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P47212

- GALA_MOUSE

UniProt

P47212 - GALA_MOUSE

Protein

Galanin peptides

Gene

Gal

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: UniProtKB
    2. type 1 galanin receptor binding Source: UniProtKB
    3. type 2 galanin receptor binding Source: UniProtKB
    4. type 3 galanin receptor binding Source: UniProtKB

    GO - Biological processi

    1. feeding behavior Source: Ensembl
    2. inflammatory response Source: Ensembl
    3. negative regulation of lymphocyte proliferation Source: Ensembl
    4. nervous system development Source: MGI
    5. neuropeptide signaling pathway Source: MGI
    6. positive regulation of apoptotic process Source: Ensembl
    7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    8. regulation of glucocorticoid metabolic process Source: Ensembl
    9. response to drug Source: Ensembl
    10. response to estrogen Source: Ensembl
    11. response to insulin Source: Ensembl

    Keywords - Molecular functioni

    Hormone, Neuropeptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin peptides
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Gal
    Synonyms:Galn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:95637. Gal.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. Golgi apparatus Source: Ensembl
    3. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 3011By similarityPRO_0000010451Add
    BLAST
    Peptidei33 – 6129GalaninBy similarityPRO_0000010452Add
    BLAST
    Peptidei65 – 12460Galanin message-associated peptideBy similarityPRO_0000010453Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611Threonine amideBy similarity
    Modified residuei118 – 1181PhosphoserineBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Phosphoprotein

    Proteomic databases

    PRIDEiP47212.

    PTM databases

    PhosphoSiteiP47212.

    Expressioni

    Gene expression databases

    ArrayExpressiP47212.
    BgeeiP47212.
    CleanExiMM_GAL.
    GenevestigatoriP47212.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000025842.

    Structurei

    3D structure databases

    ProteinModelPortaliP47212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the galanin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44932.
    HOGENOMiHOG000112690.
    HOVERGENiHBG005799.
    InParanoidiP47212.
    KOiK05244.
    OMAiHAIDNHR.
    OrthoDBiEOG79SF01.
    PhylomeDBiP47212.
    TreeFamiTF335850.

    Family and domain databases

    InterProiIPR008174. Galanin.
    IPR008175. Galanin_pre.
    IPR013068. GMAP.
    [Graphical view]
    PfamiPF01296. Galanin. 1 hit.
    PF06540. GMAP. 1 hit.
    [Graphical view]
    PRINTSiPR00273. GALANIN.
    ProDomiPD005962. Galanin. 1 hit.
    PD012185. GMAP. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00071. Galanin. 1 hit.
    [Graphical view]
    PROSITEiPS00861. GALANIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47212-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGSVILLG WLLLVVTLSA TLGLGMPAKE KRGWTLNSAG YLLGPHAIDN    50
    HRSFSDKHGL TGKRELQLEV EERRPGSVDV PLPESNIVRT IMEFLSFLHL 100
    KEAGALDSLP GIPLATSSED LEKS 124
    Length:124
    Mass (Da):13,471
    Last modified:February 1, 1996 - v1
    Checksum:iB49B03B60FACEFD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38580
    , L38576, L38577, L38578, L38579 Genomic DNA. Translation: AAB41545.1.
    BC044055 mRNA. Translation: AAH44055.1.
    Z23069 mRNA. Translation: CAA80610.1.
    CCDSiCCDS29396.1.
    PIRiJC5480.
    S34301.
    RefSeqiNP_034383.1. NM_010253.3.
    UniGeneiMm.4655.

    Genome annotation databases

    EnsembliENSMUST00000025842; ENSMUSP00000025842; ENSMUSG00000024907.
    GeneIDi14419.
    KEGGimmu:14419.
    UCSCiuc008fwj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38580
    , L38576 , L38577 , L38578 , L38579 Genomic DNA. Translation: AAB41545.1 .
    BC044055 mRNA. Translation: AAH44055.1 .
    Z23069 mRNA. Translation: CAA80610.1 .
    CCDSi CCDS29396.1.
    PIRi JC5480.
    S34301.
    RefSeqi NP_034383.1. NM_010253.3.
    UniGenei Mm.4655.

    3D structure databases

    ProteinModelPortali P47212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000025842.

    PTM databases

    PhosphoSitei P47212.

    Proteomic databases

    PRIDEi P47212.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025842 ; ENSMUSP00000025842 ; ENSMUSG00000024907 .
    GeneIDi 14419.
    KEGGi mmu:14419.
    UCSCi uc008fwj.1. mouse.

    Organism-specific databases

    CTDi 51083.
    MGIi MGI:95637. Gal.

    Phylogenomic databases

    eggNOGi NOG44932.
    HOGENOMi HOG000112690.
    HOVERGENi HBG005799.
    InParanoidi P47212.
    KOi K05244.
    OMAi HAIDNHR.
    OrthoDBi EOG79SF01.
    PhylomeDBi P47212.
    TreeFami TF335850.

    Miscellaneous databases

    NextBioi 286005.
    PROi P47212.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47212.
    Bgeei P47212.
    CleanExi MM_GAL.
    Genevestigatori P47212.

    Family and domain databases

    InterProi IPR008174. Galanin.
    IPR008175. Galanin_pre.
    IPR013068. GMAP.
    [Graphical view ]
    Pfami PF01296. Galanin. 1 hit.
    PF06540. GMAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00273. GALANIN.
    ProDomi PD005962. Galanin. 1 hit.
    PD012185. GMAP. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00071. Galanin. 1 hit.
    [Graphical view ]
    PROSITEi PS00861. GALANIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterisation of the mouse preprogalanin gene."
      Kofler B., Liu M.L., Jacoby A.S., Shine J., Iismaa T.P.
      Gene 182:71-75(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "cDNA sequence, ligand biding, and regulation of galanin/GMAP in mouse brain."
      Lundkvist J., Land T., Kahl U., Bedecs K., Bartfai T.
      Neurosci. Lett. 200:121-124(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-124.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiGALA_MOUSE
    AccessioniPrimary (citable) accession number: P47212
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3