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P47168 (TTI2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TEL2-interacting protein 2
Gene names
Name:TTI2
Ordered Locus Names:YJR136C
ORF Names:J2124
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the ASTRA complex probably in chromatin remodeling.

Subunit structure

Component of the ASTRA chromatin remodeling machinery complex composed of at least RVB1, RVB2, TRA1, TEL2, TT1 and TTI2. Component of the TTT complex composed of TEL2, TTI1 and TTI2. Interacts with TEL2 and TTI1. Ref.6 Ref.7

Subcellular location

Cytoplasm. Nucleus Probable Ref.4.

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the TTI2 family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Molecular functionChromatin regulator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchromatin modification

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 10688190PubMed 16429126PubMed 18719252. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TTI1P360973EBI-25698,EBI-26630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421TEL2-interacting protein 2
PRO_0000203122

Sequences

Sequence LengthMass (Da)Tools
P47168 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 12042525F61D8D3F

FASTA42148,649
        10         20         30         40         50         60 
MTAVTDIIDE LNDSSLSSTR LRELCLQLRK KTDTGCAITV SDEVNLIESL SYHSISPGVD 

        70         80         90        100        110        120 
IQINTDVLQT IDYYFQRNKS EHDEIMCVLI SKLQPLLLKR KSNFELKEQR NLGLKPTLGM 

       130        140        150        160        170        180 
SLKEDNLMQA WVSQGGLKGI PLFYVILLHL KRRDISTNLS WIIPGILNIL DDTTDIRRIK 

       190        200        210        220        230        240 
LRGVLLLQTL LNHTFMNETN DSKWIQFSST GLFPLFEKTL INMCYFLPPS YNADETIAIW 

       250        260        270        280        290        300 
RVVFPTIQSL YKVEFLDNYT KYQYHLEKFM SEIILQNIIP RASLAYENLT LYALECTMNI 

       310        320        330        340        350        360 
LRLQREGSVV HLQRLIFVLG EYIVRNPFYT TFPKLISKTL SVVSTLIKVC PNERIVAHRF 

       370        380        390        400        410        420 
DILSLILVTY DKCSQEDALN ESILQQCKET ISWLLNCDCA MGEQLSTLSK QPRFQLLFEF 


S 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment."
Shevchenko A., Roguev A., Schaft D., Buchanan L., Habermann B., Sakalar C., Thomas H., Krogan N.J., Shevchenko A., Stewart A.F.
Genome Biol. 9:R167.1-R167.22(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE ASTRA COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."
Takai H., Xie Y., de Lange T., Pavletich N.P.
Genes Dev. 24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TEL2 AND TTI1.
[8]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49636 Genomic DNA. Translation: CAA89668.1.
AY692606 Genomic DNA. Translation: AAT92625.1.
BK006943 Genomic DNA. Translation: DAA08921.1.
PIRS57159.
RefSeqNP_012670.3. NM_001181794.3.

3D structure databases

ProteinModelPortalP47168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33892. 204 interactions.
DIPDIP-1913N.
IntActP47168. 8 interactions.
MINTMINT-387607.
STRING4932.YJR136C.

Proteomic databases

MaxQBP47168.
PaxDbP47168.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJR136C; YJR136C; YJR136C.
GeneID853601.
KEGGsce:YJR136C.

Organism-specific databases

CYGDYJR136c.
SGDS000003897. TTI2.

Phylogenomic databases

eggNOGNOG68750.
HOGENOMHOG000066090.
OMACKETISW.
OrthoDBEOG744TN8.

Enzyme and pathway databases

BioCycYEAST:G3O-31753-MONOMER.

Gene expression databases

GenevestigatorP47168.

Family and domain databases

InterProIPR018870. DUF2454.
[Graphical view]
PfamPF10521. DUF2454. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974427.

Entry information

Entry nameTTI2_YEAST
AccessionPrimary (citable) accession number: P47168
Secondary accession number(s): D6VWV5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families