ID   VAMP2_XENLA             Reviewed;         114 AA.
AC   P47193; Q5D065;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   24-NOV-2009, entry version 69.
DE   RecName: Full=Vesicle-associated membrane protein 2;
DE            Short=VAMP-2;
DE   AltName: Full=Synaptobrevin-2;
DE   AltName: Full=SYBII;
GN   Name=vamp2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang X.-H., Poo M.-M.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-114.
RC   TISSUE=Embryo;
RX   MEDLINE=95324415; PubMed=7601005;
RA   Knecht A.K., Good P.J., Dawid I.B., Harland R.M.;
RT   "Dorsal-ventral patterning and differentiation of noggin-induced
RT   neural tissue in the absence of mesoderm.";
RL   Development 121:1927-1935(1995).
CC   -!- FUNCTION: Involved in the targeting and/or fusion of transport
CC       vesicles to their target membrane.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
CC       synaptic vesicle membrane; Single-pass type IV membrane protein.
CC       Cell junction, synapse, synaptosome. Note=Neuronal synaptic
CC       vesicles.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family.
CC   -!- SIMILARITY: Contains 1 v-SNARE coiled-coil homology domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF035017; AAB88138.1; -; mRNA.
DR   EMBL; BC060344; AAH60344.1; -; mRNA.
DR   EMBL; BC123114; AAI23115.1; -; mRNA.
DR   EMBL; U16801; AAA81376.1; -; mRNA.
DR   RefSeq; NP_001080944.1; -.
DR   UniGene; Xl.234; -.
DR   SMR; P47193; 23-91.
DR   GeneID; 394287; -.
DR   KEGG; xla:394287; -.
DR   CTD; 394287; -.
DR   Xenbase; XB-FEAT-5788094; vamp2.
DR   HOVERGEN; P47193; -.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR   GO; GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR001388; Synaptobrevin.
DR   InterPro; IPR016444; Synaptobrevin_met/fun.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PIRSF; PIRSF005409; Synaptobrevin_euk; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cell junction; Coiled coil; Cytoplasmic vesicle;
KW   Membrane; Synapse; Synaptosome; Transmembrane.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    114       Vesicle-associated membrane protein 2.
FT                                /FTId=PRO_0000206727.
FT   TOPO_DOM      2     92       Cytoplasmic (Potential).
FT   TRANSMEM     93    111       Anchor for type IV membrane protein
FT                                (Potential).
FT   TOPO_DOM    112    114       Vesicular (Potential).
FT   DOMAIN       29     89       v-SNARE coiled-coil homology.
FT   MOD_RES       2      2       N-acetylserine (By similarity).
SQ   SEQUENCE   114 AA;  12473 MW;  AEF2EDDCDF2D1DBF CRC64;
     MSAPAAGPPA AAPGDGAPQG PPNLTSNRRL QQTQAQVDEV VDIMRVNVDK VLERDTKLSE
     LDDRADALQA GASQFETSAA KLKRKYWWKN MKMMIIMGVI CAIILIIIIV YFST
//