SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P47128

- EAF6_YEAST

UniProt

P47128 - EAF6_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Chromatin modification-related protein EAF6
Gene
EAF6, YJR082C, J1854
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.1 Publication

GO - Biological processi

  1. DNA repair Source: SGD
  2. histone acetylation Source: SGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein EAF6
Alternative name(s):
ESA1-associated factor 6
Gene namesi
Name:EAF6
Ordered Locus Names:YJR082C
ORF Names:J1854
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR082c.
SGDiS000003842. EAF6.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. NuA3 histone acetyltransferase complex Source: SGD
  2. NuA4 histone acetyltransferase complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Chromatin modification-related protein EAF6
PRO_0000086901Add
BLAST

Proteomic databases

MaxQBiP47128.
PaxDbiP47128.

Expressioni

Gene expression databases

GenevestigatoriP47128.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6.3 Publications

Protein-protein interaction databases

BioGridi33837. 146 interactions.
DIPiDIP-4058N.
IntActiP47128. 20 interactions.
MINTiMINT-475875.
STRINGi4932.YJR082C.

Structurei

3D structure databases

ProteinModelPortaliP47128.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 4343 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the EAF6 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG322253.
HOGENOMiHOG000000817.
KOiK11344.
OMAiETEYFSH.
OrthoDBiEOG73FR1B.

Family and domain databases

InterProiIPR015418. Hist_AcTrfase_NuA4_cplx.
[Graphical view]
PfamiPF09340. NuA4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47128-1 [UniParc]FASTAAdd to Basket

« Hide

MTDELKSYEA LKAELKKSLQ DRREQEDTFD NLQQEIYDKE TEYFSHNSNN    50
NHSGHGGAHG SKSHYSGNII KGFDTFSKSH HSHADSAFNN NDRIFSLSSA 100
TYVKQQHGQS QND 113
Length:113
Mass (Da):12,895
Last modified:February 1, 1996 - v1
Checksum:i396029BD06F31E6C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49581 Genomic DNA. Translation: CAA89609.1.
L47993 Genomic DNA. Translation: AAB39305.1.
AY557889 Genomic DNA. Translation: AAS56215.1.
BK006943 Genomic DNA. Translation: DAA08867.1.
PIRiS57101.
RefSeqiNP_012615.3. NM_001181739.3.

Genome annotation databases

EnsemblFungiiYJR082C; YJR082C; YJR082C.
GeneIDi853544.
KEGGisce:YJR082C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49581 Genomic DNA. Translation: CAA89609.1 .
L47993 Genomic DNA. Translation: AAB39305.1 .
AY557889 Genomic DNA. Translation: AAS56215.1 .
BK006943 Genomic DNA. Translation: DAA08867.1 .
PIRi S57101.
RefSeqi NP_012615.3. NM_001181739.3.

3D structure databases

ProteinModelPortali P47128.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33837. 146 interactions.
DIPi DIP-4058N.
IntActi P47128. 20 interactions.
MINTi MINT-475875.
STRINGi 4932.YJR082C.

Proteomic databases

MaxQBi P47128.
PaxDbi P47128.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR082C ; YJR082C ; YJR082C .
GeneIDi 853544.
KEGGi sce:YJR082C.

Organism-specific databases

CYGDi YJR082c.
SGDi S000003842. EAF6.

Phylogenomic databases

eggNOGi NOG322253.
HOGENOMi HOG000000817.
KOi K11344.
OMAi ETEYFSH.
OrthoDBi EOG73FR1B.

Enzyme and pathway databases

BioCyci YEAST:G3O-31710-MONOMER.

Miscellaneous databases

NextBioi 974266.

Gene expression databases

Genevestigatori P47128.

Family and domain databases

InterProi IPR015418. Hist_AcTrfase_NuA4_cplx.
[Graphical view ]
Pfami PF09340. NuA4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
    Huang M.-E., Manus V., Chuat J.-C., Galibert F.
    Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres."
    Zhang H., Richardson D.O., Roberts D.N., Utley R.T., Erdjument-Bromage H., Tempst P., Cote J., Cairns B.R.
    Mol. Cell. Biol. 24:9424-9436(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4."
    Krogan N.J., Baetz K., Keogh M.-C., Datta N., Sawa C., Kwok T.C.Y., Thompson N.J., Davey M.G., Pootoolal J., Hughes T.R., Emili A., Buratowski S., Hieter P., Greenblatt J.F.
    Proc. Natl. Acad. Sci. U.S.A. 101:13513-13518(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs."
    Taverna S.D., Ilin S., Rogers R.S., Tanny J.C., Lavender H., Li H., Baker L., Boyle J., Blair L.P., Chait B.T., Patel D.J., Aitchison J.D., Tackett A.J., Allis C.D.
    Mol. Cell 24:785-796(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NUA3 COMPLEX, IDENTIFICATION IN THE NUA3 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiEAF6_YEAST
AccessioniPrimary (citable) accession number: P47128
Secondary accession number(s): D6VWQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi