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Protein

T-complex protein 1 subunit beta

Gene

cct-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit beta
Short name:
TCP-1-beta
Alternative name(s):
CCT-beta
Gene namesi
Name:cct-2
Synonyms:cctb
ORF Names:T21B10.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT21B10.7; CE16437; WBGene00000378; cct-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529T-complex protein 1 subunit betaPRO_0000128318Add
BLAST

Proteomic databases

EPDiP47207.
PaxDbiP47207.

2D gel databases

World-2DPAGE0011:P47207.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_Y39A1A.3G5EEN74EBI-896048,EBI-2412943

Protein-protein interaction databases

BioGridi39748. 1 interaction.
IntActiP47207. 3 interactions.
STRINGi6239.T21B10.7.1.

Structurei

3D structure databases

ProteinModelPortaliP47207.
SMRiP47207. Positions 11-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0363. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226736.
InParanoidiP47207.
KOiK09494.
OMAiCVLVTHV.
OrthoDBiEOG7Q5HD3.
PhylomeDBiP47207.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012716. Chap_CCT_beta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02341. chap_CCT_beta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPVQILKDN AQEERGESAR LSSFVGAIAI GDLVKSTLGP KGMDKILISG
60 70 80 90 100
NPESAGGIKV TNDGATILKS IGVDNPAAKV LVDMSMTQDH EVGDGTTSVT
110 120 130 140 150
VLAAELLKEA EKLVNQRIHP QTIISGYRRA LGIAQESLKK SSIESGDNIR
160 170 180 190 200
DDLLKIARTT LGSKILSQHK EHFAQLAVDA VLRLKGSGNL DAIQIIKKLG
210 220 230 240 250
GSMNESYLDE GFLLEKLPGM FQPRRVEKAK ILIANTPMDT DKVKVFGSRV
260 270 280 290 300
RVDGVAKVAE LEAAEKLKMK EKVDKILAHN CNVFINRQLI YNYPEQLFAD
310 320 330 340 350
AKVMAIEHAD FEGIERLALV LGGEIVSTFD SPQTAQFGSC DLIEEIMIGE
360 370 380 390 400
DRLLRFSGVK LGEACSVVLR GATQQILDES ERSLHDALCV LVTHVKESKT
410 420 430 440 450
VAGAGASEIL MSSAIAVEAQ KVAGKEALAV EAFGRALAQL PTIICDNAGL
460 470 480 490 500
DSAELVTRLR AEHANGRHNM GIDIEKGEVA DVTKLGVIES YNVKLCMVSS
510 520
AAEATEQILR VDDIIKAAPR ARAQDNRPC
Length:529
Mass (Da):56,975
Last modified:March 28, 2003 - v2
Checksum:i07806C9AF26D79B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti427 – 4271A → S in AAA93233 (PubMed:7576182).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25632 mRNA. Translation: AAA93233.1.
Z68318, AL031268 Genomic DNA. Translation: CAA92697.1.
PIRiT18589.
RefSeqiNP_741031.1. NM_171985.5.
UniGeneiCel.38662.

Genome annotation databases

EnsemblMetazoaiT21B10.7.1; T21B10.7.1; WBGene00000378.
T21B10.7.2; T21B10.7.2; WBGene00000378.
GeneIDi174421.
KEGGicel:CELE_T21B10.7.
UCSCiT21B10.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25632 mRNA. Translation: AAA93233.1.
Z68318, AL031268 Genomic DNA. Translation: CAA92697.1.
PIRiT18589.
RefSeqiNP_741031.1. NM_171985.5.
UniGeneiCel.38662.

3D structure databases

ProteinModelPortaliP47207.
SMRiP47207. Positions 11-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39748. 1 interaction.
IntActiP47207. 3 interactions.
STRINGi6239.T21B10.7.1.

2D gel databases

World-2DPAGE0011:P47207.

Proteomic databases

EPDiP47207.
PaxDbiP47207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT21B10.7.1; T21B10.7.1; WBGene00000378.
T21B10.7.2; T21B10.7.2; WBGene00000378.
GeneIDi174421.
KEGGicel:CELE_T21B10.7.
UCSCiT21B10.7.1. c. elegans.

Organism-specific databases

CTDi174421.
WormBaseiT21B10.7; CE16437; WBGene00000378; cct-2.

Phylogenomic databases

eggNOGiKOG0363. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226736.
InParanoidiP47207.
KOiK09494.
OMAiCVLVTHV.
OrthoDBiEOG7Q5HD3.
PhylomeDBiP47207.

Enzyme and pathway databases

ReactomeiR-CEL-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiP47207.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012716. Chap_CCT_beta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02341. chap_CCT_beta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of four new tcp-1-related cct genes from the nematode Caenorhabditis elegans."
    Leroux M.R., Candido E.P.M.
    DNA Cell Biol. 14:951-960(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTCPB_CAEEL
AccessioniPrimary (citable) accession number: P47207
Secondary accession number(s): Q22628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 28, 2003
Last modified: June 8, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.