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P47043

- ZAP1_YEAST

UniProt

P47043 - ZAP1_YEAST

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Protein

Zinc-responsive transcriptional regulator ZAP1

Gene

ZAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri579 – 60426C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri616 – 64126C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 73026C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri738 – 76225C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri796 – 81823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri824 – 84623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: SGD
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: SGD
  3. zinc ion binding Source: SGD

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  2. regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation Source: SGD
  3. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31519-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-responsive transcriptional regulator ZAP1
Gene namesi
Name:ZAP1
Ordered Locus Names:YJL056C
ORF Names:J1145
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL056c.
SGDiS000003592. ZAP1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Zinc-responsive transcriptional regulator ZAP1PRO_0000046859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei156 – 1561Phosphoserine1 Publication
Modified residuei166 – 1661Phosphoserine1 Publication
Modified residuei515 – 5151Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP47043.
PaxDbiP47043.

Expressioni

Gene expression databases

GenevestigatoriP47043.

Interactioni

Protein-protein interaction databases

BioGridi33698. 72 interactions.
DIPiDIP-1565N.
IntActiP47043. 5 interactions.
MINTiMINT-386852.
STRINGi4932.YJL056C.

Structurei

Secondary structure

1
880
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi593 – 60311Combined sources
Beta strandi626 – 6294Combined sources
Helixi630 – 64011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZW8NMR-A578-641[»]
ProteinModelPortaliP47043.
SMRiP47043. Positions 578-641, 712-879.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47043.

Family & Domainsi

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri579 – 60426C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri616 – 64126C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 73026C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri738 – 76225C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri796 – 81823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri824 – 84623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120724.
HOGENOMiHOG000141792.
InParanoidiP47043.
OMAiGHIHNYN.
OrthoDBiEOG708W7K.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P47043-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDALTPRDSP KRDDSMATSA ATAASAKPDA LTIGKEGIVH GHIHNYNNLT
60 70 80 90 100
YIHGHLHHSA PVNDSSASAT PAAAAVADAA TSAFASGASH DMGGDCHVNE
110 120 130 140 150
KCKEYTDCQH FEFLNYHNNP SLTKYNDTAT YNSNNHSFAN NFHSVASDPT
160 170 180 190 200
SPQQNSKSDL PRRKDSWFND DLILLPSSKK NKPNPPPGSD DCYCTPKILE
210 220 230 240 250
ICCDETHPKS EANIKQGESD QPTKKDISEN GNDVAIFTDV KNDHLMPNFN
260 270 280 290 300
LHDQYCNSTN HDSHNHNNTV PDSFSQLMSH LSEIDCDLTC DTPCTASTSA
310 320 330 340 350
TSGHKFVQDH QSSNNDDVFH KYCKFCEEST DNQPCSKHMH LESKPPQLPP
360 370 380 390 400
KCSSLRKPTN TLQGTNHAYH EHILNTDMDL KILEDLCNIS SLYEVPFGKH
410 420 430 440 450
INHHDHNNAG NGCDGSSTGN NENGNQTMNL LLSSINRCNP KNNLNGSNNN
460 470 480 490 500
TAGATSTDHQ HHHHRIQFHS HKPNRNNIVN NSGISAANTT ADLTNNDLND
510 520 530 540 550
LISREYSYER FRNQSEPPSL PKVTHQNQKN RRSWPTKDLE STDFSSLEDS
560 570 580 590 600
LPSSISPPIQ TTSTINFNWC FKEEKNNDLK CKWKECPESC SSLFDLQRHL
610 620 630 640 650
LKDHVSQDFK HPMEPLACNW EDCDFLGDDT CSIVNHINCQ HGINFDIQFA
660 670 680 690 700
NPDSFLPGSI SKEKHHLLHC PNPQTHEVSK ADGAPDMTSA NDVSNIPPIK
710 720 730 740 750
QPEQVICQWD GCNKSFSSAQ ELNDHLEAVH LTRGKSEYQC LWHDCHRTFP
760 770 780 790 800
QRQKLIRHLK VHSKYKPYKC KTCKRCFSSE ETLVQHTRTH SGEKPYKCHI
810 820 830 840 850
CNKKFAISSS LKIHIRTHTG EKPLQCKICG KRFNESSNLS KHIKTHQKKY
860 870 880
KCSDCSKSFD DLGKLNSQKV KCALERKPYL
Length:880
Mass (Da):98,866
Last modified:February 1, 1996 - v1
Checksum:i4B0C2E818FAFE7F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49331 Genomic DNA. Translation: CAA89347.1.
BK006943 Genomic DNA. Translation: DAA08742.1.
PIRiS56828.
RefSeqiNP_012479.1. NM_001181489.1.

Genome annotation databases

EnsemblFungiiYJL056C; YJL056C; YJL056C.
GeneIDi853390.
KEGGisce:YJL056C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49331 Genomic DNA. Translation: CAA89347.1 .
BK006943 Genomic DNA. Translation: DAA08742.1 .
PIRi S56828.
RefSeqi NP_012479.1. NM_001181489.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZW8 NMR - A 578-641 [» ]
ProteinModelPortali P47043.
SMRi P47043. Positions 578-641, 712-879.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33698. 72 interactions.
DIPi DIP-1565N.
IntActi P47043. 5 interactions.
MINTi MINT-386852.
STRINGi 4932.YJL056C.

Proteomic databases

MaxQBi P47043.
PaxDbi P47043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL056C ; YJL056C ; YJL056C .
GeneIDi 853390.
KEGGi sce:YJL056C.

Organism-specific databases

CYGDi YJL056c.
SGDi S000003592. ZAP1.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00770000120724.
HOGENOMi HOG000141792.
InParanoidi P47043.
OMAi GHIHNYN.
OrthoDBi EOG708W7K.

Enzyme and pathway databases

BioCyci YEAST:G3O-31519-MONOMER.

Miscellaneous databases

EvolutionaryTracei P47043.
NextBioi 973861.

Gene expression databases

Genevestigatori P47043.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-166 AND SER-515, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZAP1_YEAST
AccessioniPrimary (citable) accession number: P47043
Secondary accession number(s): D6VWC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3