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Protein

Actin-related protein 3

Gene

ARP3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).By similarity

Miscellaneous

Present with 6650 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • ATP binding Source: SGD

GO - Biological processi

  • actin cortical patch organization Source: SGD
  • actin filament organization Source: SGD
  • Arp2/3 complex-mediated actin nucleation Source: SGD
  • mitochondrion inheritance Source: SGD

Keywordsi

Molecular functionActin-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31698-MONOMER
ReactomeiR-SCE-2029482 Regulation of actin dynamics for phagocytic cup formation
R-SCE-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3
Alternative name(s):
Actin-like protein ARP3
Short name:
Actin-like protein 3
Gene namesi
Name:ARP3
Synonyms:ACT4
Ordered Locus Names:YJR065C
ORF Names:J1760
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR065C
SGDiS000003826 ARP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000890901 – 449Actin-related protein 3Add BLAST449

Proteomic databases

MaxQBiP47117
PaxDbiP47117
PRIDEiP47117
TopDownProteomicsiP47117

PTM databases

iPTMnetiP47117

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARC40P383284EBI-2933,EBI-2777

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33822, 799 interactors
DIPiDIP-2649N
IntActiP47117, 11 interactors
MINTiP47117
STRINGi4932.YJR065C

Structurei

3D structure databases

ProteinModelPortaliP47117
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP3 subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074695
HOGENOMiHOG000233339
InParanoidiP47117
KOiK18584
OMAiYVCQDIV
OrthoDBiEOG092C2IN7

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR015623 Arp3
PANTHERiPTHR11937 PTHR11937, 2 hits
PTHR11937:SF170 PTHR11937:SF170, 2 hits
PfamiView protein in Pfam
PF00022 Actin, 1 hit
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P47117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYLNNPAVV MDNGTGLTKL GFAGNDSPSW VFPTAIATAA PSNTKKSSGV
60 70 80 90 100
GAPSAVSNEA SYFGNSTSAT NFNGATGGLL SNNLSGKRGT EDLDFYIGNE
110 120 130 140 150
ALVASQGPSY SLSYPIRHGQ VENWDHMERF WENSIFKYLR TEPEDHFFLL
160 170 180 190 200
TEPPLNPPEN REQVAEIFFE SFNCAGLYIA VQAVLALAAS WTSSKVTDRS
210 220 230 240 250
LTGTVIDSGD GVTHVIPVAE GYVIGSAIKN IPIAGRDITL FIQSLLRERG
260 270 280 290 300
EADTSLRTAE KIKQEYCYVC PDIVKEFNKF DKDPSKFAQF VVENQEKTRR
310 320 330 340 350
KVVDIGYERF LAPEIFFNPE IASSDFLTPL PTVVDQTIQA CPIDVRKGLY
360 370 380 390 400
NNIVLSGGST MFKDFGRRLQ RDLKSIVNNR IAQSELLSGT KSTGVDVSVI
410 420 430 440
SHRKQRNAVW FGGSLLAQTA EFKGYCHTKK DYEEYGPEIV RNFSLFNMV
Length:449
Mass (Da):49,542
Last modified:November 1, 1995 - v1
Checksum:i5BBD87E83F476E9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37111 Genomic DNA Translation: AAC37503.1
L47993 Genomic DNA Translation: AAB39291.1
Z49565 Genomic DNA Translation: CAA89593.1
BK006943 Genomic DNA Translation: DAA08852.1
PIRiS57084
RefSeqiNP_012599.3, NM_001181723.3

Genome annotation databases

EnsemblFungiiYJR065C; YJR065C; YJR065C
GeneIDi853528
KEGGisce:YJR065C

Similar proteinsi

Entry informationi

Entry nameiARP3_YEAST
AccessioniPrimary (citable) accession number: P47117
Secondary accession number(s): D6VWN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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