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Protein

T-complex protein 1 subunit theta

Gene

CCT8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: SGD

GO - Biological processi

  • protein folding Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31485-MONOMER.
ReactomeiR-SCE-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit theta
Short name:
TCP-1-theta
Alternative name(s):
CCT-theta
Gene namesi
Name:CCT8
Ordered Locus Names:YJL008C
ORF Names:J1374
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL008C.
SGDiS000003545. CCT8.

Subcellular locationi

GO - Cellular componenti

  • chaperonin-containing T-complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283781 – 568T-complex protein 1 subunit thetaAdd BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei505PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP47079.
PRIDEiP47079.

PTM databases

iPTMnetiP47079.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi33748. 54 interactors.
DIPiDIP-2697N.
IntActiP47079. 34 interactors.
MINTiMINT-551407.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80H/P/h/p1-568[»]
4V8RX-ray3.80AQ/Aq/BQ/Bq1-568[»]
4V94X-ray3.80H/P/h/p1-568[»]
ProteinModelPortaliP47079.
SMRiP47079.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074783.
HOGENOMiHOG000226734.
InParanoidiP47079.
KOiK09500.
OMAiEEMLNFT.
OrthoDBiEOG092C2629.

Family and domain databases

CDDicd03341. TCP1_theta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012721. Chap_CCT_theta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02346. chap_CCT_theta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRLPQNPN AGLFKQGYNS YSNADGQIIK SIAAIRELHQ MCLTSMGPCG
60 70 80 90 100
RNKIIVNHLG KIIITNDAAT MLRELDIVHP AVKVLVMATE QQKIDMGDGT
110 120 130 140 150
NLVMILAGEL LNVSEKLISM GLSAVEIIQG YNMARKFTLK ELDEMVVGEI
160 170 180 190 200
TDKNDKNELL KMIKPVISSK KYGSEDILSE LVSEAVSHVL PVAQQAGEIP
210 220 230 240 250
YFNVDSIRVV KIMGGSLSNS TVIKGMVFNR EPEGHVKSLS EDKKHKVAVF
260 270 280 290 300
TCPLDIANTE TKGTVLLHNA QEMLDFSKGE EKQIDAMMKE IADMGVECIV
310 320 330 340 350
AGAGVGELAL HYLNRYGILV LKVPSKFELR RLCRVCGATP LPRLGAPTPE
360 370 380 390 400
ELGLVETVKT MEIGGDRVTV FKQEQGEISR TSTIILRGAT QNNLDDIERA
410 420 430 440 450
IDDGVAAVKG LMKPSGGKLL PGAGATEIEL ISRITKYGER TPGLLQLAIK
460 470 480 490 500
QFAVAFEVVP RTLAETAGLD VNEVLPNLYA AHNVTEPGAV KTDHLYKGVD
510 520 530 540 550
IDGESDEGVK DIREENIYDM LATKKFAINV ATEAATTVLS IDQIIMAKKA
560
GGPRAPQGPR PGNWDQED
Length:568
Mass (Da):61,662
Last modified:November 1, 1995 - v1
Checksum:i90817CA3151A52FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49284 Genomic DNA. Translation: CAA89300.1.
BK006943 Genomic DNA. Translation: DAA08784.1.
PIRiS56779.
RefSeqiNP_012526.1. NM_001181442.2.

Genome annotation databases

EnsemblFungiiYJL008C; YJL008C; YJL008C.
GeneIDi853447.
KEGGisce:YJL008C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49284 Genomic DNA. Translation: CAA89300.1.
BK006943 Genomic DNA. Translation: DAA08784.1.
PIRiS56779.
RefSeqiNP_012526.1. NM_001181442.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80H/P/h/p1-568[»]
4V8RX-ray3.80AQ/Aq/BQ/Bq1-568[»]
4V94X-ray3.80H/P/h/p1-568[»]
ProteinModelPortaliP47079.
SMRiP47079.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33748. 54 interactors.
DIPiDIP-2697N.
IntActiP47079. 34 interactors.
MINTiMINT-551407.

PTM databases

iPTMnetiP47079.

Proteomic databases

MaxQBiP47079.
PRIDEiP47079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL008C; YJL008C; YJL008C.
GeneIDi853447.
KEGGisce:YJL008C.

Organism-specific databases

EuPathDBiFungiDB:YJL008C.
SGDiS000003545. CCT8.

Phylogenomic databases

GeneTreeiENSGT00550000074783.
HOGENOMiHOG000226734.
InParanoidiP47079.
KOiK09500.
OMAiEEMLNFT.
OrthoDBiEOG092C2629.

Enzyme and pathway databases

BioCyciYEAST:G3O-31485-MONOMER.
ReactomeiR-SCE-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiP47079.

Family and domain databases

CDDicd03341. TCP1_theta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012721. Chap_CCT_theta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02346. chap_CCT_theta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPQ_YEAST
AccessioniPrimary (citable) accession number: P47079
Secondary accession number(s): D6VWG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.