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P47108

- URB2_YEAST

UniProt

P47108 - URB2_YEAST

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Protein
Nucleolar pre-ribosomal-associated protein 2
Gene
URB2, NPA2, YJR041C, J1622
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly.2 Publications

GO - Biological processi

  1. rRNA metabolic process Source: SGD
  2. rRNA processing Source: UniProtKB-KW
  3. ribosome biogenesis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar pre-ribosomal-associated protein 2
Alternative name(s):
Unhealthy ribosome biogenesis protein 2
Gene namesi
Name:URB2
Synonyms:NPA2
Ordered Locus Names:YJR041C
ORF Names:J1622
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR041c.
SGDiS000003802. URB2.

Subcellular locationi

Nucleusnucleolus 3 Publications

GO - Cellular componenti

  1. nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11741174Nucleolar pre-ribosomal-associated protein 2
PRO_0000203094Add
BLAST

Proteomic databases

MaxQBiP47108.
PaxDbiP47108.
PeptideAtlasiP47108.

Expressioni

Gene expression databases

GenevestigatoriP47108.

Interactioni

Subunit structurei

Component of very early pre-60S ribosomal particles containing 27SA2 pre-rRNA. Interacts with URB1. Together with DBP6, NOP8, URB1 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.3 Publications

Protein-protein interaction databases

BioGridi33792. 25 interactions.
DIPiDIP-6348N.
IntActiP47108. 4 interactions.
MINTiMINT-2492459.
STRINGi4932.YJR041C.

Structurei

3D structure databases

ProteinModelPortaliP47108.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG67574.
KOiK14862.
OMAiDIFSIIW.
OrthoDBiEOG7RRFGB.

Family and domain databases

InterProiIPR018849. Urb2/Npa2_C.
[Graphical view]
PfamiPF10441. Urb2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47108-1 [UniParc]FASTAAdd to Basket

« Hide

MGDLTEELSI PDNAQDLSKL LRSTSTKPHQ IAEIVSKFDK LETYFPKKEI     50
FVLDLLIDRL NNGNLDDFKT SEHTWIIFTR LLDAINDPIS IKKLLKKLKT 100
VPVMIRTFFL WPKDKLLTRS VSFIKAFFAI NDYLIVNFSV EESFQLLEHA 150
INGLSSCPTT DFALSYLQDA CNLTHVDNIT TTDNKIATCY CKHMLLPSLR 200
YFAQTKNSAS SNQSFIRLSH FMGKFLLQPR IDYMKLNKKF VQENASEITD 250
DMAYYYFATF VTFLSKDNFA QLEVIFTILG AKKPSLECRF LNLLSESKKT 300
VSQEFLEALL LEMLASTDES GVLSLIPIIL KLDIEVAIKH IFRLLELIQL 350
ENLNDPLFSS HIWDLIIQSH ANARELSDFF AKINEYCSRK GPDSYFLINH 400
PAYVKSITKQ LFTLSSLQWK NLLQALLDQV NHDSTNRVPL YLIRICLEGL 450
SEGASRATLD EVKPILSQVF TLESFNNSLQ WDLKYHIMEV YDDIVPAEEL 500
EKIDYVLSSN IFDTTSADVE ELFFYCFKLR EYISFDLSDA KKKFMRHFEI 550
LDEERKSNLS YSVVSKFATL VNNNFTREQI SSLIDSLLLN STNLSSLLKN 600
DDIFEETNIT YALINKLASS YHQTFALEAL IQIPIQCINK NVRVALINNL 650
TCESFCLDSA TRECLLHLLS SPTFKSNIET NFYELCEKTI MSPEMAISET 700
GDEKKEIEDK ISIFEKVWTN HLSQAKEPVS EKFLESGYDI VKQSMSLSNG 750
DSKLIIAGFT IAKFLKPDNK HRDIQGMAIS YAVKILENYS ENFESETIPL 800
FRISMSTLYK IITTGQGDIS KHKSRILDIF SKIMLRYHSK KVYHAPEEQE 850
MFLVHSLLTE NKLEYIFAEY LNIEHTDKCD SALGFCLEES LKQGPDAFNR 900
LLWNSAKSFS TISQPCAEKF VRVFIIMSKR IARDNNLGHH LFVIALLEAY 950
TYCDIEKFGY KSYLLLFNAI KEFLVSKPWL FSQYCIEMLL PFCLKTLAFI 1000
VNHESTDEIN EGFINIIEVI DHMLLVHRFK FSNRHHLFNS VLCQILEIIA 1050
IHDGTLCANS ADAVARLITN YCEPYNVSNA QNGQKNNLSS KISLIKQSIR 1100
KNVLVVLTKY IQLSITTQFS LNIKKSLQPG IHAIFDILSQ NELNQLNAFL 1150
DTPGKQYFKA LYLQYKKVGK WRED 1174
Length:1,174
Mass (Da):135,118
Last modified:February 1, 1996 - v1
Checksum:i7647D48DA557D4D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36344 Genomic DNA. Translation: AAA88743.1.
Z49541 Genomic DNA. Translation: CAA89568.1.
Z49542 Genomic DNA. Translation: CAA89570.1.
BK006943 Genomic DNA. Translation: DAA08828.1.
PIRiS57060.
RefSeqiNP_012575.3. NM_001181699.3.

Genome annotation databases

EnsemblFungiiYJR041C; YJR041C; YJR041C.
GeneIDi853498.
KEGGisce:YJR041C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36344 Genomic DNA. Translation: AAA88743.1 .
Z49541 Genomic DNA. Translation: CAA89568.1 .
Z49542 Genomic DNA. Translation: CAA89570.1 .
BK006943 Genomic DNA. Translation: DAA08828.1 .
PIRi S57060.
RefSeqi NP_012575.3. NM_001181699.3.

3D structure databases

ProteinModelPortali P47108.
ModBasei Search...

Protein-protein interaction databases

BioGridi 33792. 25 interactions.
DIPi DIP-6348N.
IntActi P47108. 4 interactions.
MINTi MINT-2492459.
STRINGi 4932.YJR041C.

Proteomic databases

MaxQBi P47108.
PaxDbi P47108.
PeptideAtlasi P47108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR041C ; YJR041C ; YJR041C .
GeneIDi 853498.
KEGGi sce:YJR041C.

Organism-specific databases

CYGDi YJR041c.
SGDi S000003802. URB2.

Phylogenomic databases

eggNOGi NOG67574.
KOi K14862.
OMAi DIFSIIW.
OrthoDBi EOG7RRFGB.

Enzyme and pathway databases

BioCyci YEAST:G3O-31676-MONOMER.

Miscellaneous databases

NextBioi 974137.

Gene expression databases

Genevestigatori P47108.

Family and domain databases

InterProi IPR018849. Urb2/Npa2_C.
[Graphical view ]
Pfami PF10441. Urb2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA genes and 14 new open reading frames including a gene most probably belonging to the family of ubiquitin-protein ligases."
    Huang M.-E., Chuat J.-C., Galibert F.
    Yeast 11:775-781(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: FUNCTION, INTERACTION WITH URB1.
  7. "Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification."
    Dez C., Froment C., Noaillac-Depeyre J., Monsarrat B., Caizergues-Ferrer M., Henry Y.
    Mol. Cell. Biol. 24:6324-6337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH URB1, SUBCELLULAR LOCATION.
  8. "Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a Low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis."
    Rosado I.V., Dez C., Lebaron S., Caizergues-Ferrer M., Henry Y., de la Cruz J.
    Mol. Cell. Biol. 27:1207-1221(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, IDENTIFICATION IN A COMPLEX WITH DBP6; NOP8; URB1 AND RSA3, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiURB2_YEAST
AccessioniPrimary (citable) accession number: P47108
Secondary accession number(s): D6VWL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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