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Protein

Hexose transporter HXT16

Gene

HXT16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • mannitol transport Source: SGD
  • sorbitol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31768-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT16
Gene namesi
Name:HXT16
Ordered Locus Names:YJR158W
ORF Names:J2260
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR158W.
SGDiS000003919. HXT16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 112ExtracellularSequence analysisAdd BLAST36
Transmembranei113 – 133Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini134 – 139CytoplasmicSequence analysis6
Transmembranei140 – 160Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini161 – 170ExtracellularSequence analysis10
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini192 – 197CytoplasmicSequence analysis6
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 232ExtracellularSequence analysisAdd BLAST14
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 336CytoplasmicSequence analysisAdd BLAST83
Transmembranei337 – 353Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini354 – 359ExtracellularSequence analysis6
Transmembranei360 – 377Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini378 – 384CytoplasmicSequence analysis7
Transmembranei385 – 405Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini406 – 427ExtracellularSequence analysisAdd BLAST22
Transmembranei428 – 448Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini449 – 465CytoplasmicSequence analysisAdd BLAST17
Transmembranei466 – 486Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini487ExtracellularSequence analysis1
Transmembranei488 – 508Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini509 – 567CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504051 – 567Hexose transporter HXT16Add BLAST567

Proteomic databases

PRIDEiP47185.

Interactioni

Protein-protein interaction databases

BioGridi33912. 23 interactors.
DIPiDIP-7209N.
IntActiP47185. 2 interactors.
MINTiMINT-1365148.

Structurei

3D structure databases

ProteinModelPortaliP47185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP47185.
KOiK08139.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEQSSPEI NADNLNSSAA DVHVQPPGEK EWSDGFYDKE VINGNTPDAP
60 70 80 90 100
KRGFLGYLII YLLCYPVSFG GFLPGWDSGI TAGFINMDNF KMNFGSYKHS
110 120 130 140 150
TGEYYLSNVR MGLLVAMFSV GCSIGGVAFA RLADTLGRRL AIVIVVLVYM
160 170 180 190 200
VGAIIQISSN HKWYQYFVGK IIYGLGAGGC SVLCPMLLSE IAPTDLRGGL
210 220 230 240 250
VSLYQLNMTF GIFLGYCSVY GTRKYSNTAQ WRIPVGLCFL WALIIIVGML
260 270 280 290 300
LVPESPRYLI ECERHEEACV SIAKIDKVSP EDPWVLKQAD EINAGVLAQR
310 320 330 340 350
ELGEASWKEL FSVKTKVLQR LITGILVQTF LQLTGENYFF FYGTTIFKSV
360 370 380 390 400
GLTDGFETSI VLGTVNFFST IIAVMVVDKI GRRKCLLFGA ASMMACMVIF
410 420 430 440 450
ASIGVKCLYP HGQDGPSSKG AGNAMIVFTC FYIFCFATTW APVAYIVVAE
460 470 480 490 500
SFPSKVKSKA MSISTAFNWL WQFLIGFFTP FITGSIHFYY GYVFVGCLVA
510 520 530 540 550
MFLYVFFFLP ETIGLSLEET QLLYEEGIKP WKSASWVPPS RRGASSRETE
560
AKKKSWKEVL KFPKSFN
Length:567
Mass (Da):62,920
Last modified:February 1, 1996 - v1
Checksum:iB9C3C21B97528A4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49658 Genomic DNA. Translation: CAA89691.1.
BK006943 Genomic DNA. Translation: DAA08942.1.
PIRiS57187.
RefSeqiNP_012692.3. NM_001181816.3.

Genome annotation databases

EnsemblFungiiYJR158W; YJR158W; YJR158W.
GeneIDi853623.
KEGGisce:YJR158W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49658 Genomic DNA. Translation: CAA89691.1.
BK006943 Genomic DNA. Translation: DAA08942.1.
PIRiS57187.
RefSeqiNP_012692.3. NM_001181816.3.

3D structure databases

ProteinModelPortaliP47185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33912. 23 interactors.
DIPiDIP-7209N.
IntActiP47185. 2 interactors.
MINTiMINT-1365148.

Proteomic databases

PRIDEiP47185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR158W; YJR158W; YJR158W.
GeneIDi853623.
KEGGisce:YJR158W.

Organism-specific databases

EuPathDBiFungiDB:YJR158W.
SGDiS000003919. HXT16.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP47185.
KOiK08139.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-31768-MONOMER.

Miscellaneous databases

PROiP47185.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXT16_YEAST
AccessioniPrimary (citable) accession number: P47185
Secondary accession number(s): D6VWX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.