ID   HXT16_YEAST             Reviewed;         567 AA.
AC   P47185; D6VWX6;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   08-NOV-2023, entry version 159.
DE   RecName: Full=Hexose transporter HXT16;
GN   Name=HXT16; OrderedLocusNames=YJR158W; ORFNames=J2260;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- FUNCTION: Probable glucose transporter.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; Z49658; CAA89691.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08942.1; -; Genomic_DNA.
DR   PIR; S57187; S57187.
DR   RefSeq; NP_012692.3; NM_001181816.3.
DR   AlphaFoldDB; P47185; -.
DR   SMR; P47185; -.
DR   BioGRID; 33912; 23.
DR   DIP; DIP-7209N; -.
DR   IntAct; P47185; 3.
DR   MINT; P47185; -.
DR   STRING; 4932.YJR158W; -.
DR   PaxDb; 4932-YJR158W; -.
DR   PeptideAtlas; P47185; -.
DR   EnsemblFungi; YJR158W_mRNA; YJR158W; YJR158W.
DR   GeneID; 853623; -.
DR   KEGG; sce:YJR158W; -.
DR   AGR; SGD:S000003919; -.
DR   SGD; S000003919; HXT16.
DR   VEuPathDB; FungiDB:YJR158W; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   GeneTree; ENSGT00940000176280; -.
DR   HOGENOM; CLU_001265_30_1_1; -.
DR   InParanoid; P47185; -.
DR   OrthoDB; 2020602at2759; -.
DR   BioCyc; YEAST:G3O-31768-MONOMER; -.
DR   BioGRID-ORCS; 853623; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P47185; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P47185; Protein.
DR   GO; GO:0071944; C:cell periphery; HDA:SGD.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR   GO; GO:0005353; F:fructose transmembrane transporter activity; IMP:SGD.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IMP:SGD.
DR   GO; GO:0015578; F:mannose transmembrane transporter activity; IMP:SGD.
DR   GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR   GO; GO:0008645; P:hexose transmembrane transport; IMP:SGD.
DR   GO; GO:0015797; P:mannitol transmembrane transport; IGI:SGD.
DR   GO; GO:0015795; P:sorbitol transmembrane transport; IGI:SGD.
DR   CDD; cd17356; MFS_HXT; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   NCBIfam; TIGR00879; SP; 1.
DR   PANTHER; PTHR48022:SF75; GALACTOSE TRANSPORTER-RELATED; 1.
DR   PANTHER; PTHR48022; PLASTIDIC GLUCOSE TRANSPORTER 4; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Repeat; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..567
FT                   /note="Hexose transporter HXT16"
FT                   /id="PRO_0000050405"
FT   TOPO_DOM        1..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..112
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..170
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..197
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..232
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        254..336
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..353
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        354..359
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..377
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        378..384
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..405
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        406..427
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        449..465
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        466..486
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        487
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        488..508
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        509..567
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  62920 MW;  B9C3C21B97528A4D CRC64;
     MASEQSSPEI NADNLNSSAA DVHVQPPGEK EWSDGFYDKE VINGNTPDAP KRGFLGYLII
     YLLCYPVSFG GFLPGWDSGI TAGFINMDNF KMNFGSYKHS TGEYYLSNVR MGLLVAMFSV
     GCSIGGVAFA RLADTLGRRL AIVIVVLVYM VGAIIQISSN HKWYQYFVGK IIYGLGAGGC
     SVLCPMLLSE IAPTDLRGGL VSLYQLNMTF GIFLGYCSVY GTRKYSNTAQ WRIPVGLCFL
     WALIIIVGML LVPESPRYLI ECERHEEACV SIAKIDKVSP EDPWVLKQAD EINAGVLAQR
     ELGEASWKEL FSVKTKVLQR LITGILVQTF LQLTGENYFF FYGTTIFKSV GLTDGFETSI
     VLGTVNFFST IIAVMVVDKI GRRKCLLFGA ASMMACMVIF ASIGVKCLYP HGQDGPSSKG
     AGNAMIVFTC FYIFCFATTW APVAYIVVAE SFPSKVKSKA MSISTAFNWL WQFLIGFFTP
     FITGSIHFYY GYVFVGCLVA MFLYVFFFLP ETIGLSLEET QLLYEEGIKP WKSASWVPPS
     RRGASSRETE AKKKSWKEVL KFPKSFN
//