UniProtKB - P47170 (IML1_YEAST)
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Protein
Vacuolar membrane-associated protein IML1
Gene
IML1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.1 Publication
Miscellaneous
Present with 279 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- GTPase activator activity Source: SGD
GO - Biological processi
- cellular response to amino acid starvation Source: GO_Central
- intracellular signal transduction Source: InterPro
- negative regulation of small GTPase mediated signal transduction Source: SGD
- negative regulation of TOR signaling Source: SGD
- positive regulation of autophagy Source: SGD
- positive regulation of GTPase activity Source: SGD
- protein transport Source: UniProtKB-KW
- regulation of autophagosome assembly Source: SGD
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
BioCyci | YEAST:G3O-31754-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar membrane-associated protein IML1Alternative name(s): Increased minichromosome loss protein 1 SEH-associated protein 1 |
Gene namesi | Name:IML1 Synonyms:SEA1 Ordered Locus Names:YJR138W ORF Names:J2129 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YJR138W. |
SGDi | S000003899. IML1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203123 | 1 – 1584 | Vacuolar membrane-associated protein IML1Add BLAST | 1584 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 680 | PhosphoserineCombined sources | 1 | |
Modified residuei | 737 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P47170. |
PaxDbi | P47170. |
PRIDEi | P47170. |
PTM databases
iPTMneti | P47170. |
Interactioni
Subunit structurei
Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
HSC82 | P15108 | 2 | EBI-25710,EBI-8666 |
Protein-protein interaction databases
BioGridi | 33894. 226 interactors. |
DIPi | DIP-2589N. |
IntActi | P47170. 52 interactors. |
MINTi | P47170. |
STRINGi | 4932.YJR138W. |
Structurei
3D structure databases
ProteinModelPortali | P47170. |
SMRi | P47170. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1198 – 1273 | DEPPROSITE-ProRule annotationAdd BLAST | 76 |
Sequence similaritiesi
Belongs to the IML1 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000016559. |
HOGENOMi | HOG000093241. |
InParanoidi | P47170. |
KOi | K20404. |
OMAi | IMFNKVV. |
OrthoDBi | EOG092C04JR. |
Family and domain databases
Gene3Di | 1.10.10.10. 1 hit. |
InterProi | View protein in InterPro IPR000591. DEP_dom. IPR027244. IML1. IPR036388. WH-like_DNA-bd_sf. IPR036390. WH_DNA-bd_sf. |
PANTHERi | PTHR13179. PTHR13179. 1 hit. |
Pfami | View protein in Pfam PF00610. DEP. 1 hit. PF12257. IML1. 1 hit. |
SMARTi | View protein in SMART SM00049. DEP. 1 hit. |
SUPFAMi | SSF46785. SSF46785. 1 hit. |
PROSITEi | View protein in PROSITE PS50186. DEP. 1 hit. |
i Sequence
Sequence statusi: Complete.
P47170-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFAKLHGKKQ RPISSINSQT PRTSNTTHAN SISLSSGNLI VGSNRNLRQK
60 70 80 90 100
KEQFGSQQRA SGRKLISNKE NDDNVNNGGD NNYDNGERVH RHHIPGLKIK
110 120 130 140 150
AYQAELGYHE SRFSENLVML NLVEFPDIKP GDLVELKTYH KNPSASNGDK
160 170 180 190 200
KIYFIAKDFD GETKRRAKTS NVSILSGQLQ TLLDLPSRSR IWIKLKPNKF
210 220 230 240 250
DLQADVVEFN IKDCLLNRGD MWVLSSKLVD TCVFMDQRLA FLDSIRGTIK
260 270 280 290 300
GIYRNGKKIV SGYIGEQTRI IFRSESARLI FLIQITDEMW NFEETGEQLF
310 320 330 340 350
QKMVNSFFPK IFKKWKDVDT HHTITIAFAI SMDLSDTSFK DLTPGESLKN
360 370 380 390 400
SQDYFRIVVD QVSIIHWVDI METLREEFME IRKDLLNKQT DKGYSVANGR
410 420 430 440 450
FSPVIKSNFL ELVNFATTIL TDPFKQLDLR HTTTHVMIIS PGSGLFDVDY
460 470 480 490 500
SLLRLTGKKL LSLEMTMDLI CLSKAPLHIV PLFRYRDFEN KLHHCVPLWL
510 520 530 540 550
SVFFWNDHDK KSNSEWTPRC KIYDLQMMGI TENELIREVD VEYLQLNKKV
560 570 580 590 600
KSLSEFMNDY DKNAFEVKIL CAGSNTKQSK KLNSKFDTVF ENDVVVKARK
610 620 630 640 650
IPATATTTHG NTKFIWRGPK VALPAIKDIQ KPNVIPDLSI KTIEASFYDD
660 670 680 690 700
CNTTNDKIST PTTSNNDNLE MNDSLVSVRS ADNQNTSLAL DSLKGLSKRN
710 720 730 740 750
SLKDFTQRVI TKFISNIDTS KNKKIKSTLL RDDVDNSPLG SNTPLPSSES
760 770 780 790 800
KISGLKLQQK GLADENVISK RGNLIIKKNL SIFGLPSNEI MSGSPSSYLG
810 820 830 840 850
SSHTRTSSKL SNMSDKAAFI TEGQKSKHDD SNTYSLTQQL KHRISETWVD
860 870 880 890 900
IKSPSIPVSS EFANELLPIR WKDVWPKYVA RKYSKWRSFT TPAELPITIS
910 920 930 940 950
DFPSKDDFDR NFIFRNHSVT LNTDQEQYNQ TYKDLLRDMI YMRLLTGFQI
960 970 980 990 1000
CVGRQVEKIE LSRESGESET VVNKYLDFNQ NDAFKLYLMI DSEIHRITCS
1010 1020 1030 1040 1050
SSGIIDVERY LRKDEANLFD QVPSYIPLVK TRYESSFRDA MIDPLHVKRE
1060 1070 1080 1090 1100
SLNWNQIDQV LAGYGDNLID RKWHGFRAKY VVLPTDIPPN TYSMVINGKS
1110 1120 1130 1140 1150
ETLNPEEIRV EGLRRLIGSI TRSRLRTEKE KKGRKTKREE IQPEVMFYTG
1160 1170 1180 1190 1200
PLYNFINEQQ TSLESSAINF KDSIFVNDNN LLNRNVELSK LAYQIQRGED
1210 1220 1230 1240 1250
RITLVNRKWH WKKHEKCFVG SEMVNWLIRN FSDIDTREDA IKYGQKVMKE
1260 1270 1280 1290 1300
GLFVHVLNKH NFLDGHYFYQ FSPEYVMDTN KLEKTNSHRS TLSDPKQMLR
1310 1320 1330 1340 1350
KASTGSSNDP SAMTPFSSVV PAISASNASV ADAKEPSRPI LMLSNSLVID
1360 1370 1380 1390 1400
VDPAGKSSKQ ESCTVHYDRV HNPDHCFHIR LEWLTTTPKL IDDLVGNWSR
1410 1420 1430 1440 1450
LCERYGLKMI EIPWEELCTI PSVNPFHSFV EIKLAINPWE DPEFKDRELF
1460 1470 1480 1490 1500
AKSKFYYHVY LLKASGFLLD NRASKFLQNQ DIEFDIMYSW GKPQFKYVQY
1510 1520 1530 1540 1550
IHHTGAYVAE LRENGCLFLA PNNIYISRVN PGNIIGKIHS ASSSSLDAQK
1560 1570 1580
VILNFKSTCL DYQKLRSIFL DAKEMWITGK IVED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z49638 Genomic DNA. Translation: CAA89670.1. BK006943 Genomic DNA. Translation: DAA08923.1. |
PIRi | S57161. |
RefSeqi | NP_012672.1. NM_001181796.2. |
Genome annotation databases
EnsemblFungii | YJR138W; YJR138W; YJR138W. |
GeneIDi | 853603. |
KEGGi | sce:YJR138W. |
Similar proteinsi
Entry informationi
Entry namei | IML1_YEAST | |
Accessioni | P47170Primary (citable) accession number: P47170 Secondary accession number(s): D6VWV7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |