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Protein

Uncharacterized oxidoreductase YJR096W

Gene

YJR096W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton donorBy similarity
Sitei81 – 811Lowers pKa of active site TyrBy similarity
Binding sitei115 – 1151SubstrateBy similarity

GO - Molecular functioni

  1. alditol:NADP+ 1-oxidoreductase activity Source: SGD
  2. aldo-keto reductase (NADP) activity Source: SGD

GO - Biological processi

  1. arabinose catabolic process Source: SGD
  2. cellular response to oxidative stress Source: SGD
  3. D-xylose catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYEAST:G3O-31724-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase YJR096W (EC:1.-.-.-)
Gene namesi
Ordered Locus Names:YJR096W
ORF Names:J1926
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome X

Organism-specific databases

CYGDiYJR096w.
EuPathDBiFungiDB:YJR096W.
SGDiS000003857. YJR096W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Uncharacterized oxidoreductase YJR096WPRO_0000124679Add
BLAST

Proteomic databases

MaxQBiP47137.
PaxDbiP47137.
PeptideAtlasiP47137.

Expressioni

Gene expression databases

GenevestigatoriP47137.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRP40P332032EBI-25572,EBI-701
RSP5P399403EBI-25572,EBI-16219

Protein-protein interaction databases

BioGridi33851. 40 interactions.
IntActiP47137. 9 interactions.
MINTiMINT-2492473.
STRINGi4932.YJR096W.

Structurei

3D structure databases

ProteinModelPortaliP47137.
SMRiP47137. Positions 2-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiCOG0656.
GeneTreeiENSGT00780000122454.
HOGENOMiHOG000250272.
InParanoidiP47137.
OMAiPDAYEPT.
OrthoDBiEOG7WQ83S.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPKFYKLSN GFKIPSIALG TYDIPRSQTA EIVYEGVKCG YRHFDTAVLY
60 70 80 90 100
GNEKEVGDGI IKWLNEDPGN HKREEIFYTT KLWNSQNGYK RAKAAIRQCL
110 120 130 140 150
NEVSGLQYID LLLIHSPLEG SKLRLETWRA MQEAVDEGLV KSIGVSNYGK
160 170 180 190 200
KHIDELLNWP ELKHKPVVNQ IEISPWIMRQ ELADYCKSKG LVVEAFAPLC
210 220 230 240 250
HGYKMTNPDL LKVCKEVDRN PGQVLIRWSL QHGYLPLPKT KTVKRLEGNL
260 270 280
AAYNFELSDE QMKFLDHPDA YEPTDWECTD AP
Length:282
Mass (Da):32,344
Last modified:November 1, 1995 - v1
Checksum:i692F14FB0B504B95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49596 Genomic DNA. Translation: CAA89626.1.
AY558257 Genomic DNA. Translation: AAS56583.1.
BK006943 Genomic DNA. Translation: DAA08881.1.
PIRiS57117.
RefSeqiNP_012630.1. NM_001181754.1.

Genome annotation databases

EnsemblFungiiYJR096W; YJR096W; YJR096W.
GeneIDi853559.
KEGGisce:YJR096W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49596 Genomic DNA. Translation: CAA89626.1.
AY558257 Genomic DNA. Translation: AAS56583.1.
BK006943 Genomic DNA. Translation: DAA08881.1.
PIRiS57117.
RefSeqiNP_012630.1. NM_001181754.1.

3D structure databases

ProteinModelPortaliP47137.
SMRiP47137. Positions 2-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33851. 40 interactions.
IntActiP47137. 9 interactions.
MINTiMINT-2492473.
STRINGi4932.YJR096W.

Proteomic databases

MaxQBiP47137.
PaxDbiP47137.
PeptideAtlasiP47137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR096W; YJR096W; YJR096W.
GeneIDi853559.
KEGGisce:YJR096W.

Organism-specific databases

CYGDiYJR096w.
EuPathDBiFungiDB:YJR096W.
SGDiS000003857. YJR096W.

Phylogenomic databases

eggNOGiCOG0656.
GeneTreeiENSGT00780000122454.
HOGENOMiHOG000250272.
InParanoidiP47137.
OMAiPDAYEPT.
OrthoDBiEOG7WQ83S.

Enzyme and pathway databases

BioCyciYEAST:G3O-31724-MONOMER.

Miscellaneous databases

NextBioi974308.
PROiP47137.

Gene expression databases

GenevestigatoriP47137.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYJ66_YEAST
AccessioniPrimary (citable) accession number: P47137
Secondary accession number(s): D6VWR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6960 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.