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P47168

- TTI2_YEAST

UniProt

P47168 - TTI2_YEAST

Protein

TEL2-interacting protein 2

Gene

TTI2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Component of the ASTRA complex probably in chromatin remodeling.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31753-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TEL2-interacting protein 2
    Gene namesi
    Name:TTI2
    Ordered Locus Names:YJR136C
    ORF Names:J2124
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR136c.
    SGDiS000003897. TTI2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421TEL2-interacting protein 2PRO_0000203122Add
    BLAST

    Proteomic databases

    MaxQBiP47168.
    PaxDbiP47168.

    Expressioni

    Gene expression databases

    GenevestigatoriP47168.

    Interactioni

    Subunit structurei

    Component of the ASTRA chromatin remodeling machinery complex composed of at least RVB1, RVB2, TRA1, TEL2, TT1 and TTI2. Component of the TTT complex composed of TEL2, TTI1 and TTI2. Interacts with TEL2 and TTI1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TTI1P360973EBI-25698,EBI-26630

    Protein-protein interaction databases

    BioGridi33892. 204 interactions.
    DIPiDIP-1913N.
    IntActiP47168. 8 interactions.
    MINTiMINT-387607.
    STRINGi4932.YJR136C.

    Structurei

    3D structure databases

    ProteinModelPortaliP47168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TTI2 family.Curated

    Phylogenomic databases

    eggNOGiNOG68750.
    HOGENOMiHOG000066090.
    OMAiCKETISW.
    OrthoDBiEOG744TN8.

    Family and domain databases

    InterProiIPR018870. DUF2454.
    [Graphical view]
    PfamiPF10521. DUF2454. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47168-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAVTDIIDE LNDSSLSSTR LRELCLQLRK KTDTGCAITV SDEVNLIESL    50
    SYHSISPGVD IQINTDVLQT IDYYFQRNKS EHDEIMCVLI SKLQPLLLKR 100
    KSNFELKEQR NLGLKPTLGM SLKEDNLMQA WVSQGGLKGI PLFYVILLHL 150
    KRRDISTNLS WIIPGILNIL DDTTDIRRIK LRGVLLLQTL LNHTFMNETN 200
    DSKWIQFSST GLFPLFEKTL INMCYFLPPS YNADETIAIW RVVFPTIQSL 250
    YKVEFLDNYT KYQYHLEKFM SEIILQNIIP RASLAYENLT LYALECTMNI 300
    LRLQREGSVV HLQRLIFVLG EYIVRNPFYT TFPKLISKTL SVVSTLIKVC 350
    PNERIVAHRF DILSLILVTY DKCSQEDALN ESILQQCKET ISWLLNCDCA 400
    MGEQLSTLSK QPRFQLLFEF S 421
    Length:421
    Mass (Da):48,649
    Last modified:February 1, 1996 - v1
    Checksum:i12042525F61D8D3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49636 Genomic DNA. Translation: CAA89668.1.
    AY692606 Genomic DNA. Translation: AAT92625.1.
    BK006943 Genomic DNA. Translation: DAA08921.1.
    PIRiS57159.
    RefSeqiNP_012670.3. NM_001181794.3.

    Genome annotation databases

    EnsemblFungiiYJR136C; YJR136C; YJR136C.
    GeneIDi853601.
    KEGGisce:YJR136C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49636 Genomic DNA. Translation: CAA89668.1 .
    AY692606 Genomic DNA. Translation: AAT92625.1 .
    BK006943 Genomic DNA. Translation: DAA08921.1 .
    PIRi S57159.
    RefSeqi NP_012670.3. NM_001181794.3.

    3D structure databases

    ProteinModelPortali P47168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33892. 204 interactions.
    DIPi DIP-1913N.
    IntActi P47168. 8 interactions.
    MINTi MINT-387607.
    STRINGi 4932.YJR136C.

    Proteomic databases

    MaxQBi P47168.
    PaxDbi P47168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR136C ; YJR136C ; YJR136C .
    GeneIDi 853601.
    KEGGi sce:YJR136C.

    Organism-specific databases

    CYGDi YJR136c.
    SGDi S000003897. TTI2.

    Phylogenomic databases

    eggNOGi NOG68750.
    HOGENOMi HOG000066090.
    OMAi CKETISW.
    OrthoDBi EOG744TN8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31753-MONOMER.

    Miscellaneous databases

    NextBioi 974427.

    Gene expression databases

    Genevestigatori P47168.

    Family and domain databases

    InterProi IPR018870. DUF2454.
    [Graphical view ]
    Pfami PF10521. DUF2454. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment."
      Shevchenko A., Roguev A., Schaft D., Buchanan L., Habermann B., Sakalar C., Thomas H., Krogan N.J., Shevchenko A., Stewart A.F.
      Genome Biol. 9:R167.1-R167.22(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE ASTRA COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."
      Takai H., Xie Y., de Lange T., Pavletich N.P.
      Genes Dev. 24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TEL2 AND TTI1.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTTI2_YEAST
    AccessioniPrimary (citable) accession number: P47168
    Secondary accession number(s): D6VWV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1470 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3