Reviewed, UniProtKB/Swiss-Prot P47193 (VAMP2_XENLA)

Names and origin

Protein names

Recommended name:
Vesicle-associated membrane protein 2
Short name=VAMP-2

Alternative name(s):
Synaptobrevin-2
SYBII

Gene names

Name:

vamp2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction › synapse › synaptosome. Note: Neuronal synaptic vesicles.
Sequence similarities	Belongs to the synaptobrevin family. Contains 1 v-SNARE coiled-coil homology domain.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse Synaptosome
Domain	Coiled coil Transmembrane
PTM	Acetylation
Gene Ontology (GO)
Biological process	vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synaptosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 114	113	Vesicle-associated membrane protein 2		PRO_0000206727
Regions
	Topological domain	2 – 92	91	Cytoplasmic Potential
	Transmembrane	93 – 111	19	Anchor for type IV membrane protein Potential
	Topological domain	112 – 114	3	Vesicular Potential
	Domain	29 – 89	61	v-SNARE coiled-coil homology
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47193-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: AEF2EDDCDF2D1DBF	FASTA	114	12,473
	10 20 30 40 50 60 MSAPAAGPPA AAPGDGAPQG PPNLTSNRRL QQTQAQVDEV VDIMRVNVDK VLERDTKLSE 70 80 90 100 110 LDDRADALQA GASQFETSAA KLKRKYWWKN MKMMIIMGVI CAIILIIIIV YFST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wang X.-H., Poo M.-M. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo and Testis.
[3]	"Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm." Knecht A.K., Good P.J., Dawid I.B., Harland R.M. Development 121:1927-1935(1995) [PubMed: 7601005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-114. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF035017 mRNA. Translation: AAB88138.1. BC060344 mRNA. Translation: AAH60344.1. BC123114 mRNA. Translation: AAI23115.1. U16801 mRNA. Translation: AAA81376.1.
RefSeq	NP_001080944.1.
UniGene	Xl.234
3D structure databases
SMR	P47193. Positions 23-91.
ModBase	Search...
Genome annotation databases
GeneID	394287.
KEGG	xla:394287.
Organism-specific databases
CTD	394287.
Xenbase	XB-FEAT-5788094. vamp2.
Phylogenomic databases
HOVERGEN	HBG006675.
Family and domain databases
InterPro	IPR001388. Synaptobrevin. IPR016444. Synaptobrevin_met/fun. [Graphical view]
Pfam	PF00957. Synaptobrevin. 1 hit. [Graphical view]
PIRSF	PIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTS	PR00219. SYNAPTOBREVN.
PROSITE	PS00417. SYNAPTOBREVIN. 1 hit. PS50892. V_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VAMP2_XENLA

Accession

Primary (citable) accession number: P47193
Secondary accession number(s): Q5D065

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	March 2, 2010
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)