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Protein

Chromatin modification-related protein EAF6

Gene

EAF6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.1 Publication

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • DNA repair Source: SGD
  • histone acetylation Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein EAF6
Alternative name(s):
ESA1-associated factor 6
Gene namesi
Name:EAF6
Ordered Locus Names:YJR082C
ORF Names:J1854
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR082C.
SGDiS000003842. EAF6.

Subcellular locationi

GO - Cellular componenti

  • NuA3a histone acetyltransferase complex Source: SGD
  • NuA3b histone acetyltransferase complex Source: SGD
  • NuA3 histone acetyltransferase complex Source: SGD
  • NuA4 histone acetyltransferase complex Source: SGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869011 – 113Chromatin modification-related protein EAF6Add BLAST113

Proteomic databases

MaxQBiP47128.
PRIDEiP47128.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6.3 Publications

Protein-protein interaction databases

BioGridi33837. 191 interactors.
DIPiDIP-4058N.
IntActiP47128. 21 interactors.
MINTiMINT-475875.
STRINGi4932.YJR082C.

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 6Combined sources5
Helixi8 – 43Combined sources36
Turni69 – 71Combined sources3
Helixi90 – 92Combined sources3
Helixi96 – 98Combined sources3
Helixi100 – 106Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5J9QX-ray3.25B/F/J1-113[»]
5J9TX-ray2.70B/F/J1-113[»]
5J9UX-ray2.95B/F/J1-113[»]
5J9WX-ray2.80B/F/J1-113[»]
ProteinModelPortaliP47128.
SMRiP47128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 43Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the EAF6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000000817.
InParanoidiP47128.
KOiK11344.
OMAiNNDRIFS.
OrthoDBiEOG092C5E8M.

Family and domain databases

InterProiView protein in InterPro
IPR015418. Eaf6.
PfamiView protein in Pfam
PF09340. NuA4. 1 hit.

Sequencei

Sequence statusi: Complete.

P47128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDELKSYEA LKAELKKSLQ DRREQEDTFD NLQQEIYDKE TEYFSHNSNN
60 70 80 90 100
NHSGHGGAHG SKSHYSGNII KGFDTFSKSH HSHADSAFNN NDRIFSLSSA
110
TYVKQQHGQS QND
Length:113
Mass (Da):12,895
Last modified:February 1, 1996 - v1
Checksum:i396029BD06F31E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49581 Genomic DNA. Translation: CAA89609.1.
L47993 Genomic DNA. Translation: AAB39305.1.
AY557889 Genomic DNA. Translation: AAS56215.1.
BK006943 Genomic DNA. Translation: DAA08867.1.
PIRiS57101.
RefSeqiNP_012615.3. NM_001181739.3.

Genome annotation databases

EnsemblFungiiYJR082C; YJR082C; YJR082C.
GeneIDi853544.
KEGGisce:YJR082C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEAF6_YEAST
AccessioniPrimary (citable) accession number: P47128
Secondary accession number(s): D6VWQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names