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Protein

Inner kinetochore subunit MCM22

Gene

MCM22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.1 Publication

Miscellaneous

Present with 1026 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: SGD
  • establishment of mitotic sister chromatid cohesion Source: SGD
  • meiotic cell cycle Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-31752-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Inner kinetochore subunit MCM22Curated
Alternative name(s):
CENP-K homolog1 Publication
Constitutive centromere-associated network protein MCM22Curated
Minichromosome maintenance protein 22
Gene namesi
Name:MCM22
Ordered Locus Names:YJR135C
ORF Names:J2122
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR135C
SGDiS000003896 MCM22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962831 – 239Inner kinetochore subunit MCM22Add BLAST239

Proteomic databases

MaxQBiP47167
PaxDbiP47167
PRIDEiP47167

Interactioni

Subunit structurei

Component of the heterotrimeric kinetochore subcomplex CTF3, which consists of CTF3, MCM16 and MCM22 (PubMed:11782448). The CTF3 subcomplex is part of a larger constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:12408861, PubMed:22561346). Interacts with CTF19 (PubMed:11782448).3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33890, 149 interactors
DIPiDIP-1431N
IntActiP47167, 21 interactors
MINTiP47167
STRINGi4932.YJR135C

Structurei

3D structure databases

ProteinModelPortaliP47167
SMRiP47167
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CENP-K/MCM22 family.Curated

Phylogenomic databases

HOGENOMiHOG000000826
InParanoidiP47167
OMAiVYINTIE
OrthoDBiEOG092C5TBU

Sequencei

Sequence statusi: Complete.

P47167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVEKDVLDV YIKNLENQIG NKRYFLKQAQ GAIDEITKRS LDTEGKPVNS
60 70 80 90 100
EVFTELLRKP MFFSERADPI GFSLTSNFLS LRAQSSSEWL SLMNDQSVDQ
110 120 130 140 150
KAMLLLQNNI NSDLKELLRK LQHQMTIMDS KKQDHAHIRT RKARNKELWD
160 170 180 190 200
SLADFLKGYL VPNLDDNDES IDSLTNEVML LMKRLIEHDL NLTLNDFSSK
210 220 230
TIPIYRLLLR ANIITVIEGS TNPGTKYIKL IDFNETSLT
Length:239
Mass (Da):27,568
Last modified:February 1, 1996 - v1
Checksum:i342C2A95CDBA4878
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49635 Genomic DNA Translation: CAA89666.1
BK006943 Genomic DNA Translation: DAA08919.1
PIRiS57158
RefSeqiNP_012669.1, NM_001181793.1

Genome annotation databases

EnsemblFungiiYJR135C; YJR135C; YJR135C
GeneIDi853599
KEGGisce:YJR135C

Similar proteinsi

Entry informationi

Entry nameiCENPK_YEAST
AccessioniPrimary (citable) accession number: P47167
Secondary accession number(s): D6VWV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health