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P47158

- CAF17_YEAST

UniProt

P47158 - CAF17_YEAST

Protein

Putative transferase CAF17, mitochondrial

Gene

IBA57

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Required for lysine and glutamate prototrophy and mitochondrial genome maintenance. Has a role in the maturation of mitochondrial aconitase-type and radical-SAM Fe/S proteins biotin synthase and lipoic acid synthase.1 Publication

    GO - Molecular functioni

    1. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. iron-sulfur cluster assembly Source: SGD

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31743-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative transferase CAF17, mitochondrial (EC:2.1.-.-)
    Alternative name(s):
    57 kDa iron-sulfur cluster assembly factor for biotin synthase- and aconitase-like mitochondrial proteins
    CCR4-associated factor 17
    Gene namesi
    Name:IBA57
    Synonyms:CAF17
    Ordered Locus Names:YJR122W
    ORF Names:J2043
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR122w.
    SGDiS000003883. IBA57.

    Subcellular locationi

    Mitochondrion matrix 3 Publications

    GO - Cellular componenti

    1. mitochondrial matrix Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionSequence AnalysisAdd
    BLAST
    Chaini28 – 497470Putative transferase CAF17, mitochondrialPRO_0000203117Add
    BLAST

    Proteomic databases

    MaxQBiP47158.
    PaxDbiP47158.

    Expressioni

    Inductioni

    Up-regulated during calcium shortage.1 Publication

    Gene expression databases

    GenevestigatoriP47158.

    Interactioni

    Subunit structurei

    Interacts with CCR4, ISA1 and ISA2.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YNL295WP485641EBI-25654,EBI-2046889
    YNR075C-AQ8TGJ21EBI-25654,EBI-2047109

    Protein-protein interaction databases

    BioGridi33878. 12 interactions.
    DIPiDIP-1404N.
    IntActiP47158. 13 interactions.
    MINTiMINT-385256.
    STRINGi4932.YJR122W.

    Structurei

    3D structure databases

    ProteinModelPortaliP47158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvT family. CAF17 subfamily.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0354.
    GeneTreeiENSGT00390000006465.
    HOGENOMiHOG000000825.
    KOiK06980.
    OrthoDBiEOG7P2Z2N.

    Family and domain databases

    InterProiIPR017703. YgfZ/GcvT_CS.
    [Graphical view]
    TIGRFAMsiTIGR03317. ygfZ_signature. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P47158-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFISRRCRIK GFTLKNLLWF RSSSTRFVST ESPDASAITK PDGIFNYSLL    50
    ENRTYIRIRG PDTVKFLNGL VTSKLLPHFI KKNLTTVEEN EVPTEEGTTK 100
    VDPIIPVPEF DARLGNWGLY NEKGIQGPYI SRFGLYSAFL NGKGKLITDT 150
    IIYPTPVTVS EQISNYPEYL LELHGNVVDK ILHVLQTHKL ANKIKFEKID 200
    HSSLKTWDVE VQFPNLPKDI ENPWFDNLLD PMALPKNSID ANNFAVNVLN 250
    SLFNSDPRIL GIYVERRTES MSRHYSTFPQ SFRVVTSEQV DDLSKLFNFN 300
    VFDFPFQVNK KASVQVREIR FQKGLIDSTE DYISETLLPL ELNFDFFPNT 350
    ISTNKGCYVG QELTARTYAT GILRKRLVPV KLDNYQLLDT DPERKYAEFH 400
    IDNVVEKSLA ENEPTLNPFT NKPPERTKRK QRPAGLLISN EGLYGVALLR 450
    TEHFSAAFSS DEPVEFYITT TKGENIKITP QKPFWFSDWK NNNGPHK 497
    Length:497
    Mass (Da):57,055
    Last modified:February 1, 1996 - v1
    Checksum:iA9970EBD3BF6019C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49622 Genomic DNA. Translation: CAA89653.1.
    BK006943 Genomic DNA. Translation: DAA08907.1.
    PIRiS57145.
    RefSeqiNP_012656.1. NM_001181780.1.

    Genome annotation databases

    EnsemblFungiiYJR122W; YJR122W; YJR122W.
    GeneIDi853586.
    KEGGisce:YJR122W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49622 Genomic DNA. Translation: CAA89653.1 .
    BK006943 Genomic DNA. Translation: DAA08907.1 .
    PIRi S57145.
    RefSeqi NP_012656.1. NM_001181780.1.

    3D structure databases

    ProteinModelPortali P47158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33878. 12 interactions.
    DIPi DIP-1404N.
    IntActi P47158. 13 interactions.
    MINTi MINT-385256.
    STRINGi 4932.YJR122W.

    Proteomic databases

    MaxQBi P47158.
    PaxDbi P47158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR122W ; YJR122W ; YJR122W .
    GeneIDi 853586.
    KEGGi sce:YJR122W.

    Organism-specific databases

    CYGDi YJR122w.
    SGDi S000003883. IBA57.

    Phylogenomic databases

    eggNOGi COG0354.
    GeneTreei ENSGT00390000006465.
    HOGENOMi HOG000000825.
    KOi K06980.
    OrthoDBi EOG7P2Z2N.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31743-MONOMER.

    Miscellaneous databases

    NextBioi 974385.

    Gene expression databases

    Genevestigatori P47158.

    Family and domain databases

    InterProi IPR017703. YgfZ/GcvT_CS.
    [Graphical view ]
    TIGRFAMsi TIGR03317. ygfZ_signature. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Genome-wide analysis of yeast transcription upon calcium shortage."
      Lombardia L.J., Becerra M., Rodriguez-Belmonte E., Hauser N.C., Cerdan M.E.
      Cell Calcium 32:83-91(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity."
      Clark L.B., Viswanathan P., Quigley G., Chiang Y.-C., McMahon J.S., Yao G., Chen J., Nelsbach A., Denis C.L.
      J. Biol. Chem. 279:13616-13623(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CCR4.
    7. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
      Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
      J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. "Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes."
      Gelling C., Dawes I.W., Richhardt N., Lill R., Muehlenhoff U.
      Mol. Cell. Biol. 28:1851-1861(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ISA1 AND ISA2.

    Entry informationi

    Entry nameiCAF17_YEAST
    AccessioniPrimary (citable) accession number: P47158
    Secondary accession number(s): D6VWU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2960 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3