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P47211

- GALR1_HUMAN

UniProt

P47211 - GALR1_HUMAN

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Protein

Galanin receptor type 1

Gene

GALR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  1. galanin receptor activity Source: UniProtKB
  2. neuropeptide binding Source: Ensembl
  3. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. digestion Source: ProtInc
  3. negative regulation of adenylate cyclase activity Source: ProtInc
  4. neuropeptide signaling pathway Source: ProtInc
  5. positive regulation of cortisol secretion Source: UniProt
  6. positive regulation of cytosolic calcium ion concentration Source: InterPro
  7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 1
Short name:
GAL1-R
Short name:
GALR-1
Gene namesi
Name:GALR1
Synonyms:GALNR, GALNR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:4132. GALR1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Galanin receptor type 1PRO_0000069463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi108 ↔ 187PROSITE-ProRule annotation
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
Lipidationi320 – 3201S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP47211.
PRIDEiP47211.

PTM databases

PhosphoSiteiP47211.

Expressioni

Gene expression databases

BgeeiP47211.
CleanExiHS_GALR1.
GenevestigatoriP47211.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GALP224662EBI-6624741,EBI-6624800

Protein-protein interaction databases

IntActiP47211. 1 interaction.
STRINGi9606.ENSP00000299727.

Structurei

3D structure databases

ProteinModelPortaliP47211.
SMRiP47211. Positions 35-316.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
BLAST
Topological domaini58 – 7013CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini92 – 10918ExtracellularSequence AnalysisAdd
BLAST
Topological domaini132 – 15120CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini173 – 20028ExtracellularSequence AnalysisAdd
BLAST
Topological domaini222 – 24827CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini270 – 2712ExtracellularSequence Analysis
Topological domaini293 – 34957CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei71 – 9121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei152 – 17221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei249 – 26921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiP47211.
KOiK04230.
OMAiPVAYHQG.
OrthoDBiEOG7327PK.
PhylomeDBiP47211.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47211-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG
60 70 80 90 100
NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT
110 120 130 140 150
WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR
160 170 180 190 200
NALLGVGCIW ALSIAMASPV AYHQGLFHPR ASNQTFCWEQ WPDPRHKKAY
210 220 230 240 250
VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA SKKKTAQTVL
260 270 280 290 300
VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP
310 320 330 340
IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV
Length:349
Mass (Da):38,953
Last modified:November 2, 2010 - v3
Checksum:iA0664227157B3410
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151W → C.2 Publications
Corresponds to variant rs1143093 [ dbSNP | Ensembl ].
VAR_003514
Natural varianti334 – 3341S → N.7 Publications
Corresponds to variant rs5376 [ dbSNP | Ensembl ].
VAR_014682
Natural varianti342 – 3421P → L.
Corresponds to variant rs5377 [ dbSNP | Ensembl ].
VAR_014683

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34339 mRNA. Translation: AAA50767.1.
U53511 mRNA. Translation: AAC51936.1.
U90660, U90658, U90659 Genomic DNA. Translation: AAC95397.1.
U23854 mRNA. Translation: AAB60356.1.
AY541036 mRNA. Translation: AAS47032.1.
AC100863 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66603.1.
BC095530 mRNA. Translation: AAH95530.1.
CCDSiCCDS12012.1.
PIRiI59336.
RefSeqiNP_001471.2. NM_001480.3.
UniGeneiHs.272191.

Genome annotation databases

EnsembliENST00000299727; ENSP00000299727; ENSG00000166573.
GeneIDi2587.
KEGGihsa:2587.
UCSCiuc002lms.4. human.

Polymorphism databases

DMDMi311033447.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34339 mRNA. Translation: AAA50767.1 .
U53511 mRNA. Translation: AAC51936.1 .
U90660 , U90658 , U90659 Genomic DNA. Translation: AAC95397.1 .
U23854 mRNA. Translation: AAB60356.1 .
AY541036 mRNA. Translation: AAS47032.1 .
AC100863 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66603.1 .
BC095530 mRNA. Translation: AAH95530.1 .
CCDSi CCDS12012.1.
PIRi I59336.
RefSeqi NP_001471.2. NM_001480.3.
UniGenei Hs.272191.

3D structure databases

ProteinModelPortali P47211.
SMRi P47211. Positions 35-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P47211. 1 interaction.
STRINGi 9606.ENSP00000299727.

Chemistry

BindingDBi P47211.
ChEMBLi CHEMBL4894.
GuidetoPHARMACOLOGYi 243.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P47211.

Polymorphism databases

DMDMi 311033447.

Proteomic databases

PaxDbi P47211.
PRIDEi P47211.

Protocols and materials databases

DNASUi 2587.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299727 ; ENSP00000299727 ; ENSG00000166573 .
GeneIDi 2587.
KEGGi hsa:2587.
UCSCi uc002lms.4. human.

Organism-specific databases

CTDi 2587.
GeneCardsi GC18P074962.
H-InvDB HIX0039721.
HGNCi HGNC:4132. GALR1.
MIMi 600377. gene.
neXtProti NX_P47211.
PharmGKBi PA28545.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320953.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000230487.
HOVERGENi HBG101447.
InParanoidi P47211.
KOi K04230.
OMAi PVAYHQG.
OrthoDBi EOG7327PK.
PhylomeDBi P47211.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Galanin_receptor_1.
GenomeRNAii 2587.
NextBioi 10233.
PROi P47211.
SOURCEi Search...

Gene expression databases

Bgeei P47211.
CleanExi HS_GALR1.
Genevestigatori P47211.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-15 AND ASN-334.
    Tissue: Melanoma.
  2. "Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)."
    Lorimer D.D., Matkowskj K., Benya R.V.
    Biochem. Biophys. Res. Commun. 241:558-564(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-15 AND ASN-334.
    Tissue: Small intestine.
  3. "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene."
    Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P.
    Genomics 45:496-508(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-334.
  4. Ross P.C.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-334.
    Tissue: Brain.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-334.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-334.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-334.

Entry informationi

Entry nameiGALR1_HUMAN
AccessioniPrimary (citable) accession number: P47211
Secondary accession number(s): Q4VBL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3