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Protein

Topoisomerase I damage affected protein 4

Gene

TDA4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31738-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Topoisomerase I damage affected protein 4
Gene namesi
Name:TDA4
Ordered Locus Names:YJR116W
ORF Names:J2031
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR116W
SGDiS000003877 TDA4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 79CytoplasmicSequence analysisAdd BLAST26
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 110ExtracellularSequence analysis10
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 135CytoplasmicSequence analysis4
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 162ExtracellularSequence analysis6
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 192CytoplasmicSequence analysis9
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 238ExtracellularSequence analysisAdd BLAST25
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 279CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001855441 – 279Topoisomerase I damage affected protein 4Add BLAST279

Proteomic databases

PaxDbiP47153
PRIDEiP47153

Interactioni

Protein-protein interaction databases

BioGridi33872, 40 interactors
DIPiDIP-4077N
IntActiP47153, 1 interactor
STRINGi4932.YJR116W

Structurei

3D structure databases

ProteinModelPortaliP47153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 271TLCPROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Belongs to the TMEM56 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068374
InParanoidiP47153
OMAiDKFFVIH
OrthoDBiEOG092C576N

Family and domain databases

InterProiView protein in InterPro
IPR006634 TLC-dom
PfamiView protein in Pfam
PF03798 TRAM_LAG1_CLN8, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
PROSITEiView protein in PROSITE
PS50922 TLC, 1 hit

Sequencei

Sequence statusi: Complete.

P47153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNANSTTTAI GLTSPFEKLS FFPHSSNLIL AHLHEIIFSF VFYQLAFSVV
60 70 80 90 100
APFLNKVVFR KHYTTIRDPL LKIDFNVHTV SMIQAVVSNT VLLPTLTTPM
110 120 130 140 150
HYNVVTYTDS YSSMVSSLSA GYFIWDLTMC VRYFKLYGLE FTGHAIGSVY
160 170 180 190 200
VMLLSLRPFC QPWIGRFLIY EASTPFVNIN WFIMQCNAKS KNSIPLWFNV
210 220 230 240 250
VNGLLLMTVF FVVRICWGSI ASALLFRQMW KVRDELPKFS AVTMMSLNIF
260 270
MNLLNVLWFK KMIRIAKKLA KPAPTSKLD
Length:279
Mass (Da):32,011
Last modified:February 1, 1996 - v1
Checksum:i6610293B38B7F2B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49616 Genomic DNA Translation: CAA89646.1
BK006943 Genomic DNA Translation: DAA08901.1
PIRiS57139
RefSeqiNP_012650.1, NM_001181774.1

Genome annotation databases

EnsemblFungiiYJR116W; YJR116W; YJR116W
GeneIDi853580
KEGGisce:YJR116W

Similar proteinsi

Entry informationi

Entry nameiTDA4_YEAST
AccessioniPrimary (citable) accession number: P47153
Secondary accession number(s): D6VWT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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