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Protein

UPF0136 membrane protein YJR085C

Gene

YJR085C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-31713-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0136 membrane protein YJR085C
Gene namesi
Ordered Locus Names:YJR085C
ORF Names:J1863
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR085c.
SGDiS000003845. YJR085C.

Subcellular locationi

Mitochondrion 2 Publications. Membrane Curated; Multi-pass membrane protein Curated

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105UPF0136 membrane protein YJR085CPRO_0000203105Add
BLAST

Proteomic databases

MaxQBiP47131.
PaxDbiP47131.
PeptideAtlasiP47131.

Expressioni

Inductioni

By the DNA-damaging agent methyl methanesulphonate (MMS) (at protein level).1 Publication

Gene expression databases

GenevestigatoriP47131.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TSA2Q041201EBI-25560,EBI-19631

Protein-protein interaction databases

BioGridi33840. 6 interactions.
IntActiP47131. 2 interactions.
MINTiMINT-4491887.
STRINGi4932.YJR085C.

Structurei

3D structure databases

ProteinModelPortaliP47131.
SMRiP47131. Positions 1-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0136 (TMEM14) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5548.
HOGENOMiHOG000211932.
InParanoidiP47131.
OMAiYAGYLLK.
OrthoDBiEOG78D7ZJ.

Family and domain databases

InterProiIPR005349. UPF0136_TM.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHPAYTLSL LTTAGGLMGY YRKGSIPSLV SGLVFGSVYG IAGYLLHMNR
60 70 80 90 100
DGGLEMALGA STLLLGAGVI RGMPSRFTKP VPVVLTALGG LGSYYYYNKY

KEFYP
Length:105
Mass (Da):11,250
Last modified:February 1, 1996 - v1
Checksum:iC35A1E8AB98CFFA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49585 Genomic DNA. Translation: CAA89612.1.
L47993 Genomic DNA. Translation: AAB39308.1.
AY557887 Genomic DNA. Translation: AAS56213.1.
BK006943 Genomic DNA. Translation: DAA08870.1.
PIRiS57104.
RefSeqiNP_012618.3. NM_001181742.3.

Genome annotation databases

EnsemblFungiiYJR085C; YJR085C; YJR085C.
GeneIDi853547.
KEGGisce:YJR085C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49585 Genomic DNA. Translation: CAA89612.1.
L47993 Genomic DNA. Translation: AAB39308.1.
AY557887 Genomic DNA. Translation: AAS56213.1.
BK006943 Genomic DNA. Translation: DAA08870.1.
PIRiS57104.
RefSeqiNP_012618.3. NM_001181742.3.

3D structure databases

ProteinModelPortaliP47131.
SMRiP47131. Positions 1-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33840. 6 interactions.
IntActiP47131. 2 interactions.
MINTiMINT-4491887.
STRINGi4932.YJR085C.

Proteomic databases

MaxQBiP47131.
PaxDbiP47131.
PeptideAtlasiP47131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR085C; YJR085C; YJR085C.
GeneIDi853547.
KEGGisce:YJR085C.

Organism-specific databases

CYGDiYJR085c.
SGDiS000003845. YJR085C.

Phylogenomic databases

eggNOGiCOG5548.
HOGENOMiHOG000211932.
InParanoidiP47131.
OMAiYAGYLLK.
OrthoDBiEOG78D7ZJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31713-MONOMER.

Miscellaneous databases

NextBioi974275.

Gene expression databases

GenevestigatoriP47131.

Family and domain databases

InterProiIPR005349. UPF0136_TM.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
    Huang M.-E., Manus V., Chuat J.-C., Galibert F.
    Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  7. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "Global protein expression profiling of budding yeast in response to DNA damage."
    Lee M.-W., Kim B.-J., Choi H.-K., Ryu M.-J., Kim S.-B., Kang K.-M., Cho E.-J., Youn H.-D., Huh W.-K., Kim S.-T.
    Yeast 24:145-154(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiYJ55_YEAST
AccessioniPrimary (citable) accession number: P47131
Secondary accession number(s): D6VWQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.