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P47191 (SYT1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Synaptotagmin-1
Alternative name(s):
Synaptotagmin I
Short name=SytI
p65
Gene names
Name:SYT1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subunit structure

Homotetramer Probable.

Subcellular location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle › secretory vesicle › chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note: Synaptic vesicles and chromaffin granules.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Synaptotagmin-1
PRO_0000183941

Regions

Topological domain1 – 6060Vesicular Potential
Transmembrane61 – 8222Helical; Potential
Topological domain83 – 424342Cytoplasmic Potential
Domain159 – 24789C2 1
Domain289 – 38092C2 2
Region138 – 384247Phospholipid binding Probable

Sites

Metal binding1741Calcium 2; via carbonyl oxygen By similarity
Metal binding1751Calcium 1 By similarity
Metal binding1751Calcium 2 By similarity
Metal binding1811Calcium 1 By similarity
Metal binding2331Calcium 1 By similarity
Metal binding2331Calcium 2 By similarity
Metal binding2341Calcium 1; via carbonyl oxygen By similarity
Metal binding2351Calcium 1 By similarity
Metal binding2351Calcium 2 By similarity
Metal binding2351Calcium 3 By similarity
Metal binding2381Calcium 3 By similarity
Metal binding2391Calcium 3; via carbonyl oxygen By similarity
Metal binding2411Calcium 2 By similarity
Metal binding2411Calcium 3 By similarity

Amino acid modifications

Lipidation771S-palmitoyl cysteine By similarity
Lipidation781S-palmitoyl cysteine By similarity
Lipidation801S-palmitoyl cysteine By similarity
Lipidation821S-palmitoyl cysteine By similarity
Lipidation851S-palmitoyl cysteine By similarity
Glycosylation251N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P47191 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C602676F8F679718

FASTA42447,505
        10         20         30         40         50         60 
MVSESHHEAL AAPPATTVAA ALPSNVTEPA APGGGGGKED AFSNLKKKFM NELNKIPLPP 

        70         80         90        100        110        120 
WALIAIAIVA VLLILTCCFC LCKKCLFKKK NKKKGKEKGG KNAINMKDVK DLGKTMKDQA 

       130        140        150        160        170        180 
LKDDDAETGL TDGEEKEEPK EVEKLGKIQY SLDYDFQNNQ LLVGIIQAAE LPALDMGGTS 

       190        200        210        220        230        240 
DPYVKVFLLP DKKKKYETKV HRKTLNPVFN EQFTFKVPYS ELGGKTLVMA VYDFDRFSKH 

       250        260        270        280        290        300 
DIIGEYKVAM NTVDFGHVTE EWRDLQSAEK EEQEKLGDIC FSLRYVPTAG KLTVVILEAK 

       310        320        330        340        350        360 
NLKKMDVGGL SDPYVKIHLM QNGKRLKKKK TTIKKNTLNP YYNESFSFEV PFEQIQKVQI 

       370        380        390        400        410        420 
VVTVLDYDKI GKNDAIGKVF VGYNSTGAEL RHWSDMLANP RRPIAQWHTL QPEEEVDAML 


AVKK

« Hide

References

[1]"Coordinate and noncoordinate regulation of synaptic vesicle protein genes during embryonic development."
Lou X., Bixby J.L.
Dev. Biol. 159:327-337(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S64957 mRNA. Translation: AAB28081.1.
IPIIPI00588537.
PIRI51210.
RefSeqNP_990502.1. NM_205171.1.
UniGeneGga.643.

3D structure databases

ProteinModelPortalP47191.
SMRP47191. Positions 143-421.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000016781.

Proteomic databases

PaxDbP47191.
PRIDEP47191.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000016800; ENSGALP00000016781; ENSGALG00000010319.
GeneID396083.
KEGGgga:396083.

Organism-specific databases

CTD6857.

Phylogenomic databases

eggNOGCOG5038.
GeneTreeENSGT00620000087641.
HOGENOMHOG000232127.
HOVERGENHBG005010.
InParanoidP47191.
KOK15290.
OMAHDIIGEY.
OrthoDBEOG4MGS7Q.

Family and domain databases

InterProIPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR020477. C2_dom.
IPR018029. C2_membr_targeting.
IPR001565. Synaptotagmin.
IPR015428. Synaptotagmin1.
[Graphical view]
PANTHERPTHR10024:SF39. PTHR10024:SF39. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. C2_CaLB. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816141.

Entry information

Entry nameSYT1_CHICK
AccessionPrimary (citable) accession number: P47191
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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