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Protein

Phosphoinositide 3-phosphatase

Gene

YMR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P). Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity.2 Publications

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei397 – 3971Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  • mRNA binding Source: SGD
  • phosphatidylinositol-3-phosphatase activity Source: UniProtKB
  • protein tyrosine phosphatase activity Source: InterPro

GO - Biological processi

  • phosphatidylinositol dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYEAST:G3O-31733-MONOMER.
YEAST:MONOMER3O-76.
ReactomeiR-SCE-1632852. Macroautophagy.
R-SCE-1660499. Synthesis of PIPs at the plasma membrane.
R-SCE-1660516. Synthesis of PIPs at the early endosome membrane.
R-SCE-1660517. Synthesis of PIPs at the late endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-phosphatase (EC:3.1.3.64)
Alternative name(s):
Yeast myotubularin-related protein 1
Gene namesi
Name:YMR1
Ordered Locus Names:YJR110W
ORF Names:J2007
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR110W.
SGDiS000003871. YMR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 688688Phosphoinositide 3-phosphatasePRO_0000094948Add
BLAST

Proteomic databases

MaxQBiP47147.

PTM databases

iPTMnetiP47147.

Interactioni

Protein-protein interaction databases

BioGridi33866. 47 interactions.
DIPiDIP-5260N.
IntActiP47147. 13 interactions.
MINTiMINT-486298.

Structurei

3D structure databases

ProteinModelPortaliP47147.
SMRiP47147. Positions 20-597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 637483Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210599.
InParanoidiP47147.
OMAiKADMGVL.
OrthoDBiEOG092C1B1O.

Family and domain databases

InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 3 hits.
PfamiPF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYIKIAKVS NVVLHRRGTA TQGTLHLTTH HLIFESPQLS TEFWFPYPLI
60 70 80 90 100
YGVHKNPGST LLSKLTSTNQ IQLEGTDSQN YKLYQGKDLW SFVNIKVIGK
110 120 130 140 150
DYAVFSLDFG GDLHLQARKV YDSILNLTVL SNITQLYAFI YISNNLERKL
160 170 180 190 200
PSPDSWDIYD PIKEFRRQGL DSKDETCPWR LSTVNEHYEF CPTYPSKLFV
210 220 230 240 250
PRSTSDILLK HASKFRSQKR IPVLTYHHKA TDCNILRSSQ PLPGLINQRS
260 270 280 290 300
IQDEKLVWES FNSFCNKDIR RTKHVIVDAR PRTNALAQMA LGGGTENMDN
310 320 330 340 350
YNFFLADNNM GVDKSLKLPT VTRLFLGIDN IHIVSNTAAY MTEVICQGGD
360 370 380 390 400
LNLPLEQNLI RSQKFSNWLK LNTLILKSVD MLLKSIIFNH SNVLVHCSDG
410 420 430 440 450
WDRTSQVVSL LEICLDPFYR TFEGFMILVE KDWCSFGHRF LERSGHLNSD
460 470 480 490 500
IRFHDNTMHS NFNDVDTNGD DLDIGVNTQD DYAEDDEGGE DETNLINLSR
510 520 530 540 550
ISKKFNENFK LNKKSLKFVS PVFQQFLDCV YQLLTQNPDL FEFNERFLRR
560 570 580 590 600
LVYHLYSCQY GTFLSNSEKE KFQQNLPNKT KSVWDYFRSR RKQFINPNFI
610 620 630 640 650
QRKRSGMNEH DQNLEEEEKV EWISPDLKKV QWWWQLYGRK DSEMNDELRH
660 670 680
KRDSVPISVD KKSKEHSNSD GGKGLNLSIF GFDMFNRK
Length:688
Mass (Da):80,152
Last modified:February 1, 1996 - v1
Checksum:iA097F4B98B626C01
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851Q → H in AAA66903 (PubMed:2689869).Curated
Sequence conflicti85 – 851Q → H in AAA66901 (PubMed:2689869).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49610 Genomic DNA. Translation: CAA89640.1.
M30466 Genomic DNA. Translation: AAA66903.1.
K01178 Genomic DNA. Translation: AAA66901.1.
BK006943 Genomic DNA. Translation: DAA08895.1.
PIRiS57131.
RefSeqiNP_012644.1. NM_001181768.1.

Genome annotation databases

EnsemblFungiiYJR110W; YJR110W; YJR110W.
GeneIDi853574.
KEGGisce:YJR110W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49610 Genomic DNA. Translation: CAA89640.1.
M30466 Genomic DNA. Translation: AAA66903.1.
K01178 Genomic DNA. Translation: AAA66901.1.
BK006943 Genomic DNA. Translation: DAA08895.1.
PIRiS57131.
RefSeqiNP_012644.1. NM_001181768.1.

3D structure databases

ProteinModelPortaliP47147.
SMRiP47147. Positions 20-597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33866. 47 interactions.
DIPiDIP-5260N.
IntActiP47147. 13 interactions.
MINTiMINT-486298.

PTM databases

iPTMnetiP47147.

Proteomic databases

MaxQBiP47147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR110W; YJR110W; YJR110W.
GeneIDi853574.
KEGGisce:YJR110W.

Organism-specific databases

EuPathDBiFungiDB:YJR110W.
SGDiS000003871. YMR1.

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210599.
InParanoidiP47147.
OMAiKADMGVL.
OrthoDBiEOG092C1B1O.

Enzyme and pathway databases

BioCyciYEAST:G3O-31733-MONOMER.
YEAST:MONOMER3O-76.
ReactomeiR-SCE-1632852. Macroautophagy.
R-SCE-1660499. Synthesis of PIPs at the plasma membrane.
R-SCE-1660516. Synthesis of PIPs at the early endosome membrane.
R-SCE-1660517. Synthesis of PIPs at the late endosome membrane.

Miscellaneous databases

PROiP47147.

Family and domain databases

InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 3 hits.
PfamiPF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYMR1_YEAST
AccessioniPrimary (citable) accession number: P47147
Secondary accession number(s): D6VWS9, Q12388
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1080 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.