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P47111 (VPS55_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar protein sorting-associated protein 55
Gene names
Name:VPS55
Ordered Locus Names:YJR044C
ORF Names:J1637
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in protein transport from endosomes to the vacuole. Ref.5

Subcellular location

Endosome membrane; Multi-pass membrane protein Potential Ref.5 Ref.6.

Miscellaneous

Present with 2340 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the OB-RGRP/VPS55 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Vacuolar protein sorting-associated protein 55
PRO_0000215201

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Helical; Potential
Topological domain33 – 375Lumenal Potential
Transmembrane38 – 5821Helical; Potential
Topological domain59 – 7618Cytoplasmic Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 10710Lumenal Potential
Transmembrane108 – 12821Helical; Potential
Topological domain129 – 14012Cytoplasmic Potential

Amino acid modifications

Modified residue1371Phosphoserine Ref.9

Sequences

Sequence LengthMass (Da)Tools
P47111 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 1F207E62F093FC6D

FASTA14015,664
        10         20         30         40         50         60 
MMEFKVSPLT KIISLSGFLA LGFLLVILSC ALFHNYYPLF DILIFLLAPI PNTIFNAGNK 

        70         80         90        100        110        120 
YHTSDFMSDS SNTGQDLAHF LTGMLVTSGI ALPVVFYHCQ LIGHLSCIMC MIGGLIIYSS 

       130        140 
IVIFKWFFKK DFNEDDSLFG 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA genes and 14 new open reading frames including a gene most probably belonging to the family of ubiquitin-protein ligases."
Huang M.-E., Chuat J.-C., Galibert F.
Yeast 11:775-781(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking."
Belgareh-Touze N., Avaro S., Rouille Y., Hoflack B., Haguenauer-Tsapis R.
Mol. Biol. Cell 13:1694-1708(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49544 Genomic DNA. Translation: CAA89572.1.
L36344 Genomic DNA. Translation: AAA88746.1.
AY557891 Genomic DNA. Translation: AAS56217.1.
BK006943 Genomic DNA. Translation: DAA08831.1.
PIRS57063.
RefSeqNP_012578.3. NM_001181702.3.

3D structure databases

ProteinModelPortalP47111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33796. 86 interactions.
DIPDIP-7667N.
IntActP47111. 3 interactions.
MINTMINT-485094.
STRING4932.YJR044C.

Proteomic databases

PaxDbP47111.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJR044C; YJR044C; YJR044C.
GeneID853502.
KEGGsce:YJR044C.

Organism-specific databases

CYGDYJR044c.
SGDS000003805. VPS55.

Phylogenomic databases

eggNOGNOG116508.
GeneTreeENSGT00390000006503.
HOGENOMHOG000038515.
OMAMVMSIIG.
OrthoDBEOG72C5CW.

Enzyme and pathway databases

BioCycYEAST:G3O-31679-MONOMER.

Gene expression databases

GenevestigatorP47111.

Family and domain databases

InterProIPR007262. VPS55.
[Graphical view]
PANTHERPTHR12050. PTHR12050. 1 hit.
PfamPF04133. Vps55. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974148.
PROP47111.

Entry information

Entry nameVPS55_YEAST
AccessionPrimary (citable) accession number: P47111
Secondary accession number(s): D6VWL5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families