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Protein

T-complex protein 1 subunit beta

Gene

cct-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-390471 Association of TriC/CCT with target proteins during biosynthesis
R-CEL-6798695 Neutrophil degranulation
R-CEL-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
Gene namesi
Name:cct-2
Synonyms:cctb
ORF Names:T21B10.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT21B10.7 ; CE16437 ; WBGene00000378 ; cct-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283181 – 529T-complex protein 1 subunit betaAdd BLAST529

Proteomic databases

EPDiP47207
PaxDbiP47207
PeptideAtlasiP47207
PRIDEiP47207

2D gel databases

World-2DPAGE0011:P47207

Expressioni

Gene expression databases

BgeeiWBGene00000378

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_Y39A1A.3G5EEN74EBI-896048,EBI-2412943

GO - Molecular functioni

Protein-protein interaction databases

BioGridi39748, 1 interactor
IntActiP47207, 3 interactors
STRINGi6239.T21B10.7.1

Structurei

3D structure databases

ProteinModelPortaliP47207
SMRiP47207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0363 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074930
HOGENOMiHOG000226736
InParanoidiP47207
KOiK09494
OMAiPGVHQPQ
OrthoDBiEOG091G07BP
PhylomeDBiP47207

Family and domain databases

CDDicd03336 TCP1_beta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF23 PTHR11353:SF23, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02341 chap_CCT_beta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P47207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPVQILKDN AQEERGESAR LSSFVGAIAI GDLVKSTLGP KGMDKILISG
60 70 80 90 100
NPESAGGIKV TNDGATILKS IGVDNPAAKV LVDMSMTQDH EVGDGTTSVT
110 120 130 140 150
VLAAELLKEA EKLVNQRIHP QTIISGYRRA LGIAQESLKK SSIESGDNIR
160 170 180 190 200
DDLLKIARTT LGSKILSQHK EHFAQLAVDA VLRLKGSGNL DAIQIIKKLG
210 220 230 240 250
GSMNESYLDE GFLLEKLPGM FQPRRVEKAK ILIANTPMDT DKVKVFGSRV
260 270 280 290 300
RVDGVAKVAE LEAAEKLKMK EKVDKILAHN CNVFINRQLI YNYPEQLFAD
310 320 330 340 350
AKVMAIEHAD FEGIERLALV LGGEIVSTFD SPQTAQFGSC DLIEEIMIGE
360 370 380 390 400
DRLLRFSGVK LGEACSVVLR GATQQILDES ERSLHDALCV LVTHVKESKT
410 420 430 440 450
VAGAGASEIL MSSAIAVEAQ KVAGKEALAV EAFGRALAQL PTIICDNAGL
460 470 480 490 500
DSAELVTRLR AEHANGRHNM GIDIEKGEVA DVTKLGVIES YNVKLCMVSS
510 520
AAEATEQILR VDDIIKAAPR ARAQDNRPC
Length:529
Mass (Da):56,975
Last modified:March 28, 2003 - v2
Checksum:i07806C9AF26D79B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427A → S in AAA93233 (PubMed:7576182).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25632 mRNA Translation: AAA93233.1
Z68318, AL031268 Genomic DNA Translation: CAA92697.1
PIRiT18589
RefSeqiNP_741031.1, NM_171985.5
UniGeneiCel.38662

Genome annotation databases

EnsemblMetazoaiT21B10.7.1; T21B10.7.1; WBGene00000378
T21B10.7.2; T21B10.7.2; WBGene00000378
T21B10.7.3; T21B10.7.3; WBGene00000378
GeneIDi174421
KEGGicel:CELE_T21B10.7
UCSCiT21B10.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTCPB_CAEEL
AccessioniPrimary (citable) accession number: P47207
Secondary accession number(s): Q22628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 28, 2003
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health