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Protein

Protein BIR1

Gene

BIR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act in the pleiotropic control of cell division. May participate in chromosome segregation events.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi208ZincPROSITE-ProRule annotation1
Metal bindingi211ZincPROSITE-ProRule annotation1
Metal bindingi228ZincPROSITE-ProRule annotation1
Metal bindingi237ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: SGD
  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: SGD
  • mitotic spindle assembly Source: GO_Central
  • mitotic spindle assembly checkpoint Source: SGD
  • mitotic spindle elongation Source: SGD
  • regulation of signal transduction Source: GO_Central
  • sister chromatid biorientation Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31716-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BIR1
Gene namesi
Name:BIR1
Ordered Locus Names:YJR089W
ORF Names:J1880
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR089W.
SGDiS000003849. BIR1.

Subcellular locationi

GO - Cellular componenti

  • chromosome passenger complex Source: SGD
  • condensed nuclear chromosome kinetochore Source: SGD
  • cytoplasm Source: SGD
  • nucleus Source: SGD
  • spindle Source: SGD
  • spindle microtubule Source: GO_Central
  • spindle midzone Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223881 – 954Protein BIR1Add BLAST954

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei477PhosphoserineCombined sources1
Modified residuei508PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP47134.
PRIDEiP47134.

PTM databases

iPTMnetiP47134.

Interactioni

Subunit structurei

Strongly interacts with CBF2/NDC10. Also interacts with CBF3D/SKP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IPL1P389914EBI-3648,EBI-9319
NBL1Q3E7Y65EBI-3648,EBI-9513736
SLI15P382837EBI-3648,EBI-20842

Protein-protein interaction databases

BioGridi33843. 41 interactors.
DIPiDIP-5259N.
IntActiP47134. 8 interactors.
MINTiMINT-526488.

Structurei

3D structure databases

ProteinModelPortaliP47134.
SMRiP47134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 117BIR 1Add BLAST98
Repeati153 – 241BIR 2Add BLAST89

Sequence similaritiesi

Contains 2 BIR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP47134.
OrthoDBiEOG092C0CDU.

Family and domain databases

CDDicd00022. BIR. 1 hit.
Gene3Di1.10.1170.10. 2 hits.
InterProiIPR001370. BIR_rpt.
[Graphical view]
PfamiPF00653. BIR. 2 hits.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGQIDKMEK RYSMTKLENR LRTFQDGVAL EKKKLKWSFK VIPYQAMAKL
60 70 80 90 100
GFYFDPVIDP KTSKLKKDSV RCCYCHRQTY NVRDCRSKRK DVLETLSNIM
110 120 130 140 150
RQHLTVTDNK QVCLLIYLRN KLLTDYSFHM GVSDWKNDKY FSNPDDENVI
160 170 180 190 200
NLRKFTFQDN WPHSGSQNEH PLGIEKMVNA GLMRYDSSIE GLGDPSMDKT
210 220 230 240 250
LMNDTCYCIY CKQLLQGWSI NDDPMSRHYK VSQNGNCYFF QTRNRFERIK
260 270 280 290 300
NDNDSITKNC EVSPTLGENG KREVINTKTA SQRQCPLFES PPSSTGPQLD
310 320 330 340 350
DYNEKTDISV IQHNISVLDG AQGENVKRNS VEEKEQINME NGSTTLEEGN
360 370 380 390 400
INRDVLADKK EVISTPTAKE IKRPNVQLTQ SSSPIKKKRK FKRISPRKIF
410 420 430 440 450
DEEDSEHSLN NNSANGDNKD KDLVIDFTSH IIKNRDVGRK NAILDDSTDE
460 470 480 490 500
FSFSNQGHNT FDIPIPTSSH LLKGIDSDND NVIREDDTGI NTDTKGASSK
510 520 530 540 550
HEKFSVNSEE DLNFSEVKLT GRDSSTNILI RTQIVDQNLG DIDRDKVPNG
560 570 580 590 600
GSPEVPKTHE LIRDNSEKRE AQNGEFRHQK DSTVRQSPDI LHSNKSGDNS
610 620 630 640 650
SNITAIPKEE QRRGNSKTSS IPADIHPKPR KNLQEPRSLS ISGKVVPTER
660 670 680 690 700
KLDNINIDLN FSASDFSPSS QSEQSSKSSS VISTPVASPK INLTRSLHAV
710 720 730 740 750
KELSGLKKET DDGKYFTNKQ ETIKILEDVS VKNETPNNEM LLFETGTPIA
760 770 780 790 800
SQENKSRKLF DEEFSGKELD IPIDSSTVEI KKVIKPEFEP VPSVARNLVS
810 820 830 840 850
GTSSYPRNSR LEEQRKETST SLADNSKKGS SFNEGNNEKE PNAAEWFKID
860 870 880 890 900
ENRHLVKNYF HDLLKYINNN DATLANDKDG DLAFLIKQMP AEELDMTFNN
910 920 930 940 950
WVNLKVQSIK REFIDDCDKK LDILRRDYYT ATNFIETLED DNQLIDIAKK

MGIL
Length:954
Mass (Da):108,667
Last modified:February 1, 1996 - v1
Checksum:i6B20DC16065B4C39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49589 Genomic DNA. Translation: CAA89616.1.
L47993 Genomic DNA. Translation: AAB39312.1.
BK006943 Genomic DNA. Translation: DAA08873.1.
PIRiS57108.
RefSeqiNP_012622.3. NM_001181746.3.

Genome annotation databases

EnsemblFungiiYJR089W; YJR089W; YJR089W.
GeneIDi853551.
KEGGisce:YJR089W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49589 Genomic DNA. Translation: CAA89616.1.
L47993 Genomic DNA. Translation: AAB39312.1.
BK006943 Genomic DNA. Translation: DAA08873.1.
PIRiS57108.
RefSeqiNP_012622.3. NM_001181746.3.

3D structure databases

ProteinModelPortaliP47134.
SMRiP47134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33843. 41 interactors.
DIPiDIP-5259N.
IntActiP47134. 8 interactors.
MINTiMINT-526488.

PTM databases

iPTMnetiP47134.

Proteomic databases

MaxQBiP47134.
PRIDEiP47134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR089W; YJR089W; YJR089W.
GeneIDi853551.
KEGGisce:YJR089W.

Organism-specific databases

EuPathDBiFungiDB:YJR089W.
SGDiS000003849. BIR1.

Phylogenomic databases

InParanoidiP47134.
OrthoDBiEOG092C0CDU.

Enzyme and pathway databases

BioCyciYEAST:G3O-31716-MONOMER.

Miscellaneous databases

PROiP47134.

Family and domain databases

CDDicd00022. BIR. 1 hit.
Gene3Di1.10.1170.10. 2 hits.
InterProiIPR001370. BIR_rpt.
[Graphical view]
PfamiPF00653. BIR. 2 hits.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIR1_YEAST
AccessioniPrimary (citable) accession number: P47134
Secondary accession number(s): D6VWQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.