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Protein

Outer spore wall protein 6

Gene

IRC18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in spore wall assembly.1 Publication

GO - Biological processi

  • ascospore wall assembly Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-31503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer spore wall protein 61 Publication
Alternative name(s):
Increased recombination centers protein 181 Publication
Gene namesi
Name:IRC181 Publication
Synonyms:OSW61 Publication
Ordered Locus Names:YJL037WImported
ORF Names:J1234
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL037W.
SGDiS000003574. IRC18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 174ExtracellularBy similarityAdd BLAST148
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 199CytoplasmicBy similarity4
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 224ExtracellularBy similarity4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells (PubMed:18085829). A combined deletion of the LOH1/OSW4 and IRC18/OSW6 has reduced dityrosine incorporation in the outer spore wall (PubMed:23966878).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000020306927 – 224Outer spore wall protein 6Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi104N-linked (GlcNAc...)PROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP47056.

PTM databases

iPTMnetiP47056.

Expressioni

Inductioni

In respiratory-deficient cells and by heat.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi33722. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliP47056.
SMRiP47056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OSW4/6 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068883.
InParanoidiP47056.
OrthoDBiEOG092C4GEH.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVQMIERIF LIQLCLLTVV LASSRAVVEF ESTGTKLVNS LRVLAAYSQS
60 70 80 90 100
SVCVDEKISG IERQIEEVKD MYGNHSFILK GLNGILNNKV NMLTREIQME
110 120 130 140 150
TVGNNTFETE TGKLTKGLNR AVNISPFKYI KKFKTVSTKK FESLLNKYDL
160 170 180 190 200
VAKKGGELTE EQKKKKEVLS RISRVVAATT IEAGLAQGVV DLCITVTTSL
210 220
CLVSASIGGV GFLIWLTIIY QALT
Length:224
Mass (Da):24,746
Last modified:February 1, 1996 - v1
Checksum:i6C17841176EADC1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49312 Genomic DNA. Translation: CAA89328.1.
AY558244 Genomic DNA. Translation: AAS56570.1.
BK006943 Genomic DNA. Translation: DAA08762.1.
PIRiS56809.
RefSeqiNP_012497.3. NM_001181471.3.

Genome annotation databases

EnsemblFungiiYJL037W; YJL037W; YJL037W.
GeneIDi853414.
KEGGisce:YJL037W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49312 Genomic DNA. Translation: CAA89328.1.
AY558244 Genomic DNA. Translation: AAS56570.1.
BK006943 Genomic DNA. Translation: DAA08762.1.
PIRiS56809.
RefSeqiNP_012497.3. NM_001181471.3.

3D structure databases

ProteinModelPortaliP47056.
SMRiP47056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33722. 5 interactors.

PTM databases

iPTMnetiP47056.

Proteomic databases

PRIDEiP47056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL037W; YJL037W; YJL037W.
GeneIDi853414.
KEGGisce:YJL037W.

Organism-specific databases

EuPathDBiFungiDB:YJL037W.
SGDiS000003574. IRC18.

Phylogenomic databases

GeneTreeiENSGT00530000068883.
InParanoidiP47056.
OrthoDBiEOG092C4GEH.

Enzyme and pathway databases

BioCyciYEAST:G3O-31503-MONOMER.

Miscellaneous databases

PROiP47056.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiIRC18_YEAST
AccessioniPrimary (citable) accession number: P47056
Secondary accession number(s): D6VWE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.