Reviewed, UniProtKB/Swiss-Prot P47199 (QOR_MOUSE)

Names and origin

Protein names

Recommended name:
    Quinone oxidoreductase
    EC=1.6.5.5
Alternative name(s):
    NADPH:quinone reductase
    Zeta-crystallin

Gene names

Name:

Cryz

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones are the best substrates. May act in the detoxification of xenobiotics By similarity.
Catalytic activity	NADPH + 2 quinone = NADP(+) + 2 semiquinone.
Subunit structure	Homotetramer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADPH:quinone reductase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Quinone oxidoreductase		PRO_0000160908
Experimental info
	Sequence conflict	58	1	A → T in AAH03800. Ref.2
	Sequence conflict	131 – 133	3	IPY → TMD Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P47199-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 35816C043EFE16A2	FASTA	331	35,269
	10 20 30 40 50 60 MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PVPQSHQVLI KVHACGVNPV ETYIRSGAYS 70 80 90 100 110 120 RKPALPYTPG SDVAGIIESV GDKVSAFKKG DRVFCYSTVS GGYAEFALAA DDTIYPLPET 130 140 150 160 170 180 LNFRQGAALG IPYFTACRAL FHSARARAGE SVLVHGASGG VGLATCQIAR AHGLKVLGTA 190 200 210 220 230 240 GSEEGKKLVL QNGAHEVFNH KEANYIDKIK MSVGDKDKGV DVIIEMLANE NLSNDLKLLS 250 260 270 280 290 300 HGGRVVVVGC RGPIEINPRD TMAKETSIIG VSLSSSTKEE FQQFAGLLQA GIEKGWVKPV 310 320 330 IGSEYPLEKA AQAHEDIIHG SGKTGKMILL L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse." Gonzalez P., Hernandez-Calzadilla C., Rao P.V., Rodriguez I.R., Zigler J.S. Jr., Borras T. Mol. Biol. Evol. 11:305-315(1994) [PubMed: 8170370] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
[3]	"Molecular characterization of seizure-related genes isolated by differential screening." Kajiwara K., Nagawawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E. Biochem. Biophys. Res. Commun. 219:795-799(1996) [PubMed: 8645260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-331. Strain: C57BL/6J. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S70056 mRNA. Translation: AAB30620.2. BC003800 mRNA. Translation: AAH03800.1. D78646 mRNA. Translation: BAA11463.1.
PIR	A54932.
RefSeq	NP_034098.1.
UniGene	Mm.374855
3D structure databases
HSSP	HSSP built from PDB template 1JVB based on UniProtKB P39462.
SMR	P47199. Positions 6-331.
ModBase	Search...
PTM databases
PhosphoSite	P47199.
2-D gel databases
REPRODUCTION-2DPAGE	P47199.
Genome annotation databases
Ensembl	ENSMUSG00000028199. Mus musculus. [Contig view]
GeneID	12972.
KEGG	mmu:12972.
Organism-specific databases
MGI	MGI:88527. Cryz.
Phylogenomic databases
HOGENOM	P47199.
HOVERGEN	P47199.
Gene expression databases
ArrayExpress	P47199.
CleanEx	MM_CRYZ.
GermOnline	ENSMUSG00000028199. Mus musculus.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002364. Quin_OxRdtase/zeta-crystal_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	282736.
SOURCE	Search...

Entry information

Entry name

QOR_MOUSE

Accession

Primary (citable) accession number: P47199
Secondary accession number(s): Q62508, Q99L63

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 25, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)