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P47111

- VPS55_YEAST

UniProt

P47111 - VPS55_YEAST

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Protein

Vacuolar protein sorting-associated protein 55

Gene
VPS55, YJR044C, J1637
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in protein transport from endosomes to the vacuole.1 Publication

GO - Biological processi

  1. late endosome to vacuole transport via multivesicular body sorting pathway Source: SGD
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31679-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 55
Gene namesi
Name:VPS55
Ordered Locus Names:YJR044C
ORF Names:J1637
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR044c.
SGDiS000003805. VPS55.

Subcellular locationi

Endosome membrane; Multi-pass membrane protein Reviewed prediction 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei12 – 3221Helical; Reviewed predictionAdd
BLAST
Topological domaini33 – 375Lumenal Reviewed prediction
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Topological domaini59 – 7618Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei77 – 9721Helical; Reviewed predictionAdd
BLAST
Topological domaini98 – 10710Lumenal Reviewed prediction
Transmembranei108 – 12821Helical; Reviewed predictionAdd
BLAST
Topological domaini129 – 14012Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. late endosome Source: SGD
  3. Vps55/Vps68 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Vacuolar protein sorting-associated protein 55PRO_0000215201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei137 – 1371Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP47111.

Expressioni

Gene expression databases

GenevestigatoriP47111.

Interactioni

Protein-protein interaction databases

BioGridi33796. 86 interactions.
DIPiDIP-7667N.
IntActiP47111. 3 interactions.
MINTiMINT-485094.
STRINGi4932.YJR044C.

Structurei

3D structure databases

ProteinModelPortaliP47111.

Family & Domainsi

Sequence similaritiesi

Belongs to the OB-RGRP/VPS55 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG116508.
GeneTreeiENSGT00390000006503.
HOGENOMiHOG000038515.
OMAiMVMSIIG.
OrthoDBiEOG72C5CW.

Family and domain databases

InterProiIPR007262. VPS55.
[Graphical view]
PANTHERiPTHR12050. PTHR12050. 1 hit.
PfamiPF04133. Vps55. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47111-1 [UniParc]FASTAAdd to Basket

« Hide

MMEFKVSPLT KIISLSGFLA LGFLLVILSC ALFHNYYPLF DILIFLLAPI    50
PNTIFNAGNK YHTSDFMSDS SNTGQDLAHF LTGMLVTSGI ALPVVFYHCQ 100
LIGHLSCIMC MIGGLIIYSS IVIFKWFFKK DFNEDDSLFG 140
Length:140
Mass (Da):15,664
Last modified:February 1, 1996 - v1
Checksum:i1F207E62F093FC6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49544 Genomic DNA. Translation: CAA89572.1.
L36344 Genomic DNA. Translation: AAA88746.1.
AY557891 Genomic DNA. Translation: AAS56217.1.
BK006943 Genomic DNA. Translation: DAA08831.1.
PIRiS57063.
RefSeqiNP_012578.3. NM_001181702.3.

Genome annotation databases

EnsemblFungiiYJR044C; YJR044C; YJR044C.
GeneIDi853502.
KEGGisce:YJR044C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49544 Genomic DNA. Translation: CAA89572.1 .
L36344 Genomic DNA. Translation: AAA88746.1 .
AY557891 Genomic DNA. Translation: AAS56217.1 .
BK006943 Genomic DNA. Translation: DAA08831.1 .
PIRi S57063.
RefSeqi NP_012578.3. NM_001181702.3.

3D structure databases

ProteinModelPortali P47111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33796. 86 interactions.
DIPi DIP-7667N.
IntActi P47111. 3 interactions.
MINTi MINT-485094.
STRINGi 4932.YJR044C.

Proteomic databases

PaxDbi P47111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR044C ; YJR044C ; YJR044C .
GeneIDi 853502.
KEGGi sce:YJR044C.

Organism-specific databases

CYGDi YJR044c.
SGDi S000003805. VPS55.

Phylogenomic databases

eggNOGi NOG116508.
GeneTreei ENSGT00390000006503.
HOGENOMi HOG000038515.
OMAi MVMSIIG.
OrthoDBi EOG72C5CW.

Enzyme and pathway databases

BioCyci YEAST:G3O-31679-MONOMER.

Miscellaneous databases

NextBioi 974148.
PROi P47111.

Gene expression databases

Genevestigatori P47111.

Family and domain databases

InterProi IPR007262. VPS55.
[Graphical view ]
PANTHERi PTHR12050. PTHR12050. 1 hit.
Pfami PF04133. Vps55. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA genes and 14 new open reading frames including a gene most probably belonging to the family of ubiquitin-protein ligases."
    Huang M.-E., Chuat J.-C., Galibert F.
    Yeast 11:775-781(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking."
    Belgareh-Touze N., Avaro S., Rouille Y., Hoflack B., Haguenauer-Tsapis R.
    Mol. Biol. Cell 13:1694-1708(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVPS55_YEAST
AccessioniPrimary (citable) accession number: P47111
Secondary accession number(s): D6VWL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2340 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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