Zinc-responsive transcriptional regulator ZAP1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Zinc-responsive transcriptional regulator ZAP1

Gene names

Name:	ZAP1
Ordered Locus Names:	YJL056C
ORF Names:	J1145

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	880 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 7 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 22128164. Source: SGD regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation Inferred from mutant phenotype PubMed 9271382 PubMed 9786867. Source: SGD
Cellular_component	nucleus Inferred from direct assay PubMed 10899124. Source: SGD
Molecular_function	RNA polymerase II regulatory region sequence-specific DNA binding Inferred from direct assay PubMed 9786867. Source: SGD sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from direct assay PubMed 22128164. Source: SGD zinc ion binding Inferred from direct assay PubMed 14517251 PubMed 16720702. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 880

880

Zinc-responsive transcriptional regulator ZAP1

PRO_0000046859

Regions

Zinc finger

579 – 604

26

C2H2-type 1

Zinc finger

616 – 641

26

C2H2-type 2; atypical

Zinc finger

705 – 730

26

C2H2-type 3

Zinc finger

738 – 762

25

C2H2-type 4

Zinc finger

768 – 790

23

C2H2-type 5

Zinc finger

796 – 818

23

C2H2-type 6

Zinc finger

824 – 846

23

C2H2-type 7

Secondary structure

1

.

880

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P47043 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 4B0C2E818FAFE7F6
Show »

FASTA

880

98,866

        10         20         30         40         50         60 
MDALTPRDSP KRDDSMATSA ATAASAKPDA LTIGKEGIVH GHIHNYNNLT YIHGHLHHSA 

        70         80         90        100        110        120 
PVNDSSASAT PAAAAVADAA TSAFASGASH DMGGDCHVNE KCKEYTDCQH FEFLNYHNNP 

       130        140        150        160        170        180 
SLTKYNDTAT YNSNNHSFAN NFHSVASDPT SPQQNSKSDL PRRKDSWFND DLILLPSSKK 

       190        200        210        220        230        240 
NKPNPPPGSD DCYCTPKILE ICCDETHPKS EANIKQGESD QPTKKDISEN GNDVAIFTDV 

       250        260        270        280        290        300 
KNDHLMPNFN LHDQYCNSTN HDSHNHNNTV PDSFSQLMSH LSEIDCDLTC DTPCTASTSA 

       310        320        330        340        350        360 
TSGHKFVQDH QSSNNDDVFH KYCKFCEEST DNQPCSKHMH LESKPPQLPP KCSSLRKPTN 

       370        380        390        400        410        420 
TLQGTNHAYH EHILNTDMDL KILEDLCNIS SLYEVPFGKH INHHDHNNAG NGCDGSSTGN 

       430        440        450        460        470        480 
NENGNQTMNL LLSSINRCNP KNNLNGSNNN TAGATSTDHQ HHHHRIQFHS HKPNRNNIVN 

       490        500        510        520        530        540 
NSGISAANTT ADLTNNDLND LISREYSYER FRNQSEPPSL PKVTHQNQKN RRSWPTKDLE 

       550        560        570        580        590        600 
STDFSSLEDS LPSSISPPIQ TTSTINFNWC FKEEKNNDLK CKWKECPESC SSLFDLQRHL 

       610        620        630        640        650        660 
LKDHVSQDFK HPMEPLACNW EDCDFLGDDT CSIVNHINCQ HGINFDIQFA NPDSFLPGSI 

       670        680        690        700        710        720 
SKEKHHLLHC PNPQTHEVSK ADGAPDMTSA NDVSNIPPIK QPEQVICQWD GCNKSFSSAQ 

       730        740        750        760        770        780 
ELNDHLEAVH LTRGKSEYQC LWHDCHRTFP QRQKLIRHLK VHSKYKPYKC KTCKRCFSSE 

       790        800        810        820        830        840 
ETLVQHTRTH SGEKPYKCHI CNKKFAISSS LKIHIRTHTG EKPLQCKICG KRFNESSNLS 

       850        860        870        880 
KHIKTHQKKY KCSDCSKSFD DLGKLNSQKV KCALERKPYL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. Karpfinger-Hartl L. EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z49331 Genomic DNA. Translation: CAA89347.1.
BK006943 Genomic DNA. Translation: DAA08742.1.

PIR

S56828.

RefSeq

NP_012479.1. NM_001181489.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZW8	NMR	-	A	578-641	[»]

ProteinModelPortal

P47043.

SMR

P47043. Positions 578-641, 712-879.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-1565N.

IntAct

P47043. 3 interactions.

MINT

MINT-386852.

STRING

4932.YJL056C.

Proteomic databases

PaxDb

P47043.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YJL056C; YJL056C; YJL056C.

GeneID

853390.

KEGG

sce:YJL056C.

Organism-specific databases

CYGD

YJL056c.

SGD

S000003592. ZAP1.

Phylogenomic databases

eggNOG

COG5048.

GeneTree

ENSGT00560000077283.

HOGENOM

HOG000141792.

OMA

RFNESSN.

OrthoDB

EOG4WDHMT.

Gene expression databases

Genevestigator

P47043.

GermOnline

YJL056C. Saccharomyces cerevisiae.

Family and domain databases

Gene3D

3.30.160.60. 5 hits.

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 7 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P47043.

NextBio

973861.

Entry information

Entry name

ZAP1_YEAST

Accession

Primary (citable) accession number: P47043
Secondary accession number(s): D6VWC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families