Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoporin NUP192

Gene

NUP192

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs.2 Publications

GO - Molecular functioni

  • structural constituent of nuclear pore Source: SGD

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nuclear pore organization Source: SGD
  • protein import into nucleus, docking Source: GO_Central
  • regulation of nucleocytoplasmic transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31505-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP192
Alternative name(s):
Nuclear pore protein NUP192
Gene namesi
Name:NUP192
Ordered Locus Names:YJL039C
ORF Names:J1216
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL039C.
SGDiS000003576. NUP192.

Subcellular locationi

  • Nucleusnuclear pore complex

  • Note: Cytoplasmic and nucleoplasmic side of the nuclear pore complex in the nuclear envelope (symmetric distribution).

GO - Cellular componenti

  • nuclear pore Source: SGD
  • nuclear pore inner ring Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048581 – 1683Nucleoporin NUP192Add BLAST1683

Proteomic databases

MaxQBiP47054.
PRIDEiP47054.

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEH1 and SEC1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP192 interacts with NIC96.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ASM4Q051663EBI-25846,EBI-3035
NIC96P340773EBI-25846,EBI-12056

Protein-protein interaction databases

BioGridi33718. 58 interactors.
DIPiDIP-2442N.
IntActiP47054. 23 interactors.
MINTiMINT-496527.

Structurei

Secondary structure

11683
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 16Combined sources11
Helixi22 – 33Combined sources12
Turni34 – 36Combined sources3
Helixi48 – 52Combined sources5
Beta strandi54 – 57Combined sources4
Beta strandi59 – 61Combined sources3
Beta strandi63 – 65Combined sources3
Helixi68 – 80Combined sources13
Helixi87 – 94Combined sources8
Helixi102 – 123Combined sources22
Helixi129 – 136Combined sources8
Helixi139 – 167Combined sources29
Helixi173 – 202Combined sources30
Beta strandi208 – 210Combined sources3
Helixi211 – 221Combined sources11
Helixi228 – 233Combined sources6
Helixi234 – 241Combined sources8
Helixi242 – 246Combined sources5
Helixi249 – 262Combined sources14
Helixi266 – 270Combined sources5
Helixi272 – 289Combined sources18
Turni293 – 299Combined sources7
Helixi302 – 305Combined sources4
Helixi307 – 315Combined sources9
Helixi318 – 327Combined sources10
Helixi332 – 334Combined sources3
Helixi344 – 348Combined sources5
Helixi358 – 360Combined sources3
Helixi425 – 445Combined sources21
Helixi447 – 460Combined sources14
Beta strandi463 – 465Combined sources3
Helixi469 – 474Combined sources6
Helixi477 – 489Combined sources13
Helixi493 – 496Combined sources4
Helixi498 – 501Combined sources4
Beta strandi503 – 505Combined sources3
Helixi506 – 514Combined sources9
Helixi520 – 533Combined sources14
Helixi537 – 548Combined sources12
Beta strandi549 – 553Combined sources5
Helixi555 – 572Combined sources18
Helixi603 – 622Combined sources20
Helixi625 – 642Combined sources18
Helixi650 – 660Combined sources11
Helixi665 – 668Combined sources4
Helixi669 – 680Combined sources12
Helixi689 – 699Combined sources11
Helixi703 – 716Combined sources14
Turni738 – 744Combined sources7
Beta strandi745 – 749Combined sources5
Helixi750 – 758Combined sources9
Helixi761 – 766Combined sources6
Helixi770 – 789Combined sources20
Helixi794 – 797Combined sources4
Helixi815 – 821Combined sources7
Helixi824 – 831Combined sources8
Helixi834 – 845Combined sources12
Helixi861 – 884Combined sources24
Helixi886 – 893Combined sources8
Helixi909 – 916Combined sources8
Helixi921 – 929Combined sources9
Helixi935 – 949Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IFQX-ray3.25A2-960[»]
ProteinModelPortaliP47054.
SMRiP47054.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 58Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000000809.
InParanoidiP47054.
KOiK14310.
OMAiHSWVQLV.
OrthoDBiEOG092C04O5.

Family and domain databases

InterProiIPR021827. Nup186/Nup192/Nup205.
[Graphical view]
PfamiPF11894. Nup192. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWSAIPFQT LYRSIESGEF DFDLFKEVLP DLQNLNLNTD KLKNNASRSQ
60 70 80 90 100
LEKGEIELSD GSTFKVNQEF IFEAISLSDE LNLDEIVACE LILSGDTTAN
110 120 130 140 150
NGKVQYFLRR QYILQIVSFI VNCFHEDTEL YQELIKNGAL VSNILSAFKF
160 170 180 190 200
IHTQLSEIKQ QINKAQILEN YNALFQQNIK FRRDFLLREY DILSQILYGL
210 220 230 240 250
VDKGAIMKNK DFILSLLHHV SELDSNDFFI IYYTPAFFHL FASLRVLPDA
260 270 280 290 300
DVKLLHSQFM KDLKDDSIYT KPVKVALIFI FFAYFIGWCK EDPKRRADTM
310 320 330 340 350
DFKTDVDEPM TSAVELGAIE QILIFAADTS IVEQDKSMEL FYDIRSLLER
360 370 380 390 400
HIPRLIPKQL LDDEKIFSQT TNSTYNPASA TDNMSGRGLW NPSYPGMMST
410 420 430 440 450
TGTARLNSMP NNVNEYSYTT IVLSDQTQEF FLSSFDDVLQ TIITDCAFLL
460 470 480 490 500
TKIKDAEEDS LLSGEDLTLD DISLKADLER FFLSIYFFYA SRPEYSCTFW
510 520 530 540 550
SDKESNAYGF IEWCSRCNDN LMRSCFYLMV SSLSFGPENA LNVYHYFGEN
560 570 580 590 600
SSISWKNIAQ CLSDYTKKIS NFNSSLHKRQ QFSESTHNDI DSTAVALEEG
610 620 630 640 650
LNEEAVIFLS SLLTLVGSVT YQVDEDVKSS LSKVFSDVLF EFTKINTPLV
660 670 680 690 700
GAAFKVISNL VPKLESSRTK FWSFLDSLIF KDSSLNYSSE SYRNAFTNVL
710 720 730 740 750
TKYSDVLGFL QLFHNLISIH SRENNSEYMV FGKLAFPTRL GQGYRKVGIW
760 770 780 790 800
PYFDYIFNDI LAHVDQIVDI RNKRAVQLPI LKIIYTGLCS FDYSVILNSI
810 820 830 840 850
PAAANLDALV DCENFFNYVQ ECPAIPIFNY IFTEKIYKSI FNVVDVGVDQ
860 870 880 890 900
LSIELEGGKN QAELLQLAVK IINKVLDYQE TYVEELFPIV KKHGKTDYFL
910 920 930 940 950
PKNYSLHGLR SFYDAIFFNI PLVAHLGLYV GVDDQILATN SLRILAKLSE
960 970 980 990 1000
RSNGSVASLS KRNKLLTIFD SVDESARIKD AFITQLESSI TDAGVLALKL
1010 1020 1030 1040 1050
ELLDFLTSNL SNYSRTMTIS HLLLGFQVSN VISLGPNLAT FISSGTSLLD
1060 1070 1080 1090 1100
SLISVLEASL NSITKDNIDY APMRLATAAL EIILKLCRNP LTSGLLYSYL
1110 1120 1130 1140 1150
IKENFFERIM ILDPQVTRFT TWNGSPFDNS TEEKCKNFIE SESVGAFLSF
1160 1170 1180 1190 1200
LAYRNYWTQY LGLFIHKISF SGTKSEVLTY VNYLISNTMY SVRLFSFLDP
1210 1220 1230 1240 1250
LNYGNICEPK ETLSIFTNVP LNLEQVTLNK YCSGNIYDFH KMENLMRLIK
1260 1270 1280 1290 1300
RVRAESLHSN SFSLTVSKEQ FLKDADVECI KAKSHFTNII SRNKALELNL
1310 1320 1330 1340 1350
SVLHSWVQLV QIIVTDGKLE PSTRSNFILE VFGTIIPKIS DYIEFNITFS
1360 1370 1380 1390 1400
EELVSLAVFL FDIYNRDRKL ITDKGTVDGR LYQLFKTCIQ GINSPLSSVA
1410 1420 1430 1440 1450
LRSDFYILAN HYLSRVLSDQ VGSEKVLQDL RLGSKKLVEI IWNDVVYGEG
1460 1470 1480 1490 1500
TSRVTGILLL DSLIQLANRS KENFILDSLM KTTRLLLIIR SLKNTDALLN
1510 1520 1530 1540 1550
STTEHINIDD LLYELTAFKA TVFFLIRVAE TRGGASALIE NNLFRIIAEL
1560 1570 1580 1590 1600
SFLKVDPDLG LDLMFDEVYV QNSKFLKVNV TLDNPLLVDK DANGVSLFEL
1610 1620 1630 1640 1650
IVPIFQLISA VLVSMGSSNK AVVQTVKGLL NTYKRLVIGI FKRDLLREKE
1660 1670 1680
DKKNSSDPNN QSLNEMVKLI VMLCTLTGYQ NND
Length:1,683
Mass (Da):191,535
Last modified:February 1, 1996 - v1
Checksum:iFD2D61FDEA5451C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49314 Genomic DNA. Translation: CAA89330.1.
BK006943 Genomic DNA. Translation: DAA08760.1.
PIRiS56811.
RefSeqiNP_012495.1. NM_001181473.1.

Genome annotation databases

EnsemblFungiiYJL039C; YJL039C; YJL039C.
GeneIDi853410.
KEGGisce:YJL039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49314 Genomic DNA. Translation: CAA89330.1.
BK006943 Genomic DNA. Translation: DAA08760.1.
PIRiS56811.
RefSeqiNP_012495.1. NM_001181473.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IFQX-ray3.25A2-960[»]
ProteinModelPortaliP47054.
SMRiP47054.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33718. 58 interactors.
DIPiDIP-2442N.
IntActiP47054. 23 interactors.
MINTiMINT-496527.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Proteomic databases

MaxQBiP47054.
PRIDEiP47054.

Protocols and materials databases

DNASUi853410.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL039C; YJL039C; YJL039C.
GeneIDi853410.
KEGGisce:YJL039C.

Organism-specific databases

EuPathDBiFungiDB:YJL039C.
SGDiS000003576. NUP192.

Phylogenomic databases

HOGENOMiHOG000000809.
InParanoidiP47054.
KOiK14310.
OMAiHSWVQLV.
OrthoDBiEOG092C04O5.

Enzyme and pathway databases

BioCyciYEAST:G3O-31505-MONOMER.

Miscellaneous databases

PROiP47054.

Family and domain databases

InterProiIPR021827. Nup186/Nup192/Nup205.
[Graphical view]
PfamiPF11894. Nup192. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU192_YEAST
AccessioniPrimary (citable) accession number: P47054
Secondary accession number(s): D6VWE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2520 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.