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P47108

- URB2_YEAST

UniProt

P47108 - URB2_YEAST

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Protein

Nucleolar pre-ribosomal-associated protein 2

Gene

URB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly.2 Publications

GO - Biological processi

  1. ribosome biogenesis Source: SGD
  2. rRNA metabolic process Source: SGD
  3. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar pre-ribosomal-associated protein 2
Alternative name(s):
Unhealthy ribosome biogenesis protein 2
Gene namesi
Name:URB2
Synonyms:NPA2
Ordered Locus Names:YJR041C
ORF Names:J1622
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJR041c.
SGDiS000003802. URB2.

Subcellular locationi

Nucleusnucleolus 3 Publications

GO - Cellular componenti

  1. nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11741174Nucleolar pre-ribosomal-associated protein 2PRO_0000203094Add
BLAST

Proteomic databases

MaxQBiP47108.
PaxDbiP47108.
PeptideAtlasiP47108.

Expressioni

Gene expression databases

GenevestigatoriP47108.

Interactioni

Subunit structurei

Component of very early pre-60S ribosomal particles containing 27SA2 pre-rRNA. Interacts with URB1. Together with DBP6, NOP8, URB1 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.3 Publications

Protein-protein interaction databases

BioGridi33792. 25 interactions.
DIPiDIP-6348N.
IntActiP47108. 4 interactions.
MINTiMINT-2492459.
STRINGi4932.YJR041C.

Structurei

3D structure databases

ProteinModelPortaliP47108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG67574.
InParanoidiP47108.
KOiK14862.
OMAiDIFSIIW.
OrthoDBiEOG7RRFGB.

Family and domain databases

InterProiIPR018849. Urb2/Npa2_C.
[Graphical view]
PfamiPF10441. Urb2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47108-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDLTEELSI PDNAQDLSKL LRSTSTKPHQ IAEIVSKFDK LETYFPKKEI
60 70 80 90 100
FVLDLLIDRL NNGNLDDFKT SEHTWIIFTR LLDAINDPIS IKKLLKKLKT
110 120 130 140 150
VPVMIRTFFL WPKDKLLTRS VSFIKAFFAI NDYLIVNFSV EESFQLLEHA
160 170 180 190 200
INGLSSCPTT DFALSYLQDA CNLTHVDNIT TTDNKIATCY CKHMLLPSLR
210 220 230 240 250
YFAQTKNSAS SNQSFIRLSH FMGKFLLQPR IDYMKLNKKF VQENASEITD
260 270 280 290 300
DMAYYYFATF VTFLSKDNFA QLEVIFTILG AKKPSLECRF LNLLSESKKT
310 320 330 340 350
VSQEFLEALL LEMLASTDES GVLSLIPIIL KLDIEVAIKH IFRLLELIQL
360 370 380 390 400
ENLNDPLFSS HIWDLIIQSH ANARELSDFF AKINEYCSRK GPDSYFLINH
410 420 430 440 450
PAYVKSITKQ LFTLSSLQWK NLLQALLDQV NHDSTNRVPL YLIRICLEGL
460 470 480 490 500
SEGASRATLD EVKPILSQVF TLESFNNSLQ WDLKYHIMEV YDDIVPAEEL
510 520 530 540 550
EKIDYVLSSN IFDTTSADVE ELFFYCFKLR EYISFDLSDA KKKFMRHFEI
560 570 580 590 600
LDEERKSNLS YSVVSKFATL VNNNFTREQI SSLIDSLLLN STNLSSLLKN
610 620 630 640 650
DDIFEETNIT YALINKLASS YHQTFALEAL IQIPIQCINK NVRVALINNL
660 670 680 690 700
TCESFCLDSA TRECLLHLLS SPTFKSNIET NFYELCEKTI MSPEMAISET
710 720 730 740 750
GDEKKEIEDK ISIFEKVWTN HLSQAKEPVS EKFLESGYDI VKQSMSLSNG
760 770 780 790 800
DSKLIIAGFT IAKFLKPDNK HRDIQGMAIS YAVKILENYS ENFESETIPL
810 820 830 840 850
FRISMSTLYK IITTGQGDIS KHKSRILDIF SKIMLRYHSK KVYHAPEEQE
860 870 880 890 900
MFLVHSLLTE NKLEYIFAEY LNIEHTDKCD SALGFCLEES LKQGPDAFNR
910 920 930 940 950
LLWNSAKSFS TISQPCAEKF VRVFIIMSKR IARDNNLGHH LFVIALLEAY
960 970 980 990 1000
TYCDIEKFGY KSYLLLFNAI KEFLVSKPWL FSQYCIEMLL PFCLKTLAFI
1010 1020 1030 1040 1050
VNHESTDEIN EGFINIIEVI DHMLLVHRFK FSNRHHLFNS VLCQILEIIA
1060 1070 1080 1090 1100
IHDGTLCANS ADAVARLITN YCEPYNVSNA QNGQKNNLSS KISLIKQSIR
1110 1120 1130 1140 1150
KNVLVVLTKY IQLSITTQFS LNIKKSLQPG IHAIFDILSQ NELNQLNAFL
1160 1170
DTPGKQYFKA LYLQYKKVGK WRED
Length:1,174
Mass (Da):135,118
Last modified:February 1, 1996 - v1
Checksum:i7647D48DA557D4D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36344 Genomic DNA. Translation: AAA88743.1.
Z49541 Genomic DNA. Translation: CAA89568.1.
Z49542 Genomic DNA. Translation: CAA89570.1.
BK006943 Genomic DNA. Translation: DAA08828.1.
PIRiS57060.
RefSeqiNP_012575.3. NM_001181699.3.

Genome annotation databases

EnsemblFungiiYJR041C; YJR041C; YJR041C.
GeneIDi853498.
KEGGisce:YJR041C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36344 Genomic DNA. Translation: AAA88743.1 .
Z49541 Genomic DNA. Translation: CAA89568.1 .
Z49542 Genomic DNA. Translation: CAA89570.1 .
BK006943 Genomic DNA. Translation: DAA08828.1 .
PIRi S57060.
RefSeqi NP_012575.3. NM_001181699.3.

3D structure databases

ProteinModelPortali P47108.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33792. 25 interactions.
DIPi DIP-6348N.
IntActi P47108. 4 interactions.
MINTi MINT-2492459.
STRINGi 4932.YJR041C.

Proteomic databases

MaxQBi P47108.
PaxDbi P47108.
PeptideAtlasi P47108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJR041C ; YJR041C ; YJR041C .
GeneIDi 853498.
KEGGi sce:YJR041C.

Organism-specific databases

CYGDi YJR041c.
SGDi S000003802. URB2.

Phylogenomic databases

eggNOGi NOG67574.
InParanoidi P47108.
KOi K14862.
OMAi DIFSIIW.
OrthoDBi EOG7RRFGB.

Enzyme and pathway databases

BioCyci YEAST:G3O-31676-MONOMER.

Miscellaneous databases

NextBioi 974137.

Gene expression databases

Genevestigatori P47108.

Family and domain databases

InterProi IPR018849. Urb2/Npa2_C.
[Graphical view ]
Pfami PF10441. Urb2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA genes and 14 new open reading frames including a gene most probably belonging to the family of ubiquitin-protein ligases."
    Huang M.-E., Chuat J.-C., Galibert F.
    Yeast 11:775-781(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: FUNCTION, INTERACTION WITH URB1.
  7. "Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification."
    Dez C., Froment C., Noaillac-Depeyre J., Monsarrat B., Caizergues-Ferrer M., Henry Y.
    Mol. Cell. Biol. 24:6324-6337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH URB1, SUBCELLULAR LOCATION.
  8. "Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a Low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis."
    Rosado I.V., Dez C., Lebaron S., Caizergues-Ferrer M., Henry Y., de la Cruz J.
    Mol. Cell. Biol. 27:1207-1221(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, IDENTIFICATION IN A COMPLEX WITH DBP6; NOP8; URB1 AND RSA3, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiURB2_YEAST
AccessioniPrimary (citable) accession number: P47108
Secondary accession number(s): D6VWL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3