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Protein

AP-3 complex subunit sigma

Gene

APS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.3 Publications

Miscellaneous

Present with 1240 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • Golgi to vacuole transport Source: SGD
  • protein targeting to vacuole Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31494-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma
Alternative name(s):
AP-3 complex sigma3A subunit
Adaptor-related protein complex 3 subunit sigma
Clathrin-associated/assembly/adaptor protein, small 3
Sigma-adaptin 3A
Sigma3-adaptin
Gene namesi
Name:APS3
Synonyms:YKS7
Ordered Locus Names:YJL024C
ORF Names:J1274
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL024C
SGDiS000003561 APS3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938221 – 194AP-3 complex subunit sigmaAdd BLAST194

Proteomic databases

MaxQBiP47064
PaxDbiP47064
PRIDEiP47064

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).2 Publications

Protein-protein interaction databases

BioGridi33735, 143 interactors
DIPiDIP-3978N
IntActiP47064, 4 interactors
MINTiP47064
STRINGi4932.YJL024C

Structurei

3D structure databases

ProteinModelPortaliP47064
SMRiP47064
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074761
HOGENOMiHOG000185228
InParanoidiP47064
KOiK12399
OMAiGLCNFLD
OrthoDBiEOG092C59LG

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR027155 APS3
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PTHR11753:SF2 PTHR11753:SF2, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequencei

Sequence statusi: Complete.

P47064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHAVLIFNK KCQPRLVKFY TPVDLPKQKL LLEQVYELIS QRNSDFQSSF
60 70 80 90 100
LVTPPSLLLS NENNNDEVNN EDIQIIYKNY ATLYFTFIVD DQESELAILD
110 120 130 140 150
LIQTFVESLD RCFTEVNELD LIFNWQTLES VLEEIVQGGM VIETNVNRIV
160 170 180 190
ASVDELNKAA ESTDSKIGRL TSTGFGSALQ AFAQGGFAQW ATGQ
Length:194
Mass (Da):21,938
Last modified:November 1, 1995 - v1
Checksum:i688D81AEA77B7555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31448 Genomic DNA Translation: AAA92051.1
Z49299 Genomic DNA Translation: CAA89315.1
BK006943 Genomic DNA Translation: DAA08774.1
PIRiS56796
RefSeqiNP_012510.3, NM_001181458.3

Genome annotation databases

EnsemblFungiiYJL024C; YJL024C; YJL024C
GeneIDi853429
KEGGisce:YJL024C

Similar proteinsi

Entry informationi

Entry nameiAP3S_YEAST
AccessioniPrimary (citable) accession number: P47064
Secondary accession number(s): D6VWF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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