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Protein

T-complex protein 1 subunit delta

Gene

cct-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: WormBase

GO - Biological processi

  • post-embryonic body morphogenesis Source: WormBase
  • protein folding Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
CCT-delta
Gene namesi
Name:cct-4
ORF Names:K01C8.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK01C8.10; CE02262; WBGene00000379; cct-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283371 – 540T-complex protein 1 subunit deltaAdd BLAST540

Proteomic databases

EPDiP47208.
PaxDbiP47208.
PeptideAtlasiP47208.
PRIDEiP47208.

Expressioni

Gene expression databases

BgeeiWBGene00000379.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

  • unfolded protein binding Source: WormBase

Protein-protein interaction databases

BioGridi39659. 1 interactor.
IntActiP47208. 2 interactors.
STRINGi6239.K01C8.10.3.

Structurei

3D structure databases

ProteinModelPortaliP47208.
SMRiP47208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0358. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074956.
HOGENOMiHOG000226735.
InParanoidiP47208.
KOiK09496.
OMAiAYCVRAY.
OrthoDBiEOG091G05G4.
PhylomeDBiP47208.

Family and domain databases

CDDicd03338. TCP1_delta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012717. Chap_CCT_delta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02342. chap_CCT_delta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAVPAAAA TARQSASGRE RNFKDKDKPE SVRNSNIVAA KAVADAVRTS
60 70 80 90 100
LGPRGMDKMI QSGNGDVTIT NDGATILNQM SVIHPTAKML VELSKAQDIE
110 120 130 140 150
AGDGTTTVVV MAGALLDAAQ NLLSKGIHPT TISESFQSAA AEAEKILDEM
160 170 180 190 200
SSPVDLSNDA LLNKMATTSL NSKVVSQHSW LLAPMAVNAV KKIINSENDS
210 220 230 240 250
NVNLKMIKII KKMGDTVEES ELIEGALIDQ KTMGRGAPTR IEKAKIGLIQ
260 270 280 290 300
FQISPPKTDM ENQVIITDYA QMDRALKEER QYLLEICKQI KAAGCNVLLI
310 320 330 340 350
QKSILRDAVN ELALHFLAKM KIMCIKDIER EDIEFYSRIL GCRPVASVDH
360 370 380 390 400
FNADALGYAD LVEEIPTGGD GKVIKVTGVQ NPGHAVSILL RGSNKLVLEE
410 420 430 440 450
ADRSIHDALC VIRCLVKKKA LLPGGGAPEM EIAVKLRNLA QTQHGATQYC
460 470 480 490 500
WRAFADALEL IPYTLAENAG LSPIHTVTEL RNNHANGNSS YGVNVRKGYV
510 520 530 540
TDMVEEDVVQ PLLVTASAIK QASECVRSIL KIDDIVMAVR
Length:540
Mass (Da):58,391
Last modified:February 1, 1996 - v1
Checksum:i1AC61EA6CD0AA5CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25697 mRNA. Translation: AAA92842.1.
Z49068 Genomic DNA. Translation: CAA88861.1.
PIRiT23173.
RefSeqiNP_495750.1. NM_063349.6.
UniGeneiCel.22476.

Genome annotation databases

EnsemblMetazoaiK01C8.10.1; K01C8.10.1; WBGene00000379.
K01C8.10.2; K01C8.10.2; WBGene00000379.
GeneIDi174330.
KEGGicel:CELE_K01C8.10.
UCSCiK01C8.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25697 mRNA. Translation: AAA92842.1.
Z49068 Genomic DNA. Translation: CAA88861.1.
PIRiT23173.
RefSeqiNP_495750.1. NM_063349.6.
UniGeneiCel.22476.

3D structure databases

ProteinModelPortaliP47208.
SMRiP47208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39659. 1 interactor.
IntActiP47208. 2 interactors.
STRINGi6239.K01C8.10.3.

Proteomic databases

EPDiP47208.
PaxDbiP47208.
PeptideAtlasiP47208.
PRIDEiP47208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK01C8.10.1; K01C8.10.1; WBGene00000379.
K01C8.10.2; K01C8.10.2; WBGene00000379.
GeneIDi174330.
KEGGicel:CELE_K01C8.10.
UCSCiK01C8.10.1. c. elegans.

Organism-specific databases

CTDi174330.
WormBaseiK01C8.10; CE02262; WBGene00000379; cct-4.

Phylogenomic databases

eggNOGiKOG0358. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074956.
HOGENOMiHOG000226735.
InParanoidiP47208.
KOiK09496.
OMAiAYCVRAY.
OrthoDBiEOG091G05G4.
PhylomeDBiP47208.

Enzyme and pathway databases

ReactomeiR-CEL-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiP47208.

Gene expression databases

BgeeiWBGene00000379.

Family and domain databases

CDDicd03338. TCP1_delta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012717. Chap_CCT_delta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02342. chap_CCT_delta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPD_CAEEL
AccessioniPrimary (citable) accession number: P47208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.