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P47153

- TDA4_YEAST

UniProt

P47153 - TDA4_YEAST

Protein

Topoisomerase I damage affected protein 4

Gene

TDA4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31738-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Topoisomerase I damage affected protein 4
    Gene namesi
    Name:TDA4
    Ordered Locus Names:YJR116W
    ORF Names:J2031
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR116w.
    SGDiS000003877. TDA4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Topoisomerase I damage affected protein 4PRO_0000185544Add
    BLAST

    Proteomic databases

    PaxDbiP47153.

    Expressioni

    Gene expression databases

    GenevestigatoriP47153.

    Interactioni

    Protein-protein interaction databases

    BioGridi33872. 8 interactions.
    DIPiDIP-4077N.
    MINTiMINT-554519.
    STRINGi4932.YJR116W.

    Structurei

    3D structure databases

    ProteinModelPortaliP47153.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini54 – 7926CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini101 – 11010ExtracellularSequence Analysis
    Topological domaini132 – 1354CytoplasmicSequence Analysis
    Topological domaini157 – 1626ExtracellularSequence Analysis
    Topological domaini184 – 1929CytoplasmicSequence Analysis
    Topological domaini214 – 23825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27920CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 271202TLCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TMEM56 family.Curated
    Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG327998.
    GeneTreeiENSGT00530000068374.
    OMAiYGGIMSY.
    OrthoDBiEOG74J9MF.

    Family and domain databases

    InterProiIPR006634. TLC-dom.
    [Graphical view]
    PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view]
    SMARTiSM00724. TLC. 1 hit.
    [Graphical view]
    PROSITEiPS50922. TLC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47153-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNANSTTTAI GLTSPFEKLS FFPHSSNLIL AHLHEIIFSF VFYQLAFSVV    50
    APFLNKVVFR KHYTTIRDPL LKIDFNVHTV SMIQAVVSNT VLLPTLTTPM 100
    HYNVVTYTDS YSSMVSSLSA GYFIWDLTMC VRYFKLYGLE FTGHAIGSVY 150
    VMLLSLRPFC QPWIGRFLIY EASTPFVNIN WFIMQCNAKS KNSIPLWFNV 200
    VNGLLLMTVF FVVRICWGSI ASALLFRQMW KVRDELPKFS AVTMMSLNIF 250
    MNLLNVLWFK KMIRIAKKLA KPAPTSKLD 279
    Length:279
    Mass (Da):32,011
    Last modified:February 1, 1996 - v1
    Checksum:i6610293B38B7F2B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49616 Genomic DNA. Translation: CAA89646.1.
    BK006943 Genomic DNA. Translation: DAA08901.1.
    PIRiS57139.
    RefSeqiNP_012650.1. NM_001181774.1.

    Genome annotation databases

    EnsemblFungiiYJR116W; YJR116W; YJR116W.
    GeneIDi853580.
    KEGGisce:YJR116W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49616 Genomic DNA. Translation: CAA89646.1 .
    BK006943 Genomic DNA. Translation: DAA08901.1 .
    PIRi S57139.
    RefSeqi NP_012650.1. NM_001181774.1.

    3D structure databases

    ProteinModelPortali P47153.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33872. 8 interactions.
    DIPi DIP-4077N.
    MINTi MINT-554519.
    STRINGi 4932.YJR116W.

    Proteomic databases

    PaxDbi P47153.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR116W ; YJR116W ; YJR116W .
    GeneIDi 853580.
    KEGGi sce:YJR116W.

    Organism-specific databases

    CYGDi YJR116w.
    SGDi S000003877. TDA4.

    Phylogenomic databases

    eggNOGi NOG327998.
    GeneTreei ENSGT00530000068374.
    OMAi YGGIMSY.
    OrthoDBi EOG74J9MF.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31738-MONOMER.

    Miscellaneous databases

    NextBioi 974367.

    Gene expression databases

    Genevestigatori P47153.

    Family and domain databases

    InterProi IPR006634. TLC-dom.
    [Graphical view ]
    Pfami PF03798. TRAM_LAG1_CLN8. 1 hit.
    [Graphical view ]
    SMARTi SM00724. TLC. 1 hit.
    [Graphical view ]
    PROSITEi PS50922. TLC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    4. "Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage."
      Reid R.J., Gonzalez-Barrera S., Sunjevaric I., Alvaro D., Ciccone S., Wagner M., Rothstein R.
      Genome Res. 21:477-486(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiTDA4_YEAST
    AccessioniPrimary (citable) accession number: P47153
    Secondary accession number(s): D6VWT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3