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Protein

Cop9 signalosome complex subunit 12

Gene

CSN12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response. CSN12 forms a complex with THP3 that is recruited to transcribed genes and required for transcription elongation.4 Publications

Miscellaneous

Present with 1510 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription

Enzyme and pathway databases

BioCyciYEAST:G3O-31712-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cop9 signalosome complex subunit 12
Gene namesi
Name:CSN12
Ordered Locus Names:YJR084W
ORF Names:J1860
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR084W
SGDiS000003844 YJR084W

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210471 – 423Cop9 signalosome complex subunit 12Add BLAST423

Proteomic databases

MaxQBiP47130
PaxDbiP47130
PRIDEiP47130

Interactioni

Subunit structurei

Component of a COP9 signalosome-like (CSN) complex, composed of RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In the complex, it probably interacts directly with RRI1/CSN5, CSN9, RRI2/CSN10 and CSI1. Interacts with SEM1 and THP3.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33839, 592 interactors
DIPiDIP-6710N
IntActiP47130, 10 interactors
MINTiP47130
STRINGi4932.YJR084W

Structurei

3D structure databases

ProteinModelPortaliP47130
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 418PCIPROSITE-ProRule annotationAdd BLAST187

Sequence similaritiesi

Belongs to the CSN12 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001101
HOGENOMiHOG000000818
InParanoidiP47130
OMAiTIANTRK
OrthoDBiEOG092C4AHS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

P47130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVDIGCYFE EKRYDDKLLD FIRYDVKTPK KTKYILQRPT ATDEESVRLQ
60 70 80 90 100
RFYQLGVDLK LKYSKRRSLK KQGRIKNATE ELLRLANEQL KLFNRIVERE
110 120 130 140 150
TNWIIYPLWV MAKQLIRLAN ESSELNKDSI EECGRTIHRS FTICLNDRNP
160 170 180 190 200
RLNENKKIGC YMFANLEFSI YHRLSNKDMI KNLVKVLESR VNARDIPPLN
210 220 230 240 250
KSLAMEHKSQ VVLYNYYLGQ YYGCLENDHE RGFFHLNEAL LQCPMLYVES
260 270 280 290 300
TGKFVLQGQM EKIMILLVPL ALLTKRLYPH WDHPVIAGVI TRSKRLSQVY
310 320 330 340 350
PTLVRSVISG NLSLYEATAA SHERFFLSQG LHVVITLLRE VVFTRLVQRC
360 370 380 390 400
WQWGNDRKSI MPLKILLATK QHDSSANEDE EEQLDALECR LASAIASGLL
410 420
RAYLSHSNRC IVFSKKEPFP HSK
Length:423
Mass (Da):49,482
Last modified:February 1, 1996 - v1
Checksum:i750CDA631916A621
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49584 Genomic DNA Translation: CAA89611.1
L47993 Genomic DNA Translation: AAB39307.1
BK006943 Genomic DNA Translation: DAA08869.1
PIRiS57103
RefSeqiNP_012617.1, NM_001181741.1

Genome annotation databases

EnsemblFungiiYJR084W; YJR084W; YJR084W
GeneIDi853546
KEGGisce:YJR084W

Similar proteinsi

Entry informationi

Entry nameiCSN12_YEAST
AccessioniPrimary (citable) accession number: P47130
Secondary accession number(s): D6VWQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health