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Protein

Nucleoporin NUP192

Gene

NUP192

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs.2 Publications

GO - Molecular functioni

  • structural constituent of nuclear pore Source: SGD

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nuclear pore organization Source: SGD
  • protein transport Source: UniProtKB-KW
  • regulation of nucleocytoplasmic transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31505-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP192
Alternative name(s):
Nuclear pore protein NUP192
Gene namesi
Name:NUP192
Ordered Locus Names:YJL039C
ORF Names:J1216
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL039C.
SGDiS000003576. NUP192.

Subcellular locationi

  • Nucleusnuclear pore complex

  • Note: Cytoplasmic and nucleoplasmic side of the nuclear pore complex in the nuclear envelope (symmetric distribution).

GO - Cellular componenti

  • nuclear pore Source: SGD
  • nuclear pore inner ring Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16831683Nucleoporin NUP192PRO_0000204858Add
BLAST

Proteomic databases

MaxQBiP47054.
PeptideAtlasiP47054.

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEH1 and SEC1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. NUP192 interacts with NIC96.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NIC96P340773EBI-25846,EBI-12056

Protein-protein interaction databases

BioGridi33718. 58 interactions.
DIPiDIP-2442N.
IntActiP47054. 20 interactions.
MINTiMINT-496527.

Structurei

Secondary structure

1
1683
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1611Combined sources
Helixi22 – 3312Combined sources
Turni34 – 363Combined sources
Helixi48 – 525Combined sources
Beta strandi54 – 574Combined sources
Beta strandi59 – 613Combined sources
Beta strandi63 – 653Combined sources
Helixi68 – 8013Combined sources
Helixi87 – 948Combined sources
Helixi102 – 12322Combined sources
Helixi129 – 1368Combined sources
Helixi139 – 16729Combined sources
Helixi173 – 20230Combined sources
Beta strandi208 – 2103Combined sources
Helixi211 – 22111Combined sources
Helixi228 – 2336Combined sources
Helixi234 – 2418Combined sources
Helixi242 – 2465Combined sources
Helixi249 – 26214Combined sources
Helixi266 – 2705Combined sources
Helixi272 – 28918Combined sources
Turni293 – 2997Combined sources
Helixi302 – 3054Combined sources
Helixi307 – 3159Combined sources
Helixi318 – 32710Combined sources
Helixi332 – 3343Combined sources
Helixi344 – 3485Combined sources
Helixi358 – 3603Combined sources
Helixi425 – 44521Combined sources
Helixi447 – 46014Combined sources
Beta strandi463 – 4653Combined sources
Helixi469 – 4746Combined sources
Helixi477 – 48913Combined sources
Helixi493 – 4964Combined sources
Helixi498 – 5014Combined sources
Beta strandi503 – 5053Combined sources
Helixi506 – 5149Combined sources
Helixi520 – 53314Combined sources
Helixi537 – 54812Combined sources
Beta strandi549 – 5535Combined sources
Helixi555 – 57218Combined sources
Helixi603 – 62220Combined sources
Helixi625 – 64218Combined sources
Helixi650 – 66011Combined sources
Helixi665 – 6684Combined sources
Helixi669 – 68012Combined sources
Helixi689 – 69911Combined sources
Helixi703 – 71614Combined sources
Turni738 – 7447Combined sources
Beta strandi745 – 7495Combined sources
Helixi750 – 7589Combined sources
Helixi761 – 7666Combined sources
Helixi770 – 78920Combined sources
Helixi794 – 7974Combined sources
Helixi815 – 8217Combined sources
Helixi824 – 8318Combined sources
Helixi834 – 84512Combined sources
Helixi861 – 88424Combined sources
Helixi886 – 8938Combined sources
Helixi909 – 9168Combined sources
Helixi921 – 9299Combined sources
Helixi935 – 94915Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IFQX-ray3.25A2-960[»]
ProteinModelPortaliP47054.
SMRiP47054. Positions 1-954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili31 – 5828Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000000809.
InParanoidiP47054.
KOiK14310.
OMAiWGLSNNT.
OrthoDBiEOG74BK18.

Family and domain databases

InterProiIPR021827. Nup186/Nup192/Nup205.
[Graphical view]
PfamiPF11894. Nup192. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWSAIPFQT LYRSIESGEF DFDLFKEVLP DLQNLNLNTD KLKNNASRSQ
60 70 80 90 100
LEKGEIELSD GSTFKVNQEF IFEAISLSDE LNLDEIVACE LILSGDTTAN
110 120 130 140 150
NGKVQYFLRR QYILQIVSFI VNCFHEDTEL YQELIKNGAL VSNILSAFKF
160 170 180 190 200
IHTQLSEIKQ QINKAQILEN YNALFQQNIK FRRDFLLREY DILSQILYGL
210 220 230 240 250
VDKGAIMKNK DFILSLLHHV SELDSNDFFI IYYTPAFFHL FASLRVLPDA
260 270 280 290 300
DVKLLHSQFM KDLKDDSIYT KPVKVALIFI FFAYFIGWCK EDPKRRADTM
310 320 330 340 350
DFKTDVDEPM TSAVELGAIE QILIFAADTS IVEQDKSMEL FYDIRSLLER
360 370 380 390 400
HIPRLIPKQL LDDEKIFSQT TNSTYNPASA TDNMSGRGLW NPSYPGMMST
410 420 430 440 450
TGTARLNSMP NNVNEYSYTT IVLSDQTQEF FLSSFDDVLQ TIITDCAFLL
460 470 480 490 500
TKIKDAEEDS LLSGEDLTLD DISLKADLER FFLSIYFFYA SRPEYSCTFW
510 520 530 540 550
SDKESNAYGF IEWCSRCNDN LMRSCFYLMV SSLSFGPENA LNVYHYFGEN
560 570 580 590 600
SSISWKNIAQ CLSDYTKKIS NFNSSLHKRQ QFSESTHNDI DSTAVALEEG
610 620 630 640 650
LNEEAVIFLS SLLTLVGSVT YQVDEDVKSS LSKVFSDVLF EFTKINTPLV
660 670 680 690 700
GAAFKVISNL VPKLESSRTK FWSFLDSLIF KDSSLNYSSE SYRNAFTNVL
710 720 730 740 750
TKYSDVLGFL QLFHNLISIH SRENNSEYMV FGKLAFPTRL GQGYRKVGIW
760 770 780 790 800
PYFDYIFNDI LAHVDQIVDI RNKRAVQLPI LKIIYTGLCS FDYSVILNSI
810 820 830 840 850
PAAANLDALV DCENFFNYVQ ECPAIPIFNY IFTEKIYKSI FNVVDVGVDQ
860 870 880 890 900
LSIELEGGKN QAELLQLAVK IINKVLDYQE TYVEELFPIV KKHGKTDYFL
910 920 930 940 950
PKNYSLHGLR SFYDAIFFNI PLVAHLGLYV GVDDQILATN SLRILAKLSE
960 970 980 990 1000
RSNGSVASLS KRNKLLTIFD SVDESARIKD AFITQLESSI TDAGVLALKL
1010 1020 1030 1040 1050
ELLDFLTSNL SNYSRTMTIS HLLLGFQVSN VISLGPNLAT FISSGTSLLD
1060 1070 1080 1090 1100
SLISVLEASL NSITKDNIDY APMRLATAAL EIILKLCRNP LTSGLLYSYL
1110 1120 1130 1140 1150
IKENFFERIM ILDPQVTRFT TWNGSPFDNS TEEKCKNFIE SESVGAFLSF
1160 1170 1180 1190 1200
LAYRNYWTQY LGLFIHKISF SGTKSEVLTY VNYLISNTMY SVRLFSFLDP
1210 1220 1230 1240 1250
LNYGNICEPK ETLSIFTNVP LNLEQVTLNK YCSGNIYDFH KMENLMRLIK
1260 1270 1280 1290 1300
RVRAESLHSN SFSLTVSKEQ FLKDADVECI KAKSHFTNII SRNKALELNL
1310 1320 1330 1340 1350
SVLHSWVQLV QIIVTDGKLE PSTRSNFILE VFGTIIPKIS DYIEFNITFS
1360 1370 1380 1390 1400
EELVSLAVFL FDIYNRDRKL ITDKGTVDGR LYQLFKTCIQ GINSPLSSVA
1410 1420 1430 1440 1450
LRSDFYILAN HYLSRVLSDQ VGSEKVLQDL RLGSKKLVEI IWNDVVYGEG
1460 1470 1480 1490 1500
TSRVTGILLL DSLIQLANRS KENFILDSLM KTTRLLLIIR SLKNTDALLN
1510 1520 1530 1540 1550
STTEHINIDD LLYELTAFKA TVFFLIRVAE TRGGASALIE NNLFRIIAEL
1560 1570 1580 1590 1600
SFLKVDPDLG LDLMFDEVYV QNSKFLKVNV TLDNPLLVDK DANGVSLFEL
1610 1620 1630 1640 1650
IVPIFQLISA VLVSMGSSNK AVVQTVKGLL NTYKRLVIGI FKRDLLREKE
1660 1670 1680
DKKNSSDPNN QSLNEMVKLI VMLCTLTGYQ NND
Length:1,683
Mass (Da):191,535
Last modified:February 1, 1996 - v1
Checksum:iFD2D61FDEA5451C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49314 Genomic DNA. Translation: CAA89330.1.
BK006943 Genomic DNA. Translation: DAA08760.1.
PIRiS56811.
RefSeqiNP_012495.1. NM_001181473.1.

Genome annotation databases

EnsemblFungiiYJL039C; YJL039C; YJL039C.
GeneIDi853410.
KEGGisce:YJL039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49314 Genomic DNA. Translation: CAA89330.1.
BK006943 Genomic DNA. Translation: DAA08760.1.
PIRiS56811.
RefSeqiNP_012495.1. NM_001181473.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IFQX-ray3.25A2-960[»]
ProteinModelPortaliP47054.
SMRiP47054. Positions 1-954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33718. 58 interactions.
DIPiDIP-2442N.
IntActiP47054. 20 interactions.
MINTiMINT-496527.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Proteomic databases

MaxQBiP47054.
PeptideAtlasiP47054.

Protocols and materials databases

DNASUi853410.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL039C; YJL039C; YJL039C.
GeneIDi853410.
KEGGisce:YJL039C.

Organism-specific databases

EuPathDBiFungiDB:YJL039C.
SGDiS000003576. NUP192.

Phylogenomic databases

HOGENOMiHOG000000809.
InParanoidiP47054.
KOiK14310.
OMAiWGLSNNT.
OrthoDBiEOG74BK18.

Enzyme and pathway databases

BioCyciYEAST:G3O-31505-MONOMER.

Miscellaneous databases

PROiP47054.

Family and domain databases

InterProiIPR021827. Nup186/Nup192/Nup205.
[Graphical view]
PfamiPF11894. Nup192. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Nup192p is a conserved nucleoporin with a preferential location at the inner site of the nuclear membrane."
    Kosova B., Pante N., Rollenhagen C., Hurt E.C.
    J. Biol. Chem. 274:22646-22651(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NIC96, LOCATION WITHIN THE NPC.
  4. "Yeast nuclear pore complex assembly defects determined by nuclear envelope reconstruction."
    Gomez-Ospina N., Morgan G., Giddings T.H. Jr., Kosova B., Hurt E.C., Winey M.
    J. Struct. Biol. 132:1-5(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, NPC DE NOVO ASSEMBLY.
  5. "The yeast nuclear pore complex: composition, architecture, and transport mechanism."
    Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T.
    J. Cell Biol. 148:635-651(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, NPC SUBUNIT LOCATION.
  6. "Peering through the pore: nuclear pore complex structure, assembly, and function."
    Suntharalingam M., Wente S.R.
    Dev. Cell 4:775-789(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 2-960.

Entry informationi

Entry nameiNU192_YEAST
AccessioniPrimary (citable) accession number: P47054
Secondary accession number(s): D6VWE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2520 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.