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P47199

- QOR_MOUSE

UniProt

P47199 - QOR_MOUSE

Protein

Quinone oxidoreductase

Gene

Cryz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding By similarity.By similarity

    Catalytic activityi

    NADPH + 2 quinone = NADP+ + 2 semiquinone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531NADPBy similarity
    Binding sitei181 – 1811NADP; via amide nitrogenBy similarity
    Binding sitei200 – 2001NADPBy similarity
    Binding sitei231 – 2311NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi158 – 1614NADPBy similarity
    Nucleotide bindingi248 – 2514NADPBy similarity
    Nucleotide bindingi271 – 2733NADPBy similarity

    GO - Molecular functioni

    1. mRNA 3'-UTR binding Source: UniProtKB
    2. NADP binding Source: MGI
    3. NADPH:quinone reductase activity Source: UniProtKB
    4. NADPH binding Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein homotetramerization Source: Ensembl
    2. xenobiotic catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinone oxidoreductase (EC:1.6.5.5)
    Alternative name(s):
    NADPH:quinone reductase
    Zeta-crystallin
    Gene namesi
    Name:Cryz
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:88527. Cryz.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. Golgi apparatus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 331330Quinone oxidoreductasePRO_0000160908Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei23 – 231N6-acetyllysineBy similarity
    Modified residuei186 – 1861N6-acetyllysine1 Publication
    Modified residuei298 – 2981N6-succinyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP47199.
    PaxDbiP47199.
    PRIDEiP47199.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00134704.
    P47199.

    PTM databases

    PhosphoSiteiP47199.

    Expressioni

    Gene expression databases

    ArrayExpressiP47199.
    BgeeiP47199.
    CleanExiMM_CRYZ.
    GenevestigatoriP47199.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiP47199. 4 interactions.
    MINTiMINT-1862605.

    Structurei

    3D structure databases

    ProteinModelPortaliP47199.
    SMRiP47199. Positions 6-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0604.
    GeneTreeiENSGT00550000074483.
    HOGENOMiHOG000294672.
    HOVERGENiHBG002466.
    InParanoidiP47199.
    KOiK00344.
    OMAiCQIARAH.
    PhylomeDBiP47199.
    TreeFamiTF314255.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    IPR002364. Quin_OxRdtase/zeta-crystal_CS.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.
    PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47199-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PVPQSHQVLI KVHACGVNPV    50
    ETYIRSGAYS RKPALPYTPG SDVAGIIESV GDKVSAFKKG DRVFCYSTVS 100
    GGYAEFALAA DDTIYPLPET LNFRQGAALG IPYFTACRAL FHSARARAGE 150
    SVLVHGASGG VGLATCQIAR AHGLKVLGTA GSEEGKKLVL QNGAHEVFNH 200
    KEANYIDKIK MSVGDKDKGV DVIIEMLANE NLSNDLKLLS HGGRVVVVGC 250
    RGPIEINPRD TMAKETSIIG VSLSSSTKEE FQQFAGLLQA GIEKGWVKPV 300
    IGSEYPLEKA AQAHEDIIHG SGKTGKMILL L 331
    Length:331
    Mass (Da):35,269
    Last modified:November 1, 1995 - v1
    Checksum:i35816C043EFE16A2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581A → T in AAH03800. (PubMed:15489334)Curated
    Sequence conflicti131 – 1333IPY → TMD in BAA11463. (PubMed:8645260)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S70056 mRNA. Translation: AAB30620.2.
    BC003800 mRNA. Translation: AAH03800.1.
    D78646 mRNA. Translation: BAA11463.1.
    CCDSiCCDS17927.1.
    PIRiA54932.
    RefSeqiNP_034098.1. NM_009968.3.
    XP_006501036.1. XM_006500973.1.
    UniGeneiMm.374855.

    Genome annotation databases

    EnsembliENSMUST00000029850; ENSMUSP00000029850; ENSMUSG00000028199.
    GeneIDi12972.
    KEGGimmu:12972.
    UCSCiuc008rup.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S70056 mRNA. Translation: AAB30620.2 .
    BC003800 mRNA. Translation: AAH03800.1 .
    D78646 mRNA. Translation: BAA11463.1 .
    CCDSi CCDS17927.1.
    PIRi A54932.
    RefSeqi NP_034098.1. NM_009968.3.
    XP_006501036.1. XM_006500973.1.
    UniGenei Mm.374855.

    3D structure databases

    ProteinModelPortali P47199.
    SMRi P47199. Positions 6-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P47199. 4 interactions.
    MINTi MINT-1862605.

    Chemistry

    BindingDBi P47199.
    ChEMBLi CHEMBL4332.

    PTM databases

    PhosphoSitei P47199.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00134704.
    P47199.

    Proteomic databases

    MaxQBi P47199.
    PaxDbi P47199.
    PRIDEi P47199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029850 ; ENSMUSP00000029850 ; ENSMUSG00000028199 .
    GeneIDi 12972.
    KEGGi mmu:12972.
    UCSCi uc008rup.3. mouse.

    Organism-specific databases

    CTDi 1429.
    MGIi MGI:88527. Cryz.

    Phylogenomic databases

    eggNOGi COG0604.
    GeneTreei ENSGT00550000074483.
    HOGENOMi HOG000294672.
    HOVERGENi HBG002466.
    InParanoidi P47199.
    KOi K00344.
    OMAi CQIARAH.
    PhylomeDBi P47199.
    TreeFami TF314255.

    Miscellaneous databases

    NextBioi 282736.
    PROi P47199.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P47199.
    Bgeei P47199.
    CleanExi MM_CRYZ.
    Genevestigatori P47199.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    IPR002364. Quin_OxRdtase/zeta-crystal_CS.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    PROSITEi PS01162. QOR_ZETA_CRYSTAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse."
      Gonzalez P., Hernandez-Calzadilla C., Rao P.V., Rodriguez I.R., Zigler J.S. Jr., Borras T.
      Mol. Biol. Evol. 11:305-315(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. "Molecular characterization of seizure-related genes isolated by differential screening."
      Kajiwara K., Nagawawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.
      Biochem. Biophys. Res. Commun. 219:795-799(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-331.
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiQOR_MOUSE
    AccessioniPrimary (citable) accession number: P47199
    Secondary accession number(s): Q62508, Q99L63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3