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P47128

- EAF6_YEAST

UniProt

P47128 - EAF6_YEAST

Protein

Chromatin modification-related protein EAF6

Gene

EAF6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation.1 Publication

    GO - Biological processi

    1. DNA repair Source: SGD
    2. histone acetylation Source: SGD
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31710-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromatin modification-related protein EAF6
    Alternative name(s):
    ESA1-associated factor 6
    Gene namesi
    Name:EAF6
    Ordered Locus Names:YJR082C
    ORF Names:J1854
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR082c.
    SGDiS000003842. EAF6.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. NuA3 histone acetyltransferase complex Source: SGD
    2. NuA4 histone acetyltransferase complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 113113Chromatin modification-related protein EAF6PRO_0000086901Add
    BLAST

    Proteomic databases

    MaxQBiP47128.
    PaxDbiP47128.

    Expressioni

    Gene expression databases

    GenevestigatoriP47128.

    Interactioni

    Subunit structurei

    Component of the NuA4 histone acetyltransferase complex composed of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2. Component of the NuA3 complex, composed of at least NTO1, SAS3, TAF14, YNG1 and EAF6.3 Publications

    Protein-protein interaction databases

    BioGridi33837. 146 interactions.
    DIPiDIP-4058N.
    IntActiP47128. 20 interactions.
    MINTiMINT-475875.
    STRINGi4932.YJR082C.

    Structurei

    3D structure databases

    ProteinModelPortaliP47128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 4343Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the EAF6 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG322253.
    HOGENOMiHOG000000817.
    KOiK11344.
    OMAiETEYFSH.
    OrthoDBiEOG73FR1B.

    Family and domain databases

    InterProiIPR015418. Hist_AcTrfase_NuA4_cplx.
    [Graphical view]
    PfamiPF09340. NuA4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47128-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDELKSYEA LKAELKKSLQ DRREQEDTFD NLQQEIYDKE TEYFSHNSNN    50
    NHSGHGGAHG SKSHYSGNII KGFDTFSKSH HSHADSAFNN NDRIFSLSSA 100
    TYVKQQHGQS QND 113
    Length:113
    Mass (Da):12,895
    Last modified:February 1, 1996 - v1
    Checksum:i396029BD06F31E6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49581 Genomic DNA. Translation: CAA89609.1.
    L47993 Genomic DNA. Translation: AAB39305.1.
    AY557889 Genomic DNA. Translation: AAS56215.1.
    BK006943 Genomic DNA. Translation: DAA08867.1.
    PIRiS57101.
    RefSeqiNP_012615.3. NM_001181739.3.

    Genome annotation databases

    EnsemblFungiiYJR082C; YJR082C; YJR082C.
    GeneIDi853544.
    KEGGisce:YJR082C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49581 Genomic DNA. Translation: CAA89609.1 .
    L47993 Genomic DNA. Translation: AAB39305.1 .
    AY557889 Genomic DNA. Translation: AAS56215.1 .
    BK006943 Genomic DNA. Translation: DAA08867.1 .
    PIRi S57101.
    RefSeqi NP_012615.3. NM_001181739.3.

    3D structure databases

    ProteinModelPortali P47128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33837. 146 interactions.
    DIPi DIP-4058N.
    IntActi P47128. 20 interactions.
    MINTi MINT-475875.
    STRINGi 4932.YJR082C.

    Proteomic databases

    MaxQBi P47128.
    PaxDbi P47128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR082C ; YJR082C ; YJR082C .
    GeneIDi 853544.
    KEGGi sce:YJR082C.

    Organism-specific databases

    CYGDi YJR082c.
    SGDi S000003842. EAF6.

    Phylogenomic databases

    eggNOGi NOG322253.
    HOGENOMi HOG000000817.
    KOi K11344.
    OMAi ETEYFSH.
    OrthoDBi EOG73FR1B.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31710-MONOMER.

    Miscellaneous databases

    NextBioi 974266.

    Gene expression databases

    Genevestigatori P47128.

    Family and domain databases

    InterProi IPR015418. Hist_AcTrfase_NuA4_cplx.
    [Graphical view ]
    Pfami PF09340. NuA4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
      Huang M.-E., Manus V., Chuat J.-C., Galibert F.
      Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres."
      Zhang H., Richardson D.O., Roberts D.N., Utley R.T., Erdjument-Bromage H., Tempst P., Cote J., Cairns B.R.
      Mol. Cell. Biol. 24:9424-9436(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4."
      Krogan N.J., Baetz K., Keogh M.-C., Datta N., Sawa C., Kwok T.C.Y., Thompson N.J., Davey M.G., Pootoolal J., Hughes T.R., Emili A., Buratowski S., Hieter P., Greenblatt J.F.
      Proc. Natl. Acad. Sci. U.S.A. 101:13513-13518(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NUA4 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs."
      Taverna S.D., Ilin S., Rogers R.S., Tanny J.C., Lavender H., Li H., Baker L., Boyle J., Blair L.P., Chait B.T., Patel D.J., Aitchison J.D., Tackett A.J., Allis C.D.
      Mol. Cell 24:785-796(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE NUA3 COMPLEX, IDENTIFICATION IN THE NUA3 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiEAF6_YEAST
    AccessioniPrimary (citable) accession number: P47128
    Secondary accession number(s): D6VWQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 504 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3