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P47130

- CSN12_YEAST

UniProt

P47130 - CSN12_YEAST

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Protein

Cop9 signalosome complex subunit 12

Gene

CSN12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response. CSN12 forms a complex with THP3 that is recruited to transcribed genes and required for transcription elongation.4 Publications

GO - Biological processi

  1. adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion Source: SGD
  2. mRNA splicing, via spliceosome Source: SGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-31712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cop9 signalosome complex subunit 12
Gene namesi
Name:CSN12
Ordered Locus Names:YJR084W
ORF Names:J1860
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR084w.
SGDiS000003844. YJR084W.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. COP9 signalosome Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Cop9 signalosome complex subunit 12PRO_0000121047Add
BLAST

Proteomic databases

MaxQBiP47130.
PaxDbiP47130.
PeptideAtlasiP47130.

Expressioni

Gene expression databases

GenevestigatoriP47130.

Interactioni

Subunit structurei

Component of a COP9 signalosome-like (CSN) complex, composed of RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In the complex, it probably interacts directly with RRI1/CSN5, CSN9, RRI2/CSN10 and CSI1. Interacts with SEM1 and THP3.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RRI1Q124683EBI-763,EBI-37511
THP3Q120492EBI-763,EBI-34263

Protein-protein interaction databases

BioGridi33839. 62 interactions.
DIPiDIP-6710N.
IntActiP47130. 9 interactions.
MINTiMINT-655129.
STRINGi4932.YJR084W.

Structurei

3D structure databases

ProteinModelPortaliP47130.
SMRiP47130. Positions 209-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini298 – 415118PCIAdd
BLAST

Sequence similaritiesi

Belongs to the CSN12 family.Curated
Contains 1 PCI domain.Curated

Phylogenomic databases

eggNOGiCOG5600.
GeneTreeiENSGT00390000001101.
HOGENOMiHOG000000818.
InParanoidiP47130.
OMAiYAFRNCP.
OrthoDBiEOG712V5T.

Family and domain databases

InterProiIPR013143. PAM.
IPR000717. PCI_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00753. PAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47130 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVDIGCYFE EKRYDDKLLD FIRYDVKTPK KTKYILQRPT ATDEESVRLQ
60 70 80 90 100
RFYQLGVDLK LKYSKRRSLK KQGRIKNATE ELLRLANEQL KLFNRIVERE
110 120 130 140 150
TNWIIYPLWV MAKQLIRLAN ESSELNKDSI EECGRTIHRS FTICLNDRNP
160 170 180 190 200
RLNENKKIGC YMFANLEFSI YHRLSNKDMI KNLVKVLESR VNARDIPPLN
210 220 230 240 250
KSLAMEHKSQ VVLYNYYLGQ YYGCLENDHE RGFFHLNEAL LQCPMLYVES
260 270 280 290 300
TGKFVLQGQM EKIMILLVPL ALLTKRLYPH WDHPVIAGVI TRSKRLSQVY
310 320 330 340 350
PTLVRSVISG NLSLYEATAA SHERFFLSQG LHVVITLLRE VVFTRLVQRC
360 370 380 390 400
WQWGNDRKSI MPLKILLATK QHDSSANEDE EEQLDALECR LASAIASGLL
410 420
RAYLSHSNRC IVFSKKEPFP HSK
Length:423
Mass (Da):49,482
Last modified:February 1, 1996 - v1
Checksum:i750CDA631916A621
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49584 Genomic DNA. Translation: CAA89611.1.
L47993 Genomic DNA. Translation: AAB39307.1.
BK006943 Genomic DNA. Translation: DAA08869.1.
PIRiS57103.
RefSeqiNP_012617.1. NM_001181741.1.

Genome annotation databases

EnsemblFungiiYJR084W; YJR084W; YJR084W.
GeneIDi853546.
KEGGisce:YJR084W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49584 Genomic DNA. Translation: CAA89611.1 .
L47993 Genomic DNA. Translation: AAB39307.1 .
BK006943 Genomic DNA. Translation: DAA08869.1 .
PIRi S57103.
RefSeqi NP_012617.1. NM_001181741.1.

3D structure databases

ProteinModelPortali P47130.
SMRi P47130. Positions 209-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33839. 62 interactions.
DIPi DIP-6710N.
IntActi P47130. 9 interactions.
MINTi MINT-655129.
STRINGi 4932.YJR084W.

Proteomic databases

MaxQBi P47130.
PaxDbi P47130.
PeptideAtlasi P47130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR084W ; YJR084W ; YJR084W .
GeneIDi 853546.
KEGGi sce:YJR084W.

Organism-specific databases

CYGDi YJR084w.
SGDi S000003844. YJR084W.

Phylogenomic databases

eggNOGi COG5600.
GeneTreei ENSGT00390000001101.
HOGENOMi HOG000000818.
InParanoidi P47130.
OMAi YAFRNCP.
OrthoDBi EOG712V5T.

Enzyme and pathway databases

BioCyci YEAST:G3O-31712-MONOMER.

Miscellaneous databases

NextBioi 974272.
PROi P47130.

Gene expression databases

Genevestigatori P47130.

Family and domain databases

InterProi IPR013143. PAM.
IPR000717. PCI_dom.
[Graphical view ]
Pfami PF01399. PCI. 1 hit.
[Graphical view ]
SMARTi SM00753. PAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
    Huang M.-E., Manus V., Chuat J.-C., Galibert F.
    Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae."
    Maytal-Kivity V., Piran R., Pick E., Hofmann K., Glickman M.H.
    EMBO Rep. 3:1215-1221(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RRI1; CSN9; RRI2 AND CSI1, IDENTIFICATION IN THE COP9 SIGNALOSOME COMPLEX, FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
  5. "The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes."
    Maytal-Kivity V., Pick E., Piran R., Hofmann K., Glickman M.H.
    Int. J. Biochem. Cell Biol. 35:706-715(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RRI1/CSN5; CSN9; RRI2/CSN10 AND CSI1, IDENTIFICATION IN THE COP9 SIGNALOSOME COMPLEX.
  6. "A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing."
    Wilmes G.M., Bergkessel M., Bandyopadhyay S., Shales M., Braberg H., Cagney G., Collins S.R., Whitworth G.B., Kress T.L., Weissman J.S., Ideker T., Guthrie C., Krogan N.J.
    Mol. Cell 32:735-746(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SEM1 AND THP3.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery."
    Faza M.B., Kemmler S., Jimeno S., Gonzalez-Aguilera C., Aguilera A., Hurt E., Panse V.G.
    J. Cell Biol. 184:833-846(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SEM1 AND THP3.
  9. "New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation."
    Jimeno S., Tous C., Garcia-Rubio M.L., Ranes M., Gonzalez-Aguilera C., Marin A., Aguilera A.
    Mol. Cell. Biol. 31:674-685(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH THP3.
  10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCSN12_YEAST
AccessioniPrimary (citable) accession number: P47130
Secondary accession number(s): D6VWQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1510 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3