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P47056

- IRC18_YEAST

UniProt

P47056 - IRC18_YEAST

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Protein
Increased recombination centers protein 18
Gene
IRC18, YJL037W, J1234
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Is probably involved in a pathway contributing to genomic integrity.

GO - Biological processi

  1. ascospore wall assembly Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-31503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Increased recombination centers protein 18
Gene namesi
Name:IRC18
Ordered Locus Names:YJL037W
ORF Names:J1234
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL037w.
SGDiS000003574. IRC18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST
Transmembranei175 – 19521Helical; Reviewed prediction
Add
BLAST
Transmembranei200 – 22021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Increased recombination centers protein 18
PRO_0000203069Add
BLAST

Expressioni

Inductioni

In respiratory-deficient cells and by heat.2 Publications

Gene expression databases

GenevestigatoriP47056.

Interactioni

Protein-protein interaction databases

BioGridi33722. 5 interactions.
STRINGi4932.YJL037W.

Structurei

3D structure databases

ProteinModelPortaliP47056.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000068883.
OMAiNTFETET.
OrthoDBiEOG7CVQ8V.

Sequencei

Sequence statusi: Complete.

P47056-1 [UniParc]FASTAAdd to Basket

« Hide

MKVQMIERIF LIQLCLLTVV LASSRAVVEF ESTGTKLVNS LRVLAAYSQS    50
SVCVDEKISG IERQIEEVKD MYGNHSFILK GLNGILNNKV NMLTREIQME 100
TVGNNTFETE TGKLTKGLNR AVNISPFKYI KKFKTVSTKK FESLLNKYDL 150
VAKKGGELTE EQKKKKEVLS RISRVVAATT IEAGLAQGVV DLCITVTTSL 200
CLVSASIGGV GFLIWLTIIY QALT 224
Length:224
Mass (Da):24,746
Last modified:February 1, 1996 - v1
Checksum:i6C17841176EADC1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49312 Genomic DNA. Translation: CAA89328.1.
AY558244 Genomic DNA. Translation: AAS56570.1.
BK006943 Genomic DNA. Translation: DAA08762.1.
PIRiS56809.
RefSeqiNP_012497.3. NM_001181471.3.

Genome annotation databases

EnsemblFungiiYJL037W; YJL037W; YJL037W.
GeneIDi853414.
KEGGisce:YJL037W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49312 Genomic DNA. Translation: CAA89328.1 .
AY558244 Genomic DNA. Translation: AAS56570.1 .
BK006943 Genomic DNA. Translation: DAA08762.1 .
PIRi S56809.
RefSeqi NP_012497.3. NM_001181471.3.

3D structure databases

ProteinModelPortali P47056.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33722. 5 interactions.
STRINGi 4932.YJL037W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL037W ; YJL037W ; YJL037W .
GeneIDi 853414.
KEGGi sce:YJL037W.

Organism-specific databases

CYGDi YJL037w.
SGDi S000003574. IRC18.

Phylogenomic databases

GeneTreei ENSGT00530000068883.
OMAi NTFETET.
OrthoDBi EOG7CVQ8V.

Enzyme and pathway databases

BioCyci YEAST:G3O-31503-MONOMER.

Miscellaneous databases

NextBioi 973928.

Gene expression databases

Genevestigatori P47056.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: INDUCTION.
  5. "Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae."
    Sakaki K., Tashiro K., Kuhara S., Mihara K.
    J. Biochem. 134:373-384(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination."
    Alvaro D., Lisby M., Rothstein R.
    PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiIRC18_YEAST
AccessioniPrimary (citable) accession number: P47056
Secondary accession number(s): D6VWE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

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