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Protein

Cytochrome c oxidase assembly protein COX16, mitochondrial

Gene

COX16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:12446688, PubMed:28821616). May participate in merging the COX1 and COX2 assembly lines (PubMed:28821616).2 Publications

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX16, mitochondrial
Gene namesi
Name:COX16
Ordered Locus Names:YJL003W
ORF Names:J1403, YJR83.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL003W.
SGDiS000003540. COX16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000203080? – 118Cytochrome c oxidase assembly protein COX16, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP47081.
PaxDbiP47081.
PRIDEiP47081.

Interactioni

Protein-protein interaction databases

BioGridi33754. 77 interactors.
IntActiP47081. 1 interactor.
STRINGi4932.YJL003W.

Structurei

3D structure databases

ProteinModelPortaliP47081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX16 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000217274.
InParanoidiP47081.
KOiK18182.
OMAiATAIRYE.
OrthoDBiEOG092C5EN7.

Family and domain databases

InterProiView protein in InterPro
IPR020164. Cyt_c_Oxase_assmbl_COX16.
PfamiView protein in Pfam
PF14138. COX16. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD076120. Cyt_c_Oxase_assmbl_COX16. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSGKKFRS RRQQLVYEAS LAGRYKKALS KHPFLFFGLP FCATIVLGSF
60 70 80 90 100
WLSSFTAIKY EQGDRKVQEI NEEDILKIRK NQREFDIKEE YYRLQGLSEE
110
DWEPVRVARL KDESENVW
Length:118
Mass (Da):14,077
Last modified:February 1, 1996 - v1
Checksum:i4A45F140B802DCC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87611 Genomic DNA. Translation: CAA60919.1.
Z49278 Genomic DNA. Translation: CAA89293.1.
AY558241 Genomic DNA. Translation: AAS56567.1.
BK006943 Genomic DNA. Translation: DAA08788.1.
PIRiS55185.
RefSeqiNP_012531.1. NM_001181437.1.

Genome annotation databases

EnsemblFungiiYJL003W; YJL003W; YJL003W.
GeneIDi853454.
KEGGisce:YJL003W.

Similar proteinsi

Entry informationi

Entry nameiCOX16_YEAST
AccessioniPrimary (citable) accession number: P47081
Secondary accession number(s): D6VWH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome