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P47043

- ZAP1_YEAST

UniProt

P47043 - ZAP1_YEAST

Protein

Zinc-responsive transcriptional regulator ZAP1

Gene

ZAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri579 – 60426C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri616 – 64126C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri705 – 73026C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri738 – 76225C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri768 – 79023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri796 – 81823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri824 – 84623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II regulatory region sequence-specific DNA binding Source: SGD
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: SGD
    3. zinc ion binding Source: SGD

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    2. regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation Source: SGD
    3. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31519-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc-responsive transcriptional regulator ZAP1
    Gene namesi
    Name:ZAP1
    Ordered Locus Names:YJL056C
    ORF Names:J1145
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    CYGDiYJL056c.
    SGDiS000003592. ZAP1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 880880Zinc-responsive transcriptional regulator ZAP1PRO_0000046859Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei156 – 1561Phosphoserine1 Publication
    Modified residuei166 – 1661Phosphoserine1 Publication
    Modified residuei515 – 5151Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP47043.
    PaxDbiP47043.

    Expressioni

    Gene expression databases

    GenevestigatoriP47043.

    Interactioni

    Protein-protein interaction databases

    BioGridi33698. 72 interactions.
    DIPiDIP-1565N.
    IntActiP47043. 5 interactions.
    MINTiMINT-386852.
    STRINGi4932.YJL056C.

    Structurei

    Secondary structure

    1
    880
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi593 – 60311
    Beta strandi626 – 6294
    Helixi630 – 64011

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZW8NMR-A578-641[»]
    ProteinModelPortaliP47043.
    SMRiP47043. Positions 578-641, 712-879.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP47043.

    Family & Domainsi

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri579 – 60426C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri616 – 64126C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri705 – 73026C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri738 – 76225C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri768 – 79023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri796 – 81823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri824 – 84623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117476.
    HOGENOMiHOG000141792.
    OMAiGHIHNYN.
    OrthoDBiEOG708W7K.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P47043-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDALTPRDSP KRDDSMATSA ATAASAKPDA LTIGKEGIVH GHIHNYNNLT    50
    YIHGHLHHSA PVNDSSASAT PAAAAVADAA TSAFASGASH DMGGDCHVNE 100
    KCKEYTDCQH FEFLNYHNNP SLTKYNDTAT YNSNNHSFAN NFHSVASDPT 150
    SPQQNSKSDL PRRKDSWFND DLILLPSSKK NKPNPPPGSD DCYCTPKILE 200
    ICCDETHPKS EANIKQGESD QPTKKDISEN GNDVAIFTDV KNDHLMPNFN 250
    LHDQYCNSTN HDSHNHNNTV PDSFSQLMSH LSEIDCDLTC DTPCTASTSA 300
    TSGHKFVQDH QSSNNDDVFH KYCKFCEEST DNQPCSKHMH LESKPPQLPP 350
    KCSSLRKPTN TLQGTNHAYH EHILNTDMDL KILEDLCNIS SLYEVPFGKH 400
    INHHDHNNAG NGCDGSSTGN NENGNQTMNL LLSSINRCNP KNNLNGSNNN 450
    TAGATSTDHQ HHHHRIQFHS HKPNRNNIVN NSGISAANTT ADLTNNDLND 500
    LISREYSYER FRNQSEPPSL PKVTHQNQKN RRSWPTKDLE STDFSSLEDS 550
    LPSSISPPIQ TTSTINFNWC FKEEKNNDLK CKWKECPESC SSLFDLQRHL 600
    LKDHVSQDFK HPMEPLACNW EDCDFLGDDT CSIVNHINCQ HGINFDIQFA 650
    NPDSFLPGSI SKEKHHLLHC PNPQTHEVSK ADGAPDMTSA NDVSNIPPIK 700
    QPEQVICQWD GCNKSFSSAQ ELNDHLEAVH LTRGKSEYQC LWHDCHRTFP 750
    QRQKLIRHLK VHSKYKPYKC KTCKRCFSSE ETLVQHTRTH SGEKPYKCHI 800
    CNKKFAISSS LKIHIRTHTG EKPLQCKICG KRFNESSNLS KHIKTHQKKY 850
    KCSDCSKSFD DLGKLNSQKV KCALERKPYL 880
    Length:880
    Mass (Da):98,866
    Last modified:February 1, 1996 - v1
    Checksum:i4B0C2E818FAFE7F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49331 Genomic DNA. Translation: CAA89347.1.
    BK006943 Genomic DNA. Translation: DAA08742.1.
    PIRiS56828.
    RefSeqiNP_012479.1. NM_001181489.1.

    Genome annotation databases

    EnsemblFungiiYJL056C; YJL056C; YJL056C.
    GeneIDi853390.
    KEGGisce:YJL056C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49331 Genomic DNA. Translation: CAA89347.1 .
    BK006943 Genomic DNA. Translation: DAA08742.1 .
    PIRi S56828.
    RefSeqi NP_012479.1. NM_001181489.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZW8 NMR - A 578-641 [» ]
    ProteinModelPortali P47043.
    SMRi P47043. Positions 578-641, 712-879.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33698. 72 interactions.
    DIPi DIP-1565N.
    IntActi P47043. 5 interactions.
    MINTi MINT-386852.
    STRINGi 4932.YJL056C.

    Proteomic databases

    MaxQBi P47043.
    PaxDbi P47043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL056C ; YJL056C ; YJL056C .
    GeneIDi 853390.
    KEGGi sce:YJL056C.

    Organism-specific databases

    CYGDi YJL056c.
    SGDi S000003592. ZAP1.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117476.
    HOGENOMi HOG000141792.
    OMAi GHIHNYN.
    OrthoDBi EOG708W7K.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31519-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P47043.
    NextBioi 973861.

    Gene expression databases

    Genevestigatori P47043.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-166 AND SER-515, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZAP1_YEAST
    AccessioniPrimary (citable) accession number: P47043
    Secondary accession number(s): D6VWC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3