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Protein

T-complex protein 1 subunit epsilon

Gene

cct-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: WormBase

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • protein folding Source: WormBase

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-390471 Association of TriC/CCT with target proteins during biosynthesis
R-CEL-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit epsilon
Short name:
TCP-1-epsilon
Alternative name(s):
CCT-epsilon
Gene namesi
Name:cct-5
ORF Names:C07G2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC07G2.3a ; CE02985 ; WBGene00000380 ; cct-5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283491 – 542T-complex protein 1 subunit epsilonAdd BLAST542

Proteomic databases

EPDiP47209
PaxDbiP47209
PeptideAtlasiP47209
PRIDEiP47209

2D gel databases

World-2DPAGEi0011:P47209
0020:P47209

PTM databases

iPTMnetiP47209

Expressioni

Gene expression databases

BgeeiWBGene00000380
ExpressionAtlasiP47209 baseline

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: WormBase

Protein-protein interaction databases

BioGridi40824, 6 interactors
DIPiDIP-25588N
IntActiP47209, 7 interactors
STRINGi6239.C07G2.3a.1

Structurei

3D structure databases

ProteinModelPortaliP47209
SMRiP47209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0357 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074988
HOGENOMiHOG000226735
InParanoidiP47209
KOiK09497
OMAiYATDEYG
OrthoDBiEOG091G05G4
PhylomeDBiP47209

Family and domain databases

CDDicd03339 TCP1_epsilon, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012718 Chap_CCT_epsi
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353 PTHR11353, 1 hit
PTHR11353:SF178 PTHR11353:SF178, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02343 chap_CCT_epsi, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P47209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSSAQLLF DESGQPFIVM REQENQKRIT GVEAVKSHIL AARAVANTLR
60 70 80 90 100
TSLGPRGLDK MLVSPDGDVT ITNDGATIME KMDVQHHVAK LMVELSKSQD
110 120 130 140 150
HEIGDGTTGV VVLAGALLEE AEKLIDRGIH PIKIADGFDL ACKKALETLD
160 170 180 190 200
SISDKFPVEN RERLVETAQT SLGSKIVNRS LRQFAEIAVD AVLSVADIES
210 220 230 240 250
KDVNFEMIKM EGKVGGRLED TILVKGIVID KTMSHPQMPK ELKNAKVAIL
260 270 280 290 300
TCPFEPPKPK TKHKLDITST EDFKALRDYE RETFETMIRQ VKESGATLAI
310 320 330 340 350
CQWGFDDEAN HLLQANDLPA VRWVGGPEIE LLAIATNARI VPRFSELSKE
360 370 380 390 400
KLGTAGLVRE ITFGAAKDRM LSIEQCPNNK AVTIFVRGGN KMIIDEAKRA
410 420 430 440 450
LHDALCVIRN LVRDSRIVYG GGSAELAAAI QVAKEADRID GIEQYAFRAF
460 470 480 490 500
ADALESIPMA LAENSGLAPI DALSDLKAKQ IETGKSSLGI DAVFAGTNDM
510 520 530 540
KEQKVIETLL SKREQISLAT QVVRMILKID DVRVPDDERM GY
Length:542
Mass (Da):59,406
Last modified:February 1, 1996 - v1
Checksum:iA87D3B3FD256D1E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25698 mRNA Translation: AAA92843.1
Z32840, Z35599 Genomic DNA Translation: CAA83681.1
PIRiT19063
RefSeqiNP_741117.1, NM_171104.3
UniGeneiCel.18128

Genome annotation databases

EnsemblMetazoaiC07G2.3a.1; C07G2.3a.1; WBGene00000380
C07G2.3a.2; C07G2.3a.2; WBGene00000380
GeneIDi175588
KEGGicel:CELE_C07G2.3
UCSCiC07G2.3b.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTCPE_CAEEL
AccessioniPrimary (citable) accession number: P47209
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health