P47168 (TTI2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TEL2-interacting protein 2

Gene names

Name:	TTI2
Ordered Locus Names:	YJR136C
ORF Names:	J2124

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the ASTRA complex probably in chromatin remodeling.
Subunit structure	Component of the ASTRA chromatin remodeling machinery complex composed of at least RVB1, RVB2, TRA1, TEL2, TT1 and TTI2. Component of the TTT complex composed of TEL2, TTI1 and TTI2. Interacts with TEL2 and TTI1. Ref.6 Ref.7
Subcellular location	Cytoplasm. Nucleus Probable Ref.4.
Miscellaneous	Present with 1470 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the TTI2 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Chromatin regulator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ASTRA complex Inferred from direct assay Ref.6. Source: SGD cytoplasm Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TTI1	P36097	3	EBI-25698,EBI-26630

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	TEL2-interacting protein 2		PRO_0000203122

Sequences

	Sequence		Length	Mass (Da)
	P47168 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 12042525F61D8D3F	FASTA	421	48,649
	10 20 30 40 50 60 MTAVTDIIDE LNDSSLSSTR LRELCLQLRK KTDTGCAITV SDEVNLIESL SYHSISPGVD 70 80 90 100 110 120 IQINTDVLQT IDYYFQRNKS EHDEIMCVLI SKLQPLLLKR KSNFELKEQR NLGLKPTLGM 130 140 150 160 170 180 SLKEDNLMQA WVSQGGLKGI PLFYVILLHL KRRDISTNLS WIIPGILNIL DDTTDIRRIK 190 200 210 220 230 240 LRGVLLLQTL LNHTFMNETN DSKWIQFSST GLFPLFEKTL INMCYFLPPS YNADETIAIW 250 260 270 280 290 300 RVVFPTIQSL YKVEFLDNYT KYQYHLEKFM SEIILQNIIP RASLAYENLT LYALECTMNI 310 320 330 340 350 360 LRLQREGSVV HLQRLIFVLG EYIVRNPFYT TFPKLISKTL SVVSTLIKVC PNERIVAHRF 370 380 390 400 410 420 DILSLILVTY DKCSQEDALN ESILQQCKET ISWLLNCDCA MGEQLSTLSK QPRFQLLFEF S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment." Shevchenko A., Roguev A., Schaft D., Buchanan L., Habermann B., Sakalar C., Thomas H., Krogan N.J., Shevchenko A., Stewart A.F. Genome Biol. 9:R167.1-R167.22(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE ASTRA COMPLEX, MASS SPECTROMETRY.
[7]	"Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes." Takai H., Xie Y., de Lange T., Pavletich N.P. Genes Dev. 24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TEL2 AND TTI1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49636 Genomic DNA. Translation: CAA89668.1. AY692606 Genomic DNA. Translation: AAT92625.1. BK006943 Genomic DNA. Translation: DAA08921.1.
PIR	S57159.
RefSeq	NP_012670.3. NM_001181794.3.
3D structure databases
ProteinModelPortal	P47168.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1913N.
IntAct	P47168. 8 interactions.
MINT	MINT-387607.
STRING	4932.YJR136C.
Proteomic databases
PaxDb	P47168.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJR136C; YJR136C; YJR136C.
GeneID	853601.
KEGG	sce:YJR136C. sce:YJR139C.
Organism-specific databases
CYGD	YJR136c.
SGD	S000003897. TTI2.
Phylogenomic databases
eggNOG	NOG68750.
HOGENOM	HOG000066090.
KO	K00003.
OMA	WISPGIL.
OrthoDB	EOG4JQ76Z.
Gene expression databases
Genevestigator	P47168.
GermOnline	YJR136C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR018870. DUF2454. [Graphical view]
Pfam	PF10521. DUF2454. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	974427.

Entry information

Entry name

TTI2_YEAST

Accession

Primary (citable) accession number: P47168
Secondary accession number(s): D6VWV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program