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Protein

Zinc-responsive transcriptional regulator ZAP1

Gene

ZAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri579 – 604C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri616 – 641C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri705 – 730C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri738 – 762C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri768 – 790C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri796 – 818C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri824 – 846C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • RNA polymerase II regulatory region sequence-specific DNA binding Source: SGD
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: SGD
  • zinc ion binding Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31519-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-responsive transcriptional regulator ZAP1
Gene namesi
Name:ZAP1
Ordered Locus Names:YJL056C
ORF Names:J1145
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL056C.
SGDiS000003592. ZAP1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000468591 – 880Zinc-responsive transcriptional regulator ZAP1Add BLAST880

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP47043.
PRIDEiP47043.

PTM databases

iPTMnetiP47043.

Interactioni

Protein-protein interaction databases

BioGridi33698. 73 interactors.
DIPiDIP-1565N.
IntActiP47043. 5 interactors.
MINTiMINT-386852.

Structurei

Secondary structure

1880
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi593 – 603Combined sources11
Beta strandi626 – 629Combined sources4
Helixi630 – 640Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZW8NMR-A578-641[»]
ProteinModelPortaliP47043.
SMRiP47043.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47043.

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri579 – 604C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri616 – 641C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri705 – 730C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri738 – 762C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri768 – 790C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri796 – 818C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri824 – 846C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00860000133926.
HOGENOMiHOG000141792.
InParanoidiP47043.
OMAiGHIHNYN.
OrthoDBiEOG092C5XWP.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47043-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALTPRDSP KRDDSMATSA ATAASAKPDA LTIGKEGIVH GHIHNYNNLT
60 70 80 90 100
YIHGHLHHSA PVNDSSASAT PAAAAVADAA TSAFASGASH DMGGDCHVNE
110 120 130 140 150
KCKEYTDCQH FEFLNYHNNP SLTKYNDTAT YNSNNHSFAN NFHSVASDPT
160 170 180 190 200
SPQQNSKSDL PRRKDSWFND DLILLPSSKK NKPNPPPGSD DCYCTPKILE
210 220 230 240 250
ICCDETHPKS EANIKQGESD QPTKKDISEN GNDVAIFTDV KNDHLMPNFN
260 270 280 290 300
LHDQYCNSTN HDSHNHNNTV PDSFSQLMSH LSEIDCDLTC DTPCTASTSA
310 320 330 340 350
TSGHKFVQDH QSSNNDDVFH KYCKFCEEST DNQPCSKHMH LESKPPQLPP
360 370 380 390 400
KCSSLRKPTN TLQGTNHAYH EHILNTDMDL KILEDLCNIS SLYEVPFGKH
410 420 430 440 450
INHHDHNNAG NGCDGSSTGN NENGNQTMNL LLSSINRCNP KNNLNGSNNN
460 470 480 490 500
TAGATSTDHQ HHHHRIQFHS HKPNRNNIVN NSGISAANTT ADLTNNDLND
510 520 530 540 550
LISREYSYER FRNQSEPPSL PKVTHQNQKN RRSWPTKDLE STDFSSLEDS
560 570 580 590 600
LPSSISPPIQ TTSTINFNWC FKEEKNNDLK CKWKECPESC SSLFDLQRHL
610 620 630 640 650
LKDHVSQDFK HPMEPLACNW EDCDFLGDDT CSIVNHINCQ HGINFDIQFA
660 670 680 690 700
NPDSFLPGSI SKEKHHLLHC PNPQTHEVSK ADGAPDMTSA NDVSNIPPIK
710 720 730 740 750
QPEQVICQWD GCNKSFSSAQ ELNDHLEAVH LTRGKSEYQC LWHDCHRTFP
760 770 780 790 800
QRQKLIRHLK VHSKYKPYKC KTCKRCFSSE ETLVQHTRTH SGEKPYKCHI
810 820 830 840 850
CNKKFAISSS LKIHIRTHTG EKPLQCKICG KRFNESSNLS KHIKTHQKKY
860 870 880
KCSDCSKSFD DLGKLNSQKV KCALERKPYL
Length:880
Mass (Da):98,866
Last modified:February 1, 1996 - v1
Checksum:i4B0C2E818FAFE7F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49331 Genomic DNA. Translation: CAA89347.1.
BK006943 Genomic DNA. Translation: DAA08742.1.
PIRiS56828.
RefSeqiNP_012479.1. NM_001181489.1.

Genome annotation databases

EnsemblFungiiYJL056C; YJL056C; YJL056C.
GeneIDi853390.
KEGGisce:YJL056C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49331 Genomic DNA. Translation: CAA89347.1.
BK006943 Genomic DNA. Translation: DAA08742.1.
PIRiS56828.
RefSeqiNP_012479.1. NM_001181489.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZW8NMR-A578-641[»]
ProteinModelPortaliP47043.
SMRiP47043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33698. 73 interactors.
DIPiDIP-1565N.
IntActiP47043. 5 interactors.
MINTiMINT-386852.

PTM databases

iPTMnetiP47043.

Proteomic databases

MaxQBiP47043.
PRIDEiP47043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL056C; YJL056C; YJL056C.
GeneIDi853390.
KEGGisce:YJL056C.

Organism-specific databases

EuPathDBiFungiDB:YJL056C.
SGDiS000003592. ZAP1.

Phylogenomic databases

GeneTreeiENSGT00860000133926.
HOGENOMiHOG000141792.
InParanoidiP47043.
OMAiGHIHNYN.
OrthoDBiEOG092C5XWP.

Enzyme and pathway databases

BioCyciYEAST:G3O-31519-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP47043.
PROiP47043.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZAP1_YEAST
AccessioniPrimary (citable) accession number: P47043
Secondary accession number(s): D6VWC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.