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Protein

Nuclear import protein MOG1

Gene

MOG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the Ran-GTPase system for nuclear protein import and poly(A)+ mRNA export.2 Publications

GO - Molecular functioni

  • Ran GTPase binding Source: SGD

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • protein import into nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear import protein MOG1
Alternative name(s):
Multicopy suppressor of GSP1
Gene namesi
Name:MOG1
Ordered Locus Names:YJR074W
ORF Names:J1827
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR074W.
SGDiS000003835. MOG1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Nuclear import protein MOG1PRO_0000215203Add
BLAST

Proteomic databases

MaxQBiP47123.
PeptideAtlasiP47123.

Interactioni

Subunit structurei

Interacts with GSP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GSP2P328363EBI-11145,EBI-7934

GO - Molecular functioni

  • Ran GTPase binding Source: SGD

Protein-protein interaction databases

BioGridi33830. 185 interactions.
DIPiDIP-1356N.
IntActiP47123. 4 interactions.
MINTiMINT-384619.

Structurei

Secondary structure

1
218
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 385Combined sources
Helixi39 – 413Combined sources
Beta strandi43 – 475Combined sources
Beta strandi51 – 533Combined sources
Helixi54 – 563Combined sources
Beta strandi64 – 696Combined sources
Beta strandi78 – 803Combined sources
Beta strandi86 – 938Combined sources
Helixi100 – 11213Combined sources
Helixi113 – 1153Combined sources
Beta strandi117 – 12913Combined sources
Turni130 – 1323Combined sources
Beta strandi133 – 14311Combined sources
Beta strandi154 – 16310Combined sources
Helixi164 – 1663Combined sources
Beta strandi168 – 17710Combined sources
Helixi180 – 1867Combined sources
Turni187 – 1893Combined sources
Helixi193 – 20715Combined sources
Beta strandi210 – 2123Combined sources
Helixi214 – 2163Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EQ6X-ray1.90A30-218[»]
1JHSX-ray1.90A31-218[»]
ProteinModelPortaliP47123.
SMRiP47123. Positions 30-218.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47123.

Family & Domainsi

Sequence similaritiesi

Belongs to the MOG1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013834.
HOGENOMiHOG000247047.
InParanoidiP47123.
OMAiKELPARC.
OrthoDBiEOG7ZPNX4.

Family and domain databases

Gene3Di3.40.1000.10. 1 hit.
InterProiIPR007681. Mog1.
IPR016123. Mog1/PsbP_a/b/a-sand.
[Graphical view]
PfamiPF04603. Mog1. 1 hit.
[Graphical view]
SUPFAMiSSF55724. SSF55724. 1 hit.

Sequencei

Sequence statusi: Complete.

P47123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIEKASHIS QPVQLSTCTL IDTYPGHQGS MNNKEVELYG GAITTVVPPG
60 70 80 90 100
FIDASTLREV PDTQEVYVNS RRDEEEFEDG LATNESIIVD LLETVDKSDL
110 120 130 140 150
KEAWQFHVED LTELNGTTKW EALQEDTVQQ GTKFTGLVME VANKWGKPDL
160 170 180 190 200
AQTVVIGVAL IRLTQFDTDV VISINVPLTK EEASQASNKE LPARCHAVYQ
210
LLQEMVRKFH VVDTSLFA
Length:218
Mass (Da):24,307
Last modified:February 1, 1996 - v1
Checksum:i980156FF01A1542D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015285 Genomic DNA. Translation: BAA28825.1.
L47993 Genomic DNA. Translation: AAB39299.1.
Z49574 Genomic DNA. Translation: CAA89602.1.
BK006943 Genomic DNA. Translation: DAA08860.1.
PIRiS57093.
RefSeqiNP_012608.1. NM_001181732.1.

Genome annotation databases

EnsemblFungiiYJR074W; YJR074W; YJR074W.
GeneIDi853537.
KEGGisce:YJR074W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015285 Genomic DNA. Translation: BAA28825.1.
L47993 Genomic DNA. Translation: AAB39299.1.
Z49574 Genomic DNA. Translation: CAA89602.1.
BK006943 Genomic DNA. Translation: DAA08860.1.
PIRiS57093.
RefSeqiNP_012608.1. NM_001181732.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EQ6X-ray1.90A30-218[»]
1JHSX-ray1.90A31-218[»]
ProteinModelPortaliP47123.
SMRiP47123. Positions 30-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33830. 185 interactions.
DIPiDIP-1356N.
IntActiP47123. 4 interactions.
MINTiMINT-384619.

Proteomic databases

MaxQBiP47123.
PeptideAtlasiP47123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR074W; YJR074W; YJR074W.
GeneIDi853537.
KEGGisce:YJR074W.

Organism-specific databases

EuPathDBiFungiDB:YJR074W.
SGDiS000003835. MOG1.

Phylogenomic databases

GeneTreeiENSGT00390000013834.
HOGENOMiHOG000247047.
InParanoidiP47123.
OMAiKELPARC.
OrthoDBiEOG7ZPNX4.

Enzyme and pathway databases

BioCyciYEAST:G3O-31705-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP47123.
PROiP47123.

Family and domain databases

Gene3Di3.40.1000.10. 1 hit.
InterProiIPR007681. Mog1.
IPR016123. Mog1/PsbP_a/b/a-sand.
[Graphical view]
PfamiPF04603. Mog1. 1 hit.
[Graphical view]
SUPFAMiSSF55724. SSF55724. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue."
    Oki M., Nishimoto T.
    Proc. Natl. Acad. Sci. U.S.A. 95:15388-15393(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH GSP1, SUBCELLULAR LOCATION.
  2. "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI."
    Huang M.-E., Manus V., Chuat J.-C., Galibert F.
    Yeast 12:869-875(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Interaction between Ran and Mog1 is required for efficient nuclear protein import."
    Baker R.P., Harreman M.T., Eccleston J.F., Corbett A.H., Stewart M.
    J. Biol. Chem. 276:41255-41262(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "1.9-A resolution crystal structure of the Saccharomyces cerevisiae Ran-binding protein Mog1p."
    Stewart M., Baker R.P.
    J. Mol. Biol. 299:213-223(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 30-218.

Entry informationi

Entry nameiMOG1_YEAST
AccessioniPrimary (citable) accession number: P47123
Secondary accession number(s): D6VWP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.