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P47211 (GALR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin receptor type 1

Short name=GAL1-R
Short name=GALR-1
Gene names
Name:GALR1
Synonyms:GALNR, GALNR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Palmitoylated on at least one of the three cysteine residues present in the C-terminal part.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GALP224662EBI-6624741,EBI-6624800

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Galanin receptor type 1
PRO_0000069463

Regions

Topological domain1 – 3636Extracellular Potential
Transmembrane37 – 5721Helical; Name=1; Potential
Topological domain58 – 7013Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 10918Extracellular Potential
Transmembrane110 – 13122Helical; Name=3; Potential
Topological domain132 – 15120Cytoplasmic Potential
Transmembrane152 – 17221Helical; Name=4; Potential
Topological domain173 – 20028Extracellular Potential
Transmembrane201 – 22121Helical; Name=5; Potential
Topological domain222 – 24827Cytoplasmic Potential
Transmembrane249 – 26921Helical; Name=6; Potential
Topological domain270 – 2712Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 34957Cytoplasmic Potential

Amino acid modifications

Lipidation3201S-palmitoyl cysteine By similarity
Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Disulfide bond108 ↔ 187 By similarity

Natural variations

Natural variant151W → C. Ref.1 Ref.2
Corresponds to variant rs1143093 [ dbSNP | Ensembl ].
VAR_003514
Natural variant3341S → N. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.7 Ref.8
Corresponds to variant rs5376 [ dbSNP | Ensembl ].
VAR_014682
Natural variant3421P → L.
Corresponds to variant rs5377 [ dbSNP | Ensembl ].
VAR_014683

Sequences

Sequence LengthMass (Da)Tools
P47211 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: A0664227157B3410

FASTA34938,953
        10         20         30         40         50         60 
MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG NSLVITVLAR 

        70         80         90        100        110        120 
SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML 

       130        140        150        160        170        180 
VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGCIW ALSIAMASPV AYHQGLFHPR 

       190        200        210        220        230        240 
ASNQTFCWEQ WPDPRHKKAY VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA 

       250        260        270        280        290        300 
SKKKTAQTVL VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP 

       310        320        330        340 
IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a functional human galanin receptor."
Habert-Ortoli E., Amiranoff B., Loquet I., Laburthe M., Mayaux J.-F.
Proc. Natl. Acad. Sci. U.S.A. 91:9780-9783(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-15 AND ASN-334.
Tissue: Melanoma.
[2]"Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)."
Lorimer D.D., Matkowskj K., Benya R.V.
Biochem. Biophys. Res. Commun. 241:558-564(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS CYS-15 AND ASN-334.
Tissue: Small intestine.
[3]"Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene."
Jacoby A.S., Webb G.C., Liu M.L., Kofler B., Hort Y.J., Fathi Z., Bottema C.D.K., Shine J., Iismaa T.P.
Genomics 45:496-508(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASN-334.
[4]Ross P.C.
Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-334.
Tissue: Brain.
[5]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-334.
Tissue: Brain.
[6]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-334.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-334.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34339 mRNA. Translation: AAA50767.1.
U53511 mRNA. Translation: AAC51936.1.
U90660, U90658, U90659 Genomic DNA. Translation: AAC95397.1.
U23854 mRNA. Translation: AAB60356.1.
AY541036 mRNA. Translation: AAS47032.1.
AC100863 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66603.1.
BC095530 mRNA. Translation: AAH95530.1.
CCDSCCDS12012.1.
PIRI59336.
RefSeqNP_001471.2. NM_001480.3.
UniGeneHs.272191.

3D structure databases

ProteinModelPortalP47211.
SMRP47211. Positions 35-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP47211. 1 interaction.
STRING9606.ENSP00000299727.

Chemistry

BindingDBP47211.
ChEMBLCHEMBL4894.
GuidetoPHARMACOLOGY243.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP47211.

Polymorphism databases

DMDM311033447.

Proteomic databases

PaxDbP47211.
PRIDEP47211.

Protocols and materials databases

DNASU2587.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299727; ENSP00000299727; ENSG00000166573.
GeneID2587.
KEGGhsa:2587.
UCSCuc002lms.4. human.

Organism-specific databases

CTD2587.
GeneCardsGC18P074962.
H-InvDBHIX0039721.
HGNCHGNC:4132. GALR1.
MIM600377. gene.
neXtProtNX_P47211.
PharmGKBPA28545.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320953.
HOGENOMHOG000230487.
HOVERGENHBG101447.
InParanoidP47211.
KOK04230.
OMAPVAYHQG.
OrthoDBEOG7327PK.
PhylomeDBP47211.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP47211.
CleanExHS_GALR1.
GenevestigatorP47211.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR003906. GAL1_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01418. GALANIN1R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGalanin_receptor_1.
GenomeRNAi2587.
NextBio10233.
PROP47211.
SOURCESearch...

Entry information

Entry nameGALR1_HUMAN
AccessionPrimary (citable) accession number: P47211
Secondary accession number(s): Q4VBL7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries