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P47108

- URB2_YEAST

UniProt

P47108 - URB2_YEAST

Protein

Nucleolar pre-ribosomal-associated protein 2

Gene

URB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly.2 Publications

    GO - Biological processi

    1. ribosome biogenesis Source: SGD
    2. rRNA metabolic process Source: SGD
    3. rRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31676-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar pre-ribosomal-associated protein 2
    Alternative name(s):
    Unhealthy ribosome biogenesis protein 2
    Gene namesi
    Name:URB2
    Synonyms:NPA2
    Ordered Locus Names:YJR041C
    ORF Names:J1622
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJR041c.
    SGDiS000003802. URB2.

    Subcellular locationi

    Nucleusnucleolus 3 Publications

    GO - Cellular componenti

    1. nucleolus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11741174Nucleolar pre-ribosomal-associated protein 2PRO_0000203094Add
    BLAST

    Proteomic databases

    MaxQBiP47108.
    PaxDbiP47108.
    PeptideAtlasiP47108.

    Expressioni

    Gene expression databases

    GenevestigatoriP47108.

    Interactioni

    Subunit structurei

    Component of very early pre-60S ribosomal particles containing 27SA2 pre-rRNA. Interacts with URB1. Together with DBP6, NOP8, URB1 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.3 Publications

    Protein-protein interaction databases

    BioGridi33792. 25 interactions.
    DIPiDIP-6348N.
    IntActiP47108. 4 interactions.
    MINTiMINT-2492459.
    STRINGi4932.YJR041C.

    Structurei

    3D structure databases

    ProteinModelPortaliP47108.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG67574.
    KOiK14862.
    OMAiDIFSIIW.
    OrthoDBiEOG7RRFGB.

    Family and domain databases

    InterProiIPR018849. Urb2/Npa2_C.
    [Graphical view]
    PfamiPF10441. Urb2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47108-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDLTEELSI PDNAQDLSKL LRSTSTKPHQ IAEIVSKFDK LETYFPKKEI     50
    FVLDLLIDRL NNGNLDDFKT SEHTWIIFTR LLDAINDPIS IKKLLKKLKT 100
    VPVMIRTFFL WPKDKLLTRS VSFIKAFFAI NDYLIVNFSV EESFQLLEHA 150
    INGLSSCPTT DFALSYLQDA CNLTHVDNIT TTDNKIATCY CKHMLLPSLR 200
    YFAQTKNSAS SNQSFIRLSH FMGKFLLQPR IDYMKLNKKF VQENASEITD 250
    DMAYYYFATF VTFLSKDNFA QLEVIFTILG AKKPSLECRF LNLLSESKKT 300
    VSQEFLEALL LEMLASTDES GVLSLIPIIL KLDIEVAIKH IFRLLELIQL 350
    ENLNDPLFSS HIWDLIIQSH ANARELSDFF AKINEYCSRK GPDSYFLINH 400
    PAYVKSITKQ LFTLSSLQWK NLLQALLDQV NHDSTNRVPL YLIRICLEGL 450
    SEGASRATLD EVKPILSQVF TLESFNNSLQ WDLKYHIMEV YDDIVPAEEL 500
    EKIDYVLSSN IFDTTSADVE ELFFYCFKLR EYISFDLSDA KKKFMRHFEI 550
    LDEERKSNLS YSVVSKFATL VNNNFTREQI SSLIDSLLLN STNLSSLLKN 600
    DDIFEETNIT YALINKLASS YHQTFALEAL IQIPIQCINK NVRVALINNL 650
    TCESFCLDSA TRECLLHLLS SPTFKSNIET NFYELCEKTI MSPEMAISET 700
    GDEKKEIEDK ISIFEKVWTN HLSQAKEPVS EKFLESGYDI VKQSMSLSNG 750
    DSKLIIAGFT IAKFLKPDNK HRDIQGMAIS YAVKILENYS ENFESETIPL 800
    FRISMSTLYK IITTGQGDIS KHKSRILDIF SKIMLRYHSK KVYHAPEEQE 850
    MFLVHSLLTE NKLEYIFAEY LNIEHTDKCD SALGFCLEES LKQGPDAFNR 900
    LLWNSAKSFS TISQPCAEKF VRVFIIMSKR IARDNNLGHH LFVIALLEAY 950
    TYCDIEKFGY KSYLLLFNAI KEFLVSKPWL FSQYCIEMLL PFCLKTLAFI 1000
    VNHESTDEIN EGFINIIEVI DHMLLVHRFK FSNRHHLFNS VLCQILEIIA 1050
    IHDGTLCANS ADAVARLITN YCEPYNVSNA QNGQKNNLSS KISLIKQSIR 1100
    KNVLVVLTKY IQLSITTQFS LNIKKSLQPG IHAIFDILSQ NELNQLNAFL 1150
    DTPGKQYFKA LYLQYKKVGK WRED 1174
    Length:1,174
    Mass (Da):135,118
    Last modified:February 1, 1996 - v1
    Checksum:i7647D48DA557D4D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36344 Genomic DNA. Translation: AAA88743.1.
    Z49541 Genomic DNA. Translation: CAA89568.1.
    Z49542 Genomic DNA. Translation: CAA89570.1.
    BK006943 Genomic DNA. Translation: DAA08828.1.
    PIRiS57060.
    RefSeqiNP_012575.3. NM_001181699.3.

    Genome annotation databases

    EnsemblFungiiYJR041C; YJR041C; YJR041C.
    GeneIDi853498.
    KEGGisce:YJR041C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36344 Genomic DNA. Translation: AAA88743.1 .
    Z49541 Genomic DNA. Translation: CAA89568.1 .
    Z49542 Genomic DNA. Translation: CAA89570.1 .
    BK006943 Genomic DNA. Translation: DAA08828.1 .
    PIRi S57060.
    RefSeqi NP_012575.3. NM_001181699.3.

    3D structure databases

    ProteinModelPortali P47108.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33792. 25 interactions.
    DIPi DIP-6348N.
    IntActi P47108. 4 interactions.
    MINTi MINT-2492459.
    STRINGi 4932.YJR041C.

    Proteomic databases

    MaxQBi P47108.
    PaxDbi P47108.
    PeptideAtlasi P47108.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJR041C ; YJR041C ; YJR041C .
    GeneIDi 853498.
    KEGGi sce:YJR041C.

    Organism-specific databases

    CYGDi YJR041c.
    SGDi S000003802. URB2.

    Phylogenomic databases

    eggNOGi NOG67574.
    KOi K14862.
    OMAi DIFSIIW.
    OrthoDBi EOG7RRFGB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31676-MONOMER.

    Miscellaneous databases

    NextBioi 974137.

    Gene expression databases

    Genevestigatori P47108.

    Family and domain databases

    InterProi IPR018849. Urb2/Npa2_C.
    [Graphical view ]
    Pfami PF10441. Urb2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA genes and 14 new open reading frames including a gene most probably belonging to the family of ubiquitin-protein ligases."
      Huang M.-E., Chuat J.-C., Galibert F.
      Yeast 11:775-781(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: FUNCTION, INTERACTION WITH URB1.
    7. "Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification."
      Dez C., Froment C., Noaillac-Depeyre J., Monsarrat B., Caizergues-Ferrer M., Henry Y.
      Mol. Cell. Biol. 24:6324-6337(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH URB1, SUBCELLULAR LOCATION.
    8. "Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a Low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis."
      Rosado I.V., Dez C., Lebaron S., Caizergues-Ferrer M., Henry Y., de la Cruz J.
      Mol. Cell. Biol. 27:1207-1221(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, IDENTIFICATION IN A COMPLEX WITH DBP6; NOP8; URB1 AND RSA3, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiURB2_YEAST
    AccessioniPrimary (citable) accession number: P47108
    Secondary accession number(s): D6VWL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1660 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3