P47211 (GALR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galanin receptor type 1
Short name=GAL1-R
Short name=GALR-1

Gene names

Name:	GALR1
Synonyms:	GALNR, GALNR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara digestion Traceable author statement PubMed 8670213. Source: ProtInc negative regulation of adenylate cyclase activity Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: ProtInc plasma membrane Traceable author statement. Source: Reactome
Molecular_function	galanin receptor activity Traceable author statement Ref.1. Source: ProtInc neuropeptide binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Galanin receptor type 1		PRO_0000069463
Regions
	Topological domain	1 – 36	36	Extracellular Potential
	Transmembrane	37 – 57	21	Helical; Name=1; Potential
	Topological domain	58 – 70	13	Cytoplasmic Potential
	Transmembrane	71 – 91	21	Helical; Name=2; Potential
	Topological domain	92 – 109	18	Extracellular Potential
	Transmembrane	110 – 131	22	Helical; Name=3; Potential
	Topological domain	132 – 151	20	Cytoplasmic Potential
	Transmembrane	152 – 172	21	Helical; Name=4; Potential
	Topological domain	173 – 200	28	Extracellular Potential
	Transmembrane	201 – 221	21	Helical; Name=5; Potential
	Topological domain	222 – 248	27	Cytoplasmic Potential
	Transmembrane	249 – 269	21	Helical; Name=6; Potential
	Topological domain	270 – 271	2	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 349	57	Cytoplasmic Potential
Amino acid modifications
	Lipidation	320	1	S-palmitoyl cysteine By similarity
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
	Disulfide bond	108 ↔ 187		By similarity
Natural variations
	Natural variant	15	1	W → C. Ref.1 Ref.2 Corresponds to variant rs1143093 [ dbSNP | Ensembl ].		VAR_003514
	Natural variant	334	1	S → N. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.7 Ref.8 Corresponds to variant rs5376 [ dbSNP | Ensembl ].		VAR_014682
	Natural variant	342	1	P → L. Corresponds to variant rs5377 [ dbSNP | Ensembl ].		VAR_014683

Sequences

	Sequence		Length	Mass (Da)
	P47211 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: A0664227157B3410	FASTA	349	38,953
	10 20 30 40 50 60 MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG NSLVITVLAR 70 80 90 100 110 120 SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML 130 140 150 160 170 180 VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGCIW ALSIAMASPV AYHQGLFHPR 190 200 210 220 230 240 ASNQTFCWEQ WPDPRHKKAY VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA 250 260 270 280 290 300 SKKKTAQTVL VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP 310 320 330 340 IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a functional human galanin receptor." Habert-Ortoli E., Amiranoff B., Loquet I., Laburthe M., Mayaux J.-F. Proc. Natl. Acad. Sci. U.S.A. 91:9780-9783(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-15 AND ASN-334. Tissue: Melanoma.
[2]	"Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)." Lorimer D.D., Matkowskj K., Benya R.V. Biochem. Biophys. Res. Commun. 241:558-564(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-15 AND ASN-334. Tissue: Small intestine.
[3]	"Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene." Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P. Genomics 45:496-508(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-334.
[4]	Ross P.C. Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-334. Tissue: Brain.
[5]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-334. Tissue: Brain.
[6]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-334.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-334.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L34339 mRNA. Translation: AAA50767.1. U53511 mRNA. Translation: AAC51936.1. U90660, U90658, U90659 Genomic DNA. Translation: AAC95397.1. U23854 mRNA. Translation: AAB60356.1. AY541036 mRNA. Translation: AAS47032.1. AC100863 Genomic DNA. No translation available. CH471117 Genomic DNA. Translation: EAW66603.1. BC095530 mRNA. Translation: AAH95530.1.
IPI	IPI00306781.
PIR	I59336.
RefSeq	NP_001471.2. NM_001480.3.
UniGene	Hs.272191.
3D structure databases
ProteinModelPortal	P47211.
SMR	P47211. Positions 35-316.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000299727.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P47211.
Polymorphism databases
DMDM	311033447.
Proteomic databases
PaxDb	P47211.
PRIDE	P47211.
Protocols and materials databases
DNASU	2587.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299727; ENSP00000299727; ENSG00000166573.
GeneID	2587.
KEGG	hsa:2587.
UCSC	uc002lms.4. human.
Organism-specific databases
CTD	2587.
GeneCards	GC18P074962.
H-InvDB	HIX0039721.
HGNC	HGNC:4132. GALR1.
MIM	600377. gene.
neXtProt	NX_P47211.
PharmGKB	PA28545.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320953.
HOGENOM	HOG000230487.
HOVERGEN	HBG101447.
InParanoid	P47211.
KO	K04230.
OMA	PVAYHQG.
OrthoDB	EOG4R5036.
PhylomeDB	P47211.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	P47211.
CleanEx	HS_GALR1.
Genevestigator	P47211.
GermOnline	ENSG00000166573. Homo sapiens.
Family and domain databases
InterPro	IPR000405. Galanin_rcpt. IPR003906. Galnin_1_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01418. GALANIN1R. PR00663. GALANINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P47211.
ChEMBL	CHEMBL4894.
GenomeRNAi	2587.
NextBio	10233.
SOURCE	Search...

Entry information

Entry name

GALR1_HUMAN

Accession

Primary (citable) accession number: P47211
Secondary accession number(s): Q4VBL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.