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Protein

Myosin tail region-interacting protein MTI1

Gene

BBC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of actin cytoskeleton.1 Publication

GO - Molecular functioni

  • myosin I binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: SGD
  • cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31492-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin tail region-interacting protein MTI1
Alternative name(s):
Protein BBC1
Gene namesi
Name:BBC1
Synonyms:MTI1
Ordered Locus Names:YJL020C
ORF Names:J1286, J1305, YJL021C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL020C.
SGDiS000003557. BBC1.

Subcellular locationi

  • Cytoplasmcytoskeletonactin patch 1 Publication

  • Note: Colocalizes with cortical actin patches.

GO - Cellular componenti

  • actin cortical patch Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648391 – 1157Myosin tail region-interacting protein MTI1Add BLAST1157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei636PhosphothreonineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei850PhosphothreonineCombined sources1
Modified residuei889PhosphoserineCombined sources1
Modified residuei894PhosphothreonineCombined sources1
Modified residuei895PhosphothreonineCombined sources1
Cross-linki1012Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP47068.
PRIDEiP47068.

PTM databases

iPTMnetiP47068.

Interactioni

Subunit structurei

Binds to the SH3 domains of the type I myosins MYO3 and MYO5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AIM21P405638EBI-3437,EBI-25376
APP1P539333EBI-3437,EBI-28798
MYO3P360065EBI-3437,EBI-11670
MYO5Q044396EBI-3437,EBI-11687
YPR091CQ068332EBI-3437,EBI-37290

GO - Molecular functioni

  • myosin I binding Source: UniProtKB

Protein-protein interaction databases

BioGridi33738. 134 interactors.
DIPiDIP-2614N.
DIP-6279N.
IntActiP47068. 72 interactors.
MINTiMINT-553243.

Structurei

Secondary structure

11157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 14Combined sources9
Beta strandi21 – 23Combined sources3
Beta strandi31 – 37Combined sources7
Beta strandi39 – 48Combined sources10
Beta strandi54 – 60Combined sources7
Helixi61 – 63Combined sources3
Beta strandi64 – 66Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TG0X-ray0.97A1-68[»]
1WDXX-ray2.50A/B/C/D1-68[»]
1ZUKX-ray1.90A/B1-68[»]
2DYFNMR-B796-802[»]
ProteinModelPortaliP47068.
SMRiP47068.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47068.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 69SH3PROSITE-ProRule annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili234 – 301Sequence analysisAdd BLAST68
Coiled coili356 – 430Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 412Glu-richAdd BLAST135
Compositional biasi674 – 830Pro-richAdd BLAST157

Sequence similaritiesi

Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

InParanoidiP47068.
KOiK20521.
OMAiRTESHEE.
OrthoDBiEOG092C0BBJ.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPEVPFKV VAQFPYKSDY EDDLNFEKDQ EIIVTSVEDA EWYFGEYQDS
60 70 80 90 100
NGDVIEGIFP KSFVAVQGSE VGKEAESSPN TGSTEQRTIQ PEVEQKDLPE
110 120 130 140 150
PISPETKKET LSGPVPVPAA TVPVPAATVP VPAATAVSAQ VQHDSSSGNG
160 170 180 190 200
ERKVPMDSPK LKARLSMFNQ DITEQVPLPK STHLDLENIP VKKTIVADAP
210 220 230 240 250
KYYVPPGIPT NDTSNLERKK SLKENEKKIV PEPINRAQVE SGRIETENDQ
260 270 280 290 300
LKKDLPQMSL KERIALLQEQ QRLQAAREEE LLRKKAKLEQ EHERSAVNKN
310 320 330 340 350
EPYTETEEAE ENEKTEPKPE FTPETEHNEE PQMELLAHKE ITKTSREADE
360 370 380 390 400
GTNDIEKEQF LDEYTKENQK VEESQADEAR GENVAEESEI GYGHEDREGD
410 420 430 440 450
NDEEKEEEDS EENRRAALRE RMAKLSGASR FGAPVGFNPF GMASGVGNKP
460 470 480 490 500
SEEPKKKQHK EKEEEEPEQL QELPRAIPVM PFVDPSSNPF FRKSNLSEKN
510 520 530 540 550
QPTETKTLDP HATTEHEQKQ EHGTHAYHNL AAVDNAHPEY SDHDSDEDTD
560 570 580 590 600
DHEFEDANDG LRKHSMVEQA FQIGNNESEN VNSGEKIYPQ EPPISHRTAE
610 620 630 640 650
VSHDIENSSQ NTTGNVLPVS SPQTRVARNG SINSLTKSIS GENRRKSINE
660 670 680 690 700
YHDTVSTNSS ALTETAQDIS MAAPAAPVLS KVSHPEDKVP PHPVPSAPSA
710 720 730 740 750
PPVPSAPSVP SAPPVPPAPP ALSAPSVPPV PPVPPVSSAP PALSAPSIPP
760 770 780 790 800
VPPTPPAPPA PPAPLALPKH NEVEEHVKSS APLPPVSEEY HPMPNTAPPL
810 820 830 840 850
PRAPPVPPAT FEFDSEPTAT HSHTAPSPPP HQNVTASTPS MMSTQQRVPT
860 870 880 890 900
SVLSGAEKES RTLPPHVPSL TNRPVDSFHE SDTTPKVASI RRSTTHDVGE
910 920 930 940 950
ISNNVKIEFN AQERWWINKS APPAISNLKL NFLMEIDDHF ISKRLHQKWV
960 970 980 990 1000
VRDFYFLFEN YSQLRFSLTF NSTSPEKTVT TLQERFPSPV ETQSARILDE
1010 1020 1030 1040 1050
YAQRFNAKVV EKSHSLINSH IGAKNFVSQI VSEFKDEVIQ PIGARTFGAT
1060 1070 1080 1090 1100
ILSYKPEEGI EQLMKSLQKI KPGDILVIRK AKFEAHKKIG KNEIINVGMD
1110 1120 1130 1140 1150
SAAPYSSVVT DYDFTKNKFR VIENHEGKII QNSYKLSHMK SGKLKVFRIV

ARGYVGW
Length:1,157
Mass (Da):128,297
Last modified:January 17, 2003 - v2
Checksum:i88A5899B89CCE8ED
GO

Sequence cautioni

The sequence CAA89311 differs from that shown. Reason: Frameshift at positions 729 and 732.Curated
The sequence CAA89312 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49295 Genomic DNA. Translation: CAA89311.1. Frameshift.
Z49296 Genomic DNA. Translation: CAA89312.1. Different initiation.
AF373805 Genomic DNA. Translation: AAL57239.1.
BK006943 Genomic DNA. Translation: DAA08776.1.
PIRiS56791.
S56792.
RefSeqiNP_012514.2. NM_001181454.1.

Genome annotation databases

EnsemblFungiiYJL020C; YJL020C; YJL020C.
GeneIDi853433.
KEGGisce:YJL020C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49295 Genomic DNA. Translation: CAA89311.1. Frameshift.
Z49296 Genomic DNA. Translation: CAA89312.1. Different initiation.
AF373805 Genomic DNA. Translation: AAL57239.1.
BK006943 Genomic DNA. Translation: DAA08776.1.
PIRiS56791.
S56792.
RefSeqiNP_012514.2. NM_001181454.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TG0X-ray0.97A1-68[»]
1WDXX-ray2.50A/B/C/D1-68[»]
1ZUKX-ray1.90A/B1-68[»]
2DYFNMR-B796-802[»]
ProteinModelPortaliP47068.
SMRiP47068.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33738. 134 interactors.
DIPiDIP-2614N.
DIP-6279N.
IntActiP47068. 72 interactors.
MINTiMINT-553243.

PTM databases

iPTMnetiP47068.

Proteomic databases

MaxQBiP47068.
PRIDEiP47068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL020C; YJL020C; YJL020C.
GeneIDi853433.
KEGGisce:YJL020C.

Organism-specific databases

EuPathDBiFungiDB:YJL020C.
SGDiS000003557. BBC1.

Phylogenomic databases

InParanoidiP47068.
KOiK20521.
OMAiRTESHEE.
OrthoDBiEOG092C0BBJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31492-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP47068.
PROiP47068.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBBC1_YEAST
AccessioniPrimary (citable) accession number: P47068
Secondary accession number(s): D6VWG0, P47067, Q8X1F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 17, 2003
Last modified: November 2, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.