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P47199

- QOR_MOUSE

UniProt

P47199 - QOR_MOUSE

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Protein
Quinone oxidoreductase
Gene
Cryz
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding By similarity.

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531NADP By similarity
Binding sitei181 – 1811NADP; via amide nitrogen By similarity
Binding sitei200 – 2001NADP By similarity
Binding sitei231 – 2311NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1614NADP By similarity
Nucleotide bindingi248 – 2514NADP By similarity
Nucleotide bindingi271 – 2733NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: MGI
  2. NADPH binding Source: UniProtKB
  3. NADPH:quinone reductase activity Source: UniProtKB
  4. mRNA 3'-UTR binding Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein homotetramerization Source: Ensembl
  2. xenobiotic catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Zeta-crystallin
Gene namesi
Name:Cryz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88527. Cryz.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 331330Quinone oxidoreductase
PRO_0000160908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei23 – 231N6-acetyllysine By similarity
Modified residuei186 – 1861N6-acetyllysine1 Publication
Modified residuei298 – 2981N6-succinyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP47199.
PaxDbiP47199.
PRIDEiP47199.

2D gel databases

REPRODUCTION-2DPAGEIPI00134704.
P47199.

PTM databases

PhosphoSiteiP47199.

Expressioni

Gene expression databases

ArrayExpressiP47199.
BgeeiP47199.
CleanExiMM_CRYZ.
GenevestigatoriP47199.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

IntActiP47199. 4 interactions.
MINTiMINT-1862605.

Structurei

3D structure databases

ProteinModelPortaliP47199.
SMRiP47199. Positions 6-331.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294672.
HOVERGENiHBG002466.
InParanoidiP47199.
KOiK00344.
OMAiCQIARAH.
PhylomeDBiP47199.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47199-1 [UniParc]FASTAAdd to Basket

« Hide

MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PVPQSHQVLI KVHACGVNPV    50
ETYIRSGAYS RKPALPYTPG SDVAGIIESV GDKVSAFKKG DRVFCYSTVS 100
GGYAEFALAA DDTIYPLPET LNFRQGAALG IPYFTACRAL FHSARARAGE 150
SVLVHGASGG VGLATCQIAR AHGLKVLGTA GSEEGKKLVL QNGAHEVFNH 200
KEANYIDKIK MSVGDKDKGV DVIIEMLANE NLSNDLKLLS HGGRVVVVGC 250
RGPIEINPRD TMAKETSIIG VSLSSSTKEE FQQFAGLLQA GIEKGWVKPV 300
IGSEYPLEKA AQAHEDIIHG SGKTGKMILL L 331
Length:331
Mass (Da):35,269
Last modified:November 1, 1995 - v1
Checksum:i35816C043EFE16A2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581A → T in AAH03800. 1 Publication
Sequence conflicti131 – 1333IPY → TMD in BAA11463. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S70056 mRNA. Translation: AAB30620.2.
BC003800 mRNA. Translation: AAH03800.1.
D78646 mRNA. Translation: BAA11463.1.
CCDSiCCDS17927.1.
PIRiA54932.
RefSeqiNP_034098.1. NM_009968.3.
XP_006501036.1. XM_006500973.1.
UniGeneiMm.374855.

Genome annotation databases

EnsembliENSMUST00000029850; ENSMUSP00000029850; ENSMUSG00000028199.
GeneIDi12972.
KEGGimmu:12972.
UCSCiuc008rup.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S70056 mRNA. Translation: AAB30620.2 .
BC003800 mRNA. Translation: AAH03800.1 .
D78646 mRNA. Translation: BAA11463.1 .
CCDSi CCDS17927.1.
PIRi A54932.
RefSeqi NP_034098.1. NM_009968.3.
XP_006501036.1. XM_006500973.1.
UniGenei Mm.374855.

3D structure databases

ProteinModelPortali P47199.
SMRi P47199. Positions 6-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P47199. 4 interactions.
MINTi MINT-1862605.

Chemistry

BindingDBi P47199.
ChEMBLi CHEMBL4332.

PTM databases

PhosphoSitei P47199.

2D gel databases

REPRODUCTION-2DPAGE IPI00134704.
P47199.

Proteomic databases

MaxQBi P47199.
PaxDbi P47199.
PRIDEi P47199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029850 ; ENSMUSP00000029850 ; ENSMUSG00000028199 .
GeneIDi 12972.
KEGGi mmu:12972.
UCSCi uc008rup.3. mouse.

Organism-specific databases

CTDi 1429.
MGIi MGI:88527. Cryz.

Phylogenomic databases

eggNOGi COG0604.
GeneTreei ENSGT00550000074483.
HOGENOMi HOG000294672.
HOVERGENi HBG002466.
InParanoidi P47199.
KOi K00344.
OMAi CQIARAH.
PhylomeDBi P47199.
TreeFami TF314255.

Miscellaneous databases

NextBioi 282736.
PROi P47199.
SOURCEi Search...

Gene expression databases

ArrayExpressi P47199.
Bgeei P47199.
CleanExi MM_CRYZ.
Genevestigatori P47199.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse."
    Gonzalez P., Hernandez-Calzadilla C., Rao P.V., Rodriguez I.R., Zigler J.S. Jr., Borras T.
    Mol. Biol. Evol. 11:305-315(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "Molecular characterization of seizure-related genes isolated by differential screening."
    Kajiwara K., Nagawawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.
    Biochem. Biophys. Res. Commun. 219:795-799(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-331.
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiQOR_MOUSE
AccessioniPrimary (citable) accession number: P47199
Secondary accession number(s): Q62508, Q99L63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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