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Protein

TEL2-interacting protein 2

Gene

TTI2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ASTRA complex probably in chromatin remodeling.

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Enzyme and pathway databases

BioCyciYEAST:G3O-31753-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TEL2-interacting protein 2
Gene namesi
Name:TTI2
Ordered Locus Names:YJR136C
ORF Names:J2124
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJR136c.
EuPathDBiFungiDB:YJR136C.
SGDiS000003897. TTI2.

Subcellular locationi

  1. Cytoplasm 1 Publication
  2. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421TEL2-interacting protein 2PRO_0000203122Add
BLAST

Proteomic databases

MaxQBiP47168.
PaxDbiP47168.

Expressioni

Gene expression databases

GenevestigatoriP47168.

Interactioni

Subunit structurei

Component of the ASTRA chromatin remodeling machinery complex composed of at least RVB1, RVB2, TRA1, TEL2, TT1 and TTI2. Component of the TTT complex composed of TEL2, TTI1 and TTI2. Interacts with TEL2 and TTI1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TTI1P360973EBI-25698,EBI-26630

Protein-protein interaction databases

BioGridi33892. 204 interactions.
DIPiDIP-1913N.
IntActiP47168. 8 interactions.
MINTiMINT-387607.
STRINGi4932.YJR136C.

Structurei

3D structure databases

ProteinModelPortaliP47168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TTI2 family.Curated

Phylogenomic databases

eggNOGiNOG68750.
HOGENOMiHOG000066090.
InParanoidiP47168.
OMAiWISPGIL.
OrthoDBiEOG744TN8.

Family and domain databases

InterProiIPR018870. DUF2454.
[Graphical view]
PfamiPF10521. DUF2454. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVTDIIDE LNDSSLSSTR LRELCLQLRK KTDTGCAITV SDEVNLIESL
60 70 80 90 100
SYHSISPGVD IQINTDVLQT IDYYFQRNKS EHDEIMCVLI SKLQPLLLKR
110 120 130 140 150
KSNFELKEQR NLGLKPTLGM SLKEDNLMQA WVSQGGLKGI PLFYVILLHL
160 170 180 190 200
KRRDISTNLS WIIPGILNIL DDTTDIRRIK LRGVLLLQTL LNHTFMNETN
210 220 230 240 250
DSKWIQFSST GLFPLFEKTL INMCYFLPPS YNADETIAIW RVVFPTIQSL
260 270 280 290 300
YKVEFLDNYT KYQYHLEKFM SEIILQNIIP RASLAYENLT LYALECTMNI
310 320 330 340 350
LRLQREGSVV HLQRLIFVLG EYIVRNPFYT TFPKLISKTL SVVSTLIKVC
360 370 380 390 400
PNERIVAHRF DILSLILVTY DKCSQEDALN ESILQQCKET ISWLLNCDCA
410 420
MGEQLSTLSK QPRFQLLFEF S
Length:421
Mass (Da):48,649
Last modified:February 1, 1996 - v1
Checksum:i12042525F61D8D3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49636 Genomic DNA. Translation: CAA89668.1.
AY692606 Genomic DNA. Translation: AAT92625.1.
BK006943 Genomic DNA. Translation: DAA08921.1.
PIRiS57159.
RefSeqiNP_012670.3. NM_001181794.3.

Genome annotation databases

EnsemblFungiiYJR136C; YJR136C; YJR136C.
GeneIDi853601.
KEGGisce:YJR136C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49636 Genomic DNA. Translation: CAA89668.1.
AY692606 Genomic DNA. Translation: AAT92625.1.
BK006943 Genomic DNA. Translation: DAA08921.1.
PIRiS57159.
RefSeqiNP_012670.3. NM_001181794.3.

3D structure databases

ProteinModelPortaliP47168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33892. 204 interactions.
DIPiDIP-1913N.
IntActiP47168. 8 interactions.
MINTiMINT-387607.
STRINGi4932.YJR136C.

Proteomic databases

MaxQBiP47168.
PaxDbiP47168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR136C; YJR136C; YJR136C.
GeneIDi853601.
KEGGisce:YJR136C.

Organism-specific databases

CYGDiYJR136c.
EuPathDBiFungiDB:YJR136C.
SGDiS000003897. TTI2.

Phylogenomic databases

eggNOGiNOG68750.
HOGENOMiHOG000066090.
InParanoidiP47168.
OMAiWISPGIL.
OrthoDBiEOG744TN8.

Enzyme and pathway databases

BioCyciYEAST:G3O-31753-MONOMER.

Miscellaneous databases

NextBioi974427.
PROiP47168.

Gene expression databases

GenevestigatoriP47168.

Family and domain databases

InterProiIPR018870. DUF2454.
[Graphical view]
PfamiPF10521. DUF2454. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment."
    Shevchenko A., Roguev A., Schaft D., Buchanan L., Habermann B., Sakalar C., Thomas H., Krogan N.J., Shevchenko A., Stewart A.F.
    Genome Biol. 9:R167.1-R167.22(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE ASTRA COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."
    Takai H., Xie Y., de Lange T., Pavletich N.P.
    Genes Dev. 24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TEL2 AND TTI1.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTI2_YEAST
AccessioniPrimary (citable) accession number: P47168
Secondary accession number(s): D6VWV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 29, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.