonine amideBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei118PhosphoserineBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP47212
PRIDEiP47212

PTM databases

iPTMnetiP47212
PhosphoSitePlusiP47212

Expressioni

Gene expression databases

BgeeiENSMUSG00000024907
CleanExiMM_GAL
ExpressionAtlasiP47212 baseline and differential
GenevisibleiP47212 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025842

Structurei

3D structure databases

ProteinModelPortaliP47212
SMRiP47212
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZPR Eukaryota
ENOG410YNUP LUCA
GeneTreeiENSGT00390000009663
HOGENOMiHOG000112690
HOVERGENiHBG005799
InParanoidiP47212
KOiK05244
OMAiWSPAKEK
OrthoDBiEOG091G109K
PhylomeDBiP47212
TreeFamiTF335850

Family and domain databases

InterProiView protein in InterPro
IPR008174 Galanin
IPR008175 Galanin_pre
IPR013068 GMAP
PANTHERiPTHR16839 PTHR16839, 1 hit
PfamiView protein in Pfam
PF01296 Galanin, 1 hit
PF06540 GMAP, 1 hit
PRINTSiPR00273 GALANIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005962 Galanin, 1 hit
PD012185 GMAP, 1 hit
SMARTiView protein in SMART
SM00071 Galanin, 1 hit
PROSITEiView protein in PROSITE
PS00861 GALANIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGSVILLG WLLLVVTLSA TLGLGMPAKE KRGWTLNSAG YLLGPHAIDN
60 70 80 90 100
HRSFSDKHGL TGKRELQLEV EERRPGSVDV PLPESNIVRT IMEFLSFLHL
110 120
KEAGALDSLP GIPLATSSED LEKS
Length:124
Mass (Da):13,471
Last modified:February 1, 1996 - v1
Checksum:iB49B03B60FACEFD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38580
, L38576, L38577, L38578, L38579 Genomic DNA Translation: AAB41545.1
BC044055 mRNA Translation: AAH44055.1
Z23069 mRNA Translation: CAA80610.1
CCDSiCCDS29396.1
PIRiJC5480
S34301
RefSeqiNP_034383.1, NM_010253.4
UniGeneiMm.4655

Genome annotation databases

EnsembliENSMUST00000025842; ENSMUSP00000025842; ENSMUSG00000024907
GeneIDi14419
KEGGimmu:14419
UCSCiuc008fwj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGALA_MOUSE
AccessioniPrimary (citable) accession number: P47212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health