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P47111

- VPS55_YEAST

UniProt

P47111 - VPS55_YEAST

Protein

Vacuolar protein sorting-associated protein 55

Gene

VPS55

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Involved in protein transport from endosomes to the vacuole.1 Publication

    GO - Biological processi

    1. late endosome to vacuole transport via multivesicular body sorting pathway Source: SGD
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31679-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 55
    Gene namesi
    Name:VPS55
    Ordered Locus Names:YJR044C
    ORF Names:J1637
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR044c.
    SGDiS000003805. VPS55.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. late endosome Source: SGD
    3. Vps55/Vps68 complex Source: SGD

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Vacuolar protein sorting-associated protein 55PRO_0000215201Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei137 – 1371Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP47111.

    Expressioni

    Gene expression databases

    GenevestigatoriP47111.

    Interactioni

    Protein-protein interaction databases

    BioGridi33796. 86 interactions.
    DIPiDIP-7667N.
    IntActiP47111. 3 interactions.
    MINTiMINT-485094.
    STRINGi4932.YJR044C.

    Structurei

    3D structure databases

    ProteinModelPortaliP47111.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 375LumenalSequence Analysis
    Topological domaini59 – 7618CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 10710LumenalSequence Analysis
    Topological domaini129 – 14012CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OB-RGRP/VPS55 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG116508.
    GeneTreeiENSGT00390000006503.
    HOGENOMiHOG000038515.
    OMAiMVMSIIG.
    OrthoDBiEOG72C5CW.

    Family and domain databases

    InterProiIPR007262. VPS55.
    [Graphical view]
    PANTHERiPTHR12050. PTHR12050. 1 hit.
    PfamiPF04133. Vps55. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEFKVSPLT KIISLSGFLA LGFLLVILSC ALFHNYYPLF DILIFLLAPI    50
    PNTIFNAGNK YHTSDFMSDS SNTGQDLAHF LTGMLVTSGI ALPVVFYHCQ 100
    LIGHLSCIMC MIGGLIIYSS IVIFKWFFKK DFNEDDSLFG 140
    Length:140
    Mass (Da):15,664
    Last modified:February 1, 1996 - v1
    Checksum:i1F207E62F093FC6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49544 Genomic DNA. Translation: CAA89572.1.
    L36344 Genomic DNA. Translation: AAA88746.1.
    AY557891 Genomic DNA. Translation: AAS56217.1.
    BK006943 Genomic DNA. Translation: DAA08831.1.
    PIRiS57063.
    RefSeqiNP_012578.3. NM_001181702.3.

    Genome annotation databases

    EnsemblFungiiYJR044C; YJR044C; YJR044C.
    GeneIDi853502.
    KEGGisce:YJR044C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49544 Genomic DNA. Translation: CAA89572.1 .
    L36344 Genomic DNA. Translation: AAA88746.1 .
    AY557891 Genomic DNA. Translation: AAS56217.1 .
    BK006943 Genomic DNA. Translation: DAA08831.1 .
    PIRi S57063.
    RefSeqi NP_012578.3. NM_001181702.3.

    3D structure databases

    ProteinModelPortali P47111.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33796. 86 interactions.
    DIPi DIP-7667N.
    IntActi P47111. 3 interactions.
    MINTi MINT-485094.
    STRINGi 4932.YJR044C.

    Proteomic databases

    PaxDbi P47111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR044C ; YJR044C ; YJR044C .
    GeneIDi 853502.
    KEGGi sce:YJR044C.

    Organism-specific databases

    CYGDi YJR044c.
    SGDi S000003805. VPS55.

    Phylogenomic databases

    eggNOGi NOG116508.
    GeneTreei ENSGT00390000006503.
    HOGENOMi HOG000038515.
    OMAi MVMSIIG.
    OrthoDBi EOG72C5CW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31679-MONOMER.

    Miscellaneous databases

    NextBioi 974148.
    PROi P47111.

    Gene expression databases

    Genevestigatori P47111.

    Family and domain databases

    InterProi IPR007262. VPS55.
    [Graphical view ]
    PANTHERi PTHR12050. PTHR12050. 1 hit.
    Pfami PF04133. Vps55. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA genes and 14 new open reading frames including a gene most probably belonging to the family of ubiquitin-protein ligases."
      Huang M.-E., Chuat J.-C., Galibert F.
      Yeast 11:775-781(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking."
      Belgareh-Touze N., Avaro S., Rouille Y., Hoflack B., Haguenauer-Tsapis R.
      Mol. Biol. Cell 13:1694-1708(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVPS55_YEAST
    AccessioniPrimary (citable) accession number: P47111
    Secondary accession number(s): D6VWL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2340 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3