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Protein

Nucleolar pre-ribosomal-associated protein 2

Gene

URB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly.2 Publications

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • ribosome biogenesis Source: SGD
  • rRNA metabolic process Source: SGD
  • rRNA processing Source: UniProtKB-KW

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31676-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar pre-ribosomal-associated protein 2
Alternative name(s):
Unhealthy ribosome biogenesis protein 2
Gene namesi
Name:URB2
Synonyms:NPA2
Ordered Locus Names:YJR041C
ORF Names:J1622
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR041C
SGDiS000003802 URB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030941 – 1174Nucleolar pre-ribosomal-associated protein 2Add BLAST1174

Proteomic databases

MaxQBiP47108
PaxDbiP47108
PRIDEiP47108

PTM databases

iPTMnetiP47108

Interactioni

Subunit structurei

Component of very early pre-60S ribosomal particles containing 27SA2 pre-rRNA. Interacts with URB1. Together with DBP6, NOP8, URB1 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33792, 156 interactors
DIPiDIP-6348N
IntActiP47108, 26 interactors
MINTiP47108
STRINGi4932.YJR041C

Structurei

3D structure databases

ProteinModelPortaliP47108
SMRiP47108
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP47108
KOiK14862
OMAiDHGKWKD
OrthoDBiEOG092C03KF

Family and domain databases

InterProiView protein in InterPro
IPR018849 Urb2/Npa2_C
PfamiView protein in Pfam
PF10441 Urb2, 1 hit

Sequencei

Sequence statusi: Complete.

P47108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLTEELSI PDNAQDLSKL LRSTSTKPHQ IAEIVSKFDK LETYFPKKEI
60 70 80 90 100
FVLDLLIDRL NNGNLDDFKT SEHTWIIFTR LLDAINDPIS IKKLLKKLKT
110 120 130 140 150
VPVMIRTFFL WPKDKLLTRS VSFIKAFFAI NDYLIVNFSV EESFQLLEHA
160 170 180 190 200
INGLSSCPTT DFALSYLQDA CNLTHVDNIT TTDNKIATCY CKHMLLPSLR
210 220 230 240 250
YFAQTKNSAS SNQSFIRLSH FMGKFLLQPR IDYMKLNKKF VQENASEITD
260 270 280 290 300
DMAYYYFATF VTFLSKDNFA QLEVIFTILG AKKPSLECRF LNLLSESKKT
310 320 330 340 350
VSQEFLEALL LEMLASTDES GVLSLIPIIL KLDIEVAIKH IFRLLELIQL
360 370 380 390 400
ENLNDPLFSS HIWDLIIQSH ANARELSDFF AKINEYCSRK GPDSYFLINH
410 420 430 440 450
PAYVKSITKQ LFTLSSLQWK NLLQALLDQV NHDSTNRVPL YLIRICLEGL
460 470 480 490 500
SEGASRATLD EVKPILSQVF TLESFNNSLQ WDLKYHIMEV YDDIVPAEEL
510 520 530 540 550
EKIDYVLSSN IFDTTSADVE ELFFYCFKLR EYISFDLSDA KKKFMRHFEI
560 570 580 590 600
LDEERKSNLS YSVVSKFATL VNNNFTREQI SSLIDSLLLN STNLSSLLKN
610 620 630 640 650
DDIFEETNIT YALINKLASS YHQTFALEAL IQIPIQCINK NVRVALINNL
660 670 680 690 700
TCESFCLDSA TRECLLHLLS SPTFKSNIET NFYELCEKTI MSPEMAISET
710 720 730 740 750
GDEKKEIEDK ISIFEKVWTN HLSQAKEPVS EKFLESGYDI VKQSMSLSNG
760 770 780 790 800
DSKLIIAGFT IAKFLKPDNK HRDIQGMAIS YAVKILENYS ENFESETIPL
810 820 830 840 850
FRISMSTLYK IITTGQGDIS KHKSRILDIF SKIMLRYHSK KVYHAPEEQE
860 870 880 890 900
MFLVHSLLTE NKLEYIFAEY LNIEHTDKCD SALGFCLEES LKQGPDAFNR
910 920 930 940 950
LLWNSAKSFS TISQPCAEKF VRVFIIMSKR IARDNNLGHH LFVIALLEAY
960 970 980 990 1000
TYCDIEKFGY KSYLLLFNAI KEFLVSKPWL FSQYCIEMLL PFCLKTLAFI
1010 1020 1030 1040 1050
VNHESTDEIN EGFINIIEVI DHMLLVHRFK FSNRHHLFNS VLCQILEIIA
1060 1070 1080 1090 1100
IHDGTLCANS ADAVARLITN YCEPYNVSNA QNGQKNNLSS KISLIKQSIR
1110 1120 1130 1140 1150
KNVLVVLTKY IQLSITTQFS LNIKKSLQPG IHAIFDILSQ NELNQLNAFL
1160 1170
DTPGKQYFKA LYLQYKKVGK WRED
Length:1,174
Mass (Da):135,118
Last modified:February 1, 1996 - v1
Checksum:i7647D48DA557D4D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36344 Genomic DNA Translation: AAA88743.1
Z49541 Genomic DNA Translation: CAA89568.1
Z49542 Genomic DNA Translation: CAA89570.1
BK006943 Genomic DNA Translation: DAA08828.1
PIRiS57060
RefSeqiNP_012575.3, NM_001181699.3

Genome annotation databases

EnsemblFungiiYJR041C; YJR041C; YJR041C
GeneIDi853498
KEGGisce:YJR041C

Similar proteinsi

Entry informationi

Entry nameiURB2_YEAST
AccessioniPrimary (citable) accession number: P47108
Secondary accession number(s): D6VWL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health