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Protein

Cytochrome c oxidase assembly protein COX16, mitochondrial

Gene

COX16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:12446688, PubMed:28821616). May participate in merging the COX1 and COX2 assembly lines (PubMed:28821616).2 Publications

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-31482-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX16, mitochondrial
Gene namesi
Name:COX16
Ordered Locus Names:YJL003W
ORF Names:J1403, YJR83.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL003W
SGDiS000003540 COX16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000203080? – 118Cytochrome c oxidase assembly protein COX16, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP47081
PaxDbiP47081
PRIDEiP47081

Interactioni

Protein-protein interaction databases

BioGridi33754, 77 interactors
STRINGi4932.YJL003W

Structurei

3D structure databases

ProteinModelPortaliP47081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX16 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000217274
InParanoidiP47081
KOiK18182
OMAiATAIRYE
OrthoDBiEOG092C5EN7

Family and domain databases

InterProiView protein in InterPro
IPR020164 Cyt_c_Oxase_assmbl_COX16
PfamiView protein in Pfam
PF14138 COX16, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD076120 Cyt_c_Oxase_assmbl_COX16, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSGKKFRS RRQQLVYEAS LAGRYKKALS KHPFLFFGLP FCATIVLGSF
60 70 80 90 100
WLSSFTAIKY EQGDRKVQEI NEEDILKIRK NQREFDIKEE YYRLQGLSEE
110
DWEPVRVARL KDESENVW
Length:118
Mass (Da):14,077
Last modified:February 1, 1996 - v1
Checksum:i4A45F140B802DCC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87611 Genomic DNA Translation: CAA60919.1
Z49278 Genomic DNA Translation: CAA89293.1
AY558241 Genomic DNA Translation: AAS56567.1
BK006943 Genomic DNA Translation: DAA08788.1
PIRiS55185
RefSeqiNP_012531.1, NM_001181437.1

Genome annotation databases

EnsemblFungiiYJL003W; YJL003W; YJL003W
GeneIDi853454
KEGGisce:YJL003W

Similar proteinsi

Entry informationi

Entry nameiCOX16_YEAST
AccessioniPrimary (citable) accession number: P47081
Secondary accession number(s): D6VWH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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