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Protein

Quinone oxidoreductase

Gene

Cryz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).By similarity

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53NADPBy similarity1
Binding sitei181NADP; via amide nitrogenBy similarity1
Binding sitei200NADPBy similarity1
Binding sitei231NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 161NADPBy similarity4
Nucleotide bindingi248 – 251NADPBy similarity4
Nucleotide bindingi271 – 273NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, RNA-binding
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin
Gene namesi
Name:Cryz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88527 Cryz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4332

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001609082 – 331Quinone oxidoreductaseAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei186N6-acetyllysineCombined sources1
Modified residuei298N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP47199
MaxQBiP47199
PaxDbiP47199
PeptideAtlasiP47199
PRIDEiP47199

2D gel databases

REPRODUCTION-2DPAGEiIPI00134704
P47199

PTM databases

iPTMnetiP47199
PhosphoSitePlusiP47199
SwissPalmiP47199

Expressioni

Gene expression databases

BgeeiENSMUSG00000028199
CleanExiMM_CRYZ
ExpressionAtlasiP47199 baseline and differential
GenevisibleiP47199 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi198924, 1 interactor
IntActiP47199, 5 interactors
MINTiP47199
STRINGi10090.ENSMUSP00000029850

Chemistry databases

BindingDBiP47199

Structurei

3D structure databases

ProteinModelPortaliP47199
SMRiP47199
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1197 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
HOGENOMiHOG000294672
HOVERGENiHBG002466
InParanoidiP47199
KOiK00344
OMAiKCPVVYD
OrthoDBiEOG091G0DQO
PhylomeDBiP47199
TreeFamiTF314255

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PVPQSHQVLI KVHACGVNPV
60 70 80 90 100
ETYIRSGAYS RKPALPYTPG SDVAGIIESV GDKVSAFKKG DRVFCYSTVS
110 120 130 140 150
GGYAEFALAA DDTIYPLPET LNFRQGAALG IPYFTACRAL FHSARARAGE
160 170 180 190 200
SVLVHGASGG VGLATCQIAR AHGLKVLGTA GSEEGKKLVL QNGAHEVFNH
210 220 230 240 250
KEANYIDKIK MSVGDKDKGV DVIIEMLANE NLSNDLKLLS HGGRVVVVGC
260 270 280 290 300
RGPIEINPRD TMAKETSIIG VSLSSSTKEE FQQFAGLLQA GIEKGWVKPV
310 320 330
IGSEYPLEKA AQAHEDIIHG SGKTGKMILL L
Length:331
Mass (Da):35,269
Last modified:November 1, 1995 - v1
Checksum:i35816C043EFE16A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58A → T in AAH03800 (PubMed:15489334).Curated1
Sequence conflicti131 – 133IPY → TMD in BAA11463 (PubMed:8645260).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70056 mRNA Translation: AAB30620.2
BC003800 mRNA Translation: AAH03800.1
D78646 mRNA Translation: BAA11463.1
CCDSiCCDS17927.1
PIRiA54932
RefSeqiNP_034098.1, NM_009968.3
XP_006501036.1, XM_006500973.2
XP_011238308.1, XM_011240006.1
UniGeneiMm.374855

Genome annotation databases

EnsembliENSMUST00000029850; ENSMUSP00000029850; ENSMUSG00000028199
ENSMUST00000192462; ENSMUSP00000142105; ENSMUSG00000028199
GeneIDi12972
KEGGimmu:12972
UCSCiuc008rup.3 mouse

Similar proteinsi

Entry informationi

Entry nameiQOR_MOUSE
AccessioniPrimary (citable) accession number: P47199
Secondary accession number(s): Q62508, Q99L63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health