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P47212

- GALA_MOUSE

UniProt

P47212 - GALA_MOUSE

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Protein

Galanin peptides

Gene

Gal

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.

GO - Molecular functioni

  1. neuropeptide hormone activity Source: UniProtKB
  2. type 1 galanin receptor binding Source: UniProtKB
  3. type 2 galanin receptor binding Source: UniProtKB
  4. type 3 galanin receptor binding Source: UniProtKB

GO - Biological processi

  1. cAMP-mediated signaling Source: Ensembl
  2. feeding behavior Source: Ensembl
  3. inflammatory response Source: Ensembl
  4. negative regulation of lymphocyte proliferation Source: Ensembl
  5. negative regulation of root hair elongation Source: Ensembl
  6. nervous system development Source: MGI
  7. neuropeptide signaling pathway Source: MGI
  8. positive regulation of apoptotic process Source: Ensembl
  9. positive regulation of catagen Source: Ensembl
  10. positive regulation of cortisol secretion Source: Ensembl
  11. positive regulation of large conductance calcium-activated potassium channel activity Source: Ensembl
  12. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  13. protein kinase A signaling Source: Ensembl
  14. regulation of glucocorticoid metabolic process Source: Ensembl
  15. response to drug Source: Ensembl
  16. response to estrogen Source: Ensembl
  17. response to insulin Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_235286. Peptide ligand-binding receptors.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin peptides
Cleaved into the following 2 chains:
Gene namesi
Name:Gal
Synonyms:Galn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:95637. Gal.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. neuronal cell body Source: Ensembl
  4. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 3011By similarityPRO_0000010451Add
BLAST
Peptidei33 – 6129GalaninBy similarityPRO_0000010452Add
BLAST
Peptidei65 – 12460Galanin message-associated peptideBy similarityPRO_0000010453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Threonine amideBy similarity
Modified residuei118 – 1181PhosphoserineBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PRIDEiP47212.

PTM databases

PhosphoSiteiP47212.

Expressioni

Gene expression databases

BgeeiP47212.
CleanExiMM_GAL.
ExpressionAtlasiP47212. baseline and differential.
GenevestigatoriP47212.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025842.

Structurei

3D structure databases

ProteinModelPortaliP47212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44932.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP47212.
KOiK05244.
OMAiHAIDNHR.
OrthoDBiEOG79SF01.
PhylomeDBiP47212.
TreeFamiTF335850.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47212-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARGSVILLG WLLLVVTLSA TLGLGMPAKE KRGWTLNSAG YLLGPHAIDN
60 70 80 90 100
HRSFSDKHGL TGKRELQLEV EERRPGSVDV PLPESNIVRT IMEFLSFLHL
110 120
KEAGALDSLP GIPLATSSED LEKS
Length:124
Mass (Da):13,471
Last modified:February 1, 1996 - v1
Checksum:iB49B03B60FACEFD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38580
, L38576, L38577, L38578, L38579 Genomic DNA. Translation: AAB41545.1.
BC044055 mRNA. Translation: AAH44055.1.
Z23069 mRNA. Translation: CAA80610.1.
CCDSiCCDS29396.1.
PIRiJC5480.
S34301.
RefSeqiNP_034383.1. NM_010253.3.
UniGeneiMm.4655.

Genome annotation databases

EnsembliENSMUST00000025842; ENSMUSP00000025842; ENSMUSG00000024907.
GeneIDi14419.
KEGGimmu:14419.
UCSCiuc008fwj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38580
, L38576 , L38577 , L38578 , L38579 Genomic DNA. Translation: AAB41545.1 .
BC044055 mRNA. Translation: AAH44055.1 .
Z23069 mRNA. Translation: CAA80610.1 .
CCDSi CCDS29396.1.
PIRi JC5480.
S34301.
RefSeqi NP_034383.1. NM_010253.3.
UniGenei Mm.4655.

3D structure databases

ProteinModelPortali P47212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000025842.

PTM databases

PhosphoSitei P47212.

Proteomic databases

PRIDEi P47212.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025842 ; ENSMUSP00000025842 ; ENSMUSG00000024907 .
GeneIDi 14419.
KEGGi mmu:14419.
UCSCi uc008fwj.1. mouse.

Organism-specific databases

CTDi 51083.
MGIi MGI:95637. Gal.

Phylogenomic databases

eggNOGi NOG44932.
HOGENOMi HOG000112690.
HOVERGENi HBG005799.
InParanoidi P47212.
KOi K05244.
OMAi HAIDNHR.
OrthoDBi EOG79SF01.
PhylomeDBi P47212.
TreeFami TF335850.

Enzyme and pathway databases

Reactomei REACT_235286. Peptide ligand-binding receptors.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 286005.
PROi P47212.
SOURCEi Search...

Gene expression databases

Bgeei P47212.
CleanExi MM_GAL.
ExpressionAtlasi P47212. baseline and differential.
Genevestigatori P47212.

Family and domain databases

InterProi IPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view ]
Pfami PF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view ]
PRINTSi PR00273. GALANIN.
ProDomi PD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00071. Galanin. 1 hit.
[Graphical view ]
PROSITEi PS00861. GALANIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterisation of the mouse preprogalanin gene."
    Kofler B., Liu M.L., Jacoby A.S., Shine J., Iismaa T.P.
    Gene 182:71-75(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "cDNA sequence, ligand biding, and regulation of galanin/GMAP in mouse brain."
    Lundkvist J., Land T., Kahl U., Bedecs K., Bartfai T.
    Neurosci. Lett. 200:121-124(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-124.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiGALA_MOUSE
AccessioniPrimary (citable) accession number: P47212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3