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P47199

- QOR_MOUSE

UniProt

P47199 - QOR_MOUSE

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Protein

Quinone oxidoreductase

Gene

Cryz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).By similarity

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531NADPBy similarity
Binding sitei181 – 1811NADP; via amide nitrogenBy similarity
Binding sitei200 – 2001NADPBy similarity
Binding sitei231 – 2311NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1614NADPBy similarity
Nucleotide bindingi248 – 2514NADPBy similarity
Nucleotide bindingi271 – 2733NADPBy similarity

GO - Molecular functioni

  1. mRNA 3'-UTR binding Source: UniProtKB
  2. NADP binding Source: MGI
  3. NADPH:quinone reductase activity Source: UniProtKB
  4. NADPH binding Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein homotetramerization Source: Ensembl
  2. xenobiotic catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin
Gene namesi
Name:Cryz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88527. Cryz.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 331330Quinone oxidoreductasePRO_0000160908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei23 – 231N6-acetyllysineBy similarity
Modified residuei186 – 1861N6-acetyllysine1 Publication
Modified residuei298 – 2981N6-succinyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP47199.
PaxDbiP47199.
PRIDEiP47199.

2D gel databases

REPRODUCTION-2DPAGEIPI00134704.
P47199.

PTM databases

PhosphoSiteiP47199.

Expressioni

Gene expression databases

BgeeiP47199.
CleanExiMM_CRYZ.
ExpressionAtlasiP47199. baseline and differential.
GenevestigatoriP47199.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiP47199. 4 interactions.
MINTiMINT-1862605.

Structurei

3D structure databases

ProteinModelPortaliP47199.
SMRiP47199. Positions 6-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294672.
HOVERGENiHBG002466.
InParanoidiP47199.
KOiK00344.
OMAiCQIARAH.
PhylomeDBiP47199.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47199-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PVPQSHQVLI KVHACGVNPV
60 70 80 90 100
ETYIRSGAYS RKPALPYTPG SDVAGIIESV GDKVSAFKKG DRVFCYSTVS
110 120 130 140 150
GGYAEFALAA DDTIYPLPET LNFRQGAALG IPYFTACRAL FHSARARAGE
160 170 180 190 200
SVLVHGASGG VGLATCQIAR AHGLKVLGTA GSEEGKKLVL QNGAHEVFNH
210 220 230 240 250
KEANYIDKIK MSVGDKDKGV DVIIEMLANE NLSNDLKLLS HGGRVVVVGC
260 270 280 290 300
RGPIEINPRD TMAKETSIIG VSLSSSTKEE FQQFAGLLQA GIEKGWVKPV
310 320 330
IGSEYPLEKA AQAHEDIIHG SGKTGKMILL L
Length:331
Mass (Da):35,269
Last modified:November 1, 1995 - v1
Checksum:i35816C043EFE16A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581A → T in AAH03800. (PubMed:15489334)Curated
Sequence conflicti131 – 1333IPY → TMD in BAA11463. (PubMed:8645260)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70056 mRNA. Translation: AAB30620.2.
BC003800 mRNA. Translation: AAH03800.1.
D78646 mRNA. Translation: BAA11463.1.
CCDSiCCDS17927.1.
PIRiA54932.
RefSeqiNP_034098.1. NM_009968.3.
XP_006501036.1. XM_006500973.1.
UniGeneiMm.374855.

Genome annotation databases

EnsembliENSMUST00000029850; ENSMUSP00000029850; ENSMUSG00000028199.
GeneIDi12972.
KEGGimmu:12972.
UCSCiuc008rup.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70056 mRNA. Translation: AAB30620.2 .
BC003800 mRNA. Translation: AAH03800.1 .
D78646 mRNA. Translation: BAA11463.1 .
CCDSi CCDS17927.1.
PIRi A54932.
RefSeqi NP_034098.1. NM_009968.3.
XP_006501036.1. XM_006500973.1.
UniGenei Mm.374855.

3D structure databases

ProteinModelPortali P47199.
SMRi P47199. Positions 6-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P47199. 4 interactions.
MINTi MINT-1862605.

Chemistry

BindingDBi P47199.
ChEMBLi CHEMBL4332.

PTM databases

PhosphoSitei P47199.

2D gel databases

REPRODUCTION-2DPAGE IPI00134704.
P47199.

Proteomic databases

MaxQBi P47199.
PaxDbi P47199.
PRIDEi P47199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029850 ; ENSMUSP00000029850 ; ENSMUSG00000028199 .
GeneIDi 12972.
KEGGi mmu:12972.
UCSCi uc008rup.3. mouse.

Organism-specific databases

CTDi 1429.
MGIi MGI:88527. Cryz.

Phylogenomic databases

eggNOGi COG0604.
GeneTreei ENSGT00550000074483.
HOGENOMi HOG000294672.
HOVERGENi HBG002466.
InParanoidi P47199.
KOi K00344.
OMAi CQIARAH.
PhylomeDBi P47199.
TreeFami TF314255.

Miscellaneous databases

NextBioi 282736.
PROi P47199.
SOURCEi Search...

Gene expression databases

Bgeei P47199.
CleanExi MM_CRYZ.
ExpressionAtlasi P47199. baseline and differential.
Genevestigatori P47199.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse."
    Gonzalez P., Hernandez-Calzadilla C., Rao P.V., Rodriguez I.R., Zigler J.S. Jr., Borras T.
    Mol. Biol. Evol. 11:305-315(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "Molecular characterization of seizure-related genes isolated by differential screening."
    Kajiwara K., Nagawawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.
    Biochem. Biophys. Res. Commun. 219:795-799(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-331.
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiQOR_MOUSE
AccessioniPrimary (citable) accession number: P47199
Secondary accession number(s): Q62508, Q99L63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3