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Protein

Histone transcription regulator 3

Gene

HIR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

HIR1, HIR2 and HIR3 are repressors of histone gene transcription. They are required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. Also has a role in nucleosome assembly.2 Publications

GO - Molecular functioni

  • transcription corepressor activity Source: SGD

GO - Biological processi

  • DNA replication-independent nucleosome assembly Source: SGD
  • negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  • positive regulation of histone acetylation Source: SGD
  • transcription elongation from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31755-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone transcription regulator 3
Gene namesi
Name:HIR3
Synonyms:HPC1
Ordered Locus Names:YJR140C
ORF Names:J2161
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR140C.
SGDiS000003901. HIR3.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • HIR complex Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16481648Histone transcription regulator 3PRO_0000203124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei302 – 3021PhosphothreonineCombined sources
Modified residuei304 – 3041PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP47171.

PTM databases

iPTMnetiP47171.

Interactioni

Protein-protein interaction databases

BioGridi33896. 160 interactions.
DIPiDIP-2631N.
IntActiP47171. 7 interactions.
MINTiMINT-653897.

Structurei

3D structure databases

ProteinModelPortaliP47171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HIR3 family.Curated

Phylogenomic databases

HOGENOMiHOG000112902.
InParanoidiP47171.
OMAiLVNIWKP.
OrthoDBiEOG092C048D.

Family and domain databases

InterProiIPR033053. Hir3/CABIN1.
[Graphical view]
PANTHERiPTHR15502:SF7. PTHR15502:SF7. 3 hits.

Sequencei

Sequence statusi: Complete.

P47171-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMFNALNSN IEGEQYEAEE HSRELQIEQS FNILQDALID LKNKDFEKSD
60 70 80 90 100
SKFQELFQID VVKPDRWGMY RNSSPTLDNL RYLCYRNRGM YYHLYLENNY
110 120 130 140 150
ERLNSQELVN CILKAVENLV ESIQHSDADF AVTDLLARIF KSFNSVKLER
160 170 180 190 200
LISEYEFTKQ ENLSLLLGRH RKFLLNDLTL MMNNYVELTN KLLVPNLSDN
210 220 230 240 250
TIFERYHLEK YKDIKPEPLA FGPILSRISE MKKQDEEIMK KLDVFNVTLN
260 270 280 290 300
EESWDEVAKA LKNLLPSVKT SSLIGRNMDP YNEIEEPIEA VKFELSEAIN
310 320 330 340 350
NTPSLDRESE RQEEEQDNES VRADDKSGNL APSDIQTNEE ARPNKRTDEH
360 370 380 390 400
IDSTKPLQRS SKRFKEREQE NSKELVMDVH KRFFGEFNTL LSYIHILPFC
410 420 430 440 450
DFDTFASKFI IGSSDKQPEK FIPYTDLYEC LKSWSSRYTD IFNQNDYLSS
460 470 480 490 500
GSNENEELFQ LNALLKSNAF DDKESFPRYL NDLDSDHIRS FISEVNAGNL
510 520 530 540 550
HFHQVRLKLL FKLLGTYDEG NGRRLIIDYL WESQLLKIVL WFVFGIESNI
560 570 580 590 600
FALINKNKRQ CKYLALSIYE LLVNHLGNIV EEITNKRIQG HKSADLKSQR
610 620 630 640 650
NKVEKRIRSW HTLLEQIADE KDKELYVHFQ WTHYCFLQYT CDIVDSRLSE
660 670 680 690 700
TLTSLENTIK DSDSSLDIAY PNYRHIPALN LNTVQSQKRK IRIIQNITVE
710 720 730 740 750
DISEDTNSDT HSENHLETLE KVLLHILHPS TNHSNIDEEM VSFIFNSPFL
760 770 780 790 800
LKIRLWGVLF SSYVKKSSIQ DVQRIYFHVL DFMKGALTSP VYKESNPHGR
810 820 830 840 850
HQMLLTVLTA IGYLSSQLTA ILNSNRWESS DFVLEDYMFE KLLQTFFFFY
860 870 880 890 900
TVLFYESSAV NDVSNKSFFK RASKSSGKMK DIMIDLATLI LYYYDLQAKL
910 920 930 940 950
RTPAEQGIET TELIWSLHTL FGHFHFCDAS NGKFLDLAEK LLCQFINNDS
960 970 980 990 1000
FLQLKQILWC RYHYAIASDN FSPDLHDTKA VEMEKIHSLP LGTYLIKLQY
1010 1020 1030 1040 1050
QNKNPYLSSS KTTLKQIMDN IIEKIGDPST LDNHIISRNS FLLNEYLSRP
1060 1070 1080 1090 1100
ITADLLKHTF SGATSLYLTS PNDELQQGMT AGLFYVSSLQ SLGLYKMRKK
1110 1120 1130 1140 1150
SMQARPSELD SIIRMLKNDI IYNTNRFESW ILLGKCYSYI VEDDLIWTSD
1160 1170 1180 1190 1200
KITVPEKKDV IALTQRKAIL CYLMAISIYY SKLDRTIDDK KIILEALDDL
1210 1220 1230 1240 1250
GSMLISGYYN PMNKLCFSWK SSAENTMRLS ETGEVVMEKT KKITTISDFN
1260 1270 1280 1290 1300
IEQSIFLCFN RACSLSGDIK SQDDVFVLNW SSFYNLAKFF FKTDGGNNCK
1310 1320 1330 1340 1350
LVAKYITQGC QIAYESSPAK DPIIEPHYLL VNACYKWVKR GVIGVNEALT
1360 1370 1380 1390 1400
LLSKDNQFFQ EQEEFWVNDE GLAWDYQEKF FFDKIIRLLR HLLSVDKKKW
1410 1420 1430 1440 1450
QHRPRYRIAR ILFDDLGDVN GALEEMDSLI SAKSINKNLV NIWKPDFERP
1460 1470 1480 1490 1500
GKHFIYTYQY LVLYLDLLFA IKDFNTTGLV IKKLRRFGSG TVNVNELLER
1510 1520 1530 1540 1550
AINVYTQSAK IKLQLQDKSY VEQILPTLNY QEFLKISEQL NQVFDQGKYP
1560 1570 1580 1590 1600
EEISSGLKLA FQLKKGHSGI AFDSVCLGIY FEYLYFPLAR QDQSLTDVND
1610 1620 1630 1640
ENNPALPSSG SVTSKSTPDP TSKPSAIKKR VTKKEVFDRV RLLVDKIT
Length:1,648
Mass (Da):191,680
Last modified:February 1, 1996 - v1
Checksum:iB1F31815797852D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49640 Genomic DNA. Translation: CAA89672.1.
Z49641 Genomic DNA. Translation: CAA89674.1.
BK006943 Genomic DNA. Translation: DAA08925.1.
PIRiS57163.
RefSeqiNP_012674.1. NM_001181798.1.

Genome annotation databases

EnsemblFungiiYJR140C; YJR140C; YJR140C.
GeneIDi853605.
KEGGisce:YJR140C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49640 Genomic DNA. Translation: CAA89672.1.
Z49641 Genomic DNA. Translation: CAA89674.1.
BK006943 Genomic DNA. Translation: DAA08925.1.
PIRiS57163.
RefSeqiNP_012674.1. NM_001181798.1.

3D structure databases

ProteinModelPortaliP47171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33896. 160 interactions.
DIPiDIP-2631N.
IntActiP47171. 7 interactions.
MINTiMINT-653897.

PTM databases

iPTMnetiP47171.

Proteomic databases

MaxQBiP47171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR140C; YJR140C; YJR140C.
GeneIDi853605.
KEGGisce:YJR140C.

Organism-specific databases

EuPathDBiFungiDB:YJR140C.
SGDiS000003901. HIR3.

Phylogenomic databases

HOGENOMiHOG000112902.
InParanoidiP47171.
OMAiLVNIWKP.
OrthoDBiEOG092C048D.

Enzyme and pathway databases

BioCyciYEAST:G3O-31755-MONOMER.

Miscellaneous databases

PROiP47171.

Family and domain databases

InterProiIPR033053. Hir3/CABIN1.
[Graphical view]
PANTHERiPTHR15502:SF7. PTHR15502:SF7. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiHIR3_YEAST
AccessioniPrimary (citable) accession number: P47171
Secondary accession number(s): D6VWV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 922 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.