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P47056 (IRC18_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Increased recombination centers protein 18
Gene names
Name:IRC18
Ordered Locus Names:YJL037W
ORF Names:J1234
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Is probably involved in a pathway contributing to genomic integrity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

In respiratory-deficient cells and by heat. Ref.4 Ref.5

Disruption phenotype

Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells. Ref.6

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processascospore wall assembly

Inferred from genetic interaction PubMed 23966878. Source: SGD

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Increased recombination centers protein 18
PRO_0000203069

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane200 – 22021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P47056 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 6C17841176EADC1F

FASTA22424,746
        10         20         30         40         50         60 
MKVQMIERIF LIQLCLLTVV LASSRAVVEF ESTGTKLVNS LRVLAAYSQS SVCVDEKISG 

        70         80         90        100        110        120 
IERQIEEVKD MYGNHSFILK GLNGILNNKV NMLTREIQME TVGNNTFETE TGKLTKGLNR 

       130        140        150        160        170        180 
AVNISPFKYI KKFKTVSTKK FESLLNKYDL VAKKGGELTE EQKKKKEVLS RISRVVAATT 

       190        200        210        220 
IEAGLAQGVV DLCITVTTSL CLVSASIGGV GFLIWLTIIY QALT 

« Hide

References

« Hide 'large scale' references
[1]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Genome-wide responses to mitochondrial dysfunction."
Epstein C.B., Waddle J.A., Hale W. IV, Dave V., Thornton J., Macatee T.L., Garner H.R., Butow R.A.
Mol. Biol. Cell 12:297-308(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae."
Sakaki K., Tashiro K., Kuhara S., Mihara K.
J. Biochem. 134:373-384(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[6]"Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination."
Alvaro D., Lisby M., Rothstein R.
PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49312 Genomic DNA. Translation: CAA89328.1.
AY558244 Genomic DNA. Translation: AAS56570.1.
BK006943 Genomic DNA. Translation: DAA08762.1.
PIRS56809.
RefSeqNP_012497.3. NM_001181471.3.

3D structure databases

ProteinModelPortalP47056.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33722. 5 interactions.
STRING4932.YJL037W.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL037W; YJL037W; YJL037W.
GeneID853414.
KEGGsce:YJL037W.

Organism-specific databases

CYGDYJL037w.
SGDS000003574. IRC18.

Phylogenomic databases

GeneTreeENSGT00530000068883.
OMANTFETET.
OrthoDBEOG7CVQ8V.

Enzyme and pathway databases

BioCycYEAST:G3O-31503-MONOMER.

Gene expression databases

GenevestigatorP47056.

Family and domain databases

ProtoNetSearch...

Other

NextBio973928.

Entry information

Entry nameIRC18_YEAST
AccessionPrimary (citable) accession number: P47056
Secondary accession number(s): D6VWE6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD