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P47056

- IRC18_YEAST

UniProt

P47056 - IRC18_YEAST

Protein

Increased recombination centers protein 18

Gene

IRC18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Is probably involved in a pathway contributing to genomic integrity.

    GO - Biological processi

    1. ascospore wall assembly Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31503-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Increased recombination centers protein 18
    Gene namesi
    Name:IRC18
    Ordered Locus Names:YJL037W
    ORF Names:J1234
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL037w.
    SGDiS000003574. IRC18.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Increased recombination centers protein 18PRO_0000203069Add
    BLAST

    Expressioni

    Inductioni

    In respiratory-deficient cells and by heat.2 Publications

    Gene expression databases

    GenevestigatoriP47056.

    Interactioni

    Protein-protein interaction databases

    BioGridi33722. 5 interactions.
    STRINGi4932.YJL037W.

    Structurei

    3D structure databases

    ProteinModelPortaliP47056.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00530000068883.
    OMAiNTFETET.
    OrthoDBiEOG7CVQ8V.

    Sequencei

    Sequence statusi: Complete.

    P47056-1 [UniParc]FASTAAdd to Basket

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    MKVQMIERIF LIQLCLLTVV LASSRAVVEF ESTGTKLVNS LRVLAAYSQS    50
    SVCVDEKISG IERQIEEVKD MYGNHSFILK GLNGILNNKV NMLTREIQME 100
    TVGNNTFETE TGKLTKGLNR AVNISPFKYI KKFKTVSTKK FESLLNKYDL 150
    VAKKGGELTE EQKKKKEVLS RISRVVAATT IEAGLAQGVV DLCITVTTSL 200
    CLVSASIGGV GFLIWLTIIY QALT 224
    Length:224
    Mass (Da):24,746
    Last modified:February 1, 1996 - v1
    Checksum:i6C17841176EADC1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49312 Genomic DNA. Translation: CAA89328.1.
    AY558244 Genomic DNA. Translation: AAS56570.1.
    BK006943 Genomic DNA. Translation: DAA08762.1.
    PIRiS56809.
    RefSeqiNP_012497.3. NM_001181471.3.

    Genome annotation databases

    EnsemblFungiiYJL037W; YJL037W; YJL037W.
    GeneIDi853414.
    KEGGisce:YJL037W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49312 Genomic DNA. Translation: CAA89328.1 .
    AY558244 Genomic DNA. Translation: AAS56570.1 .
    BK006943 Genomic DNA. Translation: DAA08762.1 .
    PIRi S56809.
    RefSeqi NP_012497.3. NM_001181471.3.

    3D structure databases

    ProteinModelPortali P47056.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33722. 5 interactions.
    STRINGi 4932.YJL037W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL037W ; YJL037W ; YJL037W .
    GeneIDi 853414.
    KEGGi sce:YJL037W.

    Organism-specific databases

    CYGDi YJL037w.
    SGDi S000003574. IRC18.

    Phylogenomic databases

    GeneTreei ENSGT00530000068883.
    OMAi NTFETET.
    OrthoDBi EOG7CVQ8V.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31503-MONOMER.

    Miscellaneous databases

    NextBioi 973928.

    Gene expression databases

    Genevestigatori P47056.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: INDUCTION.
    5. "Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae."
      Sakaki K., Tashiro K., Kuhara S., Mihara K.
      J. Biochem. 134:373-384(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    6. "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination."
      Alvaro D., Lisby M., Rothstein R.
      PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiIRC18_YEAST
    AccessioniPrimary (citable) accession number: P47056
    Secondary accession number(s): D6VWE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3