Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Galanin receptor type 1

Gene

GALR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.2 Publications

GO - Molecular functioni

  • galanin receptor activity Source: UniProtKB
  • neuropeptide binding Source: Ensembl
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: GO_Central
  • digestion Source: ProtInc
  • negative regulation of adenylate cyclase activity Source: ProtInc
  • neuropeptide signaling pathway Source: ProtInc
  • positive regulation of cortisol secretion Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166573-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 1
Short name:
GAL1-R
Short name:
GALR-1
Gene namesi
Name:GALR1
Synonyms:GALNR, GALNR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:4132. GALR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 70CytoplasmicSequence analysisAdd BLAST13
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 109ExtracellularSequence analysisAdd BLAST18
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 151CytoplasmicSequence analysisAdd BLAST20
Transmembranei152 – 172Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini173 – 200ExtracellularSequence analysisAdd BLAST28
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 248CytoplasmicSequence analysisAdd BLAST27
Transmembranei249 – 269Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini270 – 271ExtracellularSequence analysis2
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 349CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2587.
OpenTargetsiENSG00000166573.
PharmGKBiPA28545.

Chemistry databases

ChEMBLiCHEMBL4894.
GuidetoPHARMACOLOGYi243.

Polymorphism and mutation databases

BioMutaiGALR1.
DMDMi311033447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694631 – 349Galanin receptor type 1Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi108 ↔ 187PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Lipidationi320S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP47211.
PRIDEiP47211.

PTM databases

iPTMnetiP47211.
PhosphoSitePlusiP47211.

Expressioni

Gene expression databases

BgeeiENSG00000166573.
CleanExiHS_GALR1.
GenevisibleiP47211. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GALP224662EBI-6624741,EBI-6624800

Protein-protein interaction databases

IntActiP47211. 1 interactor.
STRINGi9606.ENSP00000299727.

Chemistry databases

BindingDBiP47211.

Structurei

3D structure databases

ProteinModelPortaliP47211.
SMRiP47211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiP47211.
KOiK04230.
OMAiVGCIWAL.
OrthoDBiEOG091G0ZDG.
PhylomeDBiP47211.
TreeFamiTF315737.

Family and domain databases

InterProiIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG
60 70 80 90 100
NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT
110 120 130 140 150
WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR
160 170 180 190 200
NALLGVGCIW ALSIAMASPV AYHQGLFHPR ASNQTFCWEQ WPDPRHKKAY
210 220 230 240 250
VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA SKKKTAQTVL
260 270 280 290 300
VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP
310 320 330 340
IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV
Length:349
Mass (Da):38,953
Last modified:November 2, 2010 - v3
Checksum:iA0664227157B3410
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00351415W → C.2 PublicationsCorresponds to variant rs1143093dbSNPEnsembl.1
Natural variantiVAR_014682334S → N.7 PublicationsCorresponds to variant rs5376dbSNPEnsembl.1
Natural variantiVAR_014683342P → L.Corresponds to variant rs5377dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34339 mRNA. Translation: AAA50767.1.
U53511 mRNA. Translation: AAC51936.1.
U90660, U90658, U90659 Genomic DNA. Translation: AAC95397.1.
U23854 mRNA. Translation: AAB60356.1.
AY541036 mRNA. Translation: AAS47032.1.
AC100863 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66603.1.
BC095530 mRNA. Translation: AAH95530.1.
CCDSiCCDS12012.1.
PIRiI59336.
RefSeqiNP_001471.2. NM_001480.3.
UniGeneiHs.272191.

Genome annotation databases

EnsembliENST00000299727; ENSP00000299727; ENSG00000166573.
GeneIDi2587.
KEGGihsa:2587.
UCSCiuc002lms.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34339 mRNA. Translation: AAA50767.1.
U53511 mRNA. Translation: AAC51936.1.
U90660, U90658, U90659 Genomic DNA. Translation: AAC95397.1.
U23854 mRNA. Translation: AAB60356.1.
AY541036 mRNA. Translation: AAS47032.1.
AC100863 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66603.1.
BC095530 mRNA. Translation: AAH95530.1.
CCDSiCCDS12012.1.
PIRiI59336.
RefSeqiNP_001471.2. NM_001480.3.
UniGeneiHs.272191.

3D structure databases

ProteinModelPortaliP47211.
SMRiP47211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP47211. 1 interactor.
STRINGi9606.ENSP00000299727.

Chemistry databases

BindingDBiP47211.
ChEMBLiCHEMBL4894.
GuidetoPHARMACOLOGYi243.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47211.
PhosphoSitePlusiP47211.

Polymorphism and mutation databases

BioMutaiGALR1.
DMDMi311033447.

Proteomic databases

PaxDbiP47211.
PRIDEiP47211.

Protocols and materials databases

DNASUi2587.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299727; ENSP00000299727; ENSG00000166573.
GeneIDi2587.
KEGGihsa:2587.
UCSCiuc002lms.5. human.

Organism-specific databases

CTDi2587.
DisGeNETi2587.
GeneCardsiGALR1.
H-InvDBHIX0039721.
HGNCiHGNC:4132. GALR1.
MIMi600377. gene.
neXtProtiNX_P47211.
OpenTargetsiENSG00000166573.
PharmGKBiPA28545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiP47211.
KOiK04230.
OMAiVGCIWAL.
OrthoDBiEOG091G0ZDG.
PhylomeDBiP47211.
TreeFamiTF315737.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166573-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiGalanin_receptor_1.
GenomeRNAii2587.
PROiP47211.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166573.
CleanExiHS_GALR1.
GenevisibleiP47211. HS.

Family and domain databases

InterProiIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALR1_HUMAN
AccessioniPrimary (citable) accession number: P47211
Secondary accession number(s): Q4VBL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.