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P47211

- GALR1_HUMAN

UniProt

P47211 - GALR1_HUMAN

Protein

Galanin receptor type 1

Gene

GALR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

    GO - Molecular functioni

    1. galanin receptor activity Source: UniProtKB
    2. neuropeptide binding Source: Ensembl
    3. peptide hormone binding Source: UniProtKB
    4. protein binding Source: IntAct

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. digestion Source: ProtInc
    3. negative regulation of adenylate cyclase activity Source: ProtInc
    4. neuropeptide signaling pathway Source: ProtInc
    5. positive regulation of cortisol secretion Source: UniProt
    6. positive regulation of cytosolic calcium ion concentration Source: InterPro
    7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin receptor type 1
    Short name:
    GAL1-R
    Short name:
    GALR-1
    Gene namesi
    Name:GALR1
    Synonyms:GALNR, GALNR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:4132. GALR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28545.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Galanin receptor type 1PRO_0000069463Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 187PROSITE-ProRule annotation
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Lipidationi320 – 3201S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP47211.
    PRIDEiP47211.

    PTM databases

    PhosphoSiteiP47211.

    Expressioni

    Gene expression databases

    BgeeiP47211.
    CleanExiHS_GALR1.
    GenevestigatoriP47211.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GALP224662EBI-6624741,EBI-6624800

    Protein-protein interaction databases

    IntActiP47211. 1 interaction.
    STRINGi9606.ENSP00000299727.

    Structurei

    3D structure databases

    ProteinModelPortaliP47211.
    SMRiP47211. Positions 35-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini58 – 7013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini92 – 10918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini173 – 20028ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 24827CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini270 – 2712ExtracellularSequence Analysis
    Topological domaini293 – 34957CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320953.
    HOGENOMiHOG000230487.
    HOVERGENiHBG101447.
    InParanoidiP47211.
    KOiK04230.
    OMAiPVAYHQG.
    OrthoDBiEOG7327PK.
    PhylomeDBiP47211.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR003906. GAL1_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01418. GALANIN1R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47211-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG    50
    NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT 100
    WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR 150
    NALLGVGCIW ALSIAMASPV AYHQGLFHPR ASNQTFCWEQ WPDPRHKKAY 200
    VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA SKKKTAQTVL 250
    VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP 300
    IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV 349
    Length:349
    Mass (Da):38,953
    Last modified:November 2, 2010 - v3
    Checksum:iA0664227157B3410
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151W → C.2 Publications
    Corresponds to variant rs1143093 [ dbSNP | Ensembl ].
    VAR_003514
    Natural varianti334 – 3341S → N.7 Publications
    Corresponds to variant rs5376 [ dbSNP | Ensembl ].
    VAR_014682
    Natural varianti342 – 3421P → L.
    Corresponds to variant rs5377 [ dbSNP | Ensembl ].
    VAR_014683

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34339 mRNA. Translation: AAA50767.1.
    U53511 mRNA. Translation: AAC51936.1.
    U90660, U90658, U90659 Genomic DNA. Translation: AAC95397.1.
    U23854 mRNA. Translation: AAB60356.1.
    AY541036 mRNA. Translation: AAS47032.1.
    AC100863 Genomic DNA. No translation available.
    CH471117 Genomic DNA. Translation: EAW66603.1.
    BC095530 mRNA. Translation: AAH95530.1.
    CCDSiCCDS12012.1.
    PIRiI59336.
    RefSeqiNP_001471.2. NM_001480.3.
    UniGeneiHs.272191.

    Genome annotation databases

    EnsembliENST00000299727; ENSP00000299727; ENSG00000166573.
    GeneIDi2587.
    KEGGihsa:2587.
    UCSCiuc002lms.4. human.

    Polymorphism databases

    DMDMi311033447.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34339 mRNA. Translation: AAA50767.1 .
    U53511 mRNA. Translation: AAC51936.1 .
    U90660 , U90658 , U90659 Genomic DNA. Translation: AAC95397.1 .
    U23854 mRNA. Translation: AAB60356.1 .
    AY541036 mRNA. Translation: AAS47032.1 .
    AC100863 Genomic DNA. No translation available.
    CH471117 Genomic DNA. Translation: EAW66603.1 .
    BC095530 mRNA. Translation: AAH95530.1 .
    CCDSi CCDS12012.1.
    PIRi I59336.
    RefSeqi NP_001471.2. NM_001480.3.
    UniGenei Hs.272191.

    3D structure databases

    ProteinModelPortali P47211.
    SMRi P47211. Positions 35-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P47211. 1 interaction.
    STRINGi 9606.ENSP00000299727.

    Chemistry

    BindingDBi P47211.
    ChEMBLi CHEMBL4894.
    GuidetoPHARMACOLOGYi 243.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P47211.

    Polymorphism databases

    DMDMi 311033447.

    Proteomic databases

    PaxDbi P47211.
    PRIDEi P47211.

    Protocols and materials databases

    DNASUi 2587.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299727 ; ENSP00000299727 ; ENSG00000166573 .
    GeneIDi 2587.
    KEGGi hsa:2587.
    UCSCi uc002lms.4. human.

    Organism-specific databases

    CTDi 2587.
    GeneCardsi GC18P074962.
    H-InvDB HIX0039721.
    HGNCi HGNC:4132. GALR1.
    MIMi 600377. gene.
    neXtProti NX_P47211.
    PharmGKBi PA28545.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320953.
    HOGENOMi HOG000230487.
    HOVERGENi HBG101447.
    InParanoidi P47211.
    KOi K04230.
    OMAi PVAYHQG.
    OrthoDBi EOG7327PK.
    PhylomeDBi P47211.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Galanin_receptor_1.
    GenomeRNAii 2587.
    NextBioi 10233.
    PROi P47211.
    SOURCEi Search...

    Gene expression databases

    Bgeei P47211.
    CleanExi HS_GALR1.
    Genevestigatori P47211.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR003906. GAL1_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01418. GALANIN1R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-15 AND ASN-334.
      Tissue: Melanoma.
    2. "Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)."
      Lorimer D.D., Matkowskj K., Benya R.V.
      Biochem. Biophys. Res. Commun. 241:558-564(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-15 AND ASN-334.
      Tissue: Small intestine.
    3. "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene."
      Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P.
      Genomics 45:496-508(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-334.
    4. Ross P.C.
      Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-334.
      Tissue: Brain.
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-334.
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-334.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-334.

    Entry informationi

    Entry nameiGALR1_HUMAN
    AccessioniPrimary (citable) accession number: P47211
    Secondary accession number(s): Q4VBL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3