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P47137

- YJ66_YEAST

UniProt

P47137 - YJ66_YEAST

Protein

Uncharacterized oxidoreductase YJR096W

Gene

YJR096W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501Proton donorBy similarity
    Sitei81 – 811Lowers pKa of active site TyrBy similarity
    Binding sitei115 – 1151SubstrateBy similarity

    GO - Molecular functioni

    1. alditol:NADP+ 1-oxidoreductase activity Source: SGD
    2. aldo-keto reductase (NADP) activity Source: SGD
    3. protein binding Source: IntAct

    GO - Biological processi

    1. arabinose catabolic process Source: SGD
    2. cellular response to oxidative stress Source: SGD
    3. D-xylose catabolic process Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31724-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized oxidoreductase YJR096W (EC:1.-.-.-)
    Gene namesi
    Ordered Locus Names:YJR096W
    ORF Names:J1926
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR096w.
    SGDiS000003857. YJR096W.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Uncharacterized oxidoreductase YJR096WPRO_0000124679Add
    BLAST

    Proteomic databases

    MaxQBiP47137.
    PaxDbiP47137.
    PeptideAtlasiP47137.

    Expressioni

    Gene expression databases

    GenevestigatoriP47137.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRP40P332032EBI-25572,EBI-701
    RSP5P399403EBI-25572,EBI-16219

    Protein-protein interaction databases

    BioGridi33851. 39 interactions.
    IntActiP47137. 9 interactions.
    MINTiMINT-2492473.
    STRINGi4932.YJR096W.

    Structurei

    3D structure databases

    ProteinModelPortaliP47137.
    SMRiP47137. Positions 2-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG0656.
    GeneTreeiENSGT00750000118266.
    HOGENOMiHOG000250272.
    OMAiHANCERT.
    OrthoDBiEOG7WQ83S.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000097. AKR. 1 hit.
    PRINTSiPR00069. ALDKETRDTASE.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47137-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPKFYKLSN GFKIPSIALG TYDIPRSQTA EIVYEGVKCG YRHFDTAVLY    50
    GNEKEVGDGI IKWLNEDPGN HKREEIFYTT KLWNSQNGYK RAKAAIRQCL 100
    NEVSGLQYID LLLIHSPLEG SKLRLETWRA MQEAVDEGLV KSIGVSNYGK 150
    KHIDELLNWP ELKHKPVVNQ IEISPWIMRQ ELADYCKSKG LVVEAFAPLC 200
    HGYKMTNPDL LKVCKEVDRN PGQVLIRWSL QHGYLPLPKT KTVKRLEGNL 250
    AAYNFELSDE QMKFLDHPDA YEPTDWECTD AP 282
    Length:282
    Mass (Da):32,344
    Last modified:November 1, 1995 - v1
    Checksum:i692F14FB0B504B95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49596 Genomic DNA. Translation: CAA89626.1.
    AY558257 Genomic DNA. Translation: AAS56583.1.
    BK006943 Genomic DNA. Translation: DAA08881.1.
    PIRiS57117.
    RefSeqiNP_012630.1. NM_001181754.1.

    Genome annotation databases

    EnsemblFungiiYJR096W; YJR096W; YJR096W.
    GeneIDi853559.
    KEGGisce:YJR096W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49596 Genomic DNA. Translation: CAA89626.1 .
    AY558257 Genomic DNA. Translation: AAS56583.1 .
    BK006943 Genomic DNA. Translation: DAA08881.1 .
    PIRi S57117.
    RefSeqi NP_012630.1. NM_001181754.1.

    3D structure databases

    ProteinModelPortali P47137.
    SMRi P47137. Positions 2-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33851. 39 interactions.
    IntActi P47137. 9 interactions.
    MINTi MINT-2492473.
    STRINGi 4932.YJR096W.

    Proteomic databases

    MaxQBi P47137.
    PaxDbi P47137.
    PeptideAtlasi P47137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR096W ; YJR096W ; YJR096W .
    GeneIDi 853559.
    KEGGi sce:YJR096W.

    Organism-specific databases

    CYGDi YJR096w.
    SGDi S000003857. YJR096W.

    Phylogenomic databases

    eggNOGi COG0656.
    GeneTreei ENSGT00750000118266.
    HOGENOMi HOG000250272.
    OMAi HANCERT.
    OrthoDBi EOG7WQ83S.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31724-MONOMER.

    Miscellaneous databases

    NextBioi 974308.

    Gene expression databases

    Genevestigatori P47137.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000097. AKR. 1 hit.
    PRINTSi PR00069. ALDKETRDTASE.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYJ66_YEAST
    AccessioniPrimary (citable) accession number: P47137
    Secondary accession number(s): D6VWR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6960 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3