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P47199 (QOR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Quinone oxidoreductase

EC=1.6.5.5
Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin
Gene names
Name:Cryz
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding By similarity.

Catalytic activity

NADPH + 2 quinone = NADP+ + 2 semiquinone.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 331330Quinone oxidoreductase
PRO_0000160908

Regions

Nucleotide binding158 – 1614NADP By similarity
Nucleotide binding248 – 2514NADP By similarity
Nucleotide binding271 – 2733NADP By similarity

Sites

Binding site531NADP By similarity
Binding site1811NADP; via amide nitrogen By similarity
Binding site2001NADP By similarity
Binding site2311NADP By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue231N6-acetyllysine By similarity
Modified residue1861N6-acetyllysine Ref.5
Modified residue2981N6-succinyllysine Ref.4

Experimental info

Sequence conflict581A → T in AAH03800. Ref.2
Sequence conflict131 – 1333IPY → TMD in BAA11463. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P47199 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 35816C043EFE16A2

FASTA33135,269
        10         20         30         40         50         60 
MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PVPQSHQVLI KVHACGVNPV ETYIRSGAYS 

        70         80         90        100        110        120 
RKPALPYTPG SDVAGIIESV GDKVSAFKKG DRVFCYSTVS GGYAEFALAA DDTIYPLPET 

       130        140        150        160        170        180 
LNFRQGAALG IPYFTACRAL FHSARARAGE SVLVHGASGG VGLATCQIAR AHGLKVLGTA 

       190        200        210        220        230        240 
GSEEGKKLVL QNGAHEVFNH KEANYIDKIK MSVGDKDKGV DVIIEMLANE NLSNDLKLLS 

       250        260        270        280        290        300 
HGGRVVVVGC RGPIEINPRD TMAKETSIIG VSLSSSTKEE FQQFAGLLQA GIEKGWVKPV 

       310        320        330 
IGSEYPLEKA AQAHEDIIHG SGKTGKMILL L 

« Hide

References

« Hide 'large scale' references
[1]"Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse."
Gonzalez P., Hernandez-Calzadilla C., Rao P.V., Rodriguez I.R., Zigler J.S. Jr., Borras T.
Mol. Biol. Evol. 11:305-315(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[3]"Molecular characterization of seizure-related genes isolated by differential screening."
Kajiwara K., Nagawawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.
Biochem. Biophys. Res. Commun. 219:795-799(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-331.
Strain: C57BL/6J.
Tissue: Brain cortex.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S70056 mRNA. Translation: AAB30620.2.
BC003800 mRNA. Translation: AAH03800.1.
D78646 mRNA. Translation: BAA11463.1.
CCDSCCDS17927.1.
PIRA54932.
RefSeqNP_034098.1. NM_009968.3.
XP_006501036.1. XM_006500973.1.
UniGeneMm.374855.

3D structure databases

ProteinModelPortalP47199.
SMRP47199. Positions 6-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP47199. 4 interactions.
MINTMINT-1862605.

Chemistry

BindingDBP47199.
ChEMBLCHEMBL4332.

PTM databases

PhosphoSiteP47199.

2D gel databases

REPRODUCTION-2DPAGEIPI00134704.
P47199.

Proteomic databases

MaxQBP47199.
PaxDbP47199.
PRIDEP47199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029850; ENSMUSP00000029850; ENSMUSG00000028199.
GeneID12972.
KEGGmmu:12972.
UCSCuc008rup.3. mouse.

Organism-specific databases

CTD1429.
MGIMGI:88527. Cryz.

Phylogenomic databases

eggNOGCOG0604.
GeneTreeENSGT00550000074483.
HOGENOMHOG000294672.
HOVERGENHBG002466.
InParanoidP47199.
KOK00344.
OMACQIARAH.
PhylomeDBP47199.
TreeFamTF314255.

Gene expression databases

ArrayExpressP47199.
BgeeP47199.
CleanExMM_CRYZ.
GenevestigatorP47199.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
PROSITEPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282736.
PROP47199.
SOURCESearch...

Entry information

Entry nameQOR_MOUSE
AccessionPrimary (citable) accession number: P47199
Secondary accession number(s): Q62508, Q99L63
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot