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Protein

Probable transcription factor HMS2

Gene

HMS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pseudohyphal differentiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi12 – 116105By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • pseudohyphal growth Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31761-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transcription factor HMS2
Alternative name(s):
High-copy MEP suppressor 2
Gene namesi
Name:HMS2
Ordered Locus Names:YJR147W
ORF Names:J2204
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR147W.
SGDiS000003908. HMS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Probable transcription factor HMS2PRO_0000124596Add
BLAST

Proteomic databases

MaxQBiP47175.

Interactioni

Protein-protein interaction databases

BioGridi33902. 40 interactions.
MINTiMINT-4492196.

Structurei

3D structure databases

ProteinModelPortaliP47175.
SMRiP47175. Positions 13-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

GeneTreeiENSGT00610000087034.
InParanoidiP47175.
OrthoDBiEOG7ZKSNN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

P47175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATSRMEQP DVFVSKLYHL LQGNAYSNII QWSTDGSKLV IWNPDQFTKV
60 70 80 90 100
ILERFFGIHT FAAFVKQLSK YNFQKAGRPD CVEFSNIHFQ KDNINSLSLV
110 120 130 140 150
KAHQSAATPN VAAVNNMNKQ CTFHWDPFKV NSILSKAIGK PSFEKLVKNV
160 170 180 190 200
DRLQGNLDEL KSTNADSLRI IREINASLQT ISYHQFHAYQ TANFLQENFE
210 220 230 240 250
AIKKVVCPDS CLQHQQRQPK RPKRYSLLLL IPNASELSET PLMRFAGVFE
260 270 280 290 300
FMNCSLDTAT QWHPQLHPEA YDLLFVTVSP NMQQEHLIYF KRLRNLLPSF
310 320 330 340 350
PVIAIINRPV SPQDTSIAPS NYSRYYFHHF LQLGFSDILV SPFTPTQLIT

LLSKHLRT
Length:358
Mass (Da):41,192
Last modified:February 1, 1996 - v1
Checksum:iE2964157FC952D42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49646 Genomic DNA. Translation: CAA89680.1.
BK006943 Genomic DNA. Translation: DAA08931.1.
PIRiS57176.
RefSeqiNP_012681.1. NM_001181805.1.

Genome annotation databases

EnsemblFungiiYJR147W; YJR147W; YJR147W.
GeneIDi853612.
KEGGisce:YJR147W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49646 Genomic DNA. Translation: CAA89680.1.
BK006943 Genomic DNA. Translation: DAA08931.1.
PIRiS57176.
RefSeqiNP_012681.1. NM_001181805.1.

3D structure databases

ProteinModelPortaliP47175.
SMRiP47175. Positions 13-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33902. 40 interactions.
MINTiMINT-4492196.

Proteomic databases

MaxQBiP47175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR147W; YJR147W; YJR147W.
GeneIDi853612.
KEGGisce:YJR147W.

Organism-specific databases

EuPathDBiFungiDB:YJR147W.
SGDiS000003908. HMS2.

Phylogenomic databases

GeneTreeiENSGT00610000087034.
InParanoidiP47175.
OrthoDBiEOG7ZKSNN.

Enzyme and pathway databases

BioCyciYEAST:G3O-31761-MONOMER.

Miscellaneous databases

NextBioi974457.
PROiP47175.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains."
    Lorenz M.C., Heitman J.
    Genetics 150:1443-1457(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHMS2_YEAST
AccessioniPrimary (citable) accession number: P47175
Secondary accession number(s): D6VWW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2050 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.