Reviewed,
UniProtKB/Swiss-Prot P47143 (ADK_YEAST)
Last modified
January 19, 2010.
Version 91.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adenosine kinase EC=2.7.1.20 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 340 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. ADO1 does not play a major role in adenine utilization in yeast. Its physiological role could primarily be to recycle adenosine produced by the methyl cycle. |
| Catalytic activity | ATP + adenosine = ADP + AMP. |
| Cofactor | Magnesium By similarity. |
| Pathway | |
| Miscellaneous | Present with 22200 molecules/cell in log phase SD medium. Ref.4 |
| Sequence similarities | Belongs to the carbohydrate kinase pfkB family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine salvage |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | purine base metabolic process Ref.3 Inferred from mutant phenotype. Source: SGD purine ribonucleoside salvageInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from direct assay. Source: SGD nucleusInferred from direct assay. Source: SGD |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenosine kinase activity Ref.3Inferred from direct assay. Source: SGD identical protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. Karpfinger-Hartl L.EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [2] | "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J.Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | "Role of adenosine kinase in Saccharomyces cerevisiae: identification of the ADO1 gene and study of the mutant phenotypes." Lecoq K., Belloc I., Desgranges C., Daignan-Fornier B. Yeast 18:335-342(2001) [PubMed: 11223943] [Abstract] Cited for: CHARACTERIZATION. |
| [4] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [5] | "Expression in Escherichia coli of a recombinant adenosine kinase from Saccharomyces cerevisiae: purification, kinetics and substrate analyses." Barrado P., Rodriguez M.J., Jimenez A., Lobato M.F. Yeast 20:1145-1150(2003) [PubMed: 14558146] [Abstract] Cited for: CHARACTERIZATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z49605 Genomic DNA. Translation: CAA89635.1. AY558082 Genomic DNA. Translation: AAS56408.1. |
| PIR | S57126. |
| RefSeq | NP_012639.1. |
3D structure databases | |
| SMR | P47143. Positions 1-334. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-4681N. |
| IntAct | P47143. 6 interactions. |
| STRING | P47143. |
Proteomic databases | |
| PeptideAtlas | P47143. |
Genome annotation databases | |
| Ensembl | YJR105W; YJR105W; YJR105W; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 853569. |
| KEGG | sce:YJR105W. |
| NMPDR | fig|4932.3.peg.3613. |
Organism-specific databases | |
| CYGD | YJR105w. |
| SGD | S000003866. ADO1. |
Phylogenomic databases | |
| eggNOG | fuNOG07084. |
| HOGENOM | HBG314716. |
| OMA | AQWMIQQ. |
| OrthoDB | EOG9WQ2K9. |
| PhylomeDB | P47143. |
Enzyme and pathway databases | |
| BRENDA | 2.7.1.20. 250. |
Gene expression databases | |
| ArrayExpress | P47143. |
| Genevestigator | P47143. |
| GermOnline | YJR105W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR001805. Adenokinase. IPR011611. Carb/pur_kinase. IPR002173. Carboh/pur_kinase_PfkB_CS. [Graphical view] |
| PANTHER | PTHR10584:SF24. Adenokinase. 1 hit. |
| Pfam | PF00294. PfkB. 1 hit. [Graphical view] |
| PRINTS | PR00989. ADENOKINASE. |
| PROSITE | PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 974337. |
Entry information
| Entry name | ADK_YEAST | ||||||||
| Accession | Primary (citable) accession number: P47143 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome X Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names |

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