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Protein

T-complex protein 1 subunit delta

Gene

cct-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: WormBase

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • post-embryonic body morphogenesis Source: WormBase
  • protein folding Source: WormBase

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-390471 Association of TriC/CCT with target proteins during biosynthesis
R-CEL-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
CCT-delta
Gene namesi
Name:cct-4
ORF Names:K01C8.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK01C8.10 ; CE02262 ; WBGene00000379 ; cct-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283371 – 540T-complex protein 1 subunit deltaAdd BLAST540

Proteomic databases

EPDiP47208
PaxDbiP47208
PeptideAtlasiP47208
PRIDEiP47208

Expressioni

Gene expression databases

BgeeiWBGene00000379

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

GO - Molecular functioni

  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: WormBase

Protein-protein interaction databases

BioGridi39659, 1 interactor
IntActiP47208, 2 interactors
STRINGi6239.K01C8.10.3

Structurei

3D structure databases

ProteinModelPortaliP47208
SMRiP47208
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0358 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074956
HOGENOMiHOG000226735
InParanoidiP47208
KOiK09496
OMAiQFCLSPP
OrthoDBiEOG091G05G4
PhylomeDBiP47208

Family and domain databases

CDDicd03338 TCP1_delta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02342 chap_CCT_delta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P47208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAVPAAAA TARQSASGRE RNFKDKDKPE SVRNSNIVAA KAVADAVRTS
60 70 80 90 100
LGPRGMDKMI QSGNGDVTIT NDGATILNQM SVIHPTAKML VELSKAQDIE
110 120 130 140 150
AGDGTTTVVV MAGALLDAAQ NLLSKGIHPT TISESFQSAA AEAEKILDEM
160 170 180 190 200
SSPVDLSNDA LLNKMATTSL NSKVVSQHSW LLAPMAVNAV KKIINSENDS
210 220 230 240 250
NVNLKMIKII KKMGDTVEES ELIEGALIDQ KTMGRGAPTR IEKAKIGLIQ
260 270 280 290 300
FQISPPKTDM ENQVIITDYA QMDRALKEER QYLLEICKQI KAAGCNVLLI
310 320 330 340 350
QKSILRDAVN ELALHFLAKM KIMCIKDIER EDIEFYSRIL GCRPVASVDH
360 370 380 390 400
FNADALGYAD LVEEIPTGGD GKVIKVTGVQ NPGHAVSILL RGSNKLVLEE
410 420 430 440 450
ADRSIHDALC VIRCLVKKKA LLPGGGAPEM EIAVKLRNLA QTQHGATQYC
460 470 480 490 500
WRAFADALEL IPYTLAENAG LSPIHTVTEL RNNHANGNSS YGVNVRKGYV
510 520 530 540
TDMVEEDVVQ PLLVTASAIK QASECVRSIL KIDDIVMAVR
Length:540
Mass (Da):58,391
Last modified:February 1, 1996 - v1
Checksum:i1AC61EA6CD0AA5CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25697 mRNA Translation: AAA92842.1
Z49068 Genomic DNA Translation: CAA88861.1
PIRiT23173
RefSeqiNP_495750.1, NM_063349.6
UniGeneiCel.22476

Genome annotation databases

EnsemblMetazoaiK01C8.10.1; K01C8.10.1; WBGene00000379
K01C8.10.2; K01C8.10.2; WBGene00000379
GeneIDi174330
KEGGicel:CELE_K01C8.10
UCSCiK01C8.10.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTCPD_CAEEL
AccessioniPrimary (citable) accession number: P47208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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