P47137 (YJ66_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized oxidoreductase YJR096W
EC=1.-.-.-

Gene names

Ordered Locus Names:	YJR096W
ORF Names:	J1926

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Present with 6960 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-xylose catabolic process Inferred from mutant phenotype PubMed 12271459. Source: SGD arabinose catabolic process Inferred from direct assay PubMed 12271459. Source: SGD cellular response to oxidative stress Inferred from genetic interaction PubMed 17919749. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 11914276PubMed 14562095. Source: SGD nucleus Inferred from direct assay PubMed 14562095. Source: SGD
Molecular_function	alditol:NADP+ 1-oxidoreductase activity Inferred from direct assay PubMed 11306085. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRP40	P33203	2	EBI-25572,EBI-701
RSP5	P39940	3	EBI-25572,EBI-16219

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Uncharacterized oxidoreductase YJR096W		PRO_0000124679
Sites
	Active site	50	1	Proton donor By similarity
	Binding site	115	1	Substrate By similarity
	Site	81	1	Lowers pKa of active site Tyr By similarity

Sequences

	Sequence		Length	Mass (Da)
	P47137 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 692F14FB0B504B95	FASTA	282	32,344
	10 20 30 40 50 60 MVPKFYKLSN GFKIPSIALG TYDIPRSQTA EIVYEGVKCG YRHFDTAVLY GNEKEVGDGI 70 80 90 100 110 120 IKWLNEDPGN HKREEIFYTT KLWNSQNGYK RAKAAIRQCL NEVSGLQYID LLLIHSPLEG 130 140 150 160 170 180 SKLRLETWRA MQEAVDEGLV KSIGVSNYGK KHIDELLNWP ELKHKPVVNQ IEISPWIMRQ 190 200 210 220 230 240 ELADYCKSKG LVVEAFAPLC HGYKMTNPDL LKVCKEVDRN PGQVLIRWSL QHGYLPLPKT 250 260 270 280 KTVKRLEGNL AAYNFELSDE QMKFLDHPDA YEPTDWECTD AP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49596 Genomic DNA. Translation: CAA89626.1. AY558257 Genomic DNA. Translation: AAS56583.1. BK006943 Genomic DNA. Translation: DAA08881.1.
PIR	S57117.
RefSeq	NP_012630.1. NM_001181754.1.
3D structure databases
ProteinModelPortal	P47137.
SMR	P47137. Positions 2-282.
ModBase	Search...
Protein-protein interaction databases
IntAct	P47137. 9 interactions.
MINT	MINT-2492473.
STRING	4932.YJR096W.
Proteomic databases
PaxDb	P47137.
PeptideAtlas	P47137.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJR096W; YJR096W; YJR096W.
GeneID	853559.
KEGG	sce:YJR096W.
Organism-specific databases
CYGD	YJR096w.
SGD	S000003857. YJR096W.
Phylogenomic databases
eggNOG	COG0656.
GeneTree	ENSGT00600000085287.
HOGENOM	HOG000250272.
OMA	WECTDAP.
OrthoDB	EOG4G7G79.
Enzyme and pathway databases
BioCyc	YEAST:G3O-31724-MONOMER.
Gene expression databases
Genevestigator	P47137.
GermOnline	YJR096W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.20.20.100. 1 hit.
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
PANTHER	PTHR11732. PTHR11732. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	974308.

Entry information

Entry name

YJ66_YEAST

Accession

Primary (citable) accession number: P47137
Secondary accession number(s): D6VWR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program