Peptidyl-prolyl cis-trans isomerase CYP7 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P47103 (CYP7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 103. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP7
Short name=PPIase CYP7
EC=5.2.1.8

Alternative name(s):
Rotamase CYP7

Gene names

Name:	CPR7
Ordered Locus Names:	YJR032W
ORF Names:	J1585

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Plays a major role in negative regulation of the heat shock transcription factor (HSF).
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Interacts with RPD3 and CNS1.
Miscellaneous	Present with 3230 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Contains 1 PPIase cyclophilin-type domain. Contains 3 TPR repeats.

Ontologies

Keywords
Domain	Repeat TPR repeat
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein refolding Inferred from direct assay. Source: SGD response to stress Inferred from mutant phenotype. Source: SGD
Cellular component	cytosol Inferred from physical interaction. Source: SGD
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from direct assay. Source: SGD unfolded protein binding Inferred from direct assay. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
CNS1	P33313	2	EBI-5436,EBI-4806
HSC82	P15108	2	EBI-5436,EBI-8666
HSP82	P02829	3	EBI-5436,EBI-8659
RPD3	P32561	2	EBI-5436,EBI-15864

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 393

393

Peptidyl-prolyl cis-trans isomerase CYP7

PRO_0000064174

Regions

Domain

8 – 196

189

PPIase cyclophilin-type

Repeat

240 – 273

TPR 1

Repeat

292 – 325

TPR 2

Repeat

330 – 363

TPR 3

Experimental info

Sequence conflict

237

L → F in AAC49415. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P47103 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 1532F255E8016F4F
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FASTA

393

45,134

        10         20         30         40         50         60 
MIQDPLVYLD ISIDKKPIGR IVCKLFREKA PKTTENFYKL CAGDVKSPLK DQQYLSYKGN 

        70         80         90        100        110        120 
GFHRVVKNFM IQAGDIVFGT QKDSSSSSVG KGGCSIYADK EEVKTDDESF CYGNFEDENL 

       130        140        150        160        170        180 
GEFVEPFTLG MANLGSPNTN NSQFFITTYA APHLNGKHSI FGQVVHGKSV VRTIENCRVD 

       190        200        210        220        230        240 
SDGVPESDVR ISDCGVWEKT MGVPLYNASN DQIGGDVYEE YPDDDTHFGD DDFGKALEAA 

       250        260        270        280        290        300 
NIIKESGTLL FKKKDYSNAF FKYRKSLNYI NEYMPEPDVD KERNIQFINL KMKIYLNLSL 

       310        320        330        340        350        360 
VLFNLERYDD AIMYATYLLE MDNVPNRDQA KAYYRRGNSY LKKKRLDEAL QDYIFCKEKN 

       370        380        390 
PDDEVIEQRI EYVNRLIEEN KEKTRKNISK FFS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth." Duina A.A., Marsh J.A., Gaber R.F. Yeast 12:943-952(1996) [PubMed: 8873448] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The sequence of 24.3 kb from chromosome X reveals five complete open reading frames, all of which correspond to new genes, and a tandem insertion of a Ty1 transposon." Zagulski M., Babinska B., Gromadka R., Migdalski A., Rytka J., Sulicka J., Herbert C.J. Yeast 11:1179-1186(1995) [PubMed: 8619316] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U48868 Genomic DNA. Translation: AAC49415.1. Z49532 Genomic DNA. Translation: CAA89559.1. X87297 Genomic DNA. Translation: CAA60725.1. AY693103 Genomic DNA. Translation: AAT93122.1. BK006943 Genomic DNA. Translation: DAA08821.1.
PIR	S57050.
RefSeq	NP_012566.1. NM_001181690.1.
3D structure databases
ProteinModelPortal	P47103.
SMR	P47103. Positions 2-225, 241-366.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2312N.
IntAct	P47103. 8 interactions.
MINT	MINT-1540906.
STRING	P47103.
Proteomic databases
PeptideAtlas	P47103.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJR032W; YJR032W; YJR032W.
GeneID	853489.
KEGG	sce:YJR032W.
NMPDR	fig\|4932.3.peg.3540.
Organism-specific databases
CYGD	YJR032w.
SGD	S000003793. CPR7.
Phylogenomic databases
eggNOG	fuNOG05697.
GeneTree	EFGT00050000000590.
HOGENOM	HBG610621.
OMA	QFFITTY.
OrthoDB	EOG4FV08H.
Gene expression databases
ArrayExpress	P47103.
Genevestigator	P47103.
GermOnline	YJR032W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. IPR023114. Elongated_TPR_rpt_dom. IPR001440. TPR-1. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.10.150.160. Elongated_TPR_rpt_dom. 1 hit. G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit. G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
KO	K01802.
Pfam	PF00160. Pro_isomerase. 1 hit. PF00515. TPR_1. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SMART	SM00028. TPR. 3 hits. [Graphical view]
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. PS50005. TPR. 3 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	974116.

Entry information

Entry name

CYP7_YEAST

Accession

Primary (citable) accession number: P47103
Secondary accession number(s): D6VWK5, Q92323

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents