P47056 (IRC18_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Increased recombination centers protein 18

Gene names

Name:	IRC18
Ordered Locus Names:	YJL037W
ORF Names:	J1234

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Is probably involved in a pathway contributing to genomic integrity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	In respiratory-deficient cells and by heat. Ref.4 Ref.5
Disruption phenotype	Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells. Ref.6

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Increased recombination centers protein 18		PRO_0000203069
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Transmembrane	200 – 220	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P47056 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 6C17841176EADC1F	FASTA	224	24,746
	10 20 30 40 50 60 MKVQMIERIF LIQLCLLTVV LASSRAVVEF ESTGTKLVNS LRVLAAYSQS SVCVDEKISG 70 80 90 100 110 120 IERQIEEVKD MYGNHSFILK GLNGILNNKV NMLTREIQME TVGNNTFETE TGKLTKGLNR 130 140 150 160 170 180 AVNISPFKYI KKFKTVSTKK FESLLNKYDL VAKKGGELTE EQKKKKEVLS RISRVVAATT 190 200 210 220 IEAGLAQGVV DLCITVTTSL CLVSASIGGV GFLIWLTIIY QALT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Genome-wide responses to mitochondrial dysfunction." Epstein C.B., Waddle J.A., Hale W. IV, Dave V., Thornton J., Macatee T.L., Garner H.R., Butow R.A. Mol. Biol. Cell 12:297-308(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[5]	"Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae." Sakaki K., Tashiro K., Kuhara S., Mihara K. J. Biochem. 134:373-384(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[6]	"Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination." Alvaro D., Lisby M., Rothstein R. PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49312 Genomic DNA. Translation: CAA89328.1. AY558244 Genomic DNA. Translation: AAS56570.1. BK006943 Genomic DNA. Translation: DAA08762.1.
PIR	S56809.
RefSeq	NP_012497.3. NM_001181471.3.
3D structure databases
ProteinModelPortal	P47056.
ModBase	Search...
Protein-protein interaction databases
STRING	4932.YJL037W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YJL037W; YJL037W; YJL037W.
GeneID	853414.
KEGG	sce:YJL034W. sce:YJL037W.
Organism-specific databases
CYGD	YJL037w.
SGD	S000003574. IRC18.
Phylogenomic databases
GeneTree	ENSGT00530000068883.
KO	K09490.
Gene expression databases
Genevestigator	P47056.
GermOnline	YJL037W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	973928.

Entry information

Entry name

IRC18_YEAST

Accession

Primary (citable) accession number: P47056
Secondary accession number(s): D6VWE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program