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P47130

- CSN12_YEAST

UniProt

P47130 - CSN12_YEAST

Protein

Cop9 signalosome complex subunit 12

Gene

CSN12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response. CSN12 forms a complex with THP3 that is recruited to transcribed genes and required for transcription elongation.4 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion Source: SGD
    2. mRNA splicing, via spliceosome Source: SGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31712-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cop9 signalosome complex subunit 12
    Gene namesi
    Name:CSN12
    Ordered Locus Names:YJR084W
    ORF Names:J1860
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR084w.
    SGDiS000003844. YJR084W.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. COP9 signalosome Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Signalosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Cop9 signalosome complex subunit 12PRO_0000121047Add
    BLAST

    Proteomic databases

    MaxQBiP47130.
    PaxDbiP47130.
    PeptideAtlasiP47130.

    Expressioni

    Gene expression databases

    GenevestigatoriP47130.

    Interactioni

    Subunit structurei

    Component of a COP9 signalosome-like (CSN) complex, composed of RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In the complex, it probably interacts directly with RRI1/CSN5, CSN9, RRI2/CSN10 and CSI1. Interacts with SEM1 and THP3.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RRI1Q124683EBI-763,EBI-37511
    THP3Q120492EBI-763,EBI-34263

    Protein-protein interaction databases

    BioGridi33839. 61 interactions.
    DIPiDIP-6710N.
    IntActiP47130. 9 interactions.
    MINTiMINT-655129.
    STRINGi4932.YJR084W.

    Structurei

    3D structure databases

    ProteinModelPortaliP47130.
    SMRiP47130. Positions 209-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini298 – 415118PCIAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CSN12 family.Curated
    Contains 1 PCI domain.Curated

    Phylogenomic databases

    eggNOGiCOG5600.
    GeneTreeiENSGT00390000001101.
    HOGENOMiHOG000000818.
    OMAiYAFRNCP.
    OrthoDBiEOG712V5T.

    Family and domain databases

    InterProiIPR013143. PAM.
    IPR000717. PCI_dom.
    [Graphical view]
    PfamiPF01399. PCI. 1 hit.
    [Graphical view]
    SMARTiSM00753. PAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVDIGCYFE EKRYDDKLLD FIRYDVKTPK KTKYILQRPT ATDEESVRLQ    50
    RFYQLGVDLK LKYSKRRSLK KQGRIKNATE ELLRLANEQL KLFNRIVERE 100
    TNWIIYPLWV MAKQLIRLAN ESSELNKDSI EECGRTIHRS FTICLNDRNP 150
    RLNENKKIGC YMFANLEFSI YHRLSNKDMI KNLVKVLESR VNARDIPPLN 200
    KSLAMEHKSQ VVLYNYYLGQ YYGCLENDHE RGFFHLNEAL LQCPMLYVES 250
    TGKFVLQGQM EKIMILLVPL ALLTKRLYPH WDHPVIAGVI TRSKRLSQVY 300
    PTLVRSVISG NLSLYEATAA SHERFFLSQG LHVVITLLRE VVFTRLVQRC 350
    WQWGNDRKSI MPLKILLATK QHDSSANEDE EEQLDALECR LASAIASGLL 400
    RAYLSHSNRC IVFSKKEPFP HSK 423
    Length:423
    Mass (Da):49,482
    Last modified:February 1, 1996 - v1
    Checksum:i750CDA631916A621
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49584 Genomic DNA. Translation: CAA89611.1.
    L47993 Genomic DNA. Translation: AAB39307.1.
    BK006943 Genomic DNA. Translation: DAA08869.1.
    PIRiS57103.
    RefSeqiNP_012617.1. NM_001181741.1.

    Genome annotation databases

    EnsemblFungiiYJR084W; YJR084W; YJR084W.
    GeneIDi853546.
    KEGGisce:YJR084W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49584 Genomic DNA. Translation: CAA89611.1 .
    L47993 Genomic DNA. Translation: AAB39307.1 .
    BK006943 Genomic DNA. Translation: DAA08869.1 .
    PIRi S57103.
    RefSeqi NP_012617.1. NM_001181741.1.

    3D structure databases

    ProteinModelPortali P47130.
    SMRi P47130. Positions 209-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33839. 61 interactions.
    DIPi DIP-6710N.
    IntActi P47130. 9 interactions.
    MINTi MINT-655129.
    STRINGi 4932.YJR084W.

    Proteomic databases

    MaxQBi P47130.
    PaxDbi P47130.
    PeptideAtlasi P47130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR084W ; YJR084W ; YJR084W .
    GeneIDi 853546.
    KEGGi sce:YJR084W.

    Organism-specific databases

    CYGDi YJR084w.
    SGDi S000003844. YJR084W.

    Phylogenomic databases

    eggNOGi COG5600.
    GeneTreei ENSGT00390000001101.
    HOGENOMi HOG000000818.
    OMAi YAFRNCP.
    OrthoDBi EOG712V5T.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31712-MONOMER.

    Miscellaneous databases

    NextBioi 974272.
    PROi P47130.

    Gene expression databases

    Genevestigatori P47130.

    Family and domain databases

    InterProi IPR013143. PAM.
    IPR000717. PCI_dom.
    [Graphical view ]
    Pfami PF01399. PCI. 1 hit.
    [Graphical view ]
    SMARTi SM00753. PAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
      Huang M.-E., Manus V., Chuat J.-C., Galibert F.
      Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae."
      Maytal-Kivity V., Piran R., Pick E., Hofmann K., Glickman M.H.
      EMBO Rep. 3:1215-1221(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RRI1; CSN9; RRI2 AND CSI1, IDENTIFICATION IN THE COP9 SIGNALOSOME COMPLEX, FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
    5. "The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes."
      Maytal-Kivity V., Pick E., Piran R., Hofmann K., Glickman M.H.
      Int. J. Biochem. Cell Biol. 35:706-715(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RRI1/CSN5; CSN9; RRI2/CSN10 AND CSI1, IDENTIFICATION IN THE COP9 SIGNALOSOME COMPLEX.
    6. "A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing."
      Wilmes G.M., Bergkessel M., Bandyopadhyay S., Shales M., Braberg H., Cagney G., Collins S.R., Whitworth G.B., Kress T.L., Weissman J.S., Ideker T., Guthrie C., Krogan N.J.
      Mol. Cell 32:735-746(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SEM1 AND THP3.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. "Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery."
      Faza M.B., Kemmler S., Jimeno S., Gonzalez-Aguilera C., Aguilera A., Hurt E., Panse V.G.
      J. Cell Biol. 184:833-846(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SEM1 AND THP3.
    9. "New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation."
      Jimeno S., Tous C., Garcia-Rubio M.L., Ranes M., Gonzalez-Aguilera C., Marin A., Aguilera A.
      Mol. Cell. Biol. 31:674-685(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH THP3.
    10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCSN12_YEAST
    AccessioniPrimary (citable) accession number: P47130
    Secondary accession number(s): D6VWQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1510 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3