Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoinositide 3-phosphatase

Gene

YMR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P). Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity.2 Publications

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei397Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • mRNA binding Source: SGD
  • phosphatidylinositol-3-phosphatase activity Source: UniProtKB
  • protein tyrosine phosphatase activity Source: InterPro

GO - Biological processi

  • phosphatidylinositol dephosphorylation Source: UniProtKB

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-76
ReactomeiR-SCE-1632852 Macroautophagy
R-SCE-1660499 Synthesis of PIPs at the plasma membrane
R-SCE-1660516 Synthesis of PIPs at the early endosome membrane
R-SCE-1660517 Synthesis of PIPs at the late endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-phosphatase (EC:3.1.3.64)
Alternative name(s):
Yeast myotubularin-related protein 1
Gene namesi
Name:YMR1
Ordered Locus Names:YJR110W
ORF Names:J2007
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YJR110W
SGDiS000003871 YMR1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949481 – 688Phosphoinositide 3-phosphataseAdd BLAST688

Proteomic databases

MaxQBiP47147
PaxDbiP47147
PRIDEiP47147

PTM databases

iPTMnetiP47147

Interactioni

Protein-protein interaction databases

BioGridi33866, 65 interactors
DIPiDIP-5260N
IntActiP47147, 15 interactors
MINTiP47147
STRINGi4932.YJR110W

Structurei

3D structure databases

ProteinModelPortaliP47147
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 637Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST483

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118832
HOGENOMiHOG000210599
InParanoidiP47147
KOiK18083
OMAiTRSVWDY
OrthoDBiEOG092C1B1O

Family and domain databases

InterProiView protein in InterPro
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF06602 Myotub-related, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P47147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYIKIAKVS NVVLHRRGTA TQGTLHLTTH HLIFESPQLS TEFWFPYPLI
60 70 80 90 100
YGVHKNPGST LLSKLTSTNQ IQLEGTDSQN YKLYQGKDLW SFVNIKVIGK
110 120 130 140 150
DYAVFSLDFG GDLHLQARKV YDSILNLTVL SNITQLYAFI YISNNLERKL
160 170 180 190 200
PSPDSWDIYD PIKEFRRQGL DSKDETCPWR LSTVNEHYEF CPTYPSKLFV
210 220 230 240 250
PRSTSDILLK HASKFRSQKR IPVLTYHHKA TDCNILRSSQ PLPGLINQRS
260 270 280 290 300
IQDEKLVWES FNSFCNKDIR RTKHVIVDAR PRTNALAQMA LGGGTENMDN
310 320 330 340 350
YNFFLADNNM GVDKSLKLPT VTRLFLGIDN IHIVSNTAAY MTEVICQGGD
360 370 380 390 400
LNLPLEQNLI RSQKFSNWLK LNTLILKSVD MLLKSIIFNH SNVLVHCSDG
410 420 430 440 450
WDRTSQVVSL LEICLDPFYR TFEGFMILVE KDWCSFGHRF LERSGHLNSD
460 470 480 490 500
IRFHDNTMHS NFNDVDTNGD DLDIGVNTQD DYAEDDEGGE DETNLINLSR
510 520 530 540 550
ISKKFNENFK LNKKSLKFVS PVFQQFLDCV YQLLTQNPDL FEFNERFLRR
560 570 580 590 600
LVYHLYSCQY GTFLSNSEKE KFQQNLPNKT KSVWDYFRSR RKQFINPNFI
610 620 630 640 650
QRKRSGMNEH DQNLEEEEKV EWISPDLKKV QWWWQLYGRK DSEMNDELRH
660 670 680
KRDSVPISVD KKSKEHSNSD GGKGLNLSIF GFDMFNRK
Length:688
Mass (Da):80,152
Last modified:February 1, 1996 - v1
Checksum:iA097F4B98B626C01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85Q → H in AAA66903 (PubMed:2689869).Curated1
Sequence conflicti85Q → H in AAA66901 (PubMed:2689869).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49610 Genomic DNA Translation: CAA89640.1
M30466 Genomic DNA Translation: AAA66903.1
K01178 Genomic DNA Translation: AAA66901.1
BK006943 Genomic DNA Translation: DAA08895.1
PIRiS57131
RefSeqiNP_012644.1, NM_001181768.1

Genome annotation databases

EnsemblFungiiYJR110W; YJR110W; YJR110W
GeneIDi853574
KEGGisce:YJR110W

Entry informationi

Entry nameiYMR1_YEAST
AccessioniPrimary (citable) accession number: P47147
Secondary accession number(s): D6VWS9, Q12388
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health